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Linx for GERD

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https://www.readbyqxmd.com/read/30214323/spotlight-on-the-linx%C3%A2-reflux-management-system-for-the-treatment-of-gastroesophageal-reflux-disease-evidence-and-research
#1
REVIEW
Jonathan Zadeh, Anthony Andreoni, Daniela Treitl, Kfir Ben-David
Background: The initial approach to gastroesophageal reflux disease (GERD) management typically involves lifestyle modification and medical therapy utilizing acid reducing agents such as histamine blockers and proton pump inhibitors. In severe cases refractory to such treatments, surgical therapy may be indicated. The gold standard for surgical treatment of GERD is the laparoscopic Nissen fundoplication. In recent years, a new technique known as magnetic sphincter augmentation (MSA) has been developed using the Linx™ Reflux Management System...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/30027381/comparison-of-the-outcome-of-laparoscopic-procedures-for-gerd
#2
REVIEW
Fabrizio Rebecchi, Marco Ettore Allaix, Lorenzo Cinti, Milica Nestorović, Mario Morino
A total laparoscopic fundoplication has become the procedure of choice for the surgical treatment of gastroesophageal reflux disease in patients with normal esophageal motility, with reduced postoperative pain, faster recovery and similar long-term outcomes compared to conventional open total fundoplication. Most controversial surgical aspects are the division of the short gastric vessels and the insertion of a bougie to calibrate the wrap. The anterior 180° and the posterior partial fundoplications lead to similar control of heartburn when compared to total fundoplication with lower risk of dysphagia...
September 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29697454/objective-evidence-of-reflux-control-after-magnetic-sphincter-augmentation-one-year-results-from-a-post-approval-study
#3
Brian E Louie, C Daniel Smith, Christopher C Smith, Reginald C W Bell, George Kevin Gillian, Jeffrey S Mandel, Kyle A Perry, Walter Kurt Birkenhagen, Paul A Taiganides, Christy M Dunst, Howard M McCollister, John C Lipham, Leena K Khaitan, Shawn T Tsuda, Blair A Jobe, Shanu N Kothari, Jon C Gould
OBJECTIVE: To report 1-year results from a 5-year mandated study. SUMMARY BACKGROUND DATA: In 2012, the United States Food and Drug Administration approved magnetic sphincter augmentation (MSA) with the LINX Reflux Management System (Torax Medical, Shoreview, MN), a novel device for the surgical treatment of gastroesophageal reflux disease (GERD). Continued assessment of safety and effectiveness has been monitored in a Post Approval Study. METHODS: Multicenter, prospective study of patients with pathologic acid reflux confirmed by esophageal pH testing undergoing MSA...
April 24, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29509533/new-minimally-invasive-endoscopic-and-surgical-therapies-for-gastroesophageal-reflux-disease-gerd
#4
REVIEW
Alexandru Eugen Nicolau, Adrian Lobonţiu, Silviu Constantinoiu
GERD has become one of the most frequent pathology of the upper GI tract. It is a spectrum disease and is a progressive disease as well. Serious and severe complications are possible. The mainstream therapy in most of the patients is the medical therapy with PPI's. The most severe cases with an impaired LES (Lower Esophageal Sphincter) function as well as important anatomical disruptions are of surgical indication, the gold standard being laparoscopic fundoplication, an elective therapy with long term follow up outcomes at the expense of de novo symptoms associated with fundoplications in general...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29471155/early-results-of-magnetic-sphincter-augmentation-versus-fundoplication-for-gastroesophageal-reflux-disease-systematic-review-and-meta-analysis
#5
REVIEW
Alberto Aiolfi, Emanuele Asti, Daniele Bernardi, Gianluca Bonitta, Emanuele Rausa, Stefano Siboni, Luigi Bonavina
BACKGROUND: Laparoscopic Nissen and Toupet fundoplication (LF) are currently considered gold-standard surgical treatment for Gastroesophageal Reflux Disease (GERD). Magnetic Sphincter Augmentation (MSA) is an innovative surgical procedure that has been showed to be effective to control GERD symptoms and to reduce esophageal acid exposure. The aim of this systematic review and meta-analysis was to compare early outcomes of LF and MSA. MATERIALS AND METHODS: PubMed, MEDLINE, Embase, and Cochrane databases were consulted matching the terms "Gastroesophageal reflux or heartburn", "LINX or magnetic sphincter augmentation" and "fundoplication"...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/28420936/linx-reflux-management-system-is-it-a-permanent-solution-for-gerd
#6
Shirin Siddiqi, Saad Ullah, Najwa Pervin
No abstract text is available yet for this article.
