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Excess Iodine

Gopalakrishnan C Nair, Misha J C Babu, Riju Menon, Pradeep Jacob
Introduction: Thyroidectomy is effective and safe procedure for permanent cure of hyperthyroidism (HT). Iodine preparations are widely used before operation to prevent excess blood loss. Ideal regimen for refractory HT is debated. This retrospective case-control study is designed to study the efficacy of various regimens of preoperative preparations. Materials and Methods: Case records, anesthesia charts, and follow-up details of hyperthyroid patients undergoing thyroidectomy were reviewed and compared with an age- and sex-matched euthyroid patients operated during the same period...
May 2018: Indian Journal of Endocrinology and Metabolism
Juliane Léger, Jean Claude Carel
Hyperthyroidism in children is a rare heterogeneous syndrome characterized by excessive thyroid hormone production. Its manifestations differ according to disease severity. For all forms of hyperthyroidism, treatment aims to restore a euthyroid state, enabling the child to demonstrate appropriate metabolism, growth, and neurocognitive development. Graves' disease is the most frequent cause of hyperthyroidism in children. Treatment modalities include antithyroid drugs, with the advantage that prolonged treatment for several years can be followed by freedom from medical intervention in about 40-50% of cases...
August 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
Y C Venu Gopal Reddy, Anuj Sharma, Adheesh P Shetty, Syed Mohideen Abdul Kader
Background: Iodine deficiency is a common preventable cause of intellectual and developmental disabilities. Iodine in the form of potassium iodate is added to the common salt under the National Iodine Deficiency Disorder Control Program in India. Overdose of iodate can lead to retinal toxicity. Case presentation: We hereby present a case of a 34 year old male patient who presented to us 10 years following iodate ingestion. There was widespread outer retinal atrophy, foveal atrophy and sub-retinal fibrosis noted on fundus evaluation...
2018: International Journal of Retina and Vitreous
Deotima Sarkar, Arijit Chakraborty, Adipa Saha, Amar K Chandra
Background Iodine is a nonpareil constituent of thyroid hormones (THs) and a prime regulator of thyroid gland functioning. Although essential at recommended levels for the prevention of iodine deficiency disorders (IDDs), exposure to excess iodine reportedly causes hypothyroidism, hyperthyroidism, and several other emerging deleterious impacts. The objective of the present study is to explore the influence of excess iodide exposure on carbohydrate and lipid metabolism along with the histoarchitecture of certain associated organs such as the pancreas, liver, kidney, and skeletal and cardiac muscle because information on those aspects was found to be scanty...
August 1, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Tyler Hamby, Nayana Kunnel, John S Dallas, Don P Wilson
Background Excessive iodine exposure is an often overlooked cause of neonatal hypothyroidism. Case presentation We present an infant with iodine-induced hypothyroidism, which was detected at age 15 days by newborn screening. The infant's iodine excess resulted from maternal intake of seaweed soup both during and after pregnancy. Treatment included discontinuation of seaweed soup, temporary interruption of breastfeeding and short-term levothyroxine therapy. By age 4 months, the infant's hypothyroidism had resolved, and her growth and development were normal...
July 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Marine Roulier, Maïté Bueno, Yves Thiry, Frédéric Coppin, Paul-Olivier Redon, Isabelle Le Hécho, Florence Pannier
Radioiodine is of health concerns in case of nuclear events. Possible pathways and rates of flow are essential information for risk assessment. Forest ecosystems could influence the global cycle of long-lived radioiodine isotope (129 I) with transfer processes similar to stable isotope (127 I). Understanding iodine cycling in forest involves study of the ecosystem as a whole. In this context, we determined the 127 I contents and distribution in soil, tree compartments and atmospheric inputs during a three years in situ monitoring of a temperate beech forest stand...
July 16, 2018: Science of the Total Environment
Jessica Farebrother, Michael Zimmermann, Fatma Abdallah, Vincent Assey, Ralph Fingerhut, Wanjiku N Gichohi-Wainaina, Izzledin Hussein, Anselimo Makokha, Kalil Sagno, Juliawati Untoro, Michael Watts, Maria Andersson
Background Acute excess iodine intake can damage the thyroid, but the effects of chronic excess iodine intake are uncertain. Few data exist for pregnant and lactating women, and infants exposed to excessive iodine intakes. Methods This was a multicenter cross-sectional study. At study sites in rural Kenya and urban Tanzania previously reporting iodine excess in children, we measured urinary iodine concentration (UIC) and TSH, total T4 and thyroglobulin (Tg) in school-age children (SAC), women of reproductive age (WRA), pregnant (PW) and lactating women, and breastfeeding and weaning infants...
