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Oral AND health

Cátia Sofia da Costa Domingues, Beatriz Prazeres Serambeque, Mafalda Sofia Laranjo Cândido, Carlos Miguel Machado Marto, Francisco José de Baptista Veiga, Ana Bela Sarmento Antunes Cruz Ribeiro, Ana Rita Ramalho Figueiras, Maria Filomena Roque Botelho, Marília de Assunção Rodrigues Ferreira Dourado
BACKGROUND: Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial-mesenchymal transition is emerging as a hallmark in OSCC. METHODS: In this study, we described the role of microRNAs in epithelial-mesenchymal transition regulation in OSCC based on a PubMed search using articles published in English between January 1, 2010, and January 31, 2018...
August 18, 2018: Head & Neck
Yoshinori Aragane, Hideaki Higashino
BACKGROUND: Far-infrared is well known with various therapeutic benefits. Recently, we have developed a novel far-infrared bathing system called the Enseki sandbath. In this regard, we focused on physical nature of ceramic to radiate far-infrared rays when heated adequately. METHODS: A bathtub was filled with ceramic beads and was equipped with computerized system which enabled to supply hot water over the ceramic beads and to drain out when beads were sufficiently heated...
August 18, 2018: Photodermatology, Photoimmunology & Photomedicine
Sheridan M Hoy
Tecovirimat (TPOXX® ) is an orthopoxvirus-specific antiviral drug developed by SIGA Technologies in conjunction with the US Department of Health and Human Services' Biomedical Advances Research and Development Authority. It acts by inhibiting the activity of the orthopoxvirus VP37 envelope wrapping protein, thereby preventing the formation of egress-competent enveloped virions, which are essential for dissemination of the virus in the host. In July 2018, oral tecovirimat was approved in the USA for the treatment of human smallpox disease caused by variola virus in adults and paediatric patients weighing ≥ 13 kg...
August 17, 2018: Drugs
Juan Huang, Renyong Jia, Haoyue Shen, Mingshu Wang, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Ying Wu, Qiao Yang, Zhongqiong Yin, Anchun Cheng
A flavivirus, named duck tembusu virus (DTMUV), emerged in China in 2010. This virus has caused great economic losses in the poultry industry in China and may pose a threat to public health. As a safe, efficient and convenient vaccine development strategy, DNA-based vaccines have become a popular approach for both human and veterinary applications. Attenuated bacteria have been widely used as vehicles to deliver heterologous antigens to the immune system. Thus, an efficient and low-cost oral delivery DNA vaccine SL7207 (pVAX1-SME) based on envelope proteins (prM and E) of DTMUV and attenuated Salmonella typhimurium aroA- strain SL7207 was developed and evaluated in this study...
August 17, 2018: Scientific Reports
Janneke Francisca Maria Scheerman, Pepijn van Empelen, Cor van Loveren, Berno van Meijel
BACKGROUND: The insertion of fixed orthodontic appliances increases the risk of dental caries, particularly in adolescents. Caries can be prevented through good oral health behavior. To support adolescents with fixed orthodontic appliances and for promoting oral health behavior, we developed a theory- and evidence-based mHealth program, the WhiteTeeth app. OBJECTIVE: The objective of our paper was to describe the systematic development and content of the WhiteTeeth app...
August 17, 2018: JMIR MHealth and UHealth
Céline E Toutain, Patrick Brossard, Stephen B King, Rainer Helbig
BACKGROUND: Robenacoxib is a non-steroidal anti-inflammatory drug available for canine and feline use for the control of pain and inflammation marketed as Onsior™. The aim of this target animal safety study was to evaluate the 6-month safety profile of oral robenacoxib administration. It was a randomized, negative-controlled, parallel group study. Thirty-two healthy, young, experimentally naïve, purebred Beagle dogs were administered 0 (sham control, Group 1), 2, 6, and 10 mg/kg robenacoxib (corresponding to the upper end of the dosage range [1X, Group 2] and multiples thereof [3X and 5X, Group 3 and 4]), orally once daily for 6 months...
August 17, 2018: BMC Veterinary Research
Yaoyue Liang, Satomi Kagota, Kana Maruyama, Yuri Oonishi, Shino Miyauchi-Wakuda, Yoshihiko Ito, Shizuo Yamada, Kazumasa Shinozuka
AIMS: Royal jelly (RJ) has a variety of reported biological activities, including vasorelaxation and blood pressure-lowering effects. Although functional foods are positively used for health, the effects of RJ on the cardiovascular system in healthy individuals have not been well studied. Therefore, we investigated the mechanisms underlying the vasorelaxation effects of RJ in healthy control rats to evaluate whether the peripheral circulation was increased. MAIN METHODS: We used fresh RJ to examine the vasorelaxation effects and related mechanisms in Wistar rats using organ bath techniques...
