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Type one diabetes mellitus

Shigekuni Hosogi, Masahiro Ohsawa, Ikuo Kato, Atsukazu Kuwahara, Toshio Inui, Akio Inui, Yoshinori Marunaka
Diabetes mellitus is a well-known common disease and one of the most serious social problems in the worldwide. Although various types of drugs are developed, the number of patients suffering from diabetes mellitus is still increasing. Ninjin'yoeito (NYT) is one of formulas used in Japanese traditional herbal medicines for improving various types of metabolic disorders. However, the effect of NYT on diabetes mellitus has not yet been investigated. In the present study, we tried to clarify the action of NYT on the serum glucose level in streptozotocin (STZ)-induced diabetic mice...
2018: Frontiers in Nutrition
Paweł Mochalski, Eva Diem, Karl Unterkofler, Axel Mündlein, Heinz Drexel, Chris A Mayhew, Andreas Leiherer
Breath analysis offers a non-invasive and rapid diagnostic method for detecting various volatile organic compounds that could be indicators for different diseases, particularly metabolic disorders including type 2 diabetes mellitus. The development of type 2 diabetes mellitus is closely linked to metabolic dysfunction of adipose tissue and adipocytes. However, the VOC profile of human adipocytes has not yet been investigated. Gas chromatography with mass spectrometric detection and head-space needle trap extraction (two-bed Carbopack X/Carboxen 1000 needle traps) were applied to profile VOCs produced and metabolised by human Simpson Golabi Behmel Syndrome adipocytes...
November 28, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Parisa Goodarzi, Khadijeh Falahzadeh, Hamidreza Aghayan, Moloud Payab, Bagher Larijani, Sepideh Alavi-Moghadam, Akram Tayanloo-Beik, Hossein Adibi, Kambiz Gilany, Babak Arjmand
Regenerative medicine as a background of stem cell research and therapy has a long history. A wide variety of diseases including Parkinson's disease, heart diseases, multiple sclerosis, spinal cord injury, diabetes mellitus and etc. are candidate to be treated using different types of stem cells. There are several sources of stem cells such as bone marrow, umbilical cord, peripheral blood, germ cells and the embryo/fetus tissues. Fetal stem cells (FSCs) and embryonic stem cells (ESCs) have been described as the most potent stem cell source...
December 7, 2018: Cell and Tissue Banking
Stella Nikolaou, Shengyang Qiu, Francesca Fiorentino, Shahnawaz Rasheed, Paris Tekkis, Christos Kontovounisios
Colorectal cancer (CRC) is one of the commonest cancers in Western society with a poor prognosis in patients with advanced disease. Targeted therapy is of increasing interest and already, targeted hormone treatment for breast and prostate cancer has improved survival. The aim of this literature review is to summarise the role of hormones in CRC prognosis and treatment. A literature review of all human and animal in vivo and in vitro studies in the last 20 years, which assessed the role of hormones in CRC treatment or prognosis, was carried out...
December 10, 2018: Molecular Biology Reports
Pablo San Juan M, Angélica Pérez J, Cornelio Barrientos A
BACKGROUND: Peritonitis is the most important and frequent complication of peritoneal dialysis (PD). Bacterial infections are responsible in most cases, with characteristic symptoms. AIM: To determine the most frequent pathogens in peritonitis associated with PD in patients with chronic renal failure (CRF). Methodos: Retrospective, descriptive, cross-sectional and observational study of patients with peritonitis in PD with CRF of the emergency department, between July 2012 and June 2013...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Marcos Estica R, Daniela Seelenfreund H, Pilar Durruty A, Gloria Briones B
We report a 21 years old woman, without offspring, with diabetes mellitus diagnosed at 17 years of age, without ketosis or weight loss. Her body mass index was 18 kg/m2. Her C peptide was normal (2.3 ng/ml) and diabetes mellitus type 1 autoantibodies were negative. A monogenic diabetes Maturity Onset Diabetes of the Young (MODY) was proposed. Her family study disclosed a diabetic father and a brother with altered fasting glucose levels. The University of Exeter score for MODY yielded a 75.5% probability of MODY2...
July 2018: Revista Médica de Chile
Allison Martin, Elizabeth P Neale, Linda C Tapsell
The objective of this study was to assess the clinical utility of the AUSDRISK tool for determining risk of Type 2 diabetes mellitus (T2DM). In this secondary analysis from the HealthTrack study, the AUSDRISK tool was applied to data from overweight/obese volunteers completing a lifestyle intervention trial. Participants were volunteer residents of the Illawarra region recruited in 2014-2015. From 377 trial participants (BMI 25-40 kg/m2 , 25-54 yr), 161 provided data required for measurement of AUSDRISK, collected at 0 and 12 months...
