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https://www.readbyqxmd.com/read/30102384/loss-of-cg-methylation-in-marchantia-polymorpha-causes-disorganization-of-cell-division-and-reveals-unique-dna-methylation-regulatory-mechanisms-of-non-cg-methylation
#1
Yoko Ikeda, Ryuichi Nishihama, Shohei Yamaoka, Mario A Arteaga-Vazquez, Adolfo Aguilar-Cruz, Daniel Grimanelli, Romain Pogorelcnik, Robert A Martienssen, Katsuyuki T Yamato, Takayuki Kohchi, Takashi Hirayama, Olivier Mathieu
DNA methylation is an epigenetic mark that ensures silencing of transposable elements (TEs) and affects gene expression in many organisms. The function of different DNA methylation regulatory pathways has been largely characterized in the model plant Arabidopsis thaliana. However, far less is known about DNA methylation regulation and functions in basal land plants. Here we focus on the liverwort Marchantia polymorpha, an emerging model species that represents a basal lineage of land plants. We identified MpMET, the M...
August 9, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/30101812/guidelines-for-heart-disease-screening-in-schools-jcs-2016-jspccs-2016-digest-version
#2
Naokata Sumitomo, Reizo Baba, Shozaburo Doi, Takashi Higaki, Hitoshi Horigome, Fukiko Ichida, Hiromi Ishikawa, Mari Iwamoto, Naomi Izumida, Yuji Kasamaki, Keisuke Kuga, Yoshihide Mitani, Haruki Musha, Toshio Nakanishi, Masao Yoshinaga, Katsumi Abe, Mamoru Ayusawa, Tatsunori Hokosaki, Taichi Kato, Yoshiaki Kato, Kunio Ohta, Hirofumi Sawada, Hiroya Ushinohama, Shigeki Yoshiba, Hirotsugu Atarashi, Atsushi Hirayama, Minoru Horie, Masami Nagashima, Koichiro Niwa, Shunichi Ogawa, Ken Okumura, Hiroyuki Tsutsui
No abstract text is available yet for this article.
August 11, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/30101015/atypical-presentation-of-a-cushion-sign-positive-stomach-gastrointestinal-stromal-tumor-with-cystic-formation-a-case-report
#3
Yutaka Okagawa, Tetsuya Sumiyoshi, Hideyuki Ihara, Shutaro Oiwa, Kaho Tokuchi, Masahiro Yoshida, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Michiaki Hirayama, Hitoshi Kondo, Yumiko Oyamada, Yo Kawarada, Shuji Kitashiro, Shunichi Okushiba
Gastrointestinal stromal tumors (GIST) typically appear as solid masses, and cystic formation is uncommon. Most stomach GISTs with cystic formation progress outside the gastric wall and are frequently misdiagnosed as epigastric cystic tumors derived from pancreas or liver. An asymptomatic 72-year-old male underwent esophagogastroduodenoscopy, which revealed a submucosal tumor (SMT), approximately 50 mm in diameter, at the anterior wall of the gastric angle. The SMT was very soft with positive cushion sign. Endoscopic ultrasonography and contrast-enhanced computed tomography revealed that the SMT was a cystic tumor with solid component...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30097217/corrigendum-to-antithrombotic-therapy-trends-in-non-valvular-atrial-fibrillation-patients-undergoing-percutaneous-coronary-stent-implantation-results-from-a-survey-among-fellows-at-the-japanese-college-of-cardiology-j-cardiol-72-2-2018-113-119
#4
https://www.readbyqxmd.com/read/30097030/mycetoma-a-clinical-dilemma-in-resource-limited-settings
#5
REVIEW
Pembi Emmanuel, Shyam Prakash Dumre, Stephen John, Juntra Karbwang, Kenji Hirayama
BACKGROUND: Mycetoma is a chronic mutilating disease of the skin and the underlying tissues caused by fungi or bacteria. Although recently included in the list of neglected tropical diseases by the World Health Organization, strategic control and preventive measures are yet to be outlined. Thus, it continues to pose huge public health threat in many tropical and sub-tropical countries. If not detected and managed early, it results into gruesome deformity of the limbs. Its low report and lack of familiarity may predispose patients to misdiagnosis and delayed treatment initiation...
August 10, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/30094710/a-reexamination-on-the-deficiency-of-riboflavin-accumulation-in-malpighian-tubules-in-larval-translucent-mutants-of-the-silkworm-bombyx-mori
#6
Haokun Zhang, Takashi Kiuchi, Chikara Hirayama, Yutaka Banno, Susumu Katsuma, Toru Shimada
A variety of insects accumulate high contents of riboflavin (vitamin B2 ) in their Malpighian tubules (MTs). Although this process is known to be genetically controlled, the mechanism is not known. In the 1940s and the 1950s, several studies showed that riboflavin contents were low in the MTs of some Bombyx mori (silkworm) mutants with translucent larval skin mutations (e.g., w-3, od, oa, and otm) and that genes responsible for these translucent mutations also affected riboflavin accumulation in the MTs. Since the 2000s, it has been shown that the w-3 gene encodes an ABC transporter, whereas genes responsible for od, oa, and otm mutations encode for the biogenesis of lysosome-related organelles...
