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https://www.readbyqxmd.com/read/30552308/hypoglycemic-side-effects-of-sulfonylureas-and-repaglinide-in-ageing-patients-knowledge-and-self-management
#1
I A Harsch, R H Kaestner, P C Konturek
Insulinotropic oral antidiabetics (OAD) such as sulfonylureas and (SU) glinides are among the frequently prescribed OAD. Side effects are the potential to induce hypoglycemias and weight gain. The aim was to assess the self-managing skills in case of a hypoglycemic event in an elderly type 2 diabetic patient population. In a 2-year period, 160 hospitalized patients (mean age 77.4 years) under insulinotrophic OAD were interviewed using a standardized questionnaire. Additionally, possible dementia was evaluated by using the Mini-Mental State Examination (MMSE) and the Clock-Drawing Test (CDT)...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30552072/treatment-of-asthma-in-smokers-a-questionnaire-survey-in-japanese-clinical-practice
#2
Hiroaki Saito, Kimitake Tsuchiya, Sahoko Chiba, Tomoyuki Ogata, Reina Imase, Tamon Yagi, Yuka Mishima, Torahiko Jinta, Kazuhito Saito, Reiko Taki, Susumu Isogai, Yasuto Jin, Tsutomu Kawasaki, Ichiro Natsume, Yoshihiro Miyashita, Jun Takagiwa, Nobuo Ishiwata, Tomoshige Chiaki, Masato Kishi, Yoshikazu Tsukada, Motohisa Yamasaki, Naohiko Inase, Yasunari Miyazaki
BACKGROUND: Cigarette smoking in patients with asthma leads to poor symptom control. As patients who are current smokers have been excluded from enrollment in many clinical trials on asthma, there are few reports on the treatment in current smokers with asthma. In this study, we aimed to assess how respiratory physicians manage asthma in current smokers in Japan. METHODS: Respiratory physicians in 16 Japanese hospitals answered a questionnaire on treatment for patients with asthma between December 2014 and February 2015...
December 11, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/30548018/overcoming-obstacles-in-lipid-lowering-therapy-in-patients-with-hiv-a-systematic-review-of-current-evidence
#3
Coco C Dekkers, Jan Westerink, Andy I M Hoepelman, Joop E Arends
Cardiovascular risk management in human immunodeficiency virus (HIV)-infected individuals is gaining increased attention due to the rising incidence and prevalence of cardiovascular disease in this population. Despite the availability of efficacious treatment strategies, implementation of guideline advocated preventive therapy, such as lipid-lowering therapy with statins, is hampered by perceived, expected, and real side effects as well as by expected interactions with combination antiretroviral therapy. These obstacles to optimal treatment have resulted in a large gap between the number of patients in whom lipid-lowering therapy is indicated and those actually taking lipid-lowering medication...
2018: AIDS Reviews
https://www.readbyqxmd.com/read/30546878/energy-handling-in-renal-tubular-epithelial-cells-of-the-hamster-a-native-hibernator-under-warm-anoxia-or-reoxygenation
#4
Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Spyridon Golfinopoulos, Vassilios Liakopoulos, Ioannis Stefanidis
Ischemia-reperfusion (I-R) injury causes several diseases, including acute kidney injury. Hibernating mammals survive periods of torpor with a marked drop in tissue perfusion, interspersed with periods of arousal, and consequently I-R injury. In the present study, sensitivity to anoxia and/or reoxygenation and alterations in cellular ATP and homeostasis of the two most energy consuming processes, protein translation and Na+ -K+ -ATPase function, were evaluated in renal proximal tubular epithelial cells of mouse or native hibernator hamster origin...
December 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30545547/prenatal-diagnosis-of-coarctation-of-the-aorta-with-ventricular-septal-defect-a-case-report
#5
Yi-Ling Huang, Kang-Hong Hsu, Enkhzaya Chuluunbaatar, Tzu-Ming Wen, Yi-Ying Li, Ming-Ren Chen, Chung-I Chang, Tung-Yao Chang
OBJECTIVE: To present an accurate prenatal diagnosis of coarctation of the aorta with ventricular septal defect and to illustrate how early diagnosis in prenatal period with proper referral and counseling can optimize management. CASE REPORT: A case with coarctation of the aorta with ventricle septal defect was found to have an abnormal three vessel view at 12 weeks, and with close follow-ups, coarctation of the aorta with ventricle septal defect was diagnosed at 24 weeks...
