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https://www.readbyqxmd.com/read/29927746/ameliorative-potential-of-acupressure-on-gestational-diabetes-mellitus-a-randomized-controlled-trial
#1
Fayiz F El-Shamy, Sanad S El-Kholy, Mahmoud Labib, Ahmed M Kabel
Background and aim Gestational diabetes mellitus (GDM) poses a threat to the mother and child. The aim of this study was to examine the effect of acupressure on the glycemic control and insulin requirement of GDM females. Materials and methods Thirty GDM female patients were randomized to either the study group (SG; n=15), which was treated with acupressure and the standard antenatal care, or the control group (CG; n=15), which was treated with the standard antenatal care. Fasting and 2-h post-prandial blood glucose levels, requirement for insulin and insulin resistance were measured at 24 and 36 weeks' gestation (WG)...
June 21, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29927618/sertoli-cells-engineered-to-express-insulin-to-lower-blood-glucose-in-diabetic-mice
#2
Gurvinder Kaur, Lea Ann Thompson, Rachel L Babcock, Karl Mueller, Jannette M Dufour
Long-term survival of allo- and xenotransplanted immune-privileged Sertoli cells (SCs) is well documented suggesting that SCs can be used to deliver foreign proteins for cell-based gene therapy. The aim of this study was to use a lentivirus carrying proinsulin cDNA to achieve stable expression and lowering of blood glucose levels (BGLs). A SC line transduced with the lentivirus (MSC-LV-mI) maintained stable insulin expression in vitro. These MSC-LV-mI cells were transplanted and grafts were analyzed for cell survival, continued proinsulin mRNA, and insulin protein expression...
June 21, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29927216/-research-advances-in-hydrogen-sulfide-and-diabetes-mellitus-as-well-as-diabetic-complications
#3
Yue Gu, Li-Ping Xie, Guo-Liang Meng, Yong Ji
Diabetes and its complications continue to be an increasing global health problem. Hydrogen sulfide (H2S)has emerged as the third gasotransmitter following the nitric oxide and carbon monoxide in the body, and plays an important role in both physiology and pathophysiology. Recent work has suggested important roles for H2S in the regulation of pancreatic β-cell function, as well as development of insulin resistance and diabetic complications. Targeting H2S represents a novel therapeutic approach in diabetes and its associated complications...
June 21, 2018: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
https://www.readbyqxmd.com/read/29927023/genetic-basis-of-early-onset-mody-like-diabetes-in-japan-and-features-of-patients-without-mutations-in-the-major-mody-genes-dominance-of-maternal-inheritance
#4
Tohru Yorifuji, Shinji Higuchi, Rie Kawakita, Yuki Hosokawa, Takane Aoyama, Akiko Murakami, Yoshiko Kawae, Kazue Hatake, Hironori Nagasaka, Nobuyoshi Tamagawa
BACKGROUND: Causative mutations cannot be identified in the majority of Asian patients with suspected maturity-onset diabetes of the young (MODY). OBJECTIVES: To elucidate the genetic basis of Japanese patients with MODY-like diabetes and gain insight into the etiology of patients without mutations in the major MODY genes. SUBJECTS: 263 Japanese patients with early-onset, nonobese, MODY-like diabetes mellitus referred to Osaka City General Hospital for diagnosis...
June 21, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29926685/-effect-of-saffron-aqueous-extract-on-the-level-of-blood-glucose-in-experimental-diabetes-mice
#5
Shi-Ping Jiang, Qian Shen, Yu Lu, Yong-Qiu Yan, Ying-Peng Tong, Ping Wang
OBJECTIVES: To investigate the effects of saffron aqueous extract (SE) on blood glucose, lipid and pancreatic tissue in streptozocin-induced diabetes mice. METHODS: Diabetes mellitus mice were established by intraperitoneal injection of streptozocin (60 mg/kg) for two consecutive days. The 30 well-established diabetes mice were randomly divided into three groups( n =10):diabetic mellitus (DM) group, SE treated (SE) group and positive control (metformin hydrochloride, MH) group...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926676/-effect-of-two-kinds-of-fermented-food-on-blood-glucose-and-lipids-in-induced-diabetic-mice
#6
Yong-Qiu Yan, Guan-Hai Dai, Shi-Ping Jiang, Yu Lu, Ying-Peng Tong, Ping Wang
OBJECTIVES: To investigate the effect of two kinds of fermented food, noni juice and natto, on blood glucose and lipids in induced diabetic mice. METHODS: Female (ICR) mice were induced into diabetes by an injection of alloxan (55 mg/kg, i. v.). After 72 hours, those mice whose fasting blood glucose levels were over 12.00 mmol/L and urine sugar was strongly positive (+ + +) were regarded as diabetical model and were randomly divided into three groups ( n =10):diabetical model (DM) group, noni juice (NJ) group and natto (NT) group...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29925944/a-stromal-cell-population-that-inhibits-adipogenesis-in-mammalian-fat-depots
#7
Petra C Schwalie, Hua Dong, Magda Zachara, Julie Russeil, Daniel Alpern, Nassila Akchiche, Christian Caprara, Wenfei Sun, Kai-Uwe Schlaudraff, Gianni Soldati, Christian Wolfrum, Bart Deplancke
Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities1,2 . Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes3-14 , our understanding of their in vivo origin and properties is incomplete2,15,16 . This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots 17 , which has proven difficult to molecularly dissect using classical approaches such as fluorescence-activated cell sorting and Cre-lox lines based on candidate marker genes16,18 ...
June 20, 2018: Nature
https://www.readbyqxmd.com/read/29925930/elevated-t-cell-levels-in-peripheral-blood-predict-poor-clinical-response-following-rituximab-treatment-in-new-onset-type-1-diabetes
#8
Peter S Linsley, Carla J Greenbaum, Mario Rosasco, Scott Presnell, Kevan C Herold, Matthew J Dufort
Biologic treatment of type 1 diabetes (T1D) with agents including anti-CD3 (otelixizumab and teplizumab), anti-CD20 (rituximab), LFA3Ig (alafacept), and CTLA4Ig (abatacept) results in transient stabilization of insulin C-peptide, a surrogate for endogenous insulin secretion. With the goal of inducing more robust immune tolerance, we used systems biology approaches to elucidate mechanisms associated with C-peptide stabilization in clinical trial blood samples from new-onset T1D subjects treated with the B cell-depleting drug, rituximab...
June 21, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29925744/effect-of-lipoprotein-associated-phospholipase-a2-inhibitor-on-insulin-resistance-in-streptozotocin-induced-diabetic-pregnant-rats
#9
Guo-Hua Wang, Jun Jin, Li-Zhou Sun
This paper aims to investigate the influence of lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, darapladib, on insulin resistance (IR) in streptozotocin (STZ)-induced diabetic pregnant rats. The rat models were divided into Control (normal pregnancy), STZ + saline (STZ-induced diabetic pregnant rats), STZ + Low-dose and STZ + High-dose darapladib (STZ-induced diabetic pregnant rats treated with low-/high-dose darapladib) groups. Pathological changes were observed by Hematoxylin-eosin (HE) and Immunohistochemistry staining...
June 21, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29925691/pan-ampk-activator-o304-improves-glucose-homeostasis-and-microvascular-perfusion-in-mice-and-type-2-diabetes-patients
#10
Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist, Madelene Ericsson, Björn Eriksson, Kajsa Linde, Jacob Westman, Thomas Edlund, Helena Edlund
AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is activated in response to an energy shortage imposed by physical activity and caloric restriction. We here report on the identification of PAN-AMPK activator O304, which - in diet-induced obese mice - increased glucose uptake in skeletal muscle, reduced β cell stress, and promoted β cell rest. Accordingly, O304 reduced fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29925687/androgen-excess-in-pancreatic-%C3%AE-cells-and-neurons-predisposes-female-mice-to-type-2-diabetes
#11
Guadalupe Navarro, Camille Allard, Jamie J Morford, Weiwei Xu, Suhuan Liu, Adrien Jr Molinas, Sierra M Butcher, Nicholas Hf Fine, Manuel Blandino-Rosano, Venkata N Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A Jacobson, Prasad V Katakam, David J Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis
Androgen excess predisposes women to type 2 diabetes (T2D), but the mechanism of this is poorly understood. We report that female mice fed a Western diet and exposed to chronic androgen excess using dihydrotestosterone (DHT) exhibit hyperinsulinemia and insulin resistance associated with secondary pancreatic β cell failure, leading to hyperglycemia. These abnormalities are not observed in mice lacking the androgen receptor (AR) in β cells and partially in neurons of the mediobasal hypothalamus (MBH) as well as in mice lacking AR selectively in neurons...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29925367/genetic-interaction-effects-reveal-lipid-metabolic-and-inflammatory-pathways-underlying-common-metabolic-disease-risks
#12
Hyung Jun Woo, Jaques Reifman
BACKGROUND: Common metabolic diseases, including type 2 diabetes, coronary artery disease, and hypertension, arise from disruptions of the body's metabolic homeostasis, with relatively strong contributions from genetic risk factors and substantial comorbidity with obesity. Although genome-wide association studies have revealed many genomic loci robustly associated with these diseases, biological interpretation of such association is challenging because of the difficulty in mapping single-nucleotide polymorphisms (SNPs) onto the underlying causal genes and pathways...
