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Muyinatu A Lediju Bell, Joshua Shubert
In intraoperative settings, the presence of acoustic clutter and reflection artifacts from metallic surgical tools often reduces the effectiveness of ultrasound imaging and complicates the localization of surgical tool tips. We propose an alternative approach for tool tracking and navigation in these challenging acoustic environments by augmenting ultrasound systems with a light source (to perform photoacoustic imaging) and a robot (to autonomously and robustly follow a surgical tool regardless of the tissue medium)...
October 19, 2018: Scientific Reports
Kristina Nadine Heye, Valentin Rousson, Walter Knirsch, Ingrid Beck, Rabia Liamlahi, Vera Bernet, Hitendu Dave, Beatrice Latal
OBJECTIVE: To determine growth and its relationship to IQ in children with congenital heart disease (CHD) undergoing cardiopulmonary bypass surgery within the first year of life. STUDY DESIGN: Prospective single-center cohort study on 143 children (91 males) with different types of CHD (29 univentricular). Children with recognized genetic disorders were excluded. Growth (weight, height, and head circumference [HC]) was assessed at birth, before surgery, and at 1, 4, and 6 years and compared with Swiss growth charts...
October 16, 2018: Journal of Pediatrics
Zaman Mirzadeh, Tsinsue Chen, Kristina M Chapple, Margaret Lambert, John P Karis, Rohit Dhall, Francisco A Ponce
BACKGROUND: Deep brain stimulation (DBS) is well-established, evidence-based therapy for Parkinson disease, essential tremor, and primary dystonia. Clinical outcome studies have recently shown that "asleep" DBS lead placement, performed using intraoperative imaging with stereotactic accuracy as the surgical endpoint, has motor outcomes comparable to traditional "awake" DBS using microelectrode recording (MER), but with shorter case times and improved speech fluency...
October 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
Maria-Ioanna Stefanou, Dominik Rath, Vera Stadler, Hardy Richter, Florian Hennersdorf, Henning F Lausberg, Mario Lescan, Simon Greulich, Sven Poli, Meinrad P Gawaz, Ulf Ziemann, Annerose M Mengel
Background: Cardiac myxoma (CM) is the most frequent, cardiac benign tumor and is associated with enhanced risk for cerebrovascular events (CVE). Although surgical CM excision is the only curative treatment to prevent CVE recurrence, in recent reports conservative treatment with antiplatelet or anticoagulant agents in high-risk patients with CM-related CVE has been discussed. Methods: Case records at the University Hospital of Tübingen between 2005 and 2017 were screened to identify patients with CM-related CVE...
2018: Frontiers in Neurology
Robert Francis Dallapiazza, Darrin J Lee, Philippe De Vloo, Anton Fomenko, Clement Hamani, Mojgan Hodaie, Suneil K Kalia, Alfonso Fasano, Andres M Lozano
There are several different surgical procedures that are used to treat essential tremor (ET), including deep brain stimulation (DBS) and thalamotomy procedures with radiofrequency (RF), radiosurgery (RS) and most recently, focused ultrasound (FUS). Choosing a surgical treatment requires a careful presentation and discussion of the benefits and drawbacks of each. We conducted a literature review to compare the attributes and make an appraisal of these various procedures. DBS was the most commonly reported treatment for ET...
October 18, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
J Sung, O Kwon, D Kim, K Kim
INTRODUCTION: Intracranial complications of acute rhinosinusitis are rare, but may turn life-threatening. CASE SUMMARY: We report a healthy 30-year-old male who complained of frontal headache, which developed while on a plane. A brain CT showed a low-density lesion on the left frontal convexity with right maxillary and ethmoid sinusitis. Despite receiving intravenous antibiotics, a follow-up brain CT showed two lesions with adjacent dural and leptomeningeal enhancement...
October 15, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
Leonello Tacconi, Roberto Spinelli, Francesco Signorelli
BACKGROUND: Traditional wound closure techniques include skin sutures and metal clips. Cyanoacrylate (2-Octyl-Cyanoacrylate "Dermabond C", by Ethicon, Germany) has good neovascularization, epithelialization and antimicrobial activity properties and a fast application procedure. This study presents our long-term experience. METHODS: We retrospectively selected 362 patients who underwent brain surgery from January 2007 to March 2017. Exclusion criteria was applied for repeat surgeries, emergency/post-traumatic procedures, wound infections, wounds longer than 16 centimeters, skull base cases, post-operative patients who stayed in the ICU more than 1 day...