December 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/30543980/local-topographic-and-edaphic-factors-largely-predict-shrub-encroachment-in-mediterranean-drylands
#6
Alice Nunes, Melanie Köbel, Pedro Pinho, Paula Matos, Edoardo A C Costantini, Cristina Soares, Francesco de Bello, Otília Correia, Cristina Branquinho
Shrub encroachment influences several ecosystem services in drylands worldwide. Yet, commonly used strategies to reduce encroachment show a low medium-term success, calling for a better understanding of its causes. Previous works identified multiple drivers responsible for this phenomenon, including anthropogenic and environmental causes. However, the relative effect of climate, topography and edaphic factors on shrub encroachment is not fully understood nor has been properly quantified in Mediterranean Basin drylands...
December 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30540711/clinical-management-of-pediatric-achalasia-a-survey-of-current-practice
#7
Marinde van Lennep, Michiel P van Wijk, Taher I M Omari, Silvia Salvatore, Marc A Benninga, Maartje M J Singendonk
OBJECTIVES: Pediatric achalasia is a rare neurodegenerative disorder of the esophagus that requires treatment. Different diagnostic and treatment modalities are available, but there are no data that show how children can best be diagnosed and treated. We aimed to identify current practices regarding the diagnostic and therapeutic approach toward children with achalasia. METHODS: Information on the current practice regarding the management of pediatric achalasia was collected by an online-based survey sent to members of the European and North American Societies for Pediatric Gastroenterology Hepatology and Nutrition involved in pediatric achalasia care...
December 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30540702/characterization-of-brain-signatures-to-add-precision-to-self-management-health-information-interventions
#8
Shirley M Moore, Carol M Musil, Anthony I Jack, Megan L Alder, David M Fresco, Allison Webel, Kathy D Wright, Abdus Sattar, Patricia Higgins
BACKGROUND: Although many of the proposed mediating processes of self-management interventions are operationally defined as cognitive processes (e.g., acquiring and using information, self-efficacy, motivation, decision-making), little is known about their underlying brain mechanisms. Brain biomarkers of how people process health information may be an important characteristic on which to individualize health information to optimize self-management of chronic conditions. OBJECTIVES: We describe a program of research addressing the identification of brain biomarkers that differentially predict responses to two types of health information (analytic-focused and emotion-focused) designed to support optimal self-management of chronic conditions...
December 12, 2018: Nursing Research
https://www.readbyqxmd.com/read/30539299/habitat-use-of-sympatric-prey-suggests-divergent-anti-predator-responses-to-recolonizing-gray-wolves
#9
Justin A Dellinger, Carolyn R Shores, Apryle Craig, Michael R Heithaus, William J Ripple, Aaron J Wirsing
The non-consumptive effects of predators on prey are now widely recognized, but the need remains for studies identifying the factors that determine how particular prey species respond behaviorally when threatened with predation. We took advantage of ongoing gray wolf (Canis lupus) recolonization in eastern Washington, USA, to contrast habitat use of two sympatric prey species-mule (Odocoileus hemionus) and white-tailed (O. virginianus) deer-at sites with and without established wolf packs. Under the hypothesis that the nature and scale of responses by these ungulates to wolf predation risk depend on their divergent flight tactics (i...
December 11, 2018: Oecologia
https://www.readbyqxmd.com/read/30530149/social-equity-shapes-zone-selection-balancing-aquatic-biodiversity-conservation-and-ecosystem-services-delivery-in-the-transboundarydanube-river-basin
#10
Sami Domisch, Karan Kakouei, Javier Martínez-López, Kenneth J Bagstad, Ainhoa Magrach, Stefano Balbi, Ferdinando Villa, Andrea Funk, Thomas Hein, Florian Borgwardt, Virgilio Hermoso, Sonja C Jähnig, Simone D Langhans
Freshwater biodiversity is declining, despite national and international efforts to manage and protect freshwater ecosystems. Ecosystem-based management (EBM) has been proposed as an approach that could more efficiently and adaptively balance ecological and societal needs. However, this raises the question of how social and ecological objectives can be included in an integrated management plan. Here, we present a generic model-coupling framework tailored to address this question for freshwater ecosystems, using three components: biodiversity, ecosystem services (ESS), and a spatial prioritisation that aims to balance the spatial representation of biodiversity and ESS supply and demand...
