Evan L Barrios, Jack R Leary, Dijoia B Darden, Jaimar C Rincon, Micah Willis, Valerie E Polcz, Gwendolyn S Gillies, Jennifer A Munley, Marvin L Dirain, Ricardo Ungaro, Dina C Nacionales, Marie-Pierre L Gauthier, Shawn D Larson, Laurence Morel, Tyler J Loftus, Alicia M Mohr, Robert Maile, Michael P Kladde, Clayton E Mathews, Maigan A Brusko, Todd M Brusko, Lyle L Moldawer, Rhonda Bacher, Philip A Efron
INTRODUCTION: Sepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who develop chronic critical illness. METHODS: Cellular Indexing of Transcriptomes and Epitopes by Sequencing and transcriptomic analysis are used to describe MDSC subpopulations based on differential gene expression, RNA velocities, and biologic process clustering...
2024: Frontiers in Immunology