July 18, 2018: Thyroid: Official Journal of the American Thyroid Association
Nina Gedberg, Jesper Karmisholt, Michael Gade, Rune V Fisker, Victor Iyer, Lars J Petersen
Incidental focal uptake of 18F-fluorodeoxyglucose (FDG) in the thyroid on positron emission tomography (PET/CT) is rare but often associated with malignancy. The epidemiology of thyroid incidentalomas has only to some extent been described in countries with iodine deficiency. Here we report data from Denmark, a country with known iodine deficiency and wide access to PET/CT. All FDG PET/CT comprising the head and neck region, during 2014, were retrospectively reviewed, and patients with focal FDG uptake in the thyroid gland were identified...
July 17, 2018: Diagnostics
Qi Li, Jia Chen, Zongyao Huyan, Yuxing Kou, Lirong Xu, Xiuzhu Yu, Jin-Ming Gao
Fats and oils are essential food components. Their quality and safety pose major concerns for consumers and food producers because of factors such as oxidation and rancidity, excessive levels of trans fatty acid (TFA), and widespread adulteration. Thus, a rapid and easy-to-use technique must be exploited for quality parameter evaluation and monitoring to ensure the edibility, safety, and quality of fats and oils. In the last decades, Fourier transform infrared (FTIR) spectroscopy has shown great potential in analyzing fats and oils given its speed and simplicity...
July 16, 2018: Critical Reviews in Food Science and Nutrition
Gabriela Pocovi-Gerardino, María Correa-Rodríguez, José Luis Callejas-Rubio, Raquel Ríos-Fernández, Norberto Ortego-Centeno, Blanca Rueda-Medina
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Despite the influence of diet on inflammation, dietary habits in patients with systemic lupus erythematosus (SLE) are not well established. The study objective was to assess dietary intake and nutritional status in SLE patients. PATIENTS AND METHODS: A cross-sectional study was conducted in 92 patients with SLE. Nutritional status was determined by body mass index (BMI) and energy/nutrient distribution of diet was analyzed and compared to a control group...
July 8, 2018: Endocrinología, Diabetes y Nutrición
Dalila Cunha Oliveira, Amanda Nogueira-Pedro, Ed Wilson Santos, Araceli Hastreiter, Graziela Batista Silva, Primavera Borelli, Ricardo Ambrósio Fock
Micronutrients are indispensable for adequate metabolism, such as biochemical function and cell production. The production of blood cells is named haematopoiesis and this process is highly consuming due to the rapid turnover of the haematopoietic system and consequent demand for nutrients. It is well established that micronutrients are relevant to blood cell production, although some of the mechanisms of how micronutrients modulate haematopoiesis remain unknown. The aim of the present review is to summarise the effect of Fe, Mn, Ca, Mg, Na, K, Co, iodine, P, Se, Cu, Li and Zn on haematopoiesis...
July 9, 2018: Nutrition Research Reviews
(no author information available yet)
Ong CB, Herdt TH, Fitzgerald SD. Hyperplastic goiter in two adult dairy cows. J Vet Diagn Invest 2014;26:810-814. (Original doi: 10.1177/1040638714554441). The use of mineral supplements as a top dressing and trace mineralized salt noted by the authors was based on non-documented verbal comments and not based on direct observation. Therefore, the definitive source of the excess iodine measured in the thyroid gland of the 2 cows examined was not identified. The acknowledgments for this case report have been revised to reflect appropriate contributors to the case...
July 2018: Journal of Veterinary Diagnostic Investigation
Olynka Vega-Vega, Jorge I Fonseca-Correa, Angeles Mendoza-De la Garza, Rodolfo Rincón-Pedrero, Angeles Espinosa-Cuevas, Yolanda Baeza-Arias, Omar Dary, Bertha Herrero-Bervera, Iris Nieves-Anaya, Ricardo Correa-Rotter
Initiatives to reduce sodium intake are encouraged globally, yet there is concern about compromised iodine intake supplied through salt. The aim of the present study was to determine baseline sodium, potassium, and iodine intake in a sample of workers from our Institution in Mexico City (SALMEX Cohort). Methods . From a cohort of 1009 workers, appropriate 24-h urine and three-day dietary recall was collected in a sample of 727 adult subjects for assessment of urinary sodium, potassium, and iodine concentrations...
