keyword
MENU ▼
Read by QxMD icon Read
search

Diabetes insulin

keyword
https://www.readbyqxmd.com/read/29058284/glycemic-index-glycemic-load-and-glycemic-response-to-pomelo-in-patients-with-type-2-diabetes
#1
Shi-Ying Shao, Wei-Jie Xu, Jing Tao, Jian-Hua Zhang, Xin-Rong Zhou, Gang Yuan, Yan Yang, Jing Zhang, Hong-Yan Zhang, Qiang Xu, Xiu-Xin Deng, Shu-Hong Hu, Mu-Xun Zhang, Zhe-Long Liu, Xue-Feng Yu
Food intake has a great influence on blood glucose in patients with diabetes. This study was to determine the glycemic index (GI) and glycemic load (GL) of a particular pomelo named Majia pomelo and its effects on postprandial glucose (PPG) in patients with type 2 diabetes (T2D). Twenty healthy subjects and 20 T2D patients (controlled on lifestyle measures and/or metformin) were tested on 2 separate days with 50 g of glucose and 50 g equivalent of carbohydrates from Majia pomelo for GI measurement. To test effects of Majia pomelo on PPG, 19 hospitalized T2D patients (controlled on insulin therapy) were selected for a 9-day study...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29058194/characterization-of-mc4r-regulation-of-the-kir7-1-channel-using-the-tl-flux-assay
#2
Michael J Litt, Roger D Cone, Masoud Ghamari-Langroudi
The family of inward rectifying potassium channels (Kir channels) plays crucial roles in the regulation of heart rhythms, renal excretion, insulin release, and neuronal activity. Their dysfunction has been attributed to numerous diseases such as cardiac arrhythmia, kidney failure and electrolyte imbalance, diabetes mellitus, epilepsy, retinal degeneration, and other neuronal disorders. We have recently demonstrated that the melanocortin-4 receptor (MC4R), a Gαs-coupled GPCR, regulates Kir7.1 activity through a mechanism independent of Gαs and cAMP...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29058186/methods-for-characterizing-disease-associated-atp-sensitive-potassium-channel-mutations
#3
Balamurugan Kandasamy, Show-Ling Shyng
The ATP-sensitive potassium (KATP) channel formed by the inwardly rectifying potassium channel Kir6.2 and the sulfonylurea receptor 1 (SUR1) plays a key role in regulating insulin secretion. Genetic mutations in KCNJ11 or ABCC8 which encode Kir6.2 and SUR1 respectively are major causes of insulin secretion disorders: those causing loss of channel function lead to congenital hyperinsulinism, whereas those causing gain of channel function result in neonatal diabetes and in some cases developmental delay, epilepsy, and neonatal diabetes, referred to as the DEND syndrome...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29058131/insulin-and-its-cardiovascular-effects-what-is-the-current-evidence
#4
REVIEW
Sahana Pai Dongerkery, Pamela R Schroeder, Mansur E Shomali
PURPOSE OF REVIEW: In this article, we examine the nature of the complex relationship between insulin and cardiovascular disease. With metabolic abnormalities comes increased risk for cardiovascular complications. We discuss the key factors implicated in development and progression of cardiovascular disease, its relationship to insulin therapy, and what can be learned from large, recent cardiovascular outcome studies. RECENT FINDINGS: Preclinical studies suggest that insulin has positive effects of facilitating glucose entry into cells and maintaining euglycemia and negative effects of favoring obesity and atherogenesis under certain conditions...
October 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/29057642/insulin-therapy-for-adult-patients-with-type-2-diabetes-mellitus-a-position-statement-of-the-korean-diabetes-association-2017
#5
Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel and traditional insulin analogues has also been accumulated. Following global trends, many results of clinical trials, especially concerning the clinical efficacy and safety of insulin therapy, have been published about Korean patients with T2DM...
