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Tasuku Hirayama
Intracellular labile iron is an iron species which is not or weakly bound to proteins and depicts an important effect on homeostatic regulation in cells. An excess or deficiency of iron can cause oxidative damage to key cellular biomolecules. The behavior and concentrations of labile iron are difficult to monitor, but the specific redox state of the Fe ions is relevant to the physiological and pathological properties that we would like to study. We have developed a series of turn-on type fluorescent probes that are highly selective to the labile Fe(II) ions, and we have tested their applications to cellular level imaging...
October 31, 2018: Acta Histochemica et Cytochemica
Miwa Goto, Shinsuke Ifuku, Kazuo Azuma, Hidetoshi Arima, Shinichiro Kaneko, Daisuke Iohara, Fumitoshi Hirayama, Makoto Anraku
Pelleted preparations were formulated from sacran (Sac), an anionic, sulfated, carboxyl-containing polysaccharide, which is extracted from the Japanese indigenous cyanobacterium Aphanothece sacrum, and surface-deacetylated chitin nanofibers (SDACNF). The use of this material as an extended-release excipient for tetrahydrocurcumin (THC), a model drug that is used to treat wounds via its radical scavenging ability was examined. The THC used in the study was complexed with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), which increases its water solubility...
November 26, 2018: International Journal of Biological Macromolecules
Ikuya Miyamoto, Tetsu Takahashi, Tatsurou Tanaka, Bunichi Hirayama, Kenko Tanaka, Toru Yamazaki, Yasuhiro Morimoto, Izumi Yoshioka
OBJECTIVES: The mechanism of late implant failure is unclear. This study examined the association between sclerosing cancellous bone images and the risk of late implant failures using multi-detector row computed tomography (CT) imaging data. METHODS: We performed a case-control study. The study group consisted of consecutive patients with implant failures treated at Kyushu Dental University between 2001 and 2016. CT data for late failure of 36 implants in 16 patients were available...
September 2018: Oral Radiology
Masatoshi Hirayama
The lacrimal glands produce tears to support a healthy homeostatic environment on the ocular surface. The lacrimal gland dysfunction characteristic of dry eye disease causes ocular discomfort and visual disturbances and in severe cases can result in a loss of vision. The demand for adequate restoration of lacrimal gland function has been intensified due to advances in stem cell biology, developmental biology, and bioengineering technologies. In addition to conventional therapies, including artificial tears, tear alternatives (such as autologous serum eye drops) and salivary gland transplantation, a regenerative medicine approach has been identified as a novel strategy to restore the function of the lacrimal gland...
November 1, 2018: Investigative Ophthalmology & Visual Science
Takafumi Kubo, Kuniaki Hirayama, Nobuhiro Nakamura, Mitsuru Higuchi
The deceleration sub-phase during the back squat (BSQ) makes it difficult to stimulate the muscles throughout the full range of motion, and it has only been reported for one load during BSQ. The purpose of this study was to investigate whether a deceleration sub-phase occurs during BSQ with different loads and to assess the influence of load on the deceleration sub-phase duration and negative impulse during the deceleration sub-phase. Sixteen healthy men (mean ± standard deviation: age: 25 ± 3 years; height: 1...
December 2018: Journal of Sports Science & Medicine
Yushi Kunugi, Toshi H Arimura, Kazuyuki Iwata, Eiji Komatsu, Yoshie Hirayama
To attain cleaner air, it is important that authorities make informed decisions when selecting a strategy. Concentrations of particulate matter with an aerodynamic diameter of less than or equal to 2.5 μm (PM 2.5) are high in the Tokyo metropolitan area, even though concentrations of particulate matter with an aerodynamic diameter of less than or equal to 10 μm (PM10) have dropped dramatically since the implementation of the NOx-PM Act. Currently, monitored concentration levels continue to exceed the designated ambient air quality standard set by the Japanese Ministry of the Environment...
2018: PloS One
Mohammed Abdellatif, Sherief Ghozy, Mohamed Gomaa Kamel, Sameh Samir Elawady, Mohamed Mohy Eldeen Ghorab, Andrew Wassef Attia, Truong Thi Le Huyen, Diep Trong Vien Duy, Kenji Hirayama, Nguyen Tien Huy
Macrolides are bacteriostatic antibiotics with a broad spectrum of activity against Gram-positive bacteria. The aim of this study was to systematically review and meta-analyze the association between infantile hypertrophic pyloric stenosis (IHPS) and macrolides. Nine databases were searched systematically for studies with information on the association between macrolides and IHPS. We combined findings using random effects models. Our study revealed 18 articles investigating the association between macrolides and IHPS...
