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https://www.readbyqxmd.com/read/30323874/microglial-activation-an-important-process-in-the-onset-of-epilepsy
#1
Hu Zhao, Changgeng Zhu, Donghui Huang
This study aimed to investigate the effects of microglial activation on the onset of epilepsy. Microglias cultured in vitro were stimulated with different concentrations of coriaria lactone (CL), and the effects on cell cycle and apoptosis were examined using flow cytometry. Then microglia were stimulated with 5×10-5 mol/L CL, and levels of cyclin D1 and interleukin-1β (IL-1β) mRNA were measured by fluorescence quantitative PCR; tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in supernatant were detected by radioimmunoassay...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30295907/left-pan-hippocampal-low-grade-glioma-2-stage-transsylvian-transventricular-and-paramedian-supracerebellar-transtentorial-approaches-2-dimensional-operative-video
#2
Juan C Fernandez-Miranda
The surgical goal for low-grade gliomas (LGGs) is to maximize resection while minimizing morbidity. Pan-hippocampal LGGs extend from the hippocampal head to the hippocampal tail, and involve the parahippocampal gyrus and uncus. Given their anteroposterior extension, they cannot be completely removed with 1 single approach, requiring a 2-stage front-to-back operation. In this video, we present the case of a 52-yr-old man with new onset of generalized seizures and a dominant-side, nonenhancing, pan-hippocampal infiltrative lesion compatible with a low-grade glioma...
October 5, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30269583/surgical-treatment-of-epilepsy-in-vietnam-program-development-and-international-collaboration
#3
Brandon G Rocque, Matthew C Davis, Samuel G McClugage, Dang Anh Tuan, Donald T King, Nguyen Thi Huong, Nguyen Thi Bich Van, Pongkiat Kankirawatana, Cao Vu Hung, Le Nam Thang, James M Johnston, Nguyen Duc Lien
OBJECTIVE: The purpose of this report was to describe an international collaboration model to facilitate the surgical treatment of children with epilepsy in Vietnam. METHODS: This model uses three complementary methods to achieve a meaningful expansion in epilepsy surgery capacity: US-based providers visiting Hanoi, Vietnam; Vietnamese providers visiting the US; and ongoing telecollaboration, including case review and real-time mentorship using internet-based communication platforms...
October 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/30265190/placental-alkaline-phosphatase-levels-in-cerebrospinal-fluid-can-have-a-decisive-role-in-the-differential-diagnosis-of-intracranial-germ-cell-tumors
#4
Yasuo Aihara, Sinichiro Watanabe, Kosaku Amano, Kana Komatsu, Kentaro Chiba, Kosuke Imanaka, Tomokatsu Hori, Takashi Ohba, Hitoshi Dairoku, Yoshikazu Okada, Osami Kubo, Takakazu Kawamata
OBJECTIVE: Placental alkaline phosphatase (PLAP) in CSF can provide a very high diagnostic value in cases of intracranial germ cell tumors (GCTs), especially in pure germinomas, to the level of not requiring histological confirmation. Unlike other tumor markers, reliable data analysis with respect to the diagnostic value of PLAP serum or CSF levels has not been available until now. This is the first systematic and comprehensive study examining the diagnostic value of CSF PLAP in patients with intracranial GCTs...
September 28, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30261376/management-of-choroid-plexus-tumors-in-infants-and-young-children-up-to-4-years-of-age-an-institutional-experience
#5
Chinmaya Dash, Skanda Moorthy, Kanwaljeet Garg, Pankaj Kumar Singh, Amandeep Kumar, Hitesh Gurjar, P Sarat Chandra, Sasank Sarad Kale
PURPOSE: Choroid plexus tumors (CPT) are rare tumors characterized by papillary and intraventricular growth. The young age of presentation of such tumors, especially in infants as well as the lack of consensus on adjuvant therapy in case of aCPP and CPC create dilemma for the management of such tumors. We discuss the presentation, management, complications and outcome in 15 patients (children <=4 years) and review pertinent literature METHODS: We retrospectively analyzed the case records of all patients with choroid plexus tumors who were operated in our institute from January 2010 to March 2018...