October 15, 2018: World Neurosurgery
Yanrong Zhu, Ke Wang, Zhiqiang Ma, Dong Liu, Yang Yang, Meng Sun, Aidong Wen, Yuewen Hao, Shanbo Ma, Fang Ren, Zhenlong Xin, Yue Li, Shouyin Di, Juntian Liu
Sepsis-induced brain injury is frequently encountered in critically ill patients with severe systemic infection. Butein (3,4,2',4'-tetrahydroxychalcone) has been demonstrated as the neuro-protective agent via reducing inflammation and oxidative stress on neurons. Moreover, activation of silent information regulator 1 (SIRT1) inhibits apoptosis, oxidation and inflammation thus alleviating sepsis-induced multiorgan injuries. In present study, we show that butein administrated intraperitoneally (10 mg/kg) saved mice from sepsis-induced lethality by increasing 7-day survival rate after cecal ligation and puncture (CLP) surgery...
October 15, 2018: Toxicology and Applied Pharmacology
Brooks V Udelsman, Pamela S Jones, Yanik J Bababekov, Bob S Carter, David C Chang
No abstract text is available yet for this article.
October 17, 2018: Neurosurgery
Hikmat Permana, Guntur Darmawan, Ervita Ritonga, Maya Kusumawati, Miftahurachman Miftahurachman, Nanny Natalia Soetedjo
Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1.5:1. Ectopic ACC are considered to be extremely rare with no exact incidence data yet. We report an interesting case of hepatic ACC in a young woman with clinical signs of virilization.A-21-year old Sundanese woman visited our endocrine clinic with progressive hirsutism over the face, body, and extremities starting 14 years previously. She had irregular, heavy periods when she was 7 years old...
July 2018: Acta Medica Indonesiana
Junaid H Siddiqui, Zakiyah Aldaajani, Raja Mehanna, Barbara Kelly Changizi, Danish Bhatti, Ziyah Ghazi Al-Johani, Aparna Wagle Shukla, Hubert H Fernandez, Jawad A Bajwa
Parkinson's disease (PD) is increasing in prevalence due to a growing elderly population. Although there is no cure, there are exercise therapies and medications for mild to moderate disease. For more advanced disease, infusion or surgical interventions including deep brain stimulation surgery, levodopa carbidopa intestinal gel and subcutaneous apomorphine infusion are considered. As these interventions become increasingly available, it is imperative for a neurologist involved in the care of advanced PD to be aware of the indications and timing for these interventions...
October 17, 2018: Expert Review of Neurotherapeutics
Danilo Cardim, Chiara Robba, Basil Matta, Graham Tytherleigh-Strong, Niel Kang, Bernhard Schmidt, Joseph Donnelly, Leanne Calviello, Peter Smielewski, Marek Czosnyka
Although the beach-chair position (BCP) is widely used during shoulder surgery, it has been reported to associate with a reduction in cerebral blood flow, oxygenation, and risk of brain ischaemia. We assessed cerebral haemodynamics using a multiparameter transcranial Doppler-derived approach in patients undergoing shoulder surgery. 23 anaesthetised patients (propofol (2 mg/kg)) without history of neurologic pathology undergoing elective shoulder surgery were included. Arterial blood pressure (ABP, monitored with a finger-cuff plethysmograph calibrated at the auditory meatus level) and cerebral blood flow velocity (FV, monitored in the middle cerebral artery) were recorded in supine and in BCP...
October 17, 2018: Journal of Clinical Monitoring and Computing
P Jaulent, E Vignot, R Chapurlat
Fibrous dysplasia of bone is a stem cell bone disease due to a somatic GNAS mutation which can affect craniofacial bones. Although craniofacial fibrous dysplasia is a benign and progressive disorder, it can cause mass effect on the cranial structures. We describe an 18-year-old man, without past medical history, came at the emergency department with progressively worsening headache, associated with vomiting. Cranial bone CT and then brain MRI revealed fibrous dysplasia of occipital bone with intraosseous cyst, compression of right sigmoid vein...
October 16, 2018: Osteoporosis International
Hiroyuki Ohbe, Tomoaki Koakutsu, Shigeki Kushimoto
STUDY DESIGN: Retrospective single-institution observational study. OBJECTIVE: Spinal cord injury (SCI) is associated with a high prevalence of hyponatremia, which can cause various clinical symptoms and increase mortality. We aimed to analyze the risk factors for hyponatremia in patients with acute SCI. SETTING: Trauma Center, Tohoku University Hospital, Japan METHODS: We reviewed the medical records of patients with SCI admitted between January 2008 and November 2016...
