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Intraventricular tumor

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https://www.readbyqxmd.com/read/30503293/factors-predicting-ventriculostomy-revision-at-a-large-academic-medical-center
#1
Ashwin G Ramayya, Gregory Glauser, Brendan Mcshane, Marc Branche, Saurabh Sinha, Svetlana Kvint, Vivek Buch, Kalil G Abdullah, David Kung, H Isaac Chen, Neil R Malhotra, Ali Ozturk
BACKGROUND: Freehand bedside ventriculostomy placement can result in catheter malfunction requiring a revision procedure and cause significant patient morbidity. We performed a single-center retrospective review to assess factors related to this complication. METHODS: Using an administrative database and chart review, we identified 101 first-time EVD placements performed at the bedside. We collected data regarding demographics, medical co-morbidities, complications and catheter tip location...
November 29, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30500581/lateral-intraventricular-anaplastic-meningioma-a-series-of-5-patients-at-a-single-institution-and-literature-review
#2
Hongxu Chen, Rui Lai, Xinpu Tang, Zhiyong Liu, Jianguo Xu
OBJECTIVE: Lateral intraventricular anaplastic meningiomas (LIAMs) are rare lesions. The aim of this study is to clarify clinical and radiological characteristics, the optimal treatment strategies of LIAMs with long-term follow-up. PATIENTS AND METHODS: From September 2008 to September 2017, 5 LIAM patients were enrolled in our study. The clinical profiles, radiological features, treatment strategies, and outcomes were retrospectively analyzed. RESULTS: Five patients (all females, mean age 48...
November 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30497142/chordoma-of-the-corpus-callosum-case-report
#3
(no author information available yet)
Chordomas are neoplasms that typically arise from midline skeletal structures and rarely originate within the intradural compartment of the CNS. A chordoma arising from the corpus callosum has not been previously described. The authors report the surgical management of a chordoma originating within the splenium of the corpus callosum. To determine the incidence and distribution of intracranial intradural chordoma, a literature search for additional cases was performed. MEDLINE was searched using the MeSH keyword "chordoma," yielding 2010 articles...
November 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30460634/infusion-of-5-azacytidine-5-aza-into-the-fourth-ventricle-or-resection-cavity-in-children-with-recurrent-posterior-fossa-ependymoma-a-pilot-clinical-trial
#4
David I Sandberg, Bangning Yu, Rajan Patel, John Hagan, Emilie Miesner, Jennifer Sabin, Sarah Smith, Stephen Fletcher, Manish N Shah, Rachael W Sirianni, Michael D Taylor
BACKGROUND: DNA methylation inhibitors are logical therapeutic candidates for ependymomas originating in the posterior fossa of the brain. Our objective was to test the safety of infusing 5-Azacytidine (5-AZA), a DNA methylation inhibitor, directly into cerebrospinal fluid (CSF) spaces of the fourth ventricle or tumor resection cavity in children with recurrent ependymoma originating in the posterior fossa. MATERIALS AND METHODS: In patients with recurrent ependymoma whose disease originated in the posterior fossa, a maximal safe subtotal tumor resection was performed...
November 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/30439524/tetraventricular-atypical-central-neurocytoma-case-report
#5
Vikas Singh, Ashwin Borkar, Aliasgar Moiyadi, Prakash Shetty
BACKGROUND: Central neurocytomas are benign tumors accounting for < 0.5% of all intracranial tumours. They are usually intraventricular, the commonest site being the lateral ventricles and are associated with good prognosis if they are completely resected surgically. CASE AND DESCRIPTION: We report a case of middle aged lady who was evaluated for recent onset headache and Magnetic resonance imaging (MRI) brain was suggestive of solid-cystic intraventricular mass spanning all the ventricles...
