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Type one diabetes mellitus

E A J M Spaans, P R van Dijk, K H Groenier, P L P Brand, N Kleefstra, H J G Bilo
BACKGROUND: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children. Studies on costs related to T1DM are scarce and focused primarily on the costs directly related to diabetes. We aimed to investigate both the overall healthcare costs and the more specific costs related to the management of diabetes. METHODS: This is a retrospective and observational, nationwide cohort study of all Dutch children (aged 0-18 years) with T1DM. Data were collected from the national registry for healthcare reimbursement, in which all Dutch insurance companies combine their reimbursement data...
August 17, 2018: BMC Endocrine Disorders
Sravani Tekula, Amit Khurana, Pratibha Anchi, Chandraiah Godugu
Type 1 diabetes mellitus (T1DM) is one of the major metabolic disorders with life-long dependence on insulin. The present study was designed to evaluate the antioxidant and anti-diabetic potential of Withaferin A (WA), the active constituent of Withania somnifera in multiple low doses of Streptozotocin (MLD-STZ) induced T1DM. STZ (40 mg/Kg) was administered intraperitoneally (i.p.) for 5 consecutive days to male Swiss albino mice to induce T1DM. Mice were concurrently treated with WA (2 & 10 mg/Kg)...
July 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Andrzej Czyrski, Matylda Resztak, Tadeusz Hermann
Type 2 diabetes mellitus is a worldwide health problem. Many drugs can be used in its treatment. One of them is gliclazide - the sulfonylurea derivative. It is dosed in modified release tablets. The study aimed to determine the minimum steady-state concentration of gliclazide at patients taking modified release tablets. Fasting plasma glucose, insulin level, and glycated hemoglobin were also assayed in this study. Ten patients of the primary care physician clinic took 30-90 mg of gliclazide daily. The statistical analysis proved that there is a statistically significant correlation between insulin level and body weight (p = 0...
July 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Akitsu Kawabe, Shinichi Matsumoto, Masayuki Shimoda
BACKGROUND: New methods of beta-cell replacement have been developed to maintain excellent glycemic control, improve quality of life, and even eliminate insulin injections in patients with type 1 diabetes mellitus (T1DM). Previously, we demonstrated that being insulin-free is the strongest motivation for accepting a newly developed therapy. Multiple allogeneic islet transplantations with immunosuppression using a human donor is the best option to be insulin-free, but the necessity for immunosuppression and donor shortage are major issues...
August 17, 2018: Islets
Mousab Yousef Al-Ayed, Mutasem Ababneh, Asirvatham Alwin Robert, Ahmed Salman, Abdulghani Al Saeed, Mohamed Abdulaziz Al Dawish
BACKGROUND AND AIMS: Considering that diabetic foot ulceration is one of the major health issues globally, we aimed to evaluate the risk factors associated with foot ulcers in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 81 T2DM patients (age range: 40-80 years) registered at the Diabetes Treatment Center, Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia between April and September 2015 were included in this cross-sectional study after purposive selection and assigning of patient numbers...
August 16, 2018: Current Diabetes Reviews
Fanglin He, Zhanlin Zhao, Yan Liu, Linna Lu, Yao Fu
Purpose: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5-10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore)...
2018: Journal of Ophthalmology
Maria Csobonyeiova, Stefan Polak, Lubos Danisovic
Diabetes type 1 (T1D) is a common autoimmune disease characterized by permanent destruction of the insulin-secreting β-cells in pancreatic islets, resulting in a deficiency of the glucose-lowering hormone insulin and persisting high blood glucose levels. Insulin has to be replaced by regular subcutaneous injections, and blood glucose level must be monitored due to the risk of hyperglycemia. Recently, transplantation of new pancreatic β-cells into T1D patients has come to be considered one of the most potentially effective treatments for this disease...
