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Vascular liver disease

X L Xu, J G Liu, M Sun, L Yu, Q Y Liu, Q M Bai, L J Wu, J Wang
Objective: To investigate the clinicopathologic and genetic features, pathologic diagnosis and differential diagnosis of angiofibroma of soft tissue(AFST). Methods: The clinicopathologic characteristics of 24 cases diagnosed at Fudan University Shanghai Cancer Center from 2011 to 2017 were analyzed; immunohistochemical staining and interphase fluorescence in situ hybridization (FISH) were performed, and the literatures were also reviewed. Results: There were 15 male and 9 female (male∶female=1.7∶1.0) patients with age of onset ranging from 8 to 68 years (mean, 45 years)...
August 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Koichi Masuda, Shinsuke Takenaga, Kazuhiko Morikawa, Asami Kano, Hiroya Ojiri
Sarcoidosis is a multisystemic inflammatory disease of unknown origin characterized by the formation of noncaseating granulomas and accumulation of inflammatory cells. Sarcoidosis most commonly affects the lungs and lymphoid system. However, the liver can also be involved in 50%-65% of cases. On magnetic resonance imaging, sarcoidosis lesions usually present as hypointense lesions on all sequences. However, we present a rare case of nodular liver sarcoidosis presenting with T2 hyperintense lesions. In addition, while most cases of hepatic nodular sarcoidosis present with multiple small hepatic nodules, liver masses of our case are larger than usual...
October 2018: Radiology case reports
Nina Gertsvolf, Emily Andersen, Thaer Othman, Peter Xu, Newton Phuong, Brian Butera, Naga Dharmavaram, Mary Schoenbaum, Han Tun, Andrew Yoon, Brian Kim, David M Shavelle
BACKGROUND: Patent foramen ovale (PFO) is present in approximately 20% of individuals. During liver transplantation (LT), intra-operative transesophageal echocardiography can observe transient intra-cardiac shunting of atheromatous debris via a PFO. Closure of PFOs prior to LT has thus been suggested as a potential treatment to reduce peri-operative cerebral vascular accident (CVA). The objective of this study was to assess if the presence of PFO is associated with CVA in patients undergoing LT...
June 23, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Ozlem Ercelep, Nuriye Ozdemir, Nedim Turan, Turkan Ozturk Topcu, Mukremin Uysal, Ozgur Tanriverdi, Umut Demirci, Burcu Yapar Taskoylu, Zuhat Urakcı, Ayse Ocak Duran, Asude Aksoy, Serkan Menekse, Melike Ozcelik, Mahmut Gumus
PURPOSE: Solid pseudopapillary neoplasm (SPN) is a rare, low-grade neoplasm with excellent prognosis. In this study, we evaluated clinicopathological characteristics of patients diagnosed with SPN retrospectively. METHODS: This is a retrospective study intended to characterize patients with the diagnosis of SPN between 2005 and 2015. Clinicopathological features, recurrence rate, and overall survival of 28 patients were recorded. Malignant SPN criteria were defined as the presence of distant metastasis (developed at diagnosis or during follow up) or lymph node involvement...
July 19, 2018: Current Problems in Cancer
Ying Chen, Melissa A Gilbert, Christopher M Grochowski, Deborah McEldrew, Jessica Llewellyn, Orith Waisbourd-Zinman, Hakon Hakonarson, Joan E Bailey-Wilson, Pierre Russo, Rebecca G Wells, Kathleen M Loomes, Nancy B Spinner, Marcella Devoto
Biliary atresia (BA) is a rare pediatric cholangiopathy characterized by fibrosclerosing obliteration of the extrahepatic bile ducts, leading to cholestasis, fibrosis, cirrhosis, and eventual liver failure. The etiology of BA remains unknown, although environmental, inflammatory, infectious, and genetic risk factors have been proposed. We performed a genome-wide association study (GWAS) in a European-American cohort of 343 isolated BA patients and 1716 controls to identify genetic loci associated with BA. A second GWAS was performed in an independent European-American cohort of 156 patients with BA and other extrahepatic anomalies and 212 controls to confirm the identified candidate BA-associated SNPs...
August 13, 2018: PLoS Genetics
Hongling Zhu, Tao Wang, R John Lye, Brent A French, Brian H Annex
BACKGROUND: Following systemic delivery, AAV9-mediated gene expression is significantly increased in ischemic versus non-ischemic muscle, suggesting AAV9 as an attractive vector for treating peripheral arterial disease (PAD). Potential mechanisms underlying ischemia-augmented expression include: 1) increased vascular permeability, and 2) "unmasking" of endogenous AAV9 receptors. Here, we endeavored to reconstitute the ischemic induction of AAV9 in vivo, using local injection of histamine (to increase vascular permeability) and neuraminidase (to desialylate cell surface glycans)...