November 23, 2018: European Journal of Pediatrics
Takashi Nishitsuji, Yota Yamamoto, Takashige Sugie, Takanori Akamatsu, Ryuji Hirayama, Hirotaka Nakayama, Takashi Kakue, Tomoyoshi Shimobaba, Tomoyoshi Ito
Electro-holography is a promising display technology that can reconstruct a photorealistic three-dimensional (3D) movie; however, it is yet to be realized practically owing to the need for enormous calculation power. A special-purpose computer for electro-holography, namely HORN, has been studied for over 20 years as a means to solve this problem. The latest version of HORN, HORN-8, was developed using field programmable gate array (FPGA) technology. Initially, a circuit for amplitude-type electro-holography was implemented in HORN-8; however, implementation of phase-type electro-holography has remained an issue...
October 1, 2018: Optics Express
Takafumi Kubo, Kuniaki Hirayama, Nobuhiro Nakamura, Mitsuru Higuchi
The aim of this study was to investigate whether accommodating elastic bands with barbell back squats (BSQ) increase muscular force during the deceleration subphase. Ten healthy men (mean ± standard deviation: Age: 23 ± 2 years; height: 170.5 ± 3.7 cm; mass: 66.7 ± 5.4 kg; and BSQ one repetition maximum (RM): 105 ± 23.1 kg; BSQ 1RM/body mass: 1.6 ± 0.3) were recruited for this study. The subjects performed band-resisted parallel BSQ (accommodating elastic bands each sides of barbell) with five band conditions in random order...
November 22, 2018: Sports
Hiroshi Takagi, Shunsuke Watanabe, Shoma Tanaka, Takakazu Matsuura, Izumi C Mori, Takashi Hirayama, Hiroshi Shimada, Atsushi Sakamoto
BACKGROUND: The ureides allantoin and allantoate are major metabolic intermediates of purine catabolism with high nitrogen-to-carbon ratios. Ureides play a key role in nitrogen utilization in ureide-type legumes, but their effects on growth and development in non-legume plants are poorly understood. Here, we examined the effects of knocking out genes encoding ureide-degrading enzymes, allantoinase (ALN) and allantoate amidohydrolase (AAH), on the vegetative-to-reproductive transition and subsequent growth of Arabidopsis plants...
November 20, 2018: BMC Plant Biology
Yasuomi Shimizu, Satoshi Tamada, Minoru Kato, Yukiyoshi Hirayama, Yuji Takeyama, Taro Iguchi, Marianne D Sadar, Tatsuya Nakatani
Expression of androgen receptor (AR) splice variant 7 (AR-V7) has been identified as the mechanism associated with the development of castration-resistant prostate cancer (CRPC). However, a potential link between AR-V7 expression and resistance to taxanes, such as docetaxel or cabazitaxel, has not been unequivocally demonstrated. To address this, we used LNCaP95-DR cells, which express AR-V7 and exhibit resistance to enzalutamide and docetaxel. Interestingly, LNCaP95-DR cells showed cross-resistance to cabazitaxel...
November 16, 2018: Journal of Clinical Medicine
Satoshi Anada, Kazuo Yamamoto, Hirokazu Sasaki, Naoya Shibata, Miko Matsumoto, Yujin Hori, Kouhei Kinugawa, Akihiro Imamura, Tsukasa Hirayama
The innate electric potentials in biased p- and n-type GaAs compound semiconductors and the built-in potential were successfully measured with high accuracy and precision by applying in situ phase-shifting electron holography to a wedge-shaped GaAs specimen. A cryo-focused-ion-beam system was used to prepare the 35°-wedge-shaped specimen with smooth surfaces for a precise measurement. The specimen was biased in a transmission electron microscope, and holograms with high-contrast interference fringes were recorded for the phase-shifting method...
November 17, 2018: Microscopy
Kouji Yano, Satoshi Hirayama, Naomi Misawa, Ayaka Furuta, Tsuyoshi Ueno, Yumiko Motoi, Utako Seino, Hiroyuki Ebinuma, Takeshi Ikeuchi, Wolfgang J Schneider, Hideaki Bujo, Takashi Miida
BACKGROUND: LR11 is a member of the low-density lipoprotein (LDL) receptor family with high expression in neurons. Some cell surface LR11 is cleaved and secreted into the cerebrospinal fluid (CSF) as soluble LR11 (sLR11). Patients with Alzheimer's disease (AD), particularly apolipoprotein E4 carriers, have high CSF-sLR11 and low CSF-amyloid β (Aβ) concentrations. Therefore, we assessed whether sLR11 is bound to CSF-high-density lipoprotein (HDL) and whether sLR11 competes with Aβ in binding to apoE in CSF-HDL...
