Alma-Martina Cepika, Laura Amaya, Colin Waichler, Mansi Narula, Michelle M Mantilla, Benjamin C Thomas, Pauline P Chen, Robert Arthur Freeborn, Mara Pavel-Dinu, Jason Nideffer, Matthew Porteus, Rosa Bacchetta, Fabian Müller, William J Greenleaf, Howard Y Chang, Maria Grazia Roncarolo
Human adaptive immunity is orchestrated by effector and regulatory T (Treg) cells. Natural Tregs arise in the thymus where they are shaped to recognize self-antigens, while type 1 Tregs or Tr1 cells are induced from conventional peripheral CD4 + T cells in response to peripheral antigens, such as alloantigens and allergens. Tr1 cells have been developed as a potential therapy for inducing antigen-specific tolerance, because they can be rapidly differentiated in vitro in response to a target antigen. However, the epigenetic landscape and the identity of transcription factors (TFs) that regulate differentiation, phenotype, and functions of human antigen-specific Tr1 cells is largely unknown, hindering Tr1 research and broader clinical development...
March 12, 2024: bioRxiv