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28351472/-the-missing-linx-for-gastroesophageal-reflux-disease-operative-techniques-video-for-the-linx-magnetic-sphincter-augmentation-procedure
#7
John P Kuckelman, Morgan R Barron, Matthew J Martin
In 2012 the FDA approved a magnetic sphincter augmentation (MSA) device (LINX, Torax Medical, Inc) for placement around the lower esophageal sphincter as an alternative approach to fundoplication for gastroesophageal reflux disease (GERD). This is a relatively new procedure and there is not widespread familiarization with the standard indications and techniques of device placement. We present two operative videos to highlight the standard surgical technique and technical points needed for successful LINX placement...
May 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/27981382/linx-%C3%A2-magnetic-esophageal-sphincter-augmentation-versus-nissen-fundoplication-for-gastroesophageal-reflux-disease-a-systematic-review-and-meta-analysis
#8
REVIEW
Daniel Skubleny, Noah J Switzer, Jerry Dang, Richdeep S Gill, Xinzhe Shi, Christopher de Gara, Daniel W Birch, Clarence Wong, Matthew M Hutter, Shahzeer Karmali
BACKGROUND: The LINX® magnetic sphincter augmentation system (MSA) is a surgical technique with short-term evidence demonstrating efficacy in the treatment of medically refractory or chronic gastroesophageal reflux disease (GERD). Currently, the Nissen fundoplication is the gold-standard surgical treatment for GERD. We are the first to systematically review the literature and perform a meta-analysis comparing MSA to the Nissen fundoplication. METHODS: A comprehensive search of electronic databases (e...
August 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27163959/removal-of-the-magnetic-sphincter-augmentation-device-surgical-technique-and-results-of-a-single-center-cohort-study
#9
Emanuele Asti, Stefano Siboni, Veronica Lazzari, Gianluca Bonitta, Andrea Sironi, Luigi Bonavina
OBJECTIVE: The aim of this study was to identify patients' characteristics that may predict failure and removal of the Linx sphincter augmentation device, and to report the results of 1-stage laparoscopic removal and fundoplication. BACKGROUND: The Linx device is a long-term magnetic implant that was developed as a less disruptive and more reproducible surgical option for patients with early-stage gastroesophageal reflux disease (GERD). Removal of the device has been shown to be feasible, but no long-term results of this procedure have been reported yet...
May 2017: Annals of Surgery
https://www.readbyqxmd.com/read/26659236/revaluation-of-the-efficacy-of-magnetic-sphincter-augmentation-for-treating-gastroesophageal-reflux-disease
#10
REVIEW
Hongke Zhang, Dinghui Dong, Zhengwen Liu, Shuixiang He, Liangshuo Hu, Yi Lv
BACKGROUND: Gastroesophageal reflux disease (GERD) is a prevalent disease which severely impacts the quality of life of the patients. The surgical options are limited to such patients who are not satisfied with medical therapies. Magnetic sphincter augmentation (MSA) is a new antireflux surgical technique for treating GERD, which could physiologically reinforce the lower esophageal sphincter by magnetic force. Many clinical and animal studies have focused on this new therapy. The purpose of this work was to review the feasibility, efficacy and safety of MSA as a new treatment for GERD...