August 9, 2018: Genetica
https://www.readbyqxmd.com/read/30086614/clinical-and-imaging-features-of-multiple-system-atrophy-challenges-for-an-early-and-clinically-definitive-diagnosis
#7
Hirohisa Watanabe, Yuichi Riku, Kazuhiro Hara, Kazuya Kawabata, Tomohiko Nakamura, Mizuki Ito, Masaaki Hirayama, Mari Yoshida, Masahisa Katsuno, Gen Sobue
Multiple system atrophy (MSA) is an adult-onset, progressive neurodegenerative disorder. Patients with MSA show various phenotypes during the course of their illness, including parkinsonism, cerebellar ataxia, autonomic failure, and pyramidal signs. Patients with MSA sometimes present with isolated autonomic failure or motor symptoms/ signs. The median duration from onset to the concomitant appearance of motor and autonomic symptoms is approximately 2 years but can range up to 14 years. As the presence of both motor and autonomic symptoms is essential for the current diagnostic criteria, early diagnosis is difficult when patients present with isolated autonomic failure or motor symptoms/signs...
August 9, 2018: Journal of Movement Disorders
https://www.readbyqxmd.com/read/30080751/weekly-rituximab-followed-by-monthly-rituximab-treatment-for-autoimmune-disease-associated-with-ras-associated-autoimmune-leukoproliferative-disease
#8
Hidemi Toyoda, Takao Deguchi, Shotaro Iwamoto, Kentaro Kihira, Hiroki Hori, Yoshihiro Komada, Masahiro Hirayama
Recently, a new disease of lymphocyte homeostasis caused by somatic mosaicism for the RAS mutation has been discovered (known as RALD, RAS-associated leukoproliferative disorder). Since few cases have been reported in literature, the prognosis and standard treatment for autoimmune diseases associated with RALD remain poorly understood. Standard rituximab therapy (375 mg/m for 4 wk) is effective in patients with autoimmune diseases, but early recurrences are common. We highlight the potential for monthly administration of rituximab in a patient with autoimmune thrombocytopenia and hemolytic anemia associated with RALD...
August 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30078823/three-year-clinical-outcomes-associated-with-warfarin-vs-direct-oral-anticoagulant-use-among-japanese-patients-with-atrial-fibrillation-findings-from-the-sakura-af-registry
#9
Yasuo Okumura, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Keiichiro Kuronuma, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Shoji Hanada, Kazumiki Nomoto, Ken Arima, Fumiyuki Takahashi, Tomobumi Kotani, Yukitoshi Ikeya, Seiji Fukushima, Satoru Itou, Kunio Kondo, Masaaki Chiku, Yasumi Ohno, Motoyuki Onikura, Atsushi Hirayama
BACKGROUND: Although direct oral anticoagulants (DOACs) are widely used in Japanese patients with atrial fibrillation (AF), large-scale investigations into their use, with suitable follow-up times and rates, are lacking.Methods and Results:The SAKURA AF Registry is a prospective multicenter registry created to investigate therapeutic outcomes of oral anticoagulant (OAC) use in Japanese AF patients. We conducted a study involving 3,237 enrollees from 63 institutions in the Tokyo area being treated with any of 4 DOACs (n=1,676) or warfarin (n=1,561) and followed-up for a median of 39...
August 4, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/30061251/clinical-impact-of-histological-heterogeneity-in-the-metastatic-lymph-nodes-of-patients-with-colorectal-cancer
#10
Kazuyoshi Hirayama, Makoto Sudoh, Hiroki Shimizu, Shinji Furuya, Yoshihiro Akazawa, Hiroshi Iino, Kensuke Shiraishi, Hidenori Akaike, Naohiro Hosomura, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromitsu Kawaida, Shingo Inoue, Hiroshi Kono, Hideki Fujii, Daisuke Ichikawa
AIM: The purpose of this study was to evaluate the clinical impact of histological heterogeneity in patients with node-positive colorectal cancer (CRC). PATIENTS AND METHODS: One hundred and twenty-nine patients who underwent curative surgical resection for histological node-positive CRC were enrolled. Patients were divided according to the histological heterogeneity in the primary lesion into p-hetero and p-homo groups. The p-hetero group was further divided according to histological heterogeneity in the metastatic lymph nodes into n-hetero and n-homo groups...