November 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30406318/neuroendoscopic-biopsy-analysis-of-a-series-of-80-patients
#6
Ángela Ros-Sanjuán, Bienvenido Ros-López, Guillermo Ibáñez-Botella, Miguel Domínguez-Páez, Antonio Carrasco-Brenes, Miguel Ángel Arráez-Sánchez
Neuroendoscopy enables diagnostic biopsy of intraventricular and/or paraventricular tumors and the simultaneous treatment of associated hydrocephalus in selected cases. The objective of this paper was to analyze the effectiveness and safety of this procedure. This retrospective study included 80 patients between 2 months and 78 years old diagnosed with intraventricular and/or paraventricular expansive lesion who underwent neuroendoscopic biopsy from 2004 to 2016. Collected variables were gender, age at diagnosis, clinical presentation, tumor location, surgical technique, management of hydrocephalus, pathological findings, procedure-related complications, and follow-up time...
November 7, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/30404057/sellar-atypical-teratoid-rhabdoid-tumor-presenting-with-subarachnoid-and-intraventricular-hemorrhage
#7
Karam Asmaro, Muzamil Arshad, Lara Massie, Brent Griffith, Ian Lee
BACKGROUND: Atypical teratoid/rhabdoid tumors (ATRT) are uncommon malignancies of the central nervous system and often difficult to distinguish radiographically and pathologically from other common tumors. In this report, we present the first case of sellar ATRT presenting with subarachnoid (SAH) and intraventricular (IVH) hemorrhage. CASE DESCRIPTION: A 62 year-old female presented with symptoms of headache, diabetes insipidus, hypothyroidism, and seizures was found to have a sellar tumor with hemorrhagic transformation...
November 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30359428/dexamethasone-does-not-prevent-hydrocephalus-after-severe-intraventricular-hemorrhage-in-newborn-rats
#8
Jang Hoon Lee, Yun Sil Chang, So Yoon Ahn, Se In Sung, Won Soon Park
The aim of this study was done to determine whether dexamethasone treatment prevents posthemorrhagic hydrocephalus (PHH) development and attenuates brain damage after severe IVH in newborn rats. Severe IVH was induced by injecting; 100 μL of blood into each lateral ventricle of postnatal day 4 (P4) Sprague-Dawley rats. Dexamethasone was injected intraperitoneally into rat pups at a dose of 0.5 mg/kg, 0.3 mg/kg, and 0.1 mg/kg on P5, P6, and P7, respectively. Serial brain magnetic resonance imaging and behavioral function tests, such as the negative geotaxis test and the rotarod test, were performed...
2018: PloS One
https://www.readbyqxmd.com/read/30353164/regulation-of-human-glioma-cell-migration-tumor-growth-and-stemness-gene-expression-using-a-lck-targeted-inhibitor
#9
J P Zepecki, K M Snyder, M M Moreno, E Fajardo, A Fiser, J Ness, A Sarkar, S A Toms, N Tapinos
Migration of human glioma cells (hGCs) within the brain parenchyma makes glioblastoma one of the most aggressive and lethal tumors. Studies of the cellular and molecular mechanisms underlying hGC migration are hindered by the limitations of existing glioma models. Here we developed a dorsal root ganglion axon-oligodendrocyte-hGC co-culture to study in real time the migration and interaction of hGCs with their microenvironment. hGCs interact with myelinated and non-myelinated axons through the formation of pseudopodia...
October 23, 2018: Oncogene
https://www.readbyqxmd.com/read/30350450/efficacy-of-nano-particulated-water-soluble-erlotinib-against-intracranial-metastases-of-egfr-mutant-lung-cancer
#10
Dong Ha Kim, Yun Jung Choi, Ki Jung Sung, Seon-A Yoo, Young Hoon Sung, Jeong Kon Kim, Chang-Min Choi, Miyong Yun, Eun Yong Lee, Yong Suk Jin, Seungho Cook, Jin Kyung Rho, Jae Cheol Lee
Central nervous system (CNS) metastasis is one of the serious complications of epidermal growth factor receptor (EGFR)-mutant lung cancer, which arises due to poor penetration of the brain-blood barrier by EGFR-tyrosine kinase inhibitors (EGFR-TKIs). Although osimertinib, a third-generation EGFR-TKI, has efficacy against CNS metastases, further treatment modalities are still needed as some of these lesions do not respond to osimertinib, or undergo progression after an initial response to this drug if radiotherapy has already been conducted...
