Read by QxMD icon Read

Excess Iodine

Brenda A Z Abu, Wilna Oldewage-Theron, Richmond N O Aryeetey
In Ghana, iodine deficiency was first reported in 1994 among 33% of the population. A nationwide Universal Salt Iodization (USI) program plus other complementary interventions were subsequently implemented as a response. Our paper reviews the current risks of excess iodine status in Ghana and identifies policy and research gaps. A mixed methods review of 12 policies and institutional reports and 13 peer-reviewed articles was complemented with consultations with 23 key informants (salt producers and distributors, food processors, regulatory agency officials, and healthcare providers) purposively sampled between May and August 2017...
November 29, 2018: Annals of the New York Academy of Sciences
Renuka Jayatissa, Dulitha N Fernando
In recent decades, Sri Lanka has made substantial progress in reducing the burden of micronutrient deficiencies in children by the provision of vitamin A megadose and micronutrient supplementation programs for children of 6-23 months, along with universal iodization of salt. Consumption of voluntarily fortified foods by children was also considerably increased. The objective of our study here was to review such interventions, which are beneficial in childhood, and to assess the risk of toxicity due to excessive intakes of iron, vitamin A, and iodine...
November 28, 2018: Annals of the New York Academy of Sciences
Chang Su, Tianlong Yu, Rencheng Zhao, Yunan Wang, Haihan Jia, Miao Jing, Peng Liu
BACKGROUND AND OBJECTIVES: When iodine intake is in excess, a susceptible population that has a genetic predisposition will have an increased risk of hypothyroidism or autoimmune thyroiditis. This study evaluated the vulnerability to iodine excess and subclinical thyroid disease through screening of single nucleotide polymorphisms (SNPs) in reproductive-age women to provide evidence to be used for the prevention of subclinical thyroid disease. METHODS AND STUDY DESIGN: In Shanxi province, four areas where a range of iodine exposures from low to high were chosen in each region, 60 women were anticipated to enrol, including 20 pregnant women, 20 lactating women, and 20 non-pregnant, non-lactating women...
2018: Asia Pacific Journal of Clinical Nutrition
Hayden A Evans, Jessica L Andrews, Douglas H Fabini, Molleigh B Preefer, Guang Wu, Anthony K Cheetham, Fred Wudl, Ram Seshadri
Perovskite-derived hybrid platinum iodides with the general formula A2PtIVI6 (A = formamidinium FA and guanidinium GUA) accommodate excess I2 to yield hydrogen-bond-stabilized compounds where the I2 forms catenates with I- anions on the PtI6 octahedra.
November 27, 2018: Chemical Communications: Chem Comm
Salvatore Cozzi, Andrea Slocker Escarpa, Daniel Lorenzo Parra, Dina Najjari Jamal, Josep Maria Caminal Mitjana, Josep Maria Piulats R, Ferran Guedea Edo, Cristina Gutierrez Miguelez
Introduction: Uveal melanoma is a rare tumour caused by genetic factors and alterations in the immune response. Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder characterized by an inappropriate or excessive immune response. The two main types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). A diagnosis of IBD and the use of immunosuppressive drugs are both independently associated with an increased risk of developing skin melanoma. The association between IBD and uveal melanoma (UM) has not been previously described...
January 2019: Reports of Practical Oncology and Radiotherapy
Maureen Hatch, Alina V Brenner, Elizabeth K Cahoon, Vladimir Drozdovitch, Mark P Little, Tatiana Bogdanova, Victor Shpak, Elena Bolshova, Galyna Zamotayeva, Galyna Terekhova, Evgeniy Shelkovoy, Viktoria Klochkova, Kiyohiko Mabuchi, Mykola Tronko
Background: Children and adolescents exposed to radioactive iodine-131 (I-131) in fallout from the 1986 Chernobyl nuclear accident appear to be at increased risk of thyroid cancer and benign thyroid nodules. The prenatal period is also considered radiosensitive, and the fetal thyroid can absorb I-131 from the maternal circulation. Objectives: We aimed to estimate the risk of malignant and benign thyroid nodules in individuals exposed prenatally. Methods: We studied a cohort of 2582 subjects in Ukraine with estimates of I-131 prenatal thyroid dose (mean = 72...
January 1, 2019: Journal of Clinical Endocrinology and Metabolism
Adriano Bof de Oliveira, Johannes Beck, Jörg Daniels
The reaction between 4,5,6,7-tetra-hydro-2-(4,5,6,7-tetra-hydro-1,3-benzodi-thiol-2-yl-idene)-1,3-benzodi-thiole (common name: 4,4',5,5',6,6',7,7'-octa-hydro-dibenzo-tetra-thia-fulvalene, OMTTF) and an excess of iodine in tetra-hydro-furan (THF) yielded the respective radical organic polyiodide salt, C14 H16 S4 + ·I3 - . The asymmetric unit contains one and a half formula unit of both the cation and the anion, with the half-ions completed through inversion symmetry. The (OMTTF + ) positive charge can be assigned by the bond distances and the planar structure of the C2 S2 C=CS2 C2 central fragment...
