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https://www.readbyqxmd.com/read/30120677/multiple-non-essential-transition-metals-are-accumulated-in-carotid-atherosclerotic-plaques-missing-link-in-atherosclerosis
#1
Ayhan Olcay, Erdem Tezcan, Emir Canturk, Bekir İnan, Hasan Karaoglu, Ceyhun Kucuk, Baris Akdemir, Onur Yolay
Population studies revealed that metal exposure through food, environment, and smoking was related with increased risk of cardiovascular disease. In this study, we determined complex chemical elements in surgical carotid endarterectomy specimens and carotid tissues from autopsies without atherosclerosis. Atherosclerotic plaques from 41 endarterectomies and normal carotid tissue from 30 autopsies were collected and elemental composition was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) method...
August 17, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/30120611/the-effect-of-tumor-removal-via-craniotomies-on-preoperative-hydrocephalus-in-adult-patients-with-intracranial-tumors
#2
Sayied Abdol Mohieb Hosainey, Benjamin Lassen, John K Hald, Eirik Helseth, Torstein R Meling
The efficacy of tumor removal via craniotomies on preoperative hydrocephalus (HC) in adult patients with intracranial tumors is largely unknown. Therefore, we sought to evaluate the effect of tumor resection in patients with preoperative HC and identify the incidence and risk factors for postoperative VP shunt dependency. All craniotomies for intracranial tumors at Oslo University Hospital in patients ≥ 18 years old during a 10-year period (2004-2013) were reviewed. Patients with radiologically confirmed HC requiring surgery and subsequent development of shunt dependency were identified by cross-linking our prospectively collected tumor database to surgical procedure codes for hydrocephalus treatment (AAF)...
August 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/30120537/-suprachoroidal-hydrogel-buckling
#3
REVIEW
K Boden, K Januschowski, P Szurman
Suprachoroidal hydrogel buckling is a simple and safe procedure for the treatment of rhegmatogenous retinal detachment. The advantages of modern vitrectomy and classical buckling surgery are combined in this surgical approach. Suprachoroidal buckling can be performed as a stand-alone procedure or in addition to vitrectomy. Cross-linked hyaluronic acid with a resorption time of up to 8 weeks is a suitable agent for this technique. Further studies will help to establish suprachoroidal buckling as a surgical procedure for treatment of retinal detachment...
August 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/30119102/pilomatrixoma-a-comprehensive-review-of-the-literature
#4
Christopher D Jones, Weiguang Ho, Bernard F Robertson, Eilidh Gunn, Stephen Morley
INTRODUCTION: Pilomatrixoma, also known as calcifying epithelioma of Malherbe, is a superficial benign skin tumor that arises from hair follicle matrix cells. Although pilomatrixomas are well-recognized lesions, clinically they are frequently misdiagnosed as other skin conditions. By reviewing all the literature over the past 10 years, the aims of this article are to analyze the cause, clinical presentation, management, and outcome of pilomatrixoma among children and adults to gain a more complete understanding of this lesion in today's clinical context...
September 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/30117542/guideline-implementation-team-communication-1-8-www-aornjournal-org-content-cme
#5
Terri Link
The perioperative environment is fast paced and complex. Competing responsibilities, noise and distractions, and reluctance of team members to speak up when they are aware of a potential patient safety issue are all barriers to effective communication in the perioperative setting. Communication breakdowns among health care providers can lead to medical errors and patient harm. Accurate and complete communication about the patient and the patient's care can contribute to improved efficiency, better patient outcomes, and fewer adverse events...
August 2018: AORN Journal
https://www.readbyqxmd.com/read/30117282/patients-expectations-and-experiences-of-eating-behaviour-change-after-bariatric-procedures
#6
M Opozda, G Wittert, A Chur-Hansen
Patients' pre-surgical expectations and post-surgical experiences of eating-related behaviour change after bariatric surgery may vary by procedure and time since surgery. To investigate this, data were coded from 206 Australian adults ≥2 months post-Roux-en-Y gastric bypass (RYGB; 17%), adjustable gastric band (AGB; 23%) or vertical sleeve gastrectomy (VSG; 60%) who completed an online questionnaire including open-ended questions about pre-surgical eating-related expectations and post-surgical experiences...
August 16, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/30116833/-current-therapy-of-peyronie-s-disease
#7
A Hauptmann, F M E Wagenlehner, T Diemer
Peyronie's disease (PD) is a heterogeneous disorder with the classical penile symptoms of plaque formation, penile pain, deviation, penile shortening and erectile dysfunction. The etiology is unknown. Microtraumatic lesions with the development of an inelastic fibrous scar formation at the level of the tunica albuginea are discussed as a trigger mechanism besides a questionable genetically linked atypical wound healing. A non-surgical etiological treatment is not possible although several conservative treatment regimens are applied...
August 16, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/30115022/galectin-3-expression-in-regional-lymph-nodes-and-lymph-node-metastases-of-oral-squamous-cell-carcinomas
#8
Falk Wehrhan, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I Geppert, Friedrich W Neukam, Marco Kesting, Manuel Weber
BACKGROUND: Neck dissection is standard in surgical management of oral squamous cell carcinomas (oscc). However, the immunologic link between primary tumor and lymph nodes is insufficiently understood. Galectin 3 (Gal3) promotes M2 polarization of macrophages and contributes to immunosuppression. The current study analyzes the association between Gal3 expression in regional lymph nodes of oscc with histomorphologic parameters (T-, N-, L- Pn-stage, grading) of the primary tumor. Additionally, Gal3 expression is correlated with markers of macrophage polarization (M1 vs...