June 20, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29925339/maternal-overweight-is-not-an-independent-risk-factor-for-increased-birth-weight-leptin-and-insulin-in-newborns-of-gestational-diabetic-women-observations-from-the-prospective-each-cohort-study
#13
Raffael Ott, Jens H Stupin, Andrea Loui, Elisabeth Eilers, Kerstin Melchior, Rebecca C Rancourt, Karen Schellong, Thomas Ziska, Joachim W Dudenhausen, Wolfgang Henrich, Andreas Plagemann
BACKGROUND: Both gestational diabetes mellitus (GDM) as well as overweight/obesity during pregnancy are risk factors for detrimental anthropometric and hormonal neonatal outcomes, identified to 'program' adverse health predispositions later on. While overweight/obesity are major determinants of GDM, independent effects on critical birth outcomes remain unclear. Thus, the aim of the present study was to evaluate, in women with GDM, the relative/independent impact of overweight/obesity vs...
June 20, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29925161/-effect-and-mechanism-of-mulberry-leaf-polysaccharide-on-type-1-diabetic-nephropathy-in-rats
#14
Z Zhang, L Li, Z K Li, F Wu, B Y Hang, B Y Cai, Z F Weng, L Zhao, C F Ding, Y G Du
Objective: To observe the effects of mulberry leaf polysaccharide (MLP) on insulin-like growth factor 1 (IGF-1) and insulin-like growth factor blinding protein 3 (IGFBP-3) as well as the expression of IGF-1 and IGFBP-3 mRNA in the kidney of type 1 Diabetic Nephropathy (DN) rats, and to investigate its therapeutic effects and underlying mechanisms. Methods: Type 1 DN rat model was established by intraperitoneally injecting streptozocin (STZ). SD rats were randomly divided into the control, model, insulin and MLP groups, with eight rats in each group...
June 12, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29925095/coronary-artery-bypass-grafting-in-diabetic-patients-complete-arterial-versus-internal-thoracic-artery-and-sequential-vein-grafts-a-propensity-score-matched-analysis
#15
Takashi Kunihara, Olaf Wendler, Kerstin Heinrich, Ryota Nomura, Hans-Joachim Schäfers
BACKGROUND:  The optimal choice of conduit and configuration for coronary artery bypass grafting (CABG) in diabetic patients remains somewhat controversial, even though arterial grafts have been proposed as superior. We attempted to clarify the role of complete arterial revascularization using the left internal thoracic artery (LITA) and the radial artery (RA) alone in "T-Graft" configuration on long-term outcome. METHODS AND RESULTS:  From 1994 to 2001, 104 diabetic patients with triple vessel disease underwent CABG using LITA/RA "T-Grafts" (Group-A)...