October 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29057494/a-decrease-in-serum-1-5-anhydroglucitol-levels-is-associated-with-the-presence-of-a-first-degree-family-history-of-diabetes-in-a-chinese-population-with-normal-glucose-tolerance
#6
X Hu, X He, X Ma, H Su, L Ying, J Peng, Y Wang, Y Bao, J Zhou, W Jia
AIM: This study aimed to investigate alterations in HbA1c , glycated albumin (GA) and 1,5-anhydroglucitol (1,5-AG) in Chinese first-degree relatives of individuals with diabetes (FDR) in pursuit of an index for early screening of glucose metabolism disturbance. METHODS: A total of 467 participants (age range: 20-78 years) with normal weight and normal glucose tolerance, as determined by a 75-g oral glucose tolerance test, were enrolled. HbA1c was measured using high-pressure liquid chromatography...
October 23, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29057063/is-surgical-debridement-necessary-in-the-diabetic-foot-treated-with-photodynamic-therapy
#7
João Paulo Tardivo, Rodrigo Serrano, Lívia Maria Zimmermann, Leandro Luongo Matos, Mauricio S Baptista, Maria Aparecida Silva Pinhal, Álvaro N Atallah
Background: Diabetic patients are susceptible to developing foot ulcers with serious complications such as osteomyelitis and amputations. Treatment approaches are still empirical and the benefit of usual procedures such as surgical debridement has not been properly evaluated. Photodynamic Therapy (PDT) is a non-invasive and highly efficient method for the treatment of the diabetic foot, being able to eradicate the infection and to stimulate healing, decreasing considerably the amputation risk. In the day-to-day practice of our service, we have been faced with the question whether debridement is necessary before PDT...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/29057036/effects-of-chimonanthus-nitens-oliv-leaf-extract-on-glycolipid-metabolism-and-antioxidant-capacity-in-diabetic-model-mice
#8
Hui Chen, Yan Jiang, Zhanwei Yang, Wenbing Hu, Lei Xiong, Ning Wang, Xin Liu, Guodong Zheng, Kehui Ouyang, Wenjun Wang
The paper investigated the antihyperglycemic and antihyperlipidemic efficacy and antioxidant capacity of Chimonanthus nitens Oliv. leaf extract (COE) in combination of high-glucose-fat diet-fed and streptozotocin-induced diabetic model mice. Various physiological indexes in diabetic model mice were well improved especially by oral administration of high dose of COE; the results were listed as follows. Fast blood glucose (FBG) level and serum triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDLC), and malondialdehyde (MDA) as well as MDA in liver were significantly reduced; fasting serum insulin (FINS) and insulin sensitivity index (ISI) were both increased; high-density lipoprotein cholesterol (HDLC) in serum was significantly increased; total antioxidant capacity (T-AOC), activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in serum and liver were apparently enhanced; liver coefficient (LC), liver transaminase, and alkaline phosphatase (ALP) were decreased...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29056962/chiglitazar-preferentially-regulates-gene-expression-via-configuration-restricted-binding-and-phosphorylation-inhibition-of-ppar%C3%AE
#9
De-Si Pan, Wei Wang, Nan-Song Liu, Qian-Jiao Yang, Kun Zhang, Jing-Zhong Zhu, Song Shan, Zhi-Bin Li, Zhi-Qiang Ning, Laiqiang Huang, Xian-Ping Lu
Type 2 diabetes mellitus is often treated with insulin-sensitizing drugs called thiazolidinediones (TZD), which improve insulin resistance and glycemic control. Despite their effectiveness in treating diabetes, these drugs provide little protection from eminent cardiovascular disease associated with diabetes. Here we demonstrate how chiglitazar, a configuration-restricted non-TZD peroxisome proliferator-activated receptor (PPAR) pan agonist with moderate transcription activity, preferentially regulates ANGPTL4 and PDK4, which are involved in glucose and lipid metabolism...
2017: PPAR Research
https://www.readbyqxmd.com/read/29056415/is-exercise-a-viable-therapeutic-intervention-to-mitigate-mitochondrial-dysfunction-and-insulin-resistance-induced-by-sleep-loss
#10
REVIEW
Nicholas J Saner, David J Bishop, Jonathan D Bartlett
Sleep loss has emerged as a risk factor comparable to that of physical inactivity for the development of insulin resistance, impaired glucose tolerance and type 2 diabetes mellitus. This is a concern as it was estimated in 2012 that approximately 70 million adults in the United States are sleeping less than 6 h each night, and the average nightly sleep duration of a representative sample of the U.S. adult population is reported to be significantly less than in previous decades. The underlying mechanisms responsible for chronic sleep loss induced insulin resistance include modifications in the regulation of hormone secretion, peripheral clock gene regulation, and the cellular signaling processes associated with regulating mitochondrial respiratory function...