July 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Elisabeth Schilbred Eriksen, Shashi Gulati, Ketil Moen, Per Johan Wisth, Sigbjørn Løes
PURPOSE: The study purpose was to assess whether mandibular setback surgery by intraoral vertical ramus osteotomy (IVRO) induces obstructive apnea and hypopnea in healthy Class III patients without a history of respiratory dysfunction. We hypothesized that the apnea-hypopnea index (AHI) would not exceed 5 events per hour after surgery. PATIENTS AND METHODS: A prospective cohort study was conducted. The sample was composed of healthy Class III patients without a history of obstructive sleep apnea treated with isolated mandibular setback surgery by the IVRO procedure at a university hospital...
July 24, 2018: Journal of Oral and Maxillofacial Surgery
Mary A Johnson, Sanjeeva Kariyawasam, Krishna Epari, Mohammad Ballal
BACKGROUND: Minimally invasive oesophagectomy (MIO) has a steep learning curve. We report our outcomes of a standardized 25 mm circular-stapled anastomosis using a trans-orally placed anvil (Orvil™). The objective of this study is to report the initial experience of introducing two-stage MIO to an Australian tertiary health service. METHODS: We describe our consecutive case series of all MIOs performed from a prospectively maintained database. We assessed the morbidity and mortality of MIO at our institution...
August 17, 2018: ANZ Journal of Surgery
C Bedos, N Apelian, J-N Vergnes
If dental professionals want to improve the oral health of their patients, they need to address what makes them sick: the social determinants of health. In this article, we propose a model of 'social dentistry' that shows how dentists could tackle these fundamental causes of oral disease. Socially engaged dentists conduct actions at three levels. At the individual level, they provide patient-centred care and, when necessary, liaise with local resources to better address what makes their patients sick. At the community level, they adapt their practice to the needs of the most vulnerable groups and advocate for healthier local policies...
August 17, 2018: British Dental Journal
Maria Espejo, Shirley Magabo, Angel Rivera-Castro, Mohammed Faiz, Leandro Ramirez, Cristabel Robles, Tarek Shabarek, Masood A Shariff, Balavenkatesh Kanna
OBJECTIVE: To study the knowledge, perception, and behaviors among hypertensive African-Americans in South Bronx, New York, to elucidate any gaps that could explain their poor blood pressure control. METHODS: Cross-sectional qualitative study on African-American participants with essential hypertension, on single or combined oral antihypertensive regimen. Three focus groups were presented with open-ended questions on topics including cardiovascular disease knowledge, perception, and behaviors...
August 16, 2018: Journal of Racial and Ethnic Health Disparities
Paula Kostecka-Sochoń, Barbara M Onopiuk, Ewa Dąbrowska
Cadmium is one of the main chemical pollutants found in the daily environment of developed countries. Cigarettes are a significant source of that metal, which makes it important in terms of oral cavity health. The aim of this study was to determine if increased supply of zinc in chronic exposure to cadmium might protect the sublingual gland structure against oxidative damage. The experiment took 12 months and was conducted on 72 adult male rats. They were randomized into 9 groups. Eight groups received cadmium in drinking water (as CdCl2 ) at 5 or 50 mg Cd/dm3 and/or zinc (as ZnCl2 ) at 30 or 60 mg Zn/dm3 ...
2018: Oxidative Medicine and Cellular Longevity
Maurizio Sessa, Annamaria Mascolo, Bruno D'Agostino, Antonio Casciotta, Vincenzo D'Agostino, Fausto De Michele, Mario Polverino, Giuseppe Spaziano, Mikkel Porsborg Andersen, Kristian Kragholm, Francesco Rossi, Christian Torp-Pedersen, Annalisa Capuano
Rationale: Gender-related differences in asthma prevalence, pathophysiology and clinical features induced by sex steroids have been investigated, however, how gender influences response to asthma treatments in routine clinical practice have not yet been elucidated fully. This aspect is crucial for montelukast considering the jeopardization of asthmatic patients that benefit from this treatment and the existence of evidence of gender differences in leukotriene levels. Therefore, to fulfill this medical need, we investigated the role of gender on a set of montelukast' effectiveness surrogates in adults and pediatric patients with asthma...
