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https://www.readbyqxmd.com/read/30551632/incidence-costs-and-predictors-of-non-union-delayed-union-and-mal-union-following-long-bone-fracture
#1
Christina L Ekegren, Elton R Edwards, Richard de Steiger, Belinda J Gabbe
Fracture healing complications are common and result in significant healthcare burden. The aim of this study was to determine the rate, costs and predictors of two-year readmission for surgical management of healing complications (delayed, mal, non-union) following fracture of the humerus, tibia or femur. Humeral, tibial and femoral (excluding proximal) fractures registered by the Victorian Orthopaedic Trauma Outcomes Registry over five years ( n = 3962) were linked with population-level hospital admissions data to identify two-year readmissions for delayed, mal or non-union...
December 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30547177/ginsenoside-rf-alleviates-dysmenorrhea-and-inflammation-through-the-bdnf-trkb-creb-pathway-in-a-rat-model-of-endometriosis
#2
Xuying Qin, Yan Liu, Yanchong Feng, Jie Jiang
To investigate the effects and the underlying mechanisms of ginsenoside Rf in a surgically induced rat endometriosis model, endometriosis was constructed through homologous transplantation and the Wistar rats were further randomly classified into the sham group, the estradiol valerate (E2V) control group, the endometriosis group, and the ginsenoside Rf groups (1.0, 2.0 and 4.0 mg kg-1, respectively). After 7 days of treatment, the implant volume and writhing responses were recorded. Vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were analyzed using enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) assay...
December 14, 2018: Food & Function
https://www.readbyqxmd.com/read/30544460/the-impact-of-lymphovascular-invasion-in-patients-with-prostate-cancer-following-radical-prostatectomy-and-its-association-with-their-clinicopathological-features-an-updated-prisma-compliant-systematic-review-and-meta-analysis
#3
Wei Jiang, Lijin Zhang, Bin Wu, Zhenlei Zha, Hu Zhao, Yuan Jun, Yuefang Jiang
OBJECTIVE: Numerous studies have shown that lymphovascular invasion (LVI) is linked to biochemical recurrence (BCR) in prostate cancer (PCa) patients following radical prostatectomy (RP). However, the actual clinicopathological impacts of LVI remain unclear. Thus, we performed a meta-analysis to evaluate the pathologic and prognostic impacts of LVI in PCa patients. METHODS: Following the guidance of the PRISMA statement, relevant studies were collected systematically from the PubMed, EMBASE, and Web of Science databases to identify relevant studies published before June 2018...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30544112/gender-disparities-in-vascular-access-surgical-outcomes-in-elderly-hemodialysis-patients
#4
Timmy Lee, Joyce Qian, Mae Thamer, Michael Allon
BACKGROUND: Despite national vascular access guidelines promoting the use of arteriovenous fistulas (AVF) over arteriovenous grafts (AVGs) for dialysis, AVF use is substantially lower in females. We assessed clinically relevant AVF and AVG surgical outcomes in elderly male and female patients initiating hemodialysis with a central venous catheter (CVC). METHODS: Using the United States Renal Data System standard analytic files linked with Medicare claims, we assessed incident hemodialysis patients in the United States, 9,458 elderly patients (≥67 years; 4,927 males and 4,531 females) initiating hemodialysis from July 2010 to June 2011 with a catheter and had an AVF or AVG placed within 6 months...
December 13, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/30540615/narcolepsy-anesthesia-and-sedation-a-survey-of-the-perioperative-experience-of-patients-with-narcolepsy
#5
Shelley Hershner, Rahul Kakkar, Frances Chung, Mandeep Singh, Jean Wong, Dennis Auckley
BACKGROUND: Patients with narcolepsy may be at increased perioperative risk due to the interactions among anesthesia, narcolepsy, and narcolepsy medications. This study sought to determine the perioperative experience of narcoleptic patients undergoing anesthesia or sedation, the frequency of perioperative counseling, and self-reported surgical complications. METHODS: A 22-question survey was developed by expert consensus and distributed by the Narcolepsy Network...
December 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30539389/synthesis-and-evaluation-of-topical-hydrogel-membranes-a-novel-approach-to-treat-skin-disorders
#6
Sarfaraz Ahmad, Muhammad Usman Minhas, Mahmood Ahmad, Muhammad Sohail, Qandeel Khalid, Orva Abdullah
The aim of the study was to synthesize and evaluate chitosan-based topical cross-linked hydrogel membranes of mupirocin for new pharmaceutical controlled release application. These cross-linked structured membranes were synthesized by modification of free radical polymerization. Low molecular weight (LMW) chitosan is cross-linked with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with a crosslinker N,N-methylenebisacrylamide (MBA). Hydrogel membranes were characterized by FTIR, DSC, TGA, SEM, Swelling behavior, sol-gel analysis, in vitro percent drug release at different pH, permeation across skin, ex vivo drug deposition study, irritation study and in vivo antibacterial activity of mupirocin loaded hydrogels...