October 23, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/30347963/central-neurocytoma-a-rare-brain-tumor
#11
Hozefa Runderawala, Ajay Kantharia, Pradyumna Oak, Amit Mahore
Central neurocytoma are rare, slow growing, intraventricular tumors of neuronal origin, typically located in the lateral ventricles, near the Foramen of Monroe with characteristic imaging features. They generally occur in young age with favorable prognosis. With clinical, histological and immunohistochemical background, we report a case of central neurocytoma..
April 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30323874/microglial-activation-an-important-process-in-the-onset-of-epilepsy
#12
Hu Zhao, Changgeng Zhu, Donghui Huang
This study aimed to investigate the effects of microglial activation on the onset of epilepsy. Microglias cultured in vitro were stimulated with different concentrations of coriaria lactone (CL), and the effects on cell cycle and apoptosis were examined using flow cytometry. Then microglia were stimulated with 5×10-5 mol/L CL, and levels of cyclin D1 and interleukin-1β (IL-1β) mRNA were measured by fluorescence quantitative PCR; tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in supernatant were detected by radioimmunoassay...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30295907/left-pan-hippocampal-low-grade-glioma-2-stage-transsylvian-transventricular-and-paramedian-supracerebellar-transtentorial-approaches-2-dimensional-operative-video
#13
Juan C Fernandez-Miranda
The surgical goal for low-grade gliomas (LGGs) is to maximize resection while minimizing morbidity. Pan-hippocampal LGGs extend from the hippocampal head to the hippocampal tail, and involve the parahippocampal gyrus and uncus. Given their anteroposterior extension, they cannot be completely removed with 1 single approach, requiring a 2-stage front-to-back operation. In this video, we present the case of a 52-yr-old man with new onset of generalized seizures and a dominant-side, nonenhancing, pan-hippocampal infiltrative lesion compatible with a low-grade glioma...
October 5, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30269583/surgical-treatment-of-epilepsy-in-vietnam-program-development-and-international-collaboration
#14
Brandon G Rocque, Matthew C Davis, Samuel G McClugage, Dang Anh Tuan, Donald T King, Nguyen Thi Huong, Nguyen Thi Bich Van, Pongkiat Kankirawatana, Cao Vu Hung, Le Nam Thang, James M Johnston, Nguyen Duc Lien
OBJECTIVE: The purpose of this report was to describe an international collaboration model to facilitate the surgical treatment of children with epilepsy in Vietnam. METHODS: This model uses three complementary methods to achieve a meaningful expansion in epilepsy surgery capacity: US-based providers visiting Hanoi, Vietnam; Vietnamese providers visiting the US; and ongoing telecollaboration, including case review and real-time mentorship using internet-based communication platforms...
October 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/30265190/placental-alkaline-phosphatase-levels-in-cerebrospinal-fluid-can-have-a-decisive-role-in-the-differential-diagnosis-of-intracranial-germ-cell-tumors
#15
Yasuo Aihara, Sinichiro Watanabe, Kosaku Amano, Kana Komatsu, Kentaro Chiba, Kosuke Imanaka, Tomokatsu Hori, Takashi Ohba, Hitoshi Dairoku, Yoshikazu Okada, Osami Kubo, Takakazu Kawamata
OBJECTIVE: Placental alkaline phosphatase (PLAP) in CSF can provide a very high diagnostic value in cases of intracranial germ cell tumors (GCTs), especially in pure germinomas, to the level of not requiring histological confirmation. Unlike other tumor markers, reliable data analysis with respect to the diagnostic value of PLAP serum or CSF levels has not been available until now. This is the first systematic and comprehensive study examining the diagnostic value of CSF PLAP in patients with intracranial GCTs...