August 2018: Anticancer Research
https://www.readbyqxmd.com/read/30059537/clinicopathological-comparison-between-acute-gastrointestinal-graft-versus-host-disease-and-infectious-colitis-in-patients-after-hematopoietic-stem-cell-transplantation
#11
Sae Ohwada, Tomoya Iida, Daisuke Hirayama, Gota Sudo, Toshiyuki Kubo, Masanori Nojima, Kentaro Yamashita, Hiroo Yamano, Hiroshi Nakase
The aim of this study is to elucidate the differences of the clinicopathological characteristics between acute gastrointestinal (GI)-graft-versus-host disease (GVHD) and infectious colitis (IC) after hematopoietic stem cell transplantation (HSCT). Of the 282 patients who underwent HSCT at our institution between January 1991 and December 2015, we could investigate 182 patients in detail. Of the 182 patients, we selected those who underwent colonoscopy and were diagnosed with acute GI-GVHD or IC after HSCT. Patients' backgrounds, colonoscopic findings, and pathological findings were retrospectively analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/30058991/ips-cell-serves-as-a-source-of-dendritic-cells-for-in-vitro-dengue-virus-infection-model
#12
Dao Huy Manh, Shusaku Mizukami, Shyam Prakash Dumre, Muhareva Raekiansyah, Satoru Senju, Yasuharu Nishimura, Juntra Karbwang, Nguyen Tien Huy, Kouichi Morita, Kenji Hirayama
The lack of an appropriate model has been a serious concern in dengue research pertinent to immune response and vaccine development. It remains a matter of impediment in dengue virus (DENV) studies when it comes to an in vitro model, which requires adequate quantity of dendritic cells (DC) with uniform characters. Other sources of DC, mostly monocyte derived DC (moDC), have been used despite their limitations such as quantity, proliferation, and donor dependent characters. Recent development of human iPS cells with consistent proliferation for long, stable, functional characteristics and desired HLA background has certainly offered added advantages...
July 30, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/30056812/prediction-of-zika-confirmed-cases-in-brazil-and-colombia-using-google-trends
#13
S Morsy, T N Dang, M G Kamel, A H Zayan, O M Makram, M Elhady, K Hirayama, N T Huy
Zika virus infection in humans has been linked to severe neurological sequels and foetal malformations. The rapidly evolving epidemics and serious complications made the frequent updates of Zika virus mandatory. Web search query has emerged as a low-cost real-time surveillance system to anticipate infectious diseases' outbreaks. Hence, we developed a prediction model that could predict Zika-confirmed cases based on Zika search volume in Google Trends. We extracted weekly confirmed Zika cases of two epidemic countries, Brazil and Colombia...
July 30, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/30045036/gastroesophageal-reflux-disease-related-disorders-of-systemic-sclerosis-based-on-the-analysis-of-66-patients
#14
Rie Matsuda, Nobutake Yamamichi, Takeshi Shimamoto, Hayakazu Sumida, Yu Takahashi, Chihiro Minatsuki, Shinya Kodashima, Satoshi Ono, Keiko Niimi, Yosuke Tsuji, Yoshiki Sakaguchi, Itaru Saito, Yosuke Kataoka, Itsuko Asada-Hirayama, Hikaru Kakimoto, Seiichi Yakabi, Chihiro Takeuchi, Yuta Matsumoto, Zenshiro Tamaki, Mitsuhiro Fujishiro, Yoshihide Asano, Shinichi Sato, Kazuhiko Koike
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD)-related disorders of systemic sclerosis (SSc) patients have not been adequately investigated. METHODS: Sixty-six SSc patients (5 males and 61 females; 56.6 ± 14.6 years old) who underwent esophagogastroduodenoscopy were analyzed on the basis of 16 background factors. They were additionally compared with 116 matched non-SSc subjects controlling age, sex, and use of proton pump inhibitors (PPIs). RESULTS: The mean disease duration of 66 patients was 5...
July 25, 2018: Digestion
https://www.readbyqxmd.com/read/30040045/antimetastatic-effects-of-carbon-ion-beams-on-malignant-melanomas
#15
Yoshitaka Matsumoto, Yoshiya Furusawa, Akiko Uzawa, Ryoichi Hirayama, Sachiko Koike, Koichi Ando, Koji Tsuboi, Hideyuki Sakurai
The goal of this work was to clarify the effect of carbon-ion beams on reduction of the metastatic potential of malignant melanoma using in vitro and in vivo techniques. We utilized a 290 MeV/u carbon beam with a 6-cm spread-out Bragg-peak (SOBP), 137 Cs γ rays or 200 kVp X rays for irradiation, and in vitro murine melanoma B16/BL6 cells that were implanted into C57BL/6J mice. The metastatic abilities (migration, invasion and adhesion) were suppressed by carbon ion treatment at all doses that were tested, whereas invasion and migration tended to increase after X-ray irradiation at low dose...