June 20, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29924854/food-restriction-promotes-damage-reduction-in-rat-models-of-type-2-diabetes-mellitus
#16
Carlos Vinicius Dalto da Rosa, Jéssica Men de Campos, Anacharis Babeto de Sá Nakanishi, Jurandir Fernando Comar, Isabela Peixoto Martins, Paulo Cézar de Freitas Mathias, Maria Montserrat Diaz Pedrosa, Vilma Aparecida Ferreira de Godoi, Maria Raquel Marçal Natali
There are several animal models of type 2 diabetes mellitus induction but the comparison between models is scarce. Food restriction generates benefits, such as reducing oxidative stress, but there are few studies on its effects on diabetes. The objective of this study is to evaluate the differences in physiological and biochemical parameters between diabetes models and their responses to food restriction. For this, 30 male Wistar rats were distributed in 3 groups (n = 10/group): control (C); diabetes with streptozotocin and cafeteria-style diet (DE); and diabetes with streptozotocin and nicotinamide (DN), all treated for two months (pre-food restriction period)...
2018: PloS One
https://www.readbyqxmd.com/read/29924846/prevalence-of-diabetic-retinopathy-and-diabetic-macular-edema-in-a-primary-care-based-teleophthalmology-program-for-american-indians-and-alaskan-natives
#17
Sven-Erik Bursell, Stephanie J Fonda, Drew G Lewis, Mark B Horton
BACKGROUND: Diabetes and its complications are more common in American Indians and Alaska Natives (AI/AN) than other US racial/ethnic populations. Prior reports of diabetic retinopathy (DR) prevalence in AI/AN are dated, and research on diabetic macular edema (DME) is limited. This study characterizes the recent prevalence of DR and DME in AI/AN using primary care-based teleophthalmology surveillance. METHODS: This is a multi-site, clinic-based, cross-sectional study of DR and DME...
2018: PloS One
https://www.readbyqxmd.com/read/29924740/cyanidin-3-rutinoside-protects-ins-1-pancreatic-%C3%AE-cells-against-high-glucose-induced-glucotoxicity-by-apoptosis
#18
Kung-Ha Choi, Mi Hwa Park, Hyun Ah Lee, Ji-Sook Han
Exposure to high levels of glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction, including cell apoptosis and impaired glucose-stimulated insulin secretion. The aim of this study was to explore the effect of cyanidin-3-rutinoside (C3R), a derivative of anthocyanin, on glucotoxicity-induced apoptosis in INS-1 pancreatic β cells. Glucose (30 mM) treatment induced INS-1 pancreatic β cell death, but glucotoxicity and apoptosis significantly decreased in cells treated with 50 μM C3R compared to that observed in 30 mM glucose-treated cells...
June 20, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29924641/efficacy-safety-and-acceptability-of-the-new-pen-needle-34g-%C3%A3-3-5-mm-a-cross-over-randomized-non-inferiority-trial-ago-02-study
#19
Giorgia De Berardis, Marco Scardapane, Giuseppe Lucisano, Santina Abbruzzese, Antonio Carlo Bossi, Elisa Cipponeri, Paola D'Angelo, Lucia Fontana, Roberta Lancione, Giuseppe Marelli, Luigi Sciangula, Antonio Nicolucci
OBJECTIVE: Insulin injection aspects, such as fear of injection and pain, directly affect glycemic control, patient adherence, and quality of life. Use of thinner and shorter needles could increase acceptance of injections. Aim of the study is to evaluate the non-inferiority of the new 34Gx3.5 mm needle compared to a 32GX4mm in patients with diabetes treated with insulin. METHODS: This is an open, randomized, two-period cross-over, noninferiority trial. Every treatment period lasted 3 weeks...
June 20, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29923997/euglycemic-diabetic-ketoacidosis-caused-by-dapagliflozin-a-case-report
#20
Yu-Mou Chou, Chen-June Seak, Zhong Ning Leonard Goh, Joanna Chen-Yeen Seak, Chen-Ken Seak, Chih-Chuan Lin
RATIONALE: Diabetic ketoacidosis is a serious and potentially life-threatening acute complication of diabetes mellitus (DM). Euglycemic diabetic ketoacidosis (eDKA) is however challenging to identify in the emergency department (ED) due to absence of marked hyperglycemia, often leading to delayed diagnosis and treatment. eDKA has been recently found to be associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors, one of the newest classes of antidiabetics, though there are very limited reports implicating dapagliflozin as the offending agent in ED patients...
June 2018: Medicine (Baltimore)
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