September 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30244186/2-micron-continuous-wave-laser-assisted-neuroendoscopy-clinical-experience-of-two-institutions-in-524-procedures
#6
Martin U Schuhmann, Cahit Kural, Lisanne Lalla, Florian H Ebner, Christoph Bock, Hans-Christoph Ludwig
OBJECTIVE: The aim of this study is to present the clinical experience of two neurosurgical centers with the use of a 2-micron continuous wave laser (2μ-cwL) system as standard tool in neuroendoscopic procedures and to discuss the safety and efficacy of this system. METHODS: 469 patients underwent neuroendoscopic procedures using 2μ-cwL between September 2009 and January 2015. All patient data were retrospectively reviewed. 241 (51%) patients were children and 228 (49%) adults...
September 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30240857/craniopharyngiomas-primarily-involving-the-hypothalamus-a-model-of-neurosurgical-lesions-to-elucidate-the-neurobiological-basis-of-psychiatric-disorders
#7
Jose María Pascual, Ruth Prieto, Inés Castro-Dufourny, Lorenzo Mongardi, Maria Rosdolsky, Sewan Strauss, Rodrigo Carrasco, Laura Barrios
OBJECTIVE: This study provides a systematic review and meta-analysis of psychiatric disorders caused by craniopharyngiomas and the hypothalamic alterations underlying these symptoms. METHODS: We investigated a collection of 210 craniopharyngiomas published from 1823 to 2017 providing detailed clinical and pathological information about psychiatric disturbances, including 10 of our own series, and compared the hypothalamic damage in this cohort with the present in a control cohort of 105 cases without psychiatric symptoms...
September 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30239311/management-of-severe-intraoperative-hemorrhage-during-intraventricular-neuroendoscopic-procedures-the-dry-field-technique
#8
Joachim Oertel, Stefan Linsler, Akos Csokonay, Henry W S Schroeder, Sebastian Senger
OBJECTIVE: The unexpected intraoperative intraventricular hemorrhage is a rare but feared and life-threatening complication in neuroendoscopic procedures because of loss of endoscopic vision. The authors present their experience with the so-called "dry field technique" (DFT) for the management of intraventricular hemorrhages during purely endoscopic procedures. This technique requires the aspiration of the entire intraventricular CSF to achieve clear visualization of the bleeding source...
September 21, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30219587/central-liponeurocytoma-as-a-clinical-entity
#9
REVIEW
Ali Börekci, Pınar Kuru Bektaşoğlu, Ali Fatih Ramazanoğlu, Bora Gürer, Erhan Çelikoğlu
INTRODUCTION: Liponeurocytomas are mostly localized in cerebellar hemispheres and the second most common location is the vermis. It is rarely observed within the intracranial ventricles. Here, we present a case of liponeurocytoma located in the right lateral ventricle and the systematic review of the literature. STATE OF THE ART: We searched PubMed with keyword 'central liponeurocytoma' and the references of the related articles. There were no language or year restrictions...
September 11, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/30145081/intraoperative-monitoring-of-motor-evoked-potential-for-parenchymal-brain-tumor-removal-an-analysis-of-false-negative-cases
#10
Takeru Umemura, Shigeru Nishizawa, Yoshiteru Nakano, Takeshi Saito, Takehiro Kitagawa, Ryo Miyaoka, Kohei Suzuki, Junkoh Yamamoto
Transcranial motor-evoked potential (tc-MEP) monitoring is unreliable for brain tumor removal due to its low sensitivity. According to previous literature, this is because transcranial stimulation seems to reach the deep pyramidal tract beyond the operation point and may thus yield false-negative results, where, although MEP recording is stable, postoperative motor deficits are encountered. Therefore, we aimed to analyze the causes for the false-negative results and investigate whether decreasing the stimulation intensity better reflects the operation point and can improve the sensitivity during parenchymal brain tumor removal...