December 11, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/30538643/preventing-peritoneal-dialysis-associated-fibrosis-by-therapeutic-blunting-of-peritoneal-toll-like-receptor-activity
#7
REVIEW
Anne-Catherine Raby, Mario O Labéta
Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure. PD therapy is limited by peritoneal inflammation, which leads to peritoneal membrane failure as a result of progressive fibrosis. Peritoneal infections, with the concomitant acute inflammatory response and membrane fibrosis development, worsen PD patient outcomes. Patients who remain infection-free, however, also show evidence of inflammation-induced membrane damage and fibrosis, leading to PD cessation. In this case, uraemia, prolonged exposure to bio-incompatible PD solutions and surgical catheter insertion have been reported to induce sterile peritoneal inflammation and fibrosis as a result of cellular stress or tissue injury...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30538439/impact-of-copd-on-prognosis-of-lung-cancer-from-a-perspective-on-disease-heterogeneity
#8
Wei Wang, Shuang Dou, Wenyan Dong, Mengshuang Xie, Liwei Cui, Chunyan Zheng, Wei Xiao
Background: COPD is an important comorbidity of lung cancer, but the impact of COPD on the outcomes of lung cancer remains uncertain. Because both COPD and lung cancer are heterogeneous diseases, we evaluated the link between COPD phenotypes and the prognosis of different histological subtypes of lung cancer. Methods: In this retrospective study, subjects with a newly and pathologically confirmed diagnosis of lung cancer were enrolled from patients preparing for lung cancer surgery...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30537875/questionnaires-for-knee-instability-assessment-in-people-with-anterior-cruciate-ligament-injury-a-systematic-review-of-original-questionnaires-and-their-translated-versions
#9
Ana Paula Ramos Marinho, Guilherme S Nunes, Enaiane Menezes, Magnus Benetti, Marcos de Noronha
PURPOSE: To verify the quality of questionnaires/scales regarding knee instability caused by anterior cruciate ligament (ACL) insufficiency and their translated versions. MATERIALS AND METHODS: Searches were conducted on Web of Science, Pubmed, Medline, Cinahl, and SportDiscuss. The COnsensus-based Standards for the selection of Health Measurement INstruments (COSMIN) scale was used to assess the article's quality; and the measurement properties of each questionnaire/scale were also analysed...
December 11, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/30537459/impact-of-closed-facebook-group-participation-on-female-hematology-oncology-physicians
#10
Stephanie L Graff, Julia Close, Suzanne Cole, Laurie Matt-Amaral, Rasha Beg, Merry-Jennifer Markham
PURPOSE: Meaningful connections are an important aspect of career satisfaction. The Hematology Oncology Women Physician Group (HOWPG) is a private Facebook (FB) group of 936 women who practice within the hematology/oncology (H/O) field. We hypothesized that HOWPG adds value to education, emotional wellness, and practice of oncology for its membership. A survey was conducted within HOWPG to define group impact on members. MATERIALS AND METHODS: A voluntary, anonymous 12-question online survey was distributed to members of HOWPG by sharing the survey link within the FB group...
December 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/30535713/rab38-promotes-bladder-cancer-growth-by-promoting-cell-proliferation-and-motility
#11
Da-Wei Tian, Sheng-Lai Liu, Li-Ming Jiang, Zhou-Liang Wu, Jie Gao, Hai-Long Hu, Chang-Li Wu
BACKGROUND: Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Therefore, to improve survival rates of patients with advanced bladder cancer, novel therapeutic targets are still urgently needed...
December 10, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30530803/golf-habits-among-physicians-and-surgeons-observational-cohort-study
#12
Gal Koplewitz, Daniel M Blumenthal, Nate Gross, Tanner Hicks, Anupam B Jena
OBJECTIVES: To examine patterns of golfing among physicians: the proportion who regularly play golf, differences in golf practices across specialties, the specialties with the best golfers, and differences in golf practices between male and female physicians. DESIGN: Observational study. SETTING: Comprehensive database of US physicians linked to the US Golfing Association amateur golfer database. PARTICIPANTS: 41 692 US physicians who actively logged their golf rounds in the US Golfing Association database as of 1 August 2018...
December 10, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/30529734/preoperative-endoscopic-retrograde-cholangiopancreatography-is-not-associated-with-increased-pancreatic-cancer-mortality
#13
Sheila D Rustgi, Sunil Amin, Anthony Yang, Michelle K Kim, Satish Nagula, Nikhil A Kumta, Christopher J DiMaio, Paolo Boffetta, Aimee L Lucas
BACKGROUND AND AIMS: Endoscopic Retrograde Cholangiopancreatography (ERCP) before surgery for pancreatic cancer has been associated with infectious complications after surgery. Little is known about the effects of preoperative ERCP on survival of patients with pancreatic cancer. We investigated whether ERCP before surgery affects overall survival, after controlling for confounding factors. METHODS: We used Surveillance, Epidemiology and End Results (SEER) and linked Medicare claims data to identify patients older than 65 years with cancer localized to the head of the pancreas, from 2000 through 2011...
December 6, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30527846/velopharyngeal-insufficiency-after-maxillary-advancement-in-patients-with-cleft-palate-a-survey-of-risk-assessment-in-the-united-kingdom-and-ireland
#14
R Fitzgerald, A Smyth
Patients with cleft lip and palate may require orthognathic surgery to correct severe impairments in midfacial growth. Maxillary advancement in this group, however, is linked to deterioration in velopharyngeal function (VPF), and it is not clear how cleft teams assess this risk. We therefore surveyed surgeons from 15 cleft units who provide orthognathic treatment, to gain an understanding of current practice in the UK and Ireland. A total of 16/21 surgeons from 14/15 units responded. While 14/16 surgeons agreed that these patients are at risk of a deterioration in VPF after maxillary advancement, two disagreed...
December 7, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/30527495/low-dmt1-expression-associates-with-increased-oxidative-phosphorylation-and-early-recurrence-in-hepatocellular-carcinoma
#15
Toshifumi Hoki, Eriko Katsuta, Li Yan, Kazuaki Takabe, Fumito Ito
BACKGROUND: Despite a high rate of recurrences, long-term survival can be achieved after the resection of hepatocellular carcinoma (HCC) with effective local treatment. Discovery of adverse prognostic variables to identify patients with high risk of recurrence could improve the management of HCC. Accumulating evidence showing a link between carcinogenesis and increased expression of iron import proteins and intracellular iron prompted us to investigate a role of divalent metal-ion transporter-1 (DMT1) that binds and regulates a variety of divalent metals in HCC...
February 2019: Journal of Surgical Research
https://www.readbyqxmd.com/read/30527474/surgical-resident-burnout-and-job-satisfaction-the-role-of-workplace-climate-and-perceived-support
#16
Nital P Appelbaum, Nathaniel Lee, Michael Amendola, Kelley Dodson, Brian Kaplan
BACKGROUND: Surgical residents train under immense stress, often manifesting into poor well-being. While recent research identifies methods of coping with stress, few studies empirically investigate the role of the environment on surgical resident well-being. We aimed to assess surgical resident perceptions of workplace climate, organizational support, burnout, and job satisfaction to test a mediation model identifying antecedents to well-being. MATERIALS AND METHODS: A convenience sampling of program directors from general surgery within the Eastern region of the United States were emailed to request either agenda time to collection data via paper survey or to forward an electronic survey link to their residents between March 2016 and June 2016...
February 2019: Journal of Surgical Research
https://www.readbyqxmd.com/read/30527215/association-of-frailty-index-with-perioperative-mortality-and-in-hospital-morbidity-after-elective-lower-extremity-bypass
#17
Mohammad H Eslami, Zein Saadeddin, Denis V Rybin, Gheorghe Doros, Jeffrey J Siracuse, Alik Farber
OBJECTIVE: The frailty index has been linked to adverse outcomes after surgical procedures. In this study, we evaluated the association between frailty index and outcomes after elective lower extremity bypass (LEB) for lower extremity ischemia. METHODS: The American College of Surgeons National Surgical Quality Improvement Program data set (2005-2012) was used to identify patients who underwent elective LEB using diagnostic and procedure Current Procedural Terminology codes...
October 24, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30526113/six-weeks-notice-of-the-on-call-roster-fact-or-fantasy-an-audit-study
#18
Thomas Pepper, Georgina Hicks
INTRODUCTION: Work-life balance is directly linked to morale, job satisfaction and staff retention - all of which are linked to high quality patient care. Receiving the duty roster in advance is the first step towards achieving any work-life balance, but anecdotally doctors frequently receive very little notice of this. This audit assessed NHS trusts' compliance with the Code of Practice, with specific reference to advance notification of duty rosters. METHOD: The duty roster should be made available 6 weeks before commencement of post...
December 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/30522361/higher-offset-cross-linked-polyethylene-acetabular-liners-is-wear-a-significant-clinical-concern
#19
Ryan M Chapman, Douglas W Van Citters, Danielle Chapman, David F Dalury
INTRODUCTION: Total hip arthroplasty (THA) is the 2nd most common total joint replacement surgery in the United States. However, not all THA devices perform well and need revised for several reasons including dislocation. Higher offset acetabular liners reduce this problem by creating a more anatomically/biomechanically natural hip joint, increasing soft-tissue tension, and accommodating larger femoral heads in smaller acetabular cups via increased polyethylene thickness. To our knowledge, however, in vivo wear (another failure mode) performance of offset acetabular liners remains unknown...
December 7, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/30516808/association-of-surgical-risk-with-exogenous-hormone-use-in-transgender-patients-a-systematic-review
#20
Elizabeth R Boskey, Amir H Taghinia, Oren Ganor
Importance: A growing number of transgender patients are receiving gender-affirming hormone treatments. It is unclear whether the evidence supports the current practice of routinely discontinuing these hormones prior to surgery. Objective: To determine how medications used in cross-sex hormone treatment (CSHT) affect perioperative risk. Evidence Review: A series of searches were carried out in PubMed and Excerpta Medica Database to identify articles using each of the terms testosterone, estrogen, estradiol, oral contraceptive, spironolactone, cyproterone acetate, finasteride, dutasteride, leuprolide, goserelin, and histrelin, in combination with the terms surgery, perioperative, thrombosis, thromboembolism, and operative...
December 5, 2018: JAMA Surgery
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