January 19, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29056338/selective-inhibition-of-foxo1-activator-repressor-balance-modulates-hepatic-glucose-handling
#11
Fanny Langlet, Rebecca A Haeusler, Daniel Lindén, Elke Ericson, Tyrrell Norris, Anders Johansson, Joshua R Cook, Kumiko Aizawa, Ling Wang, Christoph Buettner, Domenico Accili
Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively. The tight coupling of these events poses a dual conundrum: mechanistically, as the FOXO1 corepressor of glucokinase is unknown, and clinically, as inhibition of glucose production is predicted to increase lipogenesis. Here, we report that SIN3A is the insulin-sensitive FOXO1 corepressor of glucokinase...
October 17, 2017: Cell
https://www.readbyqxmd.com/read/29056276/phone-coaching-glycemic-control-and-diabetes-unit-visits-in-patients-treated-with-insulin
#12
Begoña Sánchez Lechuga, Florentino Carral San Laureano, Carmen Ayala Ortega, Antonia Piñero Zaldivar, Coral Expósito Carbal
No abstract text is available yet for this article.
June 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/29056268/successful-treatment-of-a-patient-with-statin-induced-myopathy-and-myotonic-dystrophy-type-ii-with-proprotein-convertase-subtilisin-kexin-type-9-inhibitor-alirocumab-praluent
#13
Mohamed K M Shakir, Terry Shin, Thanh D Hoang, Vinh Q Mai
Presently there are limited treatment options for hypercholesterolemia in patients with statin intolerance and myotonic dystrophy. A 74 year-old male presented to endocrine clinic with hypercholesterolemia (serum LDL-C 210 mg/dL), hypogonadism, insulin-controlled type 2 diabetes mellitus, and minimally elevated serum creatine kinase (CK) levels (184 U/L, ref. range 38-174). Shortly after simvastatin treatment, patient developed severe myalgias in the proximal lower and upper extremities; and serum CK increased to 317 U/L...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29056124/association-of-adipoq-c-11377g-rs266729-tnf-%C3%AE-%C3%AE-g-308a-rs1800629-and-tnf-%C3%AE-%C3%AE-g-238a-rs361525-single-nucleotide-polymorphisms-with-type-2-diabetes-mellitus-in-pakistani-population
#14
Amina Nadeem, Sadaf Mumtaz, Abdul Khaliq Naveed, Qaisar Mansoor, Muhammad Aslam, Muhammad Ismail
OBJECTIVE: To determine the frequencies of adiponectin (ADIPOQ) C-11377G, tumor necrosis factor-alpha (TNF-α) G-308A and TNF-αG-238Asingle nucleotide polymorphisms (SNP) and their association with serum levels in Pakistani T2DM and healthy population. STUDY DESIGN: Case control study. PLACE AND DURATION OF STUDY: Military Hospital, Rawalpindi, Army Medical College and Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan, from June 2012 till 2014...
October 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29056082/relationship-of-glucose-variability-with-glycated-hemoglobin-and-daily-mean-glucose-a-post-hoc-analysis-of-data-from-5-phase-3-studies
#15
Junxiang Luo, Yongming Qu, Qianyi Zhang, Annette M Chang, Scott J Jacober
BACKGROUND: The association of glucose variability (GV) with other glycemic measures is emerging as a topic of interest. The aim of this analysis is to study the correlation between GV and measures of glycemic control, such as glycated hemoglobin (HbA1c) and daily mean glucose (DMG). METHODS: Data from 5 phase 3 trials were pooled into 3 analysis groups: type 2 diabetes (T2D) treated with basal insulin only, T2D treated with basal-bolus therapy, and type 1 diabetes (T1D)...