November 15, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Ichiro Hirayama, Ryota Inokuchi, Takahiro Hiruma, Kent Doi, Naoto Morimura
No abstract text is available yet for this article.
November 2018: Clinical practice and cases in emergency medicine
Masato Hamada, Emi Minamitani, Motoaki Hirayama, Shuichi Murakami
Phonon modes in crystals can have angular momenta in general. It nevertheless cancels in equilibrium when the time-reversal symmetry is preserved. In this Letter, we show that when a temperature gradient is applied and heat current flows in the crystal, the phonon distribution becomes off equilibrium, and a finite angular momentum is generated by the heat current. This mechanism is analogous to the Edelstein effect in electronic systems. This effect requires crystals with sufficiently low crystallographic symmetries, such as polar or chiral crystal structures...
October 26, 2018: Physical Review Letters
Takatoshi Sorimachi, Takahiro Osada, Akihiro Hirayama, Hideaki Shigematsu, Kittipong Srivatanakul, Mitsunori Matsumae
OBJECTIVE: The ideal surgery for a blood blister-like aneurysm (BBA) in the internal carotid artery (ICA) involves complete termination of blood flow into the BBA by trapping of the ICA at sites both proximal and distal to the BBA. In this study, a clipping method with ICA trapping is described for the prevention of anterior choroidal artery ischemia, which is a major problem in ICA trapping with reconstruction surgery using external carotid artery-middle cerebral artery high-flow bypass (HFB)...
November 1, 2018: World Neurosurgery
Qinli Xu, Danny Suya, Qingsan Zhu, Rui Gu
BACKGROUND: Hirayama disease (HD) is a rare disease traditionally treated with non-surgical procedures. Surgical treatment, which is performed by decompression and/or fusion of the cervical spine, is generally considered for rapidly progressive or advanced cases, and the choice of surgical technique is debatable. We describe the first severe case of HD that was successfully treated by posterior lateral mass screw fixation without decompression or fusion. CASE DESCRIPTION: Our patient was a 17-year-old man who presented with progressive symptoms bilaterally with an unsatisfactory history of conservative treatment...
November 1, 2018: World Neurosurgery
Daisuke Kajiura, Hisami Yamanaka-Okumura, Akiyoshi Hirayama, Hiroshi Tatano, Keiko Endo, Mayu Honma, Kaori Igarashi, Futaba Shoji, Satsuki Ikeda, Nozomi Yamaguchi, Takafumi Katayama, Yuji Morine, Satoru Imura, Tohru Utsunomiya, Tomoyoshi Soga, Masaru Tomita, Mitsuo Shimada
OBJECTIVES: Perioperative nutritional management is essential for early recovery after liver surgery. The aim of this study was to assess changes in amino acid levels in serum and urine after hepatectomy. METHODS: Serum samples were collected from 16 patients with hepatocellular carcinoma before and 1, 3, and 14 d after hepatectomy (S0, S1, S3, and S14, respectively). Spot urine samples were collected before and 3 d after the hepatectomy (U0 and U3). Metabolites in the serum and urine were analyzed...
August 7, 2018: Nutrition
Daiki Kobayashi, Takaho Tokuda, Kyosuke Sato, Hiroki Okanishi, Megumi Nagayama, Mio Hirayama, Sumio Ohtsuki, Norie Araki
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that predisposes individuals to developing benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). The mechanism of NF1-tumorigenesis or the curatives have not been established. Using unique trascriptome and proteome integration method, iPEACH (1), we previously identified translationally controlled tumor protein (TCTP) as a novel biological target for NF1-associated tumors (2). Here, we identified specific TCTP-interacting proteins by sequential affinity purification and data-independent mass spectrometry acquisition (AP-DIA/SWATH), to investigate the role of TCTP in NF1-associated malignant tumors...
October 31, 2018: Molecular & Cellular Proteomics: MCP
Kosuke Kurihara, Hidemi Toyoda, Keishirou Amoano, Mikihiro Inoue, Keiichi Uchida, Hiroyuki Sakurai, Akinobu Hayashi, Masahiro Hirayama
No abstract text is available yet for this article.
October 30, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
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