July 24, 2018: Radiation Research
https://www.readbyqxmd.com/read/30038100/hirayama-disease-cervical-flexion-induced-myelopathy-progressing-to-spastic-paraparesis-a-report-on-three-cases-with-literature-review
#16
Veeramani Preethish-Kumar, Kiran Polavarapu, Saraswati Nashi, Kajari Bhattacharya, Jitender Saini, Seena Vengalil, Nupur Pruthi, Dhananjay I Bhat, Atchayaram Nalini
Hirayama disease (HD)/cervical flexion-induced myelopathy (CFIM) is a lower motor neuron disease conventionally affecting a single upper extremity. We describe three men progressing after a long stable period to develop severe spastic paraparesis and bladder disturbances as a protracted implication of HD. The age at onset was 20, 24, and 15 years, while the age at presentation was 27, 41, and 57 years, respectively. The second phase of disease progression occurred after 4, 13, and 28 years of stationary period...
July 2018: Neurology India
https://www.readbyqxmd.com/read/30033140/surgical-treatment-of-diverticulitis-and-its-complications-a-systematic-review-and-meta-analysis-of-randomized-control-trials
#17
REVIEW
Ali Mahmoud Ahmed, Abdelrahman Tarek Moahammed, Omar Mohamed Mattar, Esraa Mowafy Mohamed, Esraa Abdelmon'em Faraag, Ammar Mohammed AlSafadi, Kenji Hirayama, Nguyen Tien Huy
PURPOSE: The surgical interventions of diverticulitis vary according to its grade and severity. There is a controversy about the best of these different surgical procedures. We aimed to systematically review and meta-analyze randomized controlled trials (RCTs) comparing outcomes and complications between different surgical approaches for acute diverticulitis and its complications. METHODS: Nine electronic databases including PubMed, Scopus, and Web of Science were searched for RCTs comparing different surgical procedures for different grades of diverticulitis...
July 19, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/30032190/the-putative-peptide-gene-fep1-regulates-iron-deficiency-response-in-arabidopsis
#18
Takashi Hirayama, Gui Jie Lei, Naoki Yamaji, Naoki Nakagawa, Jian Feng Ma
Iron is an essential element for all organisms, and plants have developed sophisticated systems to acquire iron and maintain iron homeostasis. We found that an Arabidopsis thaliana abscisic acid-hypersensitive mutant, aba hypersensitive germination2-1 (ahg2-1), that is known to be defective in mitochondrial mRNA regulation had increased expression of iron deficiency response genes. The ahg2-1 mutant had lower heme levels than the wild type. Transcriptome data further revealed that novel genes encoding short polypeptides were highly expressed in this mutant...
July 19, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/30031056/effect-of-the-demineralisation-efficacy-of-mdp-utilized-on-the-bonding-performance-of-mdp-based-all-in-one-adhesives
#19
Kou Fujita Nakajima, Toru Nikaido, Michael Francis Burrow, Taro Iwasaki, Yasuhiro Tanimoto, Satoshi Hirayama, Norihiro Nishiyama
OBJECTIVES: The amounts of calcium salt of 10-methacryloyloxydecyl dihydrogen phosphate (MDP-Ca salt) and dicalcium phosphate dihydride (DCPD) with an amorphous phase produced by the demineralisation of enamel and dentin were determined using commercial MDP-based 2-hydroxyethyl methacrylate (HEMA)-containing and HEMA-free all-in-one adhesives. The effect of the amount of MDP-Ca salt produced on bonding performance to enamel and dentin was then characterized. METHODS: Three types of commercial HEMA-containing adhesives (Scotchbond Universal Adhesive, Clearfil Tri-S Bond ND, Clearfil Tri-S Bond ND Quick), a commercial HEMA-free adhesive (G-Bond Plus) and an experimental HEMA-free adhesive were used...
July 18, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/30029794/demineralization-capacity-of-commercial-10-methacryloyloxydecyl-dihydrogen-phosphate-based-all-in-one-adhesive
#20
Kou Fujita Nakajima, Toru Nikaido, Akishi Arita, Satoshi Hirayama, Norihiro Nishiyama
OBJECTIVE: We determined the amounts of calcium salt of 10-methacryloyloxydecyl dihydrogen phosphate (MDP-Ca salt) and dicalcium phosphate dihydride (DCPD) with an amorphous phase developed during the application of commercial MDP-based all-in-one adhesives to enamel and dentin. This is because the demineralization by MDP and following calcium salt formation of MDP may be limited by an ionic bond formation of MDP to hydroxyapaptite in the enamel and dentin and following intermediary layer formation of MDP, since MDP forms a chemically-stable adsorption layer...
July 17, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
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