October 16, 2018: Spinal Cord
Yong Woo An, Andrea DiTrani Lobacz, Tim Lehmann, Jochen Baumeister, William C Rose, Jill S Higginson, Jeffrey Rosen, Charles Buz Swanik
The purpose of this study was to identify how the brain simultaneously perceives proprioceptive input during joint loading in anterior cruciate ligament reconstruction (ACLR) patients, when compared to healthy controls. Seventeen ACLR patients (ACLR) and seventeen controls (CONT) were tested for the somatosensory cortical activation using electroencephalography (EEG) while measuring knee laxity using a knee arthrometer. The relationship between cortical activation and joint laxity within group was also examined...
October 16, 2018: Scandinavian Journal of Medicine & Science in Sports
Ryosuke Matsuda, Kentaro Tamura, Fumihiko Nishimura, Ichiro Nakagawa, Yasushi Motoyama
BACKGROUND: To avoid permanent neurologic deficits and preserve brain function in and near the eloquent area, intraoperative electrical stimulation mapping (IESM) is necessary. However, little is known about how these subcortical regions are involved in calculation processing function in patients with glioma. CASE DESCRIPTION: We report the case of a 56-year-old right-handed woman working at a primary school as a teacher who had recurrent left parietal glioma. She underwent initial surgical resection for a low-grade glioma present in the left parietal lobe 14 months prior to recurrence...
October 13, 2018: World Neurosurgery
Ingmar Blümcke, Roland Coras, Annika K Wefers, David Capper, Eleonora Aronica, Albert Becker, Mrinalini Honavar, Thomas J Stone, Thomas S Jacques, Hajime Miyata, Angelika Mühlebner, Jose Pimentel, Figen Söylemezoğlu, Maria Thom
Low-grade epilepsy-associated brain tumours (LEAT) are the second most common cause for drug-resistant, focal epilepsy, i.e. ganglioglioma (GG) and dysembryoplastic neuroepithelial tumours (DNT). However, molecular pathogenesis, risk factors for malignant progression, and their frequent association with drug-resistant focal seizures remain poorly understood. This contrasts recent progress in understanding the molecular-genetic basis and targeted treatment options in diffuse gliomas. The Neuropathology Task Force of the International League against Epilepsy examined available literature to identify common obstacles in diagnosis and research of LEAT...
October 16, 2018: Neuropathology and Applied Neurobiology
Mythri Pullela, Mehmet N Agaoglu, Anand C Joshi, Sevda Agaoglu, David K Coats, Vallabh E Das
Purpose: Although widely practiced, surgical treatment of strabismus has varying levels of success and permanence. In this study we investigated adaptive responses within the brain and the extraocular muscles (EOM) that occur following surgery and therefore determine long-term success of the treatment. Methods: Single cell responses were collected from cells in the oculomotor and abducens nuclei before and after two monkeys (M1, M2) with exotropia (divergent strabismus) underwent a strabismus correction surgery that involved weakening of the lateral rectus (LR) and strengthening of the medial rectus (MR) muscle of one eye...
October 1, 2018: Investigative Ophthalmology & Visual Science
Saoussen Bacha, Hela Cherif, Della Rabaa, Sonia Habibech, Sana Cheikhrouhou, Hager Racil, Naouel Chaouch, Mohamed Lamine Megdiche, Abdellatif Chabbou
BACKGROUND: The prognosis of patients with non-small cell lung cancer (NSCLC) with brain metastasis (BM) is dark. The aim of our study was to analyze the prognostic factors after the onset of BM and to evaluate the current management of BM. METHODS: We conducted a retrospective study that included 100 patients diagnosed with primary NSCLC with BM. Survival was analysed using Kaplan Meier curve.Univariate survival analysis was performed to assess the prognostic value of sex, age, gender, performance status, histologic type, tumor size, BM features and treatment modality of primary lung tumor and BM...
March 2018: La Tunisie Médicale
Jacopo Agrimi, Carlotta Baroni, Ekene Anakor, Vincenzo Lionetti
The number of obese patients undergoing cardiac and non cardiac surgery is rapidly increasing because they are more prone to concomitant diseases, such as diabetes, thrombosis, sleep-disordered breathing, cardiovascular and cerebrovascular diseases. Even if guidelines are already available to manage anesthesia and surgery of obese patients, the assessment of the perioperative morbidity and mortality from heart and brain disorders in morbidly obese surgical patients will be challenging in the next years. The present review will recapitulate the new mechanisms underlying the heart-brain axis vulnerability during the perioperative period in morbidly obese patients...
October 15, 2018: Current Medicinal Chemistry
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