August 12, 2018: Journal of Gene Medicine
Jun-Jun Yeh, Cheng-Li Lin, Chia-Hung Kao
AIMS: To evaluate the relationship between cardiovascular diseases (CVDs) and pneumonia in the general population. METHODS: This retrospective observational study included two cohorts, namely CVD (n = 28,363) and non-CVD (n = 28,363) cohorts, which were matched by propensity score and examined for cases of pneumonia. Data were obtained from 2000 to 2011. In both cohorts, pneumonia risk was measured using multivariable Cox proportional hazard models. RESULTS: With the non-CVD cohort as reference, the corresponding adjusted hazard ratios (aHRs) [95% confidence intervals (CIs)] of pneumonia were 2...
August 8, 2018: European Journal of Internal Medicine
Zoltan Czigany, Marcus N Scherer, Johann Pratschke, Markus Guba, Silvio Nadalin, Arianeb Mehrabi, Gabriela Berlakovich, Xavier Rogiers, Jacques Pirenne, Jan Lerut, Zoltan Mathe, Philipp Dutkowski, Bo-Göran Ericzon, Massimo Malagó, Nigel Heaton, Wenzel Schöning, Jan Bednarsch, Ulf Peter Neumann, Georg Lurje
BACKGROUND: Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage liver disease. However, technical aspects of OLT are still subject of ongoing debate and are widely based on personal experience and local institutional protocols. METHODS: An international online survey was sent out to all liver transplant centers (n = 52) within the Eurotransplant, Swisstransplant, Scandiatransplant, and British Transplant Society networks...
August 10, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Raghdaa Hamdan Al Zarzour, Mohammed A Alshawsh, Muhammad Asif, Majed Ahmed Al-Mansoub, Zahurin Mohamed, Mariam Ahmad, Amin Malik Shah Abdul Majid, Mohd Zaini Asmawi, Gurjeet Kaur, Dhamraa Waleed Al-Dualimi, Mun Fei Yam
The growth of adipose tissues is considered angiogenesis-dependent during non-alcoholic fatty liver disease (NAFLD). We have recently reported that our standardized 50% methanolic extract (ME) of Phyllanthus niruri (50% ME of P. niruri ) has alleviated NAFLD in Sprague⁻Dawley rats. This study aimed to assess the molecular mechanisms of action, and to further evaluate the antiangiogenic effect of this extract . NAFLD was induced by eight weeks of high-fat diet, and treatment was applied for four weeks. Antiangiogenic activity was assessed by aortic ring assay and by in vitro tests...
August 9, 2018: Nutrients
Giuseppina Novo, Francesca Macaione, Lydia Giannitrapani, Maria Giovanna Minissale, Vito Bonomo, Francesco Indovina, Salvatore Petta, Maurizio Soresi, Giuseppe Montalto, Salvatore Novo, Antonio Craxi, Anna Licata
BACKGROUND: Cirrhosis is associated with morpho-functional cardiovascular alterations. AIMS: To detect early features of cardiovascular damage in HCV-compensated cirrhotic patients using myocardial deformation indices and carotid arterial stiffness, and further, to evaluate their short-term behaviour after HCV eradication with direct antiviral agents (DAAs). METHODS: Thirty-nine consecutive patients with HCV cirrhosis, without previous cardiovascular events, were studied and matched for age, gender and cardiovascular risk factors to 39 controls without liver or cardiovascular disease...
August 10, 2018: Alimentary Pharmacology & Therapeutics
A M Coates, A M Hill, S Y Tan
PURPOSE OF REVIEW: We review recent epidemiological and clinical studies investigating the consumption of tree nuts and peanuts and cardiovascular disease (CVD) mortality as well as CVD risk factors. RECENT FINDINGS: A greater consumption of tree nuts and peanuts is associated with a reduced risk of CVD mortality, as well as lower CVD events. Furthermore, risk factors associated with the development of CVD such as dyslipidemia, impaired vascular function, and hypertension are improved with regular tree nut and peanut consumption through a range of mechanism associated with their nutrient-rich profiles...
August 9, 2018: Current Atherosclerosis Reports
Anargyros Bakopoulos, Nikolaos Koliakos, Diamantis I Tsilimigras, Dimitrios Schizas, Demetrios Moris, Argiris Angelopoulos, Spyridon Spanakos, Eleftherios Spartalis, Pavlos Patapis, Panagiotis Skandalakis, Theodoros Troupis
HCC rupture is a potentially life-threatening complication owing to underlying vascular dysfunction and coagulopathy. There is still a debate in the literature concerning the best approach in patients presenting in the emergency setting with shock due to spontaneous HCC rupture. In the current report, we describe the case of a 66-year-old female patient with ruptured HCC who was treated successfully by emergency transarterial embolization (TAE) with complete response proved by gradual shrinkage of the tumor...