March 2019: Preventive Medicine Reports
Afreen Idris Shariff, Sohail Syed, Rebecca A Shelby, Jeremy Force, Jeffrey Melson Clarke, David D'Alessio, Leonor Corsino
Over the last decade, there has been a shift in the focus of cancer therapy from conventional cytotoxic drugs to therapies more specifically directed to cancer cells. These novel therapies include immunotherapy, targeted therapy and precision medicine, each developed in great part with a goal of limiting collateral destruction of normal tissues, while enhancing tumor destruction. Although this approach is sound in theory, even new, specific therapies have some undesirable, 'off target effects', in great part due to molecular pathways shared by neoplastic and normal cells...
February 1, 2019: Journal of Molecular Endocrinology
Seham E Abdelsadek, Entesar O El Saghier, Sabah I Abdel Raheem
Background: Some clinical studies demonstrated a significant association between vitamin D deficiency and diabetic peripheral neuropathy (DPN). Objective: This study aims to evaluate the correlation between serum levels of 25(OH) vitamin D and DPN in Egyptian patients with type 2 diabetes mellitus (T2DM). Patients and method: Sixty patients were known to have T2DM, which classified into the following: group I included 40 patients with DPN and group II included 20 diabetic patients, without DPN, compared with 30 apparently healthy subjects of matched age and sex as control group...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
B Z Tursunov, Kh Kh Usmanov, S N Temirov
Presented herein are the results of treatment of five 63-to-72-year-old patients (four men and one woman) with critical upper limb ischaemia, which is one of rarely encountered pathologies. All patients suffered from type 2 diabetes mellitus. Two of them had end-stage renal disease (ESRD) and for 2 years were on haemodialysis. Four patients had gangrene of 1 finger and one patient had gangrene of 2 fingers. The main diagnostic methods included duplex scanning with measuring the gradient of pressure between the humeral and radial arteries, and MSCT angiography...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Guofu Zhang, Xiaoyi Wang, Xu Zhang, Qian Li, Shangzhi Xu, Li Huang, Yu Zhang, Lixia Lin, Duan Gao, Meng Wu, Guoqiang Sun, Yang Song, Chunrong Zhong, Xuefeng Yang, Liping Hao, Hongying Yang, Lei Yang, Nianhong Yang
BACKGROUND: Antimony (Sb) has been associated with type 2 diabetes in previous studies. However, the role of Sb in the incidence of Gestational diabetes mellitus (GDM) remains unclear. OBJECTIVES: We investigated the association between Sb exposure during early pregnancy and the risk of GDM. METHODS: We performed a prospective study of 2093 pregnant women from the Tongji Maternal and Child Health Cohort (TMCHC). Sb concentrations were measured in urine samples during early pregnancy by ICP-MS...
December 5, 2018: Environment International
Amber Werbrouck, Masja Schmidt, Koen Putman, Katrien Benhalima, Nick Verhaeghe, Lieven Annemans, Steven Simoens
AIMS: Women with gestational diabetes mellitus (GDM) are more likely to develop type 2 diabetes mellitus (T2DM) as compared to women with normoglycemic pregnancies. This study aims to explore the literature on cost(-effectiveness) of screening and prevention of T2DM in women with prior GDM. METHODS: Five databases were systematically searched, inclusion criteria were: (1) women with (prior) GDM; (2) post-partum screening or prevention of T2DM; and (3) health-economic evaluations...
December 6, 2018: Diabetes Research and Clinical Practice
Mehedi Hasan, Bayejid Hosen, Mostafijur Rahman, M Zakir Hossain Howlader, Yearul Kabir
AIMS: ATP-binding cassette transporter A1 (ABCA1) gene polymorphism has been reported as one of the genetic risk factors for T2DM in various populations with conflicting results. The aim of this study is to investigate the association of ABCA1 C69T polymorphism and lipid profile with T2DM in Bangladeshi population. MATERIALS AND METHODS: A total of 102 T2DM subjects and 98 healthy controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the PCR-RFLP technique...