November 28, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30529414/comparing-landowner-support-for-wild-hog-management-options-in-tennessee
#11
Cristina Watkins, Carlotta A Caplenor, Neelam C Poudyal, Lisa I Muller, Chuck Yoest
Wild hogs (Sus scrofa) are an invasive, non-native species quickly gaining ground on private, as well as public, lands in Tennessee and much of the United States. Wildlife management personnel may benefit from assessing stakeholders' views towards various management options to control and eradicate wild hogs. A statewide mail survey of 5000 randomly selected landowners in Tennessee counties known to have wild hogs yielded 1620 completed responses (33% response rate). Using this dataset, an index of potential for conflict among landowner groups was computed for each of eleven management options, which varied from leaving the wild hogs alone, to both lethal and non-lethal options...
December 4, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/30527436/taiwan-consensus-statement-on-the-management-of-chronic-hepatitis-b
#12
Rong-Nan Chien, Jia-Horng Kao, Cheng-Yuan Peng, Chien-Hung Chen, Chun-Jen Liu, Yi-Hsiang Huang, Tsung-Hui Hu, Hwa-I Yang, Sheng-Nan Lu, Yen-Hsuan Ni, Won-Long Chuang, Chuan-Mo Lee, Jaw-Chin Wu, Pei-Jer Chen, Yun-Fan Liaw
The experts of Taiwan Association for the Study of Liver (TASL) have actively participated and led the guidelines on hepatitis B virus (HBV) management by Asian Pacific Association for the Study of Liver (APASL) which is the first international association for the study of liver to publish the statement on HBV management before. However, there are more and more new data on the natural history and treatment of HBV infection in the past decade. These include new application of an old biomarker (quantitative HBsAg), clinical significance of HBV genotype and naturally occurring mutations, the role of non-invasive examination in evaluating severity of hepatic fibrosis, clinical significance of outcome calculators, new drug or new combination strategies towards more effective therapy and organ transplantation including liver and non-liver transplantation...
December 5, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/30527193/prediagnosis-weight-loss-a-stronger-factor-than-bmi-to-predict-survival-in-patients-with-lung-cancer
#13
Hugues Morel, Bruno Raynard, Michel d'Arlhac, Pierre-Alexandre Hauss, Emmanuelle Lecuyer, Gérard Oliviero, Clothilde Marty, Jean-Pierre Gury, Bernard Asselain, Michel Grivaux, Didier Debieuvre
OBJECTIVES: Recent studies have demonstrated that elevated BMI is associated with improved survival in patients with lung cancer. According to the authors, this "obesity paradox" could be a true benefit or a spurious relationship. In this context, data from the French KBP-2010-CPHG cohort (7,051 patients followed up for primary lung cancer diagnosed in 2010 in the respiratory medicine departments of 104 nonacademic hospitals) were analyzed. METHODS: Patients were stratified according to BMI at diagnosis using the definition of the French-Speaking Society of Clinical Nutrition and Metabolism (Société Francophone de Nutrition Clinique et Métabolisme)...
December 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/30526597/brief-report-the-association-between-recreational-versus-therapeutic-marijuana-use-on-hazardous-alcohol-consumption-and-alcohol-associated-behavioral-consequences-among-adults-living-with-hiv-in-florida
#14
Zachary L Mannes, Erin G Ferguson, Larry E Burrell, Robert L Cook, Nicole Ennis
BACKGROUND: Though marijuana use has previously been associated with risky alcohol use, studies often do not delineate between the effect of recreational versus therapeutic marijuana use, particularly among people living with HIV (PLWH). In this study, we examined the association between recreational versus therapeutic marijuana use to manage HIV symptoms (i.e., improve appetite/gain weight, induce sleep, relieve nausea/vomiting, relieve pain, relieve anxiety/depression/stress) on hazardous alcohol consumption and associated behavioral consequences among PLWH...
December 7, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/30525777/on-the-job-and-off-the-job-embeddedness-differentially-influence-relationships-between-informal-job-search-and-turnover
#15
Caitlin M Porter, Richard A Posthuma, Carl P Maertz, Janice R W Joplin, James Rigby, Mary Gordon, Krisanne Graves
Whereas informal job search (i.e., using personal contacts for job search) is positively associated with the receipt of job offers, research has yet to consider the extent to which informal job search translates into current employees' turnover decisions or to investigate factors that may restrain (or facilitate) the translation of informal job search into turnover decisions. In this study, we propose that on-the-job and off-the-job embeddedness play distinct roles in strengthening or weakening the positive relationship between informal job search and turnover intentions and behavior...
December 10, 2018: Journal of Applied Psychology
https://www.readbyqxmd.com/read/30525769/a-longitudinal-cohort-study-of-symptoms-and-other-concerns-among-nigerian-people-with-stages-3-5-chronic-kidney-diseases-study-protocol
#16
Andrew T Olagunju, Babatunde Fadipe, Rotimi W Buraimoh, Olagoke K Ale, Theophilus I Umeizudike, Raphael E Ogbolu, Nasur Buyinza, Jonathan Bayuo, Barbara Mutedzi, Kennedy Nkhoma, Eve Namisango, Katherine Bristowe, Deokhee Yi, Julia Downing, Olatunji F Aina, Joseph D Adeyemi, Fliss E M Murtagh, Richard Harding
BACKGROUND: The burden of symptoms and other concerns in chronic kidney disease (CKD) is known to be high, adversely affecting the quality of life of the growing number of those with this condition in developing countries. In this paper, we describe the protocol of a longitudinal observational study among people living with CKD. The study is developed to assess the bio-psychosocial factors associated with palliative care symptoms and concerns, and pattern of health services usage among Nigerians with stages 3-5 CKD...
October 17, 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/30521690/optical-coherence-tomography-for-diagnosing-skin-cancer-in-adults
#17
REVIEW
Lavinia Ferrante di Ruffano, Jacqueline Dinnes, Jonathan J Deeks, Naomi Chuchu, Susan E Bayliss, Clare Davenport, Yemisi Takwoingi, Kathie Godfrey, Colette O'Sullivan, Rubeta N Matin, Hamid Tehrani, Hywel C Williams
BACKGROUND: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions...
December 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30521524/integrated-aedes-management-for-the-control-of-aedes-borne-diseases
#18
REVIEW
David Roiz, Anne L Wilson, Thomas W Scott, Dina M Fonseca, Frédéric Jourdain, Pie Müller, Raman Velayudhan, Vincent Corbel
BACKGROUND: Diseases caused by Aedes-borne viruses, such as dengue, Zika, chikungunya, and yellow fever, are emerging and reemerging globally. The causes are multifactorial and include global trade, international travel, urbanisation, water storage practices, lack of resources for intervention, and an inadequate evidence base for the public health impact of Aedes control tools. National authorities need comprehensive evidence-based guidance on how and when to implement Aedes control measures tailored to local entomological and epidemiological conditions...
December 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30515771/how-i-manage-children-with-diamond-blackfan-anaemia
#19
REVIEW
Marije Bartels, Marc Bierings
Diamond-Blackfan anaemia (DBA) is a rare inherited marrow failure disorder, characterized by hypoplastic anaemia, congenital anomalies and a predisposition to cancer as a result of ribosomal dysfunction. Historically, treatment is based on glucocorticoids and/or blood transfusions, which is accompanied by significant toxicity and long-term sequelae. Currently, stem cell transplantation is the only curative option for the haematological DBA phenotype. Whereas this procedure has been quite successful in the last decade in selected patients, novel therapies and biological insights are still warranted to improve clinical care for all DBA patients...
December 4, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30514351/exploring-the-efficacy-of-an-electronic-symptom-assessment-and-self-care-intervention-to-preserve-physical-function-in-individuals-receiving-neurotoxic-chemotherapy
#20
Robert Knoerl, Edie Weller, Barbara Halpenny, Donna Berry
BACKGROUND: Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function, clinicians infrequently assess and manage CIPN. Interventions that prioritize the early identification of CIPN to provide prompt treatment may reduce the impact of CIPN on physical function. The purpose of this paper is to compare self-reported physical function in individuals receiving neurotoxic chemotherapy between Electronic Symptom Assessment-Cancer (ESRA-C) intervention group (e...
December 4, 2018: BMC Cancer
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