Shirin Ilkhanizadeh, Aileen Gracias, Andreas K O Åslund, Marcus Bäck, Rozalyn Simon, Edel Kavanagh, Bianca Migliori, Christina Neofytou, Sven Nelander, Bengt Westermark, Lene Uhrbom, Karin Forsberg-Nilsson, Peter Konradsson, Ana I Teixeira, Per Uhlén, Bertrand Joseph, Ola Hermanson, K Peter R Nilsson
There is an urgent need for simple and non-invasive identification of live neural stem/progenitor cells (NSPCs) in the developing and adult brain as well as in disease, such as in brain tumors, due to the potential clinical importance in prognosis, diagnosis, and treatment of diseases of the nervous system. Here, we report a luminescent conjugated oligothiophene (LCO), named p-HTMI, for non-invasive and non-amplified real-time detection of live human patient-derived glioblastoma (GBM) stem cell-like cells and NSPCs...
August 30, 2023: ACS Applied Bio Materials