September 28, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30261376/management-of-choroid-plexus-tumors-in-infants-and-young-children-up-to-4-years-of-age-an-institutional-experience
#16
Chinmaya Dash, Skanda Moorthy, Kanwaljeet Garg, Pankaj Kumar Singh, Amandeep Kumar, Hitesh Gurjar, P Sarat Chandra, Sasank Sarad Kale
PURPOSE: Choroid plexus tumors (CPT) are rare tumors characterized by papillary and intraventricular growth. The young age of presentation of such tumors, especially in infants as well as the lack of consensus on adjuvant therapy in case of aCPP and CPC create dilemma for the management of such tumors. We discuss the presentation, management, complications and outcome in 15 patients (children <=4 years) and review pertinent literature METHODS: We retrospectively analyzed the case records of all patients with choroid plexus tumors who were operated in our institute from January 2010 to March 2018...
September 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30244186/two-micron-continuous-wave-laser-assisted-neuroendoscopy-clinical-experience-of-two-institutions-in-524-procedures
#17
Martin U Schuhmann, Cahit Kural, Lisanne Lalla, Florian H Ebner, Christoph Bock, Hans-Christoph Ludwig
OBJECTIVE: To present the clinical experience of 2 neurosurgical centers with the use of a 2-micron continuous-wave laser (2μ-cwL) system as standard tool in neuroendoscopic procedures and to discuss the safety and efficacy of this system. METHODS: In total, 469 patients underwent neuroendoscopic procedures using 2μ-cwL between September 2009 and January 2015. All patient data were retrospectively reviewed. In total, 241 (51%) patients were children and 228 (49%) adults...
September 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30240857/craniopharyngiomas-primarily-involving-the-hypothalamus-a-model-of-neurosurgical-lesions-to-elucidate-the-neurobiological-basis-of-psychiatric-disorders
#18
Jose María Pascual, Ruth Prieto, Inés Castro-Dufourny, Lorenzo Mongardi, Maria Rosdolsky, Sewan Strauss, Rodrigo Carrasco, Laura Barrios
OBJECTIVE: This study provides a systematic review and meta-analysis of psychiatric disorders caused by craniopharyngiomas and the hypothalamic alterations underlying these symptoms. METHODS: We investigated a collection of 210 craniopharyngiomas reported from 1823 to 2017 providing detailed clinical and pathologic information about psychiatric disturbances, including 10 of our own series, and compared the hypothalamic damage in this cohort with the present in a control cohort of 105 cases without psychiatric symptoms...
December 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30239311/management-of-severe-intraoperative-hemorrhage-during-intraventricular-neuroendoscopic-procedures-the-dry-field-technique
#19
Joachim Oertel, Stefan Linsler, Akos Csokonay, Henry W S Schroeder, Sebastian Senger
OBJECTIVE: The unexpected intraoperative intraventricular hemorrhage is a rare but feared and life-threatening complication in neuroendoscopic procedures because of loss of endoscopic vision. The authors present their experience with the so-called "dry field technique" (DFT) for the management of intraventricular hemorrhages during purely endoscopic procedures. This technique requires the aspiration of the entire intraventricular CSF to achieve clear visualization of the bleeding source...
September 21, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30219587/central-liponeurocytoma-as-a-clinical-entity
#20
REVIEW
Ali Börekci, Pınar Kuru Bektaşoğlu, Ali Fatih Ramazanoğlu, Bora Gürer, Erhan Çelikoğlu
INTRODUCTION: Liponeurocytomas are mostly localized in cerebellar hemispheres and the second most common location is the vermis. It is rarely observed within the intracranial ventricles. Here, we present a case of liponeurocytoma located in the right lateral ventricle and the systematic review of the literature. STATE OF THE ART: We searched PubMed with keyword 'central liponeurocytoma' and the references of the related articles. There were no language or year restrictions...
September 11, 2018: Neurologia i Neurochirurgia Polska
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