June 25, 2018: Nutrients
Mengwei Jia, Xiaoguang Shi, Xiaolan Gu, Haixia Guan, Xiaochun Teng, Di Teng, Chenling Fan, Yongze Li, Zhongyan Shan, Weiping Teng, Yushu Li
To evaluate the relationship between smoking and both antithyroperoxidase antibody (TPOAb) and antithyroglobulin antibody (TgAb) positivity in subjects from Panshan, Zhangwu, and Huanghua with mildly deficient, more than adequate, and excessive iodine intake, respectively. Smoking-related data were collected by questionnaire, and laboratory measurements of TPOAb, TgAb, and thyrotropin (TSH) were determined at baseline and follow-up. (1) A 1.48-fold increased risk of TPOAb positivity was found in smokers than in non-smokers after adjusting for confounders (age, sex, and areas) (OR[95% CI] = 1...
June 25, 2018: Biological Trace Element Research
Subramanian Kannan, Sudha Rathna Prabhu, Shriraam Mahadevan
No abstract text is available yet for this article.
March 2018: Indian Journal of Endocrinology and Metabolism
Eliza Sharma, Suyash Dahal, Pratibha Sharma, Abani Bhandari, Vishal Gupta, Sumit Dahal
Background: There is an increased risk of second primary malignancies with thyroid cancer. However, the risk and characters of secondary salivary gland malignancy (sSGM) in patients with thyroid cancer have not been evaluated before. Methods: We used the Surveillance Epidemiology and End Results (SEER) 18 registry to identify thyroid cancer patients from 1973 to 2014. We then calculated the risk of sSGM using standardized incidence ratio and excess risk. Separately, all cases of primary salivary gland malignancy (pSGM) diagnosed between 1973 - 2014 were extracted from the SEER 18 registry, and their characteristics compared with sSGM using independent samples t -test for continuous variables and Chi-square tests for categorical variables...
July 2018: Journal of Clinical Medicine Research
Yugui Dou, Yanling Wang, Wei Sun, Yongqin Cao, Xiaonan Zhu, Jing Zheng
OBJECTIVE: To assess the iodine nutrition and thyroid function of lactatingwomen in different iodine nutrition level of children in Gansu Province, and provide a scientific basis for iodine supplementation. METHODS: Liangzhou district( the median urinary iodine was greater than or equal to 300 g/L), Linze county( the median urinary iodine was from 200 to 299 g/L) and Huating county( the median urinary iodine was from100 to 199 g/L) were selected according to 8-10 years old children urinary iodine in2009...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Zuolong Sun, Xiao Wang, Jin Chen, Peng Duan, Jing Wang, Ying Liu, Huailan Guo
OBJECTIVE: To explore the influences of iodine excess on insulin secret function of mouse insulinoma cells β-TC-6 and the mechanism. METHODS: β-TC-6 cells were treated with excessive iodine( Na I) in vitro. After 24 hour of exposure, the MTT assay was used to measure the cell viabilities. β-TC-6 cells, after 24 hour of exposure in excessive iodine, were stimulated with Krebs-Ringer bicarbonate buffer containing 5. 6mmol/L glucose for 1 hour at 37 ℃, then the supernatant was collected for insulin determination by ELISA kit...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Kosuke Inoue, Angela M Leung, Takehiro Sugiyama, Tetsuro Tsujimoto, Noriko Makita, Masaomi Nangaku, Beate R Ritz
BACKGROUND: Iodine deficiency has long been recognized as an important public health problem. Global approaches such as salt iodization that aim to overcome iodine deficiency have been successful. Meanwhile, they have led to excessive iodine consumption in some populations, thereby increasing the risks of iodine-induced thyroid dysfunction, as well as the comorbidities and mortality associated with hypothyroidism and hyperthyroidism. This study aimed to elucidate whether iodine intake is associated with mortality among U...
July 2018: Thyroid: Official Journal of the American Thyroid Association
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