August 16, 2018: Experimental and Clinical Endocrinology & Diabetes
Shao-Jun Li, Yu-Fen Zhang, Se-Hui Ma, Yao Yi, Hong-Yan Yu, Lei Pei, Dan Feng
BACKGROUND: NLRP3 inflammasome plays a prominent role in the pathogenesis and progression of many diseases, such as type 2 diabetes mellitus, obesity, atherosclerosis, and Alzheimer's disease. However, little knowledge is known about the role of NLRP3 inflammasome in central post-stroke pain (CPSP). METHODS: We selected relevant studies by searching PubMed, Embase, and Medline from inception through February, 2018. We systematically reviewed available publications according to the terms "NLRP3 inflammasome" and "stroke" or "central post-stroke pain" in the title/abstract field...
August 2018: Medicine (Baltimore)
Tami L Jakubowski, Tracy Perron, Anne Farrell, Carole Kenner, Christy Hullings
BACKGROUND: The Smart Nutrition and Conditioning for Kids (SNACK) program was developed in response to the 2010 Childhood Obesity Study () recognizing a 49% childhood obesity rate in Trenton New Jersey. Lifestyle influences contributing to childhood obesity and Type 2 diabetes mellitus include poor food choices, inadequate access to healthy foods, decrease in physical activity, and insufficient access to safe play environments. METHODS: Second-grade students were selected by teachers to be in the SNACK intervention group or a control group based on their classroom assignment...
September 2018: MCN. the American Journal of Maternal Child Nursing
Eun Young Joo, Ji Eun Lee, Hee Sook Kang, Shin Goo Park, Yong Hee Hong, Young Lim Shin, Min Sohn
BACKGROUND: This study aimed to evaluate the relationship between the frequency of self-monitoring of blood glucose (SMBG) and glycosylated hemoglobin (HbA1c) levels among Korean adolescents with type 1 diabetes mellitus (T1DM). Factors affecting the SMBG frequency were analyzed in order to improve their glycemic control. METHODS: Sixty-one adolescents aged 13 to 18 years with T1DM were included from one tertiary center. Clinical and biochemical variables were recorded...
June 29, 2018: Diabetes & Metabolism Journal
Seung Jin Han, Edward J Boyko
Although overweight/obesity is a major risk factor for the development of type 2 diabetes mellitus, there is increasing evidence that overweight or obese patients with type 2 diabetes mellitus experience lower mortality compared with patients of normal weight. This paradoxical finding, known as the "obesity paradox," occurs in other chronic diseases, and in type 2 diabetes mellitus is particularly perplexing given that lifestyle intervention with one goal being weight reduction is an important feature of the management of this condition...
May 31, 2018: Diabetes & Metabolism Journal
Xu-Nian Wu, Ya-Dan Huang, Jin-Xuan Li, Yan-Fa Yu, Zhou Qian, Chen Zhang, Yinuo Wu, Hai-Bin Luo
The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPAR γ agonists such as rosiglitazone exhibited remarkable preclinical and clinical treatment effects for these two diseases. In this study, a series of PDE9 inhibitors combining the pharmacophore of rosiglitazone were discovered. All the compounds possessed remarkable affinities towards PDE9 and four of them have the IC50 values <5 nmol/L. In addition, these four compounds showed low cell toxicity in human SH-SY5Y neuroblastoma cells...
July 2018: Acta Pharmaceutica Sinica. B
Lu Lu, Yixiang Deng, Xuejin Li, He Li, George Em Karniadakis
Accumulation and aggregation of amyloid are associated with the pathogenesis of many human diseases, such as Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM). Therefore, a quantitative understanding of the molecular mechanisms causing different aggregated structures and biomechanical properties of amyloid fibrils could shed some light into the progression of these diseases. In this work, we develop coarse-grained molecular dynamics (CGMD) models to simulate the dynamic self-assembly of two types of amyloids (amylin and amyloid β (Aβ))...
August 14, 2018: Journal of Physical Chemistry. B
Velibor Čabarkapa, Mirjana Djerić, Milena Mitrović, Sunčica Kojić-Damjanov, Ivana Isakov, Bojan Vuković, Djordje Popović
In both types of diabetes mellitus (DM), type 1 and type 2 (T1DM and T2DM), there are both endocrine and exocrine dysfunctions of the pancreas (PED), as well as disturbances in serum magnesium levels. The aim of this study was to examine the frequency of PED according to the level of fecal elastase-1 (FE-1) in patients with T1DM and T2DM, determining the correlation of the level of FE-1 with certain anthropometric parameters, certain indicators of metabolic regulation of diabetes, and certain nutritive markers of PED...
