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Excess Iodine

John E Strobeck, Jonathan Feldschuh, Wayne L Miller
OBJECTIVES: This study performed a retrospective outcome analyses of a large cohort of mixed ejection fraction patients admitted for acute heart failure (HF), whose inpatient care was guided by individual quantitative blood volume analysis (BVA) results. BACKGROUND: Decongestion strategies in patients hospitalized for HF are based on clinical assessment of volume and have not integrated a quantitative intravascular volume metric. METHODS: Propensity score control matching analysis was performed in 245 consecutive HF admissions to a community hospital (September 2007 to April 2014; 78 ± 10 years of age; 50% with HF with reduced ejection fraction [HFrEF]; and 30% with Stage 4 chronic kidney disease)...
October 4, 2018: JACC. Heart Failure
Aikebaier Renaguli, Y Z Luo, X L Wang, Yimamu Dilidaer, Wulamu Muyeshsaer, Julaiti Guzailinuer, Y Y Zhang, Y Y Xin, Yanying Guo
Objective: To investigate the relationship between thyrotropin (TSH) and urine iodine in pregnant women of Han and Uygur ethnic groups in People's Hospital of Xinjiang Uygur Autonomous Region. Methods: A total of 1 568 pregnant who completed screening of TSH and urine iodine in People's Hospital of Xinjiang Uygur Autonomous Region hospital from August 2014 to December 2017 were included in the study, 956 cases were Han and the other 612 were Uygur. Basic clinical data, serum TSH, thyroid peroxidase autoantibody (TPOAb) , and urine iodine levels were retrospectively analyzed...
September 25, 2018: Zhonghua Fu Chan Ke za Zhi
Yanting Chen, Wen Chen, Cong Du, Lili Fan, Wei Wang, Min Gao, Yixin Zhang, Tingkai Cui, Yunmeng Hao, Elizabeth N Pearce, Chongdan Wang, Wanqi Zhang
Pregnant women are more vulnerable to iodine deficiency and iodine excess. The study aimed to assess the changes in iodine nutrition and thyroid function of pregnant women exposed to different iodine sources resulting in various iodine intakes during pregnancy. From 2016 to 2017, 2004 healthy pregnant women aged 20-35 years from Shandong and Tianjin, China, were enrolled. Urinary iodine concentration (UIC), drinking water iodine content (WIC), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroid hormone (FT4), thyroglobulin (Tg), serum thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured...
October 2, 2018: Biological Trace Element Research
Hye In Kim, Hyun-Kyung Oh, So Young Park, Hye Won Jang, Myung-Hee Shin, Ji Min Han, Ji Cheol Bae, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
PURPOSE: In iodine-sufficient areas, autoimmune hypothyroidism has been regarded as the major subtype of hypothyroidism. Non-immune-related hypothyroidism has received little attention because it is considered to be rare. The aim of this study was to evaluate the prevalence of non-immune-related hypothyroidism in Korea and to identify its associating factors. METHODS: A total of 6434 participants in the Korea National Health and Nutrition Examination Survey VI (2013-2015) without known thyroid disease who were examined for thyroid stimulating hormone, free thyroxine, TPO Ab, and urine iodine concentration (UIC) were enrolled...
October 1, 2018: European Journal of Nutrition
Adipa Saha, Sandip Mukherjee, Ankita Bhattacharjee, Deotima Sarkar, Arijit Chakraborty, Arnab Banerjee, Amar K Chandra
Altered lymphocytic activity and its subset ratio found responsible for initiating abnormal autoimmune responses in mans and animals after excess iodine exposure. Study objective is to reveal excess iodine induced impairment of peripheral blood lymphocytes (PBL), its functional status, antioxidant balance, DNA damage, proliferation assay and serum cytokine levels (IL6 and TNF α)in adult male rats to understand the onset of autoimmune alterations if any indirectly that is unexplored. Experimental animals were grouped depending on doses of iodine (KI) treatment with moderately excess-7mg/kg bw (100EI) and excessively excess-35mg/kg bw (500EI)for 30 days to analyze IL6 and TNF α, haematological indices, oxidative stress, lymphocytic DNA damage and proliferation status...