September 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26162926/gastroesophageal-reflux-management-with-the-linx%C3%A2-system-for-gastroesophageal-reflux-disease-following-laparoscopic-sleeve-gastrectomy
#11
Kenneth Desart, Georgios Rossidis, Michael Michel, Tamara Lux, Kfir Ben-David
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained significant popularity in the USA, and consequently resulted in patients experiencing new-onset gastroesophageal reflux disease (GERD) following this bariatric procedure. Patients with GERD refractory to medical therapy present a more challenging situation limiting the surgical options to further treat the de novo GERD symptoms since the gastric fundus to perform a fundoplication is no longer an option. OBJECTIVES: The aim of this study is to determine if the LINX® magnetic sphincter augmentation system is a safe and effective option for patients with new gastroesophageal reflux disease following laparoscopic sleeve gastrectomy...
October 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26039726/evaluation-of-the-linx-antireflux-procedure
#12
REVIEW
Eric G Sheu, David W Rattner
PURPOSE OF REVIEW: To evaluate the current data on the safety, efficacy, and indications for magnetic sphincter augmentation (MSA) using the LINX device to treat gastroesophageal reflux disease (GERD). RECENT FINDINGS: The LINX device has demonstrated excellent safety and GERD efficacy in several recent nonblinded, single arm studies with strict inclusion criteria and up to 3 years follow-up. Dysphagia has been the most common adverse effect occurring after LINX...
July 2015: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/25616745/-interventional-procedures-in-the-treatment-of-gastroesophageal-reflux-disease
#13
REVIEW
O O Koch, G Köhler, H Wundsam, M Weitzendorfer, G O Spaun, K Emmanuel
For patients with gastroesophageal reflux disease (GERD) who suffer from severe symptoms despite adequate medical therapy, interventional procedures are the only option for improving symptoms and thus the quality of life. In the clinical practice it is decisive if a hiatal hernia (HH) is present or not and whether it is larger or smaller than 2-3 cm. Patients who have a HH > 2-3 cm should undergo laparoscopic fundoplication with hiatal hernia repair. Patients with a larger HH are no longer eligible for endoscopic therapy as closure of the HH is not endoscopically possible...
October 2015: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/25608629/microalgae-lipid-characterization
#14
Linxing Yao, Jose A Gerde, Show-Ling Lee, Tong Wang, Kamel A Harrata
To meet the growing interest of utilizing microalgae biomass in the production of biofuels and nutraceutical and pharmaceutical lipids, we need suitable analytical methods and a comprehensive database for their lipid components. The objective of the present work was to demonstrate methodology and provide data on fatty acid composition, lipid class content and composition, characteristics of the unsaponifiables, and type of chlorophylls of five microalgae. Microalgae lipids were fractionated into TAG, FFA, and polar lipids using TLC, and the composition of fatty acids in total lipids and in each lipid class, hydrocarbons, and sterols were determined by GC-MS...
February 18, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25595928/optimizing-patient-selection-and-outcomes-for-surgical-treatment-of-gerd-and-achalasia
#15
Steven R DeMeester
Gastroesophageal reflux disease is a common disorder in the United States and other western countries. In addition to troublesome symptoms, this condition is associated with impaired quality of life and the potential for disease progression to esophageal adenocarcinoma. Acid suppression medications are extremely effective for the relief of heartburn symptoms, but don't address the physiologic derangements that cause reflux. The goal of an antireflux procedure is to correct these defects and abolish the dietary and lifestyle compromises that accompany medical therapy for gastroesophageal reflux...
March 2015: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/25264655/magnetic-sphincter-augmentation-with-the-linx-device-for-gastroesophageal-reflux-disease-after-u-s-food-and-drug-administration-approval
#16
Jessica L Reynolds, Joerg Zehetner, Nikolai Bildzukewicz, Namir Katkhouda, Giovanni Dandekar, John C Lipham
Magnetic sphincter augmentation (MSA) of the gastroesophageal junction with the LINX Reflux Management System is an alternative to fundoplication for gastroesophageal reflux disease (GERD) that was approved by the U.S. Food and Drug Administration (FDA) in March 2012. This is a prospective observational study of all patients who underwent placement of the LINX at two institutions from April 2012 to December 2013 to evaluate our clinical experience with the LINX device after FDA approval. There were no intraoperative complications and only four mild postoperative morbidities: three urinary retentions and one readmission for dehydration...