November 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Teba González, Idoia Larretxi, Juan Carlos Vitoria, Luis Castaño, Edurne Simón, Itziar Churruca, Virginia Navarro, Arrate Lasa
The aim of the present work was to analyze the body composition and dietary profile of Spanish celiac men and to compare them to control men and celiac women from our previous studies. Forty-two celiac men (31.5 ± 11.9 years) were recruited and anthropometric measurements were taken. Analysis of energy consumption, macro- and micronutrient intake and food frequency consumption was carried out. Celiac men were more overweight and obese than celiac women, but less than the control population, reporting the same energy intake and macronutrient distribution...
November 8, 2018: Nutrients
Michael E Serafico, Leah A Perlas, Joselita Rosario C Ulanday, Marco P De Leon, Marites V Alibayan, Josefina A Desnacido, Glen Melvin P Gironella, Imelda A Agdeppa, Mario V Capanzana
OBJECTIVES: Globally, although progress in eliminating iodine deficiency disorders (IDD) has been reported, IDD is still considered to be a global health problem. As school-aged children are the most accessible population group, their urinary iodine (UI) concentration data are accepted and used as an indicator of IDD for the general population. The aim of this study was to reassess the national, regional, and provincial estimates of UI as a measure of IDD among Filipino school-aged children...
July 31, 2018: Nutrition
Carolina G Moreno, Oscar Gálvez, Vicente López-Arza Moreno, Eva María Espildora-García, María Teresa Baeza-Romero
The main source of atmospheric iodine is the heterogeneous reaction of aqueous iodide (I-) with ozone (O3), which takes place in surface seawater and probably in sea-salt aerosols. However, there are seemingly contradictory conclusions about whether this heterogeneous reaction occurs in the bulk of the aqueous phase, via O3 dissolution, or at the aqueous surface, via O3 adsorption. In this work, the ozone uptake coefficient has been calculated as a function of the concentration of aqueous iodide ([I-]aq) and gaseous ozone near the aqueous surface ([O3]gs) by estimating parameters of the resistor model using results of previous studies...
November 7, 2018: Physical Chemistry Chemical Physics: PCCP
Qian He, Xiao Hui Su, Peng Liu, Li Jun Fan, Fan Gang Meng, Li Xiang Liu, Ming Li, Shou Jun Liu
OBJECTIVE: The aim of this study was to evaluate the impact of the revised Chinese National Standard GB26878-2011 'Iodine Content in Edible Salt' on the iodine status among the Chinese population. METHODS: In 2011 and 2014, the probability proportionate to size sampling (PPS) was used in each Chinese province to obtain the representative data. In each sampling unit, school children aged 8-10 years and pregnant women were selected. Key indicators included urinary iodine concentration (UIC), thyroid volume (TV), and the iodine content in edible household salt...
September 2018: Biomedical and Environmental Sciences: BES
Boris Smolkin, Noam Levi, Naama Karton-Lifshin, Lea Yehezkel, Yossi Zafrani, Ishay Columbus
Mild oxidation of sulfur-containing chemical warfare agents was performed in organic medium by electrophilic iodine reagents. Kinetic experiments on sulfur mustard (HD) showed rapid ( t1/2 < 3 min) and selective oxidation to the nonvesicant sulfoxide product (HD-SO) in acetonitrile or propylene carbonate solutions (9% water added) containing excess N-iodosuccinimide (NIS). Molecular iodine solutions in these solvents led to similar results as with NIS but at much slower rates ( t1/2 ∼ 90 min). Higher donor number solvents, such as THF, DMF, or DMSO, showed slower rates with both iodine and NIS...
October 25, 2018: Journal of Organic Chemistry
Teofana O Bizerea, Stefana G Dezsi, Otilia Marginean, Ramona Stroescu, Alexandru Rogobete, Otilia Bizerea-Spiridon, Constantin Ilie
BACKGROUND: The first line of defence against oxidative stress (OS) are the endogenous antioxidants, such as the Se containing compounds. During pregnancy, OS is caused by the intense growth activity of the fetus; therefore, the placenta is a key place for the activity of many seleno-compounds such as glutathione-peroxidase and thioredoxinreductase. METHODS: This review aims to establish the link between the type of selenium compounds, their concentration, their metabolic pathways, and their role in both physiologic and pathologic processes during pregnancy...
October 1, 2018: Clinical Laboratory
John E Strobeck, Jonathan Feldschuh, Wayne L Miller
OBJECTIVES: This study performed a retrospective outcome analyses of a large cohort of mixed ejection fraction patients admitted for acute heart failure (HF), whose inpatient care was guided by individual quantitative blood volume analysis (BVA) results. BACKGROUND: Decongestion strategies in patients hospitalized for HF are based on clinical assessment of volume and have not integrated a quantitative intravascular volume metric. METHODS: Propensity score control matching analysis was performed in 245 consecutive HF admissions to a community hospital (September 2007 to April 2014; 78 ± 10 years of age; 50% with HF with reduced ejection fraction [HFrEF]; and 30% with Stage 4 chronic kidney disease)...
November 2018: JACC. Heart Failure
Aikebaier Renaguli, Y Z Luo, X L Wang, Yimamu Dilidaer, Wulamu Muyeshsaer, Julaiti Guzailinuer, Y Y Zhang, Y Y Xin, Yanying Guo
Objective: To investigate the relationship between thyrotropin (TSH) and urine iodine in pregnant women of Han and Uygur ethnic groups in People's Hospital of Xinjiang Uygur Autonomous Region. Methods: A total of 1 568 pregnant who completed screening of TSH and urine iodine in People's Hospital of Xinjiang Uygur Autonomous Region hospital from August 2014 to December 2017 were included in the study, 956 cases were Han and the other 612 were Uygur. Basic clinical data, serum TSH, thyroid peroxidase autoantibody (TPOAb) , and urine iodine levels were retrospectively analyzed...
September 25, 2018: Zhonghua Fu Chan Ke za Zhi
Yanting Chen, Wen Chen, Cong Du, Lili Fan, Wei Wang, Min Gao, Yixin Zhang, Tingkai Cui, Yunmeng Hao, Elizabeth N Pearce, Chongdan Wang, Wanqi Zhang
Pregnant women are more vulnerable to iodine deficiency and iodine excess. The study aimed to assess the changes in iodine nutrition and thyroid function of pregnant women exposed to different iodine sources resulting in various iodine intakes during pregnancy. From 2016 to 2017, 2004 healthy pregnant women aged 20-35 years from Shandong and Tianjin, China, were enrolled. Urinary iodine concentration (UIC), drinking water iodine content (WIC), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroid hormone (FT4), thyroglobulin (Tg), serum thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured...
October 2, 2018: Biological Trace Element Research
Hye In Kim, Hyun-Kyung Oh, So Young Park, Hye Won Jang, Myung-Hee Shin, Ji Min Han, Ji Cheol Bae, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
PURPOSE: In iodine-sufficient areas, autoimmune hypothyroidism has been regarded as the major subtype of hypothyroidism. Non-immune-related hypothyroidism has received little attention because it is considered to be rare. The aim of this study was to evaluate the prevalence of non-immune-related hypothyroidism in Korea and to identify its associating factors. METHODS: A total of 6434 participants in the Korea National Health and Nutrition Examination Survey VI (2013-2015) without known thyroid disease who were examined for thyroid stimulating hormone, free thyroxine, TPO Ab, and urine iodine concentration (UIC) were enrolled...
October 1, 2018: European Journal of Nutrition
Adipa Saha, Sandip Mukherjee, Ankita Bhattacharjee, Deotima Sarkar, Arijit Chakraborty, Arnab Banerjee, Amar K Chandra
Altered lymphocytic activity and its subset ratio found responsible for initiating abnormal autoimmune responses in mans and animals after excess iodine exposure. Study objective is to reveal excess iodine induced impairment of peripheral blood lymphocytes (PBL), its functional status, antioxidant balance, DNA damage, proliferation assay and serum cytokine levels (IL6 and TNF α)in adult male rats to understand the onset of autoimmune alterations if any indirectly that is unexplored. Experimental animals were grouped depending on doses of iodine (KI) treatment with moderately excess-7mg/kg bw (100EI) and excessively excess-35mg/kg bw (500EI)for 30 days to analyze IL6 and TNF α, haematological indices, oxidative stress, lymphocytic DNA damage and proliferation status...
October 1, 2018: Toxicology Mechanisms and Methods
Renjuan Chen, Qian Li, Wenli Cui, Xiaoyi Wang, Qin Gao, Chunrong Zhong, Guoqiang Sun, Xinlin Chen, Guoping Xiong, Xuefeng Yang, Liping Hao, Nianhong Yang
Background: Maternal iodine status has been suggested to affect birth outcomes. Few studies have focused on its effects on fetal growth during pregnancy. Objective: This study aimed to assess maternal iodine status during early pregnancy and further examine the relation between maternal iodine status and fetal growth. Methods: A total of 2087 singleton-pregnant women participating in the Tongji Maternal and Child Health Cohort study were involved...
November 1, 2018: Journal of Nutrition
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K Park, Jong Kwan Jun, June Key Chung
BACKGROUND: Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function. METHODS: The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery...
September 2018: Endocrinology and Metabolism
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"