October 1, 2018: Toxicology Mechanisms and Methods
Renjuan Chen, Qian Li, Wenli Cui, Xiaoyi Wang, Qin Gao, Chunrong Zhong, Guoqiang Sun, Xinlin Chen, Guoping Xiong, Xuefeng Yang, Liping Hao, Nianhong Yang
Background: Maternal iodine status has been suggested to affect birth outcomes. Few studies have focused on its effects on fetal growth during pregnancy. Objective: This study aimed to assess maternal iodine status during early pregnancy and further examine the relation between maternal iodine status and fetal growth. Methods: A total of 2087 singleton-pregnant women participating in the Tongji Maternal and Child Health Cohort study were involved...
September 18, 2018: Journal of Nutrition
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K Park, Jong Kwan Jun, June Key Chung
BACKGROUND: Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function. METHODS: The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery...
September 2018: Endocrinology and Metabolism
Wei Zhao, Xinyu Li, Xinghai Xia, Zhengnan Gao, Cheng Han
Iodine is a trace element that is important for the synthesis of thyroid hormones. During pregnancy, iodine requirements are increased by approximately 50% because of physiological changes. Adequate iodine status in pregnancy is crucial for maternal health and fetal growth. The World Health Organization (WHO) recommends a daily intake of 250 μg iodine for pregnant women to maintain adequate iodine status. Severe iodine deficiency during pregnancy can result in a series of detrimental effects on maternal and fetal health including hypothyroidism, goiter, stillbirth, abortion, increased neonatal mortality, neurological damage, and intellectual impairment...
September 14, 2018: Biological Trace Element Research
Margaret P Rayman
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are examples of autoimmune thyroid disease (AITD), the commonest autoimmune condition. Antibodies to thyroid peroxidase (TPO), the enzyme that catalyses thyroid-hormone production and antibodies to the receptor for the thyroid-stimulating hormone, are characteristic of HT and GD, respectively. It is presently accepted that genetic susceptibility, environmental factors, including nutritional factors and immune disorders contribute to the development of AITD...
September 13, 2018: Proceedings of the Nutrition Society
Francesca Romana Mancini, Kalina Rajaobelina, Courtney Dow, Tina Habbal, Aurélie Affret, Beverley Balkau, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi
BACKGROUND: Iodine is an essential micronutrient needed for the production of thyroid hormones. Consequently, iodine insufficient and excessive intakes are associated with thyroid disorders. Despite the increase in diabetes prevalence worldwide and the close relationship between thyroid function and the risk of diabetes, the relationship between iodine intake and diabetes has been overlooked. The objective of the present study is to investigate the link between iodine intake and the risk of type 2 diabetes...
August 25, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Maya Michelle Kumar
Individuals with disordered eating commonly exclude salt and animal products from their diets, which may predispose them to iodine deficiency even without significant weight loss. Overconsumption of dietary supplements and "natural" foods are also commonly observed among eating disorder patients. This report describes an adolescent female with disordered eating presenting with growth and pubertal delay, found to have severe iodine deficiency (urine iodine of 18 mcg/L) and abnormal thyroid function resulting from strict avoidance of salt and animal products despite adequate caloric intake...
September 6, 2018: International Journal of Eating Disorders
Zheng Feei Ma
No abstract text is available yet for this article.
November 2018: Clinical Endocrinology
Yushan Cui, Zushan Zhang, Bin Zhang, Liang Zhao, Changchun Hou, Qiang Zeng, Junyan Nie, Jingwen Yu, Yang Zhao, Tongning Gao, Aiguo Wang, Hongliang Liu
In recent years, the detrimental effects of high iodine on intelligence are gaining tons of attention, but the relationship between high iodine and neurotoxicity is controversial. This study aimed to explore whether high iodine intake may impair intelligence and the roles of apoptosis and autophagy in high iodine-induced neurotoxicity. The results showed that high iodine exposure reduced brain coefficient and intelligence of rats, and caused histopathological abnormalities in hippocampus. Moreover, high iodine increased hippocampal apoptosis, as confirmed by elevation of apoptotic proteins and TUNEL-positive incidence...