November 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30138862/mri-of-intracranial-intraventricular-lesions
#11
REVIEW
Sudha Muly, Syrone Liu, Roland Lee, Savvas Nicolaou, Rafael Rojas, Faisal Khosa
The MRI appearance of intraventricular neoplasms is often nonspecific, however knowledge of patient age and tumor location facilitates the formulation of a differential diagnosis. Imaging and pertinent clinical features of the following intraventricular neoplasms are reviewed: ependymoma, subependymoma, central neurocytoma, subependymal giant cell tumor, choroid plexus tumors, medulloblastoma, meningioma, chordoid glioma, rosette-forming glioneuronal tumor, central nervous system lymphoma, and metastasis.
August 1, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/30133179/mesenchymal-stem-cells-for-severe-intraventricular-hemorrhage-in-preterm-infants-phase-i-dose-escalation-clinical-trial
#12
So Yoon Ahn, Yun Sil Chang, Se In Sung, Won Soon Park
We previously demonstrated that transplanting mesenchymal stem cells (MSCs) improved recovery from brain injury induced by severe intraventricular hemorrhage (IVH) in newborn rats. To assess the safety and feasibility of MSCs in preterm infants with severe IVH, we performed a phase I dose-escalation clinical trial. The first three patients received a low dose of MSCs (5 × 106 cells/kg), and the next six received a high dose (1 × 107 cells/kg). We assessed adverse outcomes, including mortality and the progress of posthemorrhagic hydrocephalus...
August 21, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/30112665/natural-history-of-intraventricular-meningiomas-systematic-review
#13
REVIEW
Benedito Jamilson Araújo Pereira, Antônio Nogueira de Almeida, Wellingson Silva Paiva, Paulo Henrique Pires de Aguiar, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie
Review the data published on the subject to create a more comprehensive natural history of intraventricular meningiomas (IVMs). A Medline search up to March 2018 using "intraventricular meningioma" returned 98 papers. As a first selection step, we adopted the following inclusion criteria: series and case reports about IVMs, as well as papers written in other languages, but abstracts written in English were evaluated. Six hundred eighty-one tumors were evaluated from 98 papers. The majority of the tumors were located in the lateral ventricles (602-88...
August 15, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/30101877/-a-case-of-leptomeningeal-carcinomatosis-involving-loss-of-eyesight-after-total-gastrectomy-for-gastric-cancer
#14
Marie Kurebayashi, Akira Hashimoto, Youhei Ikenoyama, Yuichi Tahara, Hiroyuki Fuke, Atsuya Shimizu, Masahide Kondo, Hiroshi Nakano, Toshiya Kosaka
A 78-year-old woman had undergone total gastrectomy and chemotherapy for gastric cancer (pT4N3bM0 Stage IIIC, poorly differentiated adenocarcinoma). She received S-1 monotherapy 3 times weekly (S-1 at 80mg twice daily for 14 days, every 3 weeks). She underwent routine examinations, including tumor markers and computed tomography. She had no signs of recurrent disease, but she suffered from a loss of eyesight 2 years and 8 months after the operation. A choked disc was found, but she had no headaches, nausea, or unconsciousness, which indicated high intraventricular pressure...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/30096500/patterns-of-hydrocephalus-in-rural-haiti-a-ct-based-study
#15
Ernest J Barthélemy, Yannis K Valtis, Maggie F Cochran, Louine Martineau, Kee Park, Jeffrey B Mendel, Benjamin Warf, Aaron L Berkowitz
INTRODUCTION: /Objective: Hydrocephalus is a common neurosurgical disorder that can lead to significant disability or death if not promptly identified and treated. Data on the burden of hydrocephalus in low-income countries is limited given lack of radiological resources for the diagnosis of this condition. Here, we present an analysis of patterns of hydrocephalus from a large sample of head CTs performed at a public hospital in rural Haiti, a low-income country in the Caribbean. METHODS: We analyzed reports from 3614 head CTs performed between July 2013 and January 2016 for findings that were consistent with a diagnosis of hydrocephalus (report indicating "hydrocephalus," "ventriculomegaly," or "enlargement of the ventricles")...