July 2018: Annals of Translational Medicine
Zaher Armaly, Jimmy E Jadaon, Adel Jabbour, Zaid A Abassi
Preeclampsia is a serious complication of pregnancy where it affects 5-8% of all pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman, especially in developing countries. It deleteriously affects several vital organs, including the kidneys, liver, brain, and lung. Although, the pathogenesis of preeclampsia has not yet been fully understood, growing evidence suggests that aberrations in the angiogenic factors levels and coagulopathy are responsible for the clinical manifestations of the disease...
2018: Frontiers in Physiology
Adil Rasheed, Carolyn L Cummins
Atherosclerosis is a chronic condition associated with cardiovascular disease. While largely identified by the accumulation of lipid-laden foam cells within the aorta later on in life, atherosclerosis develops over several stages and decades. During atherogenesis, various cell types of the aorta acquire a pro-inflammatory phenotype that initiates the cascade of signaling events facilitating the formation of these foam cells. The liver X receptors (LXRs) are nuclear receptors that upon activation induce the expression of transporters responsible for promoting cholesterol efflux...
August 7, 2018: International Journal of Molecular Sciences
Young-In Yoon, Sung-Gyu Lee, Deok-Bog Moon, Chul-Soo Ahn, Shin Hwang, Ki-Hun Kim, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Dong-Sik Kim, Suk-Jung Choo
OBJECTIVE: We aimed to describe our living-donor liver transplantation (LDLT) surgical technique and its long-term patency for patients with Budd-Chiari syndrome (BCS) and retrohepatic inferior vena cava (IVC) obstruction that extends up to the atrium. BACKGROUND: From a technical perspective, LDLT for BCS with an IVC obstruction up to the right atrium is one of the most challenging surgical procedures. Consequently, the optimal surgical technique for patients with BCS has not yet been elucidated...
August 3, 2018: Annals of Surgery
Frank P Schmidt, Tim Zimmermann, Till Wenz, Boris Schnorbus, Mir Abolfazl Ostad, Christina Feist, Annette Grambihler, Jörn M Schattenberg, Martin F Sprinzl, Thomas Münzel, Peter R Galle
INTRODUCTION: Chronic Hepatitis C virus infection (HCV) is associated with extrahepatic manifestations and an increased prevalence in cardiovascular disease. New direct acting antivirals (DAA) have revolutionized HCV treatment with high rates of sustained virological response (SVR). Recently it was demonstrated, that SVR reduces morbidity and overall mortality more than can be solely explained by hepatic effects, suggesting that treatment with DAA also affects cardiovascular disease. The aim of this pilot study was to identify possible underlying mechanisms behind the HCV-associated cardiovascular mortality reported by others...
August 1, 2018: International Journal of Cardiology
Rolake O Alabi, Gregory Farber, Carl P Blobel
The vasculature is a remarkably interesting, complex, and interconnected organ. It provides a conduit for oxygen and nutrients, filtration of waste products, and rapid communication between organs. Much remains to be learned about the specialized vascular beds that fulfill these diverse, yet vital functions. This review was prompted by the discovery that Notch signaling in mouse endothelial cells is crucial for the development of specialized vascular beds found in the heart, kidneys, liver, intestines, and bone...
October 1, 2018: Physiological Reviews
Katrina Lam, Vinicio de Jesus Perez
No abstract text is available yet for this article.
August 1, 2018: American Journal of Respiratory and Critical Care Medicine
Young Min Ham, Hae Seong Song, Jeong Eun Kwon, Hyelin Jeon, Hyun Jin Baek, Chang Won Kim, Weon-Jong Yoon, Eui Su Choung, Se Chan Kang
Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the pathogenesis of atherosclerosis. In particular, secretion of the pro-atherogenic cytokine tumor necrosis factor-α induces expression of endothelial adhesion molecules including P-selectin, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1), which mediate attachment of circulating monocytes and lymphocytes...
July 31, 2018: Journal of Natural Medicines
Jie Li, Zhonghu Li, Peng Jiang, Minjie Peng, Xi Zhang, Kai Chen, Hui Liu, Huaqiang Bi, Xiangde Liu, Xiaowu Li
BACKGROUND: Recent studies show that exosomes are involved in intercellular communication and that abundant circular RNAs (circRNAs) are present within exosomes. However, whether these exosomal circRNAs contribute to tumor invasion and metastasis remains unclear, as do their associated mechanisms. METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to measure the expression levels of circ-IARS in 85 pancreatic ductal adenocarcinoma (PDAC) tissues, plasma exosomes, and Hs 766 T, Hs 766 T-L2 and human microvascular vein endothelial (HUVECs) cells...
July 31, 2018: Journal of Experimental & Clinical Cancer Research: CR
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