December 7, 2018: Gene
Jong Hyun Kim, Bo Gi Park, Suel-Kee Kim, Dong-Hyun Lee, Gyung Gyu Lee, Deok-Ho Kim, Byung-Ok Choi, Kyu Back Lee, Jong-Hoon Kim
Bioengineering approaches to regulate stem cell fates aim to recapitulate the in vivo microenvironment. In recent years, manipulating the micro- and nano-scale topography of the stem cell niche has gained considerable interest for the purposes of controlling extrinsic mechanical cues to regulate stem cell fate and behavior in vitro. Here, we established an optimal nanotopographical system to improve 3-dimensional (3D) differentiation of pancreatic cells from human pluripotent stem cells (hPSCs) by testing gradient-pattern chips of nano-scale polystyrene surface structures with varying sizes and shapes...
December 6, 2018: Acta Biomaterialia
Isabel Alonso-Troncoso, Carmen Carollo-Limeres, Mónica Rios-Prego, Ipek Guler, Carmen Cadarso-Suárez, Alexis F-Mariño
INTRODUCTION AND OBJECTIVES: The worldwide prevalence of type 2 diabetes mellitus increases in parallel to that of obesity. Liraglutide (LRG), a glucagon-like peptide-1 receptor agonist, can reduce body weight. This study assessed the metabolic efficacy of LRG in real-world clinical practice. METHODS: An observational, retrospective cohort study including patients treated with LRG for at least one year (187 patients). Anthropometric and metabolic variables, a composite endpoint, factors predicting response to LRG, and cardiovascular risk over time were assessed...
December 6, 2018: Endocrinología, Diabetes y Nutrición
Dewi Hernández-Montoya, Antonio Soriano-Flores, Marcelino Esparza-Aguilar, Corina Benjet, Nathaly Llanes-Díaz
PURPOSE: To study temporal changes in the cumulative incidence (CI) of type 2 diabetes mellitus during early and late adolescence from 2003 to 2013. METHODS: This was an ecologic, analytical study of trends over time. Data were weekly reports of new cases (General Directorate of Epidemiology). Specific CI was calculated and standardized by age using the direct method (WHO). Autoregressive Integrated Moving Average models offering a better fit to the observed series were calculated and controlled by intentional screening...
November 22, 2018: Annals of Epidemiology
Clara Nilholm, Bodil Roth, Peter Höglund, Kaj Blennow, Elisabet Englund, Oskar Hansson, Henrik Zetterberg, Bodil Ohlsson
Food may induce inflammation and favor development of metabolic diseases, which have been associated with increased inflammation and potential risk of cognitive impairment. It is customary to know whether food or disease promote inflammation. Our hypothesis was that Okinawan-based Nordic (O-BN) diet leads to decreased circulating concentrations of inflammatory and neural biomarkers. The objectives of this study were to examine the effects of the O-BN diet on inflammatory and neural responses. First, 2 different breakfasts; one standard and another O-BN-based, were given in random order to 19 healthy volunteers...
December 2018: Nutrition Research
Hajime Shimoda, Tetsu Takahashi
BACKGROUND: Patients with type 1 diabetes mellitus (DM) have poor glycemic control owing to extreme impairments in glucose tolerance. There are few reports regarding dental implant surgery in patients with type 1 DM. We describe herein the perioperative glycemic management in an outpatient with type 1 DM who experienced a rare case of severe hypoglycemia during dental implant surgery. Only one such case has previously been reported. CASE PRESENTATION: A 60-year-old male patient diagnosed with type 1 DM was scheduled for dental implant primary surgery...
December 7, 2018: BMC Oral Health
Nourah Alsheridah, Saeed Akhtar
BACKGROUND: Cancer of colon and rectum (colorectal) is one of the most common cancers worldwide. There is a scarcity of published data on the risk factors for colorectal cancer (CRC) from the Middle-Eastern countries specifically in Kuwait. Therefore, this matched case-control study sought to examine the risk factors associated with CRC in Kuwait. METHODS: One hundred and three histopathologically confirmed colorectal cancer cases were recruited from Kuwait Cancer Control Centre Registry...
December 7, 2018: BMC Cancer
Yukihisa Hatakeyama, Hisashi Ohnishi, Kentaro Suda, Kayoko Okamura, Temiko Shimada, Sho Yoshimura
A 60-year-old Japanese man, with no medical or family history of diabetes, presented with acute-onset type 1 diabetes following nivolumab treatment for advanced non-small-cell lung cancer. During cycle 35 of nivolumab therapy, his glycated hemoglobin level increased from 7.6% to 9.1% in one month. Test results for islet-related and anti-thyroid peroxidase antibodies were negative. A glucagon tolerance test showed insulin dependency. Type 1 diabetes after anti-programmed death-ligand 1 antibody administration is an immune-related adverse event, and numerous reports suggest that fulminant type 1 diabetes can develop in these patients...
December 8, 2018: Journal of Oncology Pharmacy Practice
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