August 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30050611/-tuberous-sclerosis-complex-the-role-of-patient-s-history-and-clinical-examination
#16
Jawad El-Azhari, Naoufal Hjira
Tuberous sclerosis complex (TSC) is a neurocutaneous multisystemic syndrome most commonly affecting the skin, the brain, the kidneys, the lungs and the eyes. The diagnosis is based on clinical characteristics; 90% of patients have skin lesions and seizures are the initial symptom in 80% of patients. Patients with STB often show a high incidence of neuropsychiatric symptoms, including mental retardation, autism and learning difficulties. Epilepsy and brain and renal tumors are treated with aggressive therapeutic and surgical approaches...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30043262/craniopharyngioma-adherence-a-reappraisal-of-the-evidence
#17
REVIEW
Ruth Prieto, José María Pascual, Verena Hofecker, Eduard Winter, Inés Castro-Dufourny, Rodrigo Carrasco, Laura Barrios
Craniopharyngioma (CP) adherence represents a most baffling problem for the neurosurgeon. The highest priority of current surgical treatment is to maximize tumor removal without compromising the patients' long-term functional outcome. Surgical damage to the hypothalamus may be avoided or at least ameliorated with a precise knowledge regarding the type of adherence for each case. This article presents a comprehensive review of the pathological, surgical, and radiological sources of evidence supporting that CP adherence, despite being heterogenous, is characterized by repeating patterns...
July 24, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/30042916/intraventricular-anaplastic-pleomorphic-xanthoastrocytoma-very-rare-localization-and-early-recurrence-of-a-rare-tumor
#18
Fabio Roberti, Martin Baggenstos
We report a rare case of an adult, with no previous history of seizures, found to have a large intraventricular Anaplastic Pleomorphic Xanthoastrocytoma (APXA). To the best of our knowledge, this is only the second documented report of an APXA located within the ventricular system in an adult. The tumor was characterized by anaplastic features and necrosis without an elevated mitotic index, and it recurred shortly after a gross total surgical resection.
May 21, 2018: Curēus
https://www.readbyqxmd.com/read/30039530/novel-case-of-recurrent-intraventricular-atypical-central-neurocytoma-with-prominent-gangliogliomatous-differentiation-in-a-10-year-old-boy-with-10-years-of-follow-up
#19
Char-Loo Tan, Daniel Landi, Herbert Fuchs, Roger E McLendon
Central neurocytoma is a rare neuronal tumor that typically occurs in young adults. Infrequently, these tumors exhibit advanced neuronal maturation and glial differentiation, giving rise to a histologically diverse tumor, in contrast to a typical central neurocytoma. We present a novel case of intraventricular central neurocytoma with prominent gangliogliomatous differentiation that developed atypical features upon recurrence after 10 years of follow up in a 10-year-old boy. Our case provides insight into the divergent differentiation capability of a neurocytic tumor and illustrates the diverse histological features of this rare entity...
October 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/30028260/the-correlation-between-accumulation-of-amyloid-beta-with-enhanced-neuroinflammation-and-cognitive-impairment-after-intraventricular-hemorrhage
#20
Conglin Jiang, Xiang Zou, Renqing Zhu, Yimin Shi, Zehan Wu, Fan Zhao, Liang Chen
OBJECTIVE Intraventricular hemorrhage (IVH) is found in approximately 40% of intracerebral hemorrhages and is associated with increased mortality and poor functional outcome. Cognitive impairment is one of the complications and occurs due to various pathological changes. Amyloid beta (Aβ) accumulation and neuroinflammation, and the Alzheimer disease-like pathology, may contribute to cognitive impairment. Iron, the degradation product of hemoglobin, correlates with Aβ. In this study, the authors investigated the correlation between Aβ accumulation with enhanced neuroinflammation and cognitive impairment in a rat model of IVH...
July 20, 2018: Journal of Neurosurgery
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