February 1, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Ruth Martis, Caroline A Crowther, Emily Shepherd, Jane Alsweiler, Michelle R Downie, Julie Brown
BACKGROUND: Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies. OBJECTIVES: To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of the benefits and harms associated with interventions for treating GDM on women and their babies. METHODS: We searched the Cochrane Database of Systematic Reviews (5 January 2018) for reviews of treatment/management for women with GDM...
August 14, 2018: Cochrane Database of Systematic Reviews
Miodrag Stojanović, Goran Cvetanović, Marija Anđelković-Apostolović, Dijana Stojanović, Nataša Rančić
OBJECTIVE: Diabetes mellitus (DM) has been one of the leading chronic diseases worldwide over past decades. The objective of the study was to identify predictors associated with health-related quality of life (HRQOL) in diabetic patients. METHODS: A cross-sectional questionnaire-based study was conducted at the General Hospital of the city of Leskovac, between June and November 2015. The Short Form-36 (SF-36) questionnaire, EuroQol-5D (EQ-5D) and EuroQol-VAS (EQ-VAS) questionnaires were used...
June 2018: Central European Journal of Public Health
Katarzyna Birkner, Bartosz Hudzik, Piotr Desperak, Mariusz Gąsior
OBJECTIVE: The aim: We aimed at assessing the prognostic significance of diabetes mellitus in patients with NSTEMI treated with PCI as well as determining the independent predictors of worse prognosis. PATIENTS AND METHODS: Materials and methods: We performed a retrospective analysis of 830 patients hospitalized between January 2006 and December 2012 with diagnoses of NSTEMI and undergoing angiography and percutaneous coronary interventions. Patients were divided into two groups: with diabetes mellitus (246 patients) and without diabetes mellitus (584 patients)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Irina V Marchenko, Yevhen I Dubovyk, Olha I Matlai, Antonina A Biesiedina, Polina V Kniazkova, Yelizaveta A Harbuzova
OBJECTIVE: Introduction: More than 100 genes have been described associations between single nucleotide polymorphisms and type 2 diabetes mellitus (T2DM). Among these candidate genes, Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), is located on the long arm of chromosome 6 (6q23.2) and encodes for a protein which is one of the factors determining the insulin sensitivity. An allelic polymorphism in exon 4 of ENPP1 (rs1044498) has been designated K121Q and widely investigated in T2DM in different populations...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Kostiantyn V Tarasenko, Antonina M Gromova, Kateryna V Pikul, Ruslan B Lysenko, Leonid A Nesterenko
OBJECTIVE: Introduction: Obesity is one of the most important medical and social problems in many countries of the world, as it is associated with the development of the most common non-communicable diseases: cardiovascular, type II diabetes mellitus, motor disorders, non-alcoholic fatty liver disease (NHAHP) and others. The aim of this paper is to analyze the pathogenetic mechanisms of insulin resistance development in pregnant women with varying obesity degrees in early and late gestation periods...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Zhenzhong Zheng, Fan Zhang, Dengpeng Gao, Yujing Wu, Hao Wu
BACKGROUND: Cardiac microvascular endothelial cells is one of the key factors in the process of diabetic cardiomyopathy, a common chronic complication of diabetes. Fibrinogen-like protein 2 (FGL2) is linked to apoptosis, angiogenesis, and inflammatory response, all of which also occur in diabetes. Thus, we investigate the role of FGL 2 and other genes in the pathology of diabetic cardiomyopathy. METHODS: In the present study, we used high-throughput microarray to profile gene expression in rat myocardial microvascular endothelial cells (MMEC) with or without silencing the fgl2 gene and in different glucose environments...
August 11, 2018: Diabetes/metabolism Research and Reviews
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