2018: Frontiers in Pharmacology
Eun-Jeong Kim, Yong-Keum Choi
Background: The purpose of this study was to examine whether allergic rhinitis is associated with periodontal disease in a representative sample of elderly Korean people that was adjusted for socio-demographic factors, oral and general health behaviors, and systemic health status. Methods: A total of 10,643 subjects who were between 20 and 59 years of age participated in the Korean National Health and Nutrition Examination Survey and underwent cross-sectional examination...
2018: BMC Ear, Nose, and Throat Disorders
Kevin C Miller, Morie A Gertz, Francis K Buadi, Suzanne R Hayman, Robert C Wolf, Martha Q Lacy, Angela A Dispenzieri, David Dingli, Prashant Kapoor, Wilson I Gonsalves, Taxiarchis Kourelis, William J Hogan, Shaji K Kumar
Autologous stem cell transplantation (ASCT) remains a mainstay in the treatment of multiple myeloma (MM). While the procedure is generally safe, toxicities associated with high-dose melphalan conditioning are common and significantly affect patient quality of life. Recently, a propylene glycol-free melphalan formulation (PG-free MEL; Evomela®) was approved by the United States Food and Drug Administration as an ASCT-conditioning regimen for MM. PG-free MEL is more soluble and stable than propylene glycol-solubilized melphalan (PG-solubilized MEL; Alkeran®)...
August 16, 2018: Bone Marrow Transplantation
Ilse Reinders, Dorothee Volkert, Lisette C P G M de Groot, Anne Marie Beck, Ilana Feldblum, Inken Jobse, Floor Neelemaat, Marian A E de van der Schueren, Danit R Shahar, Ellen T H C Smeets, Michael Tieland, Jos W R Twisk, Hanneke A H Wijnhoven, Marjolein Visser
BACKGROUND & AIMS: Protein-energy malnutrition is a health concern among older adults. Improving nutritional status by increasing energy and protein intake likely benefits health. We therefore aimed to investigate effects of nutritional interventions in older adults (at risk of malnutrition) on change in energy intake and body weight, and explore if the intervention effect was modified by study or participants' characteristics, analysing pooled individual participant data. METHODS: We searched for RCTs investigating the effect of dietary counseling, oral nutritional supplements (ONS) or both on energy intake and weight...
August 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Raquel Rodríguez-Rodríguez, Elena Polentinos-Castro, Amaya Azcoaga-Lorenzo, Cristina González-Fernández
AIM: To estimate the prevalence of use of progestin-only contraceptive among women who request reversible contraception in Primary Care (PC). DESIGN: Multicentre cross-sectional study. SETTING: Primary Care Health Care Centres (Madrid). PARTICIPANTS: Women aged 16-50 years old, users of reversible contraception, who speak Spanish, and had attended the Primary Care Centre in the last year. MAIN MEASUREMENTS: Primary outcome: contraceptive method used: Contraception with progestins-only (yes/no)...
August 13, 2018: Atencion Primaria
Jason B Reed, Rupa R Patel, Rachel Baggaley
Oral pre-exposure prophylaxis (PrEP) has the ability to curb HIV incidence worldwide and bring us closer to ending the HIV epidemic. Scale up of PrEP service delivery has many similar challenges to those faced by voluntary medical male circumcision (VMMC) services roll-out. This article outlines ten important lessons learned during the scale up of VMMC services in sub-Saharan Africa and their application to current oral PrEP implementation efforts to promote faster expansion for public health impact.
August 16, 2018: International Journal of STD & AIDS
N Stormon, A Pradhan, A McAuliffe, P J Ford
Access to dental care is poorer for people experiencing homelessness and disadvantage due to barriers such as lengthy waiting lists, lack of transport, lack of information and fear of authorities and treatment. This study aimed to evaluate a system integration model for oral health care for clients of homeless services in Brisbane, Australia. This model aimed to provide a facilitated access pathway between homeless community organisations and a public dental service to improve access to dental care. Participants were adult (≥18 years) clients Brisbane homeless community organisations...
August 8, 2018: Evaluation and Program Planning
Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon Kyu Lee
BACKGROUND: This report presents the recent prevalence and comorbidities related to diabetes in Korea by analyzing the nationally representative data. METHODS: Using data from the Korea National Health and Nutrition Examination Survey for 2013 to 2014, the percentages and the total number of subjects over the age of 30 years with diabetes and prediabetes were estimated and applied to the National Population Census in 2014. Diagnosis of diabetes was based on fasting plasma glucose (≥126 mg/dL), current taking of antidiabetic medication, history of previous diabetes, or glycosylated hemoglobin (HbA1c) ≥6...
August 9, 2018: Diabetes & Metabolism Journal
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