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https://www.readbyqxmd.com/read/26114099/subchronic-arsenic-exposure-induces-anxiety-like-behaviors-in-normal-mice-and-enhances-depression-like-behaviors-in-the-chemically-induced-mouse-model-of-depression
#1
Chia-Yu Chang, How-Ran Guo, Wan-Chen Tsai, Kai-Lin Yang, Li-Chuan Lin, Tain-Junn Cheng, Jiunn-Jye Chuu
Accumulating evidence implicates that subchronic arsenic exposure causes cerebral neurodegeneration leading to behavioral disturbances relevant to psychiatric disorders. However, there is still little information regarding the influence of subchronic exposure to arsenic-contaminated drinking water on mood disorders and its underlying mechanisms in the cerebral prefrontal cortex. The aim of this study is to assess the effects of subchronic arsenic exposure (10 mg/LAs2O3 in drinking water) on the anxiety- and depression-like behaviors in normal mice and in the chemically induced mouse model of depression by reserpine pretreatment...
2015: BioMed Research International
https://www.readbyqxmd.com/read/23134744/room-temperature-super-extraction-system-rtses-optimizes-the-anxiolytic-and-antidepressant-like-behavioural-effects-of-traditional-xiao-yao-san-in-mice
#2
Shih-Hsi Yin, Ching-Cheng Wang, Tain-Junn Cheng, Chia-Yu Chang, Kao-Chang Lin, Wei-Chih Kan, Hsien-Yi Wang, Wenny Mei-Wen Kao, Yen-Liang Kuo, Jian-Chyi Chen, Shun-Lai Li, Chia-Hui Cheng, Jiunn-Jye Chuu
UNLABELLED: HASH(0x41af218) BACKGROUND: Xiao-Yao-San (XYS) is a Chinese medicinal formula for treating anxiety and depression. This study aims to evaluate the use of a room-temperature super-extraction system (RTSES) to extract the major active components of XYS and enhance their psycho-pharmacological effects. METHODS: The neuroprotective roles of XYS/RTSES against reserpine-derived neurotoxicity were evaluated using a glial cell injury system (in vitro) and a depression-like C57BL/6 J mouse model (in vivo)...
2012: Chinese Medicine
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