October 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29055928/new-onset-diabetes-and-non-alcoholic-fatty-liver-disease-after-liver-transplantation
#16
Antônio R Andrade, Paulo L Bittencourt, Liana Codes, Maria A Evangelista, Alessandra O Castro, Ney Boa Sorte, Carolina G Almeida, Jorge A Bastos, Helma P Cotrim
Background & Aims. Non-alcoholic fatty liver disease (NAFLD) is an emerging cause of graft dysfunction after liver transplantation (LT) frequently related to the development of new onset diabetes after LT (NODAT). This study was undertaken to evaluate the frequencies of NODAT and NAFLD after LT, to investigate their major risk factors and the impact of de novo or recurrent NAFLD in graft function. MATERIAL AND METHODS: 119 patients submitted to LT were prospectively evaluated. RESULTS: After 4 ± 1 years, NODAT, recurrent and de novo NAFLD were observed in 31%, 56% and 43% of the subjects, respectively...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29055800/anti-diabetic-potential-of-peptides-future-prospects-as-therapeutic-agents
#17
REVIEW
Marya, Haroon Khan, Seyed Mohammad Nabvi, Solomon Habtemariam
Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level and its effective control is recognized as a global challenge for clinician. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diabetes including insulin for type I and oral tablets for type II, but its effective management is still a dream. Several options are under investigation in various research laboratories for efficacious and safer agents...
October 18, 2017: Life Sciences
https://www.readbyqxmd.com/read/29055774/functional-nanoparticles-exploit-the-bile-acid-pathway-to-overcome-multiple-barriers-of-the-intestinal-epithelium-for-oral-insulin-delivery
#18
Weiwei Fan, Dengning Xia, Quanlei Zhu, Xiuying Li, Shufang He, Chunliu Zhu, Shiyan Guo, Lars Hovgaard, Mingshi Yang, Yong Gan
Oral absorption of protein/peptide-loaded nanoparticles is often limited by multiple barriers of the intestinal epithelium. In addition to mucus translocation and apical endocytosis, highly efficient transepithelial absorption of nanoparticles requires successful intracellular trafficking, especially to avoid lysosomal degradation, and basolateral release. Here, the functional material, deoxycholic acid-conjugated chitosan, is synthesized and loaded with the model protein drug insulin into deoxycholic acid-modified nanoparticles (DNPs)...
October 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/29055392/sleep-apnea-an-overlooked-cause-of-lipotoxicity
#19
Chenjuan Gu, Haris Younas, Jonathan C Jun
Obstructive sleep apnea (OSA) is a common sleep disorder associated with diabetes and cardiovascular disease. However, the mechanisms by which OSA causes cardiometabolic dysfunction are not fully elucidated. OSA increases plasma free fatty acids (FFA) during sleep, reflecting excessive adipose tissue lipolysis. In animal studies, intermittent hypoxia simulating OSA also increases FFA, and the increase is attenuated by beta-adrenergic blockade. In other contexts, excessive plasma FFA can lead to ectopic fat accumulation, insulin resistance, vascular dysfunction, and dyslipidemia...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29055125/vascular-endothelial-growth-factor-vegf-related-single-nucleotide-polymorphisms-rs10738760-and-rs6921438-are-not-associated-with-diabetic-retinopathy-dr-in-slovenian-patients-with-type-2-diabetes-mellitus-t2dm
#20
Rifet Terzić, Ines Cilenšek, Ruda Zorc Pleskovič, Sara Mankoč, Aleksandra Milutinović
Diabetic retinopathy (DR) is a complication of diabetes characterized by vascular permeability, increased tissue ischemia, and angiogenesis. One of the most important proteins involved in angiogenesis is vascular endothelial growth factor (VEGF, also known as VEGFA). A previous study demonstrated that two single nucleotide polymorphisms (SNPs), rs6921438 and rs10738760, account for nearly half the variation in circulating VEGF levels. The aim of our study was to assess the association between rs6921438 and rs10738760 and DR in Slovenian patients with type 2 diabetes mellitus (T2DM)...
October 20, 2017: Bosnian Journal of Basic Medical Sciences
keyword
keyword
16448
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"