October 2014: American Surgeon
https://www.readbyqxmd.com/read/25012804/a-comparative-trial-of-laparoscopic-magnetic-sphincter-augmentation-and-nissen-fundoplication
#17
RANDOMIZED CONTROLLED TRIAL
Eric G Sheu, Peter Nau, Barbara Nath, Braden Kuo, David W Rattner
BACKGROUND: Laparoscopic magnetic sphincter augmentation (MSA) with the LINX device is a promising new therapy for the treatment of gastroesophageal reflux disease (GERD). Initial studies have demonstrated MSA to be safe and effective. However, no direct comparison between MSA and laparoscopic Nissen fundoplication (LNF), the gold standard surgical therapy for GERD, has been performed. METHODS: A single institution, case-control study was conducted of MSA performed from 2012 to 2013 and a cohort of LNF matched for age, gender, and hiatal hernia size...
March 2015: Surgical Endoscopy
https://www.readbyqxmd.com/read/24778041/modern-gerd-treatment-feasibility-of-minimally-invasive-esophageal-sphincter-augmentation
#18
Katrin Schwameis, Michael Schwameis, Barbara Zörner, Johannes Lenglinger, Reza Asari, Franz Martin Riegler, Sebastian Friedrich Schoppmann
BACKGROUND: Gastroesophageal reflux disease (GERD) is a common chronic disease requiring adequate treatment since it represents one major cause of development of Barrett's esophagus and eventually carcinoma. Novel laparoscopic magnetic sphincter augmentation for GERD was evaluated prospectively. PATIENTS AND METHODS: A total of 23 patients with GERD underwent minimally invasive implantation of LINX™ Reflux Management System. Primary outcome measures were overall feasibility, short-term procedure safety and efficacy...
May 2014: Anticancer Research
https://www.readbyqxmd.com/read/23814607/linx-%C3%A2-reflux-management-system-in-chronic-gastroesophageal-reflux-a-novel-effective-technology-for-restoring-the-natural-barrier-to-reflux
#19
Luigi Bonavina, Greta Saino, John C Lipham, Tom R Demeester
Gastroesophageal reflux disease (GERD) results from incompetency of the lower esophageal sphincter that allows the contents of the stomach to reflux into the esophagus, the airways, and the mouth. The disease affects about 10% of the western population and has a profound negative impact on quality of life. The majority of patients are successfully treated with proton-pump inhibitors, but up to 40% have incomplete relief of symptoms even after dose adjustment. The laparoscopic Nissen fundoplication represents the surgical gold standard, but is largely underused because of the level of technical difficulty and the prevalence of side effects...
July 2013: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/23237251/linx-%C3%A2-reflux-management-system-magnetic-sphincter-augmentation-in-the-treatment-of-gastroesophageal-reflux-disease
#20
REVIEW
Luigi Bonavina, Tom R DeMeester, Robert A Ganz
Gastroesophageal reflux disease (GERD), commonly manifested by heartburn or regurgitation, is a chronic, progressive condition in which failed sphincter function allows the contents of the stomach to reflux into the esophagus, the airways and the mouth. Chronic GERD affects 10% of Western society. The majority of patients receive adequate relief from proton pump inhibitors, but up to 40% have incomplete relief of symptoms that cannot be addressed by increasing the dose of medications. The laparoscopic Nissen fundoplication is the surgical gold standard; however, the level of technical difficulty and its side effects have limited its use to less than 1% of the GERD population...
December 2012: Expert Review of Gastroenterology & Hepatology
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