August 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30113687/folate-receptor-overexpression-in-human-and-canine-meningiomas-immunohistochemistry-and-case-report-of-intraoperative-molecular-imaging
#9
John T Pierce, Steve S Cho, Shayoni Nag, Ryan Zeh, Jun Jeon, David Holt, Amy Durham, MacLean P Nasrallah, Sunil Singhal, John Y K Lee
BACKGROUND: Meningiomas are well-encapsulated benign brain tumors and surgical resection is often curative. Nevertheless, this is not always possible due to the difficulty of identifying residual disease intraoperatively. We hypothesized that meningiomas overexpress folate receptor alpha (FRα), allowing intraoperative molecular imaging by targeting FRα with a near-infrared (NIR) dye. OBJECTIVE: To determine FRα expression in both human and canine meningioma cohorts to prepare for future clinical studies...
August 3, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30113367/nonalcoholic-fatty-liver-disease-current-concepts-epidemiology-and-management-strategies
#10
Dunya Tomic, William W Kemp, Stuart K Roberts
Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent liver disease in the world. It involves a spectrum of conditions from hepatic steatosis to nonalcoholic steatohepatitis and liver fibrosis, and is a major cause of cirrhosis and hepatocellular carcinoma. It is defined by presence of steatosis in 5% of hepatocytes or more in the absence of other causes of fatty liver. The metabolic syndrome is the major known risk factor for NAFLD. Dietary contributors such as high fructose intake and coffee consumption appear to increase and decrease the risk of disease respectively, but these links are unclear...
August 14, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30111522/early-commercial-experience-from-transcatheter-aortic-valve-implantation-using-the-portico%C3%A2-bioprosthetic-valve-30-day-outcomes-in-the-multicentre-portico-1-study
#11
Francesco Maisano, Stephen Worthley, Josep Rodés-Cabau, Axel Hans-Peter Linke, Stephan Fichtlscherer, Ulrich Schäfer, Raj R Makkar, Gregory Fontana, Federico M Asch, Lars Søndergaard
AIMS: The aim of this study was to investigate the procedural and short-term outcomes of transcatheter aortic valve implantation (TAVI) with the Portico™ self-expanding, resheathable TAVI system from an ongoing long-term multicentre study. METHODS AND RESULTS: A total of 941 patients (82.4±5.9 years, 65.7% female, STS score 5.8±4.9%) with severe symptomatic aortic stenosis underwent TAVI using the Portico bioprosthesis. Patients were clinically and echocardiographically assessed at implantation, discharge and 30 days post TAVI...
August 17, 2018: EuroIntervention
https://www.readbyqxmd.com/read/30111249/evaluation-of-in-situ-gelling-chitosan-peg-copolymer-for-use-in-the-spinal-cord
#12
Ashley E Mohrman, Mahmoud Farrag, Rachel K Grimm, Nic D Leipzig
The goal of the present work was to characterize a hydrogel material for localized spinal cord delivery. To address spinal cord injuries, an injectable in situ gelling system was tested utilizing a simple, effective, and rapid cross-linking method via Michael addition. Thiolated chitosan material and maleimide-terminated polyethylene glycol material were mixed to form a hydrogel and evaluated in vitro and in vivo. Three distinct thiolated chitosan precursors were made by varying reaction conditions; a modification of chitosan with Traut's reagent (2-iminothiolane) displayed the most attractive hydrogel properties once mixed with polyethylene glycol...
August 15, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/30110507/using-data-linkage-to-report-surgical-treatment-of-breast-cancer-in-canada
#13
Gisèle Carrière, Claudia Sanmartin, Patricia Murison
BACKGROUND: National population information about the surgical treatment rate for primary cancers, including breast cancer, has remained a significant data gap in Canada. This gap has implications for cancer care planning and evaluating health system performance. New linkages between the Canadian Cancer Registry and hospital discharge records were conducted by Statistics Canada in 2016. Using already existing, routinely collected health administrative data, these linkages allow viable reporting of surgical cancer treatment for the first time for all provinces and territories (except Quebec)...
August 15, 2018: Health Reports
https://www.readbyqxmd.com/read/30101993/vitamin-d-status-is-associated-with-development-of-hospital-acquired-pressure-injuries-in-critically-ill-surgical-patients
#14
Tiffany M N Otero, Cecilia Canales, D Dante Yeh, Ali Elsayes, Donna M Belcher, Sadeq A Quraishi
BACKGROUND: Hospital-acquired pressure injuries (HAPIs) typically develop following critical illness due to immobility and suboptimal perfusion. Vitamin D helps to maintain epithelial cell integrity, particularly at barrier sites such as skin. It is unclear whether vitamin D status is a modifiable risk factor for HAPIs in critically ill patients. Our goal was to investigate the relationship between admission 25-hydroxyvitamin D (25OHD) levels with the development of HAPIs in surgical intensive care unit (ICU) patients...
August 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30100577/association-between-age-deprivation-and-specific-comorbid-conditions-and-the-receipt-of-major-surgery-in-patients-with-non-small-cell-lung-cancer-in-england-a-population-based-study
#15
Aurélien Belot, Helen Fowler, Edmund Njeru Njagi, Miguel-Angel Luque-Fernandez, Camille Maringe, Winnie Magadi, Aimilia Exarchakou, Manuela Quaresma, Adrian Turculet, Michael D Peake, Neal Navani, Bernard Rachet
INTRODUCTION: We investigated socioeconomic disparities and the role of the main prognostