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G Résimont, R Gadisseur, L Lutteri, J M Krzesinski, E Cavalier, P Delanaye
The measurement of proteinuria is a very simple tool to screen and manage kidney diseases. Its predictive role is also relevant from a cardiovascular point of view. However, the interpretation of the results is not always easy. Indeed, there are several different methods to detect or measure proteinuria (or albuminuria), varying from the measurement on a 24-hour urine collection to the simplest detection with dipsticks or measurement on a random urine sample. Some methods are measuring total proteins, whereas others are measuring more specifically albuminuria...
October 2018: Revue Médicale de Liège
A J Scheen
Drug therapy failure may occur with any medical intervention. It is badly accepted by both the physician and the patient. Drug failure may be attributed to the physician, the patient, the medication or the severity of the disease itself. Once drug failure is confirmed, causes should rapidly be identified in order to find a solution because several ones may often be offered.
October 2018: Revue Médicale de Liège
Zachary J Sirois, Sarah M Kreul, Craig F Shank
Management of displaced pediatric radial neck fractures can be fraught with challenges. This unique case presents an 11-year-old female with a Salter-Harris type II radial neck fracture and how her radial head overturned 180° with the articular surface facing the radial shaft rather than the capitellum during closed manipulation under anesthesia. The malreduction subsequently required open reduction and highlights the importance of a careful stepwise approach to managing markedly displaced radial neck fractures...
October 16, 2018: Journal of the American Academy of Orthopaedic Surgeons
M Due-Christensen, I Willaing, K Ismail, A Forbes
AIM: To explore the experiences of adults with newly diagnosed Type 1 diabetes in order to understand the adaptive processes that occur in the early phase of the condition. METHODS: We conducted longitudinal semi-structured interviews with 30 adults newly diagnosed with Type 1 diabetes (age range 20-67 years; 16 men; median diabetes duration 23.5 months), recruited from hospitals in Denmark and the UK. The data were analysed using a narrative approach. RESULTS: The narratives could be grouped into three thematic areas: the diagnosis; learning about diabetes; and learning to live with diabetes...
October 17, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
Natalia Curto-Garcia, Jean-Christophe Ianotto, Claire N Harrison
The 2016 World Health Organization (WHO) classification for myeloproliferative neoplasms (MPN) divided myelofibrosis (MF) into pre-fibrotic (pre-MF) and overt-MF categories. This new classification, particularly the entity pre-MF, has been a subject of discussion between experts. Important questions have been raised in recent years, such as the need for bone marrow trephine for diagnosis; how this is interpreted and the weighting given to it in assigning a diagnosis; determination of prognosis for pre-MF patients; including which scoring system to use and, ultimately, an evidence-based management plan for this group of patients...
October 17, 2018: British Journal of Haematology
Mabel Leng Sim Lie, Jan Lecouturier, Christopher Harding
INTRODUCTION AND HYPOTHESIS: The aim of this study was to identify modifiable factors to improve recruitment in a urology clinical trial of women with recurrent urinary tract infection (rUTI). An embedded qualitative study was conducted with patients and recruiting clinicians in the first 8 months of the trial. We present a matrix of factors influencing how patients make decisions about trial participation. METHODS: This was a qualitative study using telephone interviews...
October 17, 2018: International Urogynecology Journal
David A Woodrum, Akira Kawashima, Krzysztof R Gorny, Lance A Mynderse
In 2018, the American Cancer Society (ACS) estimates that 164,690 new cases of prostate cancer will be diagnosed and 29,430 will die due to the prostate cancer in the United States (Siegel et al., CA Cancer J Clin 67:7-30, 2018). Many men with prostate cancer are often managed with aggressive therapy including radiotherapy or surgery. No matter how expertly done, these therapies carry significant risk and morbidity to the patient's health related quality of life with impact on sexual, urinary and bowel function (Potosky et al...
2018: Advances in Experimental Medicine and Biology
Angela G Pirlott, Corey L Cook
Stereotypes, prejudices, and discriminatory behaviors directed toward people based on their sexual orientation vary broadly. Existing perspectives on sexual prejudice argue for different underlying causes, sometimes provide disparate or conflicting evidence for its roots, and typically fail to account for variances observed across studies. We propose an affordance management approach to understanding sexual prejudice, which weds the fundamental motives theory with the sociofunctional threat-based approach to prejudice to provide a broader explanation for the causes and outcomes of sexual prejudice and to explain inter- and intragroup prejudices more broadly...
October 15, 2018: Psychological Review
Gustavo Saposnik, Xavier Montalban, Daniel Selchen, Maria A Terzaghi, Fabien Bakdache, Alonso Montoya, Manuel Fruns, Fernando Caceres, Jiwon Oh
Introduction: According to previous studies, therapeutic inertia (TI) may affect 7 out of 10 physicians who care for MS patients, particularly in countries where clinical guidelines are not widely used. Limited information is available on the prevalence of TI and its associated factors across Canada. Objectives: (i) To evaluate factors associated with TI amongst neurologists caring for MS patients across Canada; (ii) to compare the prevalence of TI observed in Canadian neurologists to the prevalence of TI observed in Argentinean, Chilean, and Spanish neurologists (historical controls from prior studies)...
2018: Frontiers in Neurology
Anuj Kapilashrami
With the growing salience of ideas and reforms concerning women's human rights and gender equality, violence against women (VAW) has received heightened policy attention. Recent global calls for ending VAW identify health care systems as having a crucial role in a multisector response to tackle this social injustice. Scholars emphasize the transformative potential of such response in its ability to not only address the varied health consequences but also prevent future recurrence by enabling wider access to support and justice...
October 13, 2018: Journal of Interpersonal Violence
Stef Van Puyenbroeck, Jeroen Stouten, Gert Vande Broek
This study examined the relation between losing a game and players' destructive voice about the coach. As team performances would suffer when such behaviours are not managed properly, we tested the motivational climate as a potential mechanism by which coaches can manage these destructive behaviours. Twelve volleyball and basketball teams (N = 136) were weekly assessed during eight weeks using questionnaires. Players rated the extent to which their teammates expressed destructive voice about their coach. Each player's indegree centrality (i...
October 13, 2018: Journal of Sports Sciences
Kristen I Barton, Xiya Ma, Mustafa Ege Babadagli, Ellen Zhou, Nicholas Tonial, Christopher Newell, Abdullah Ishaque, Heather Leduc-Pessah, Tina B Marvasti, Sara Mirali, Alexander Levit, Sachin Kumar, Patrick E Steadman, Elina K Cook, Josh Abraham
The 2017 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was a national Annual General Meeting (AGM) held in Toronto, Ontario November 20-22, 2017, in conjunction with the University of Toronto Clinician Investigator Program Research Day. The theme for this year's meeting was "Roll up your sleeves-How to manage your physician scientist career", emphasizing lectures and workshops that were designed to provide tools for being proactive and successful in career planning...
October 5, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Kristen I Barton, Lauren C Capozzi, Gord Aker, Bryan G Yipp, Morley D Hollenberg, Doreen M Rabi, Paul L Beck
The health of Canadians depends on effective leadership among health care providers to facilitate the translation of new health discoveries into clinical practice. Clinician-scientists play an important role in bridging the gap between research and clinical practice, and require effective leadership skills to advance clinical practice successfully. To accelerate the leadership development in clinician scientist trainees, with the aim of developing strong leaders in administration and health advocacy, the Leaders in Medicine (LIM) training program at the University of Calgary created an Executive Leadership Coaching Program involving three phases: 1) an evidence-based evaluation tool, the Core Values IndexTM (CVI), that was used to identify the key drivers behind how individuals can be most effective in making their contribution; 2) small group workshops to debrief the results of the CVI assessment; and 3) one-on-one executive coaching sessions to facilitate the discovery, development and deployment of individual leadership capabilities...
September 30, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Najeeb Alqarni, Ran D Goldman
Question A 2-year-old boy presented to my office 2 days after he started limping. The history, physical examination, and radiology assessment revealed a toddler's fracture (TF). I understand that there is considerable variation in practice regarding management of TF. What is the best method to confirm the diagnosis? What method should be used to immobilize the affected limb and for how long? Is follow-up with a pediatric orthopedic surgeon needed? Answer Toddler's fracture, also called childhood accidental spiral tibial fracture or CAST fracture , is a fracture unique to ambulatory infants and young children...
October 2018: Canadian Family Physician Médecin de Famille Canadien
Marta Krasuska, Thomas L Webb
OBJECTIVE: The present review sought to evaluate whether - and to what extent - targeting owners' behaviour is an effective way to reduce the problem of overweight and obesity among companion dogs. METHODS: A systematic search of electronic databases identified 14 studies that evaluated the effect of an intervention targeting owners' behaviour on (i) the owner's behaviour or (ii) the weight, (iii) body fat, or (iv) body condition of the dog. We coded aspects of the study design (e...
November 1, 2018: Preventive Veterinary Medicine
Ann J Nakitende, Paul Bangirana, Noeline Nakasujja, Margaret Semrud-Clikeman, Andrew S Ssemata, Chandy C John, Richard Idro
BACKGROUND: Severe malaria in children is often associated with long-term behavioural and cognitive problems. A sizeable minority of children go on to experience repeated malaria due to the high transmission and infection rates in the region. The purpose of this study was to explore caregivers' experiences of parenting a child with a history of severe malaria followed by repeated episodes of uncomplicated malaria in comparison to healthy community children. METHODS: Thirty-one caregivers were enrolled in the study...
October 12, 2018: Malaria Journal
Bruce Jennings
Aging brings about the ordeal of coping. Younger people also cope, but for those in old age, the ordeal is so often elegiac, forced upon the self by changing functions within the body and by the outside social world, with its many impediments to the continuity of former roles, pursuits, and self-identities. Coping with change can be affirming, but when what is being forgone seems more valuable than what lies ahead, it is travail. For most, the coping is managed more moderately by a sense of resignation. This is especially true for those who survive into profound old age, when one is viewed as if being old is one's essential identity and nature...
September 2018: Hastings Center Report
I Veal, N Peat, G D Jones, V Tsianakas, J Armes
PURPOSE: Physical activity (PA) is central to self-management for people with colorectal cancer (CRC) to support health behaviour and function secondary to cancer treatment. However, there is limited evidence on how health professionals (HPs) promote PA during cancer treatment. This study aimed to investigate how and when PA is promoted throughout the chemotherapy pathway among colorectal cancer survivors. METHODS: A qualitative study was conducted with adults with CRC receiving chemotherapy at a large cancer centre...
October 11, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Joanna Burger, Michael Gochfeld, David S Kosson, Kevin G Brown, Lisa S Bliss, Amoret Bunn, James H Clarke, Henry J Mayer, Jennifer A Salisbury
Remediation and restoration of the Nation's nuclear legacy of radiological and chemical contaminated areas is an ongoing and costly challenge for the U.S. Department of Energy (DOE). For large sites, such as the Hanford and Savannah River Sites, successful remediation involves complex decisions related to remedies, end-states, timing, and sequencing of cleanup of separate and related contaminated units within a site. Hanford Site cannot clean up every unit simultaneously due to limits in funding, personnel, and technology...
February 1, 2019: Science of the Total Environment
Thomas Thaler, Marie-Sophie Attems, Mathieu Bonnefond, Darren Clarke, Amandine Gatien-Tournat, Mathilde Gralepois, Marie Fournier, Conor Murphy, Magdalena Rauter, Maria Papathoma-Köhle, Sylvie Servain, Sven Fuchs
A key challenge of hazard risk management is finding novel ways to respond to future extremes amid increasing vulnerability. Societal transformation in the context of multi-functional protection schemes offers potential in this regard. However, the drivers and barriers of societal transformation in hazard management are poorly understood. Here we interrogate drivers and barriers of societal transformation in natural hazard management through case studies in Austria, France and Ireland focusing on attempts to integrate multi-functional protection schemes in the context of flood and avalanche hazards...
February 10, 2019: Science of the Total Environment
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