November 2018: Toxicology Letters
M Alkhorayef, A Sulieman, M Mohamed-Ahmed, H I Al-Mohammed, N Alkhomashi, A K Sam, D A Bradley
With associated cure rates in excess of 90%, targeted 131 I radioactive iodine therapy has clearly improved thyroid cancer survival. Thus said, potential radiation risks to staff represent a particular concern, current study seeking to determine the radiation exposure of staff from 131 I patients during hospitalization, also estimating accumulated dose and related risk to staff during preparation of the radioactive iodine. In present study made over the three-month period 1st February to 1st May 2017, a total of 69 patient treatments were investigated (comprising a cohort of 46 females and 23 males), this being a patient treatment load typically reflective of the workload at the particular centre for such treatments...
November 2018: Applied Radiation and Isotopes
Leonidas H Duntas
PURPOSE OF REVIEW: To review the latest developments concerning the role of iodine in the pathophysiology of autoimmune thyroiditis. RECENT FINDINGS: Recent studies have provided evidence that in areas with excess iodine intake, increased incidence of autoimmune thyroiditis marked by high titers of thyroid peroxidase and thyroglobulin antibodies has occurred. Investigations in the NOD.H2h4 mouse, a strain prone to AIT, showed that they are better adapted to the Wolff-Chaikoff effect...
October 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
Adilson da Costa, Elisangela Samartin Pegas Pereira, Margareth de Oliveira Pereira, Felipe Borba Calixto Dos Santos, Raquel Fávaro, Lissa Sabino de Matos, Thaísa Saddi Tannous, Carla Oliveira Parra Duarte, Caroline Silva Pereira
Background: Excessive sweating is a clinical condition that can be improved with type-A botulinum toxin (BTX-A). Objectives: To evaluate and compare the largest diameter of sweating inhibition halo (SIH) of 5 different commercially available BTX-A, in five different doses, in a 6-month-long clinical evaluation. Methods: Twenty-five adult female volunteers were injected in the dorsal trunk area with both 100 units (100UI) and 500 units (500UI) BTX-A products, reconstituted in a ratio of 1:2...
August 11, 2018: Aesthetic Surgery Journal
Gopalakrishnan C Nair, Misha J C Babu, Riju Menon, Pradeep Jacob
Introduction: Thyroidectomy is effective and safe procedure for permanent cure of hyperthyroidism (HT). Iodine preparations are widely used before operation to prevent excess blood loss. Ideal regimen for refractory HT is debated. This retrospective case-control study is designed to study the efficacy of various regimens of preoperative preparations. Materials and Methods: Case records, anesthesia charts, and follow-up details of hyperthyroid patients undergoing thyroidectomy were reviewed and compared with an age- and sex-matched euthyroid patients operated during the same period...
May 2018: Indian Journal of Endocrinology and Metabolism
Juliane Léger, Jean Claude Carel
Hyperthyroidism in children is a rare heterogeneous syndrome characterized by excessive thyroid hormone production. Its manifestations differ according to disease severity. For all forms of hyperthyroidism, treatment aims to restore a euthyroid state, enabling the child to demonstrate appropriate metabolism, growth, and neurocognitive development. Graves' disease is the most frequent cause of hyperthyroidism in children. Treatment modalities include antithyroid drugs, with the advantage that prolonged treatment for several years can be followed by freedom from medical intervention in about 40-50% of cases...
August 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
Y C Venu Gopal Reddy, Anuj Sharma, Adheesh P Shetty, Syed Mohideen Abdul Kader
Background: Iodine deficiency is a common preventable cause of intellectual and developmental disabilities. Iodine in the form of potassium iodate is added to the common salt under the National Iodine Deficiency Disorder Control Program in India. Overdose of iodate can lead to retinal toxicity. Case presentation: We hereby present a case of a 34 year old male patient who presented to us 10 years following iodate ingestion. There was widespread outer retinal atrophy, foveal atrophy and sub-retinal fibrosis noted on fundus evaluation...
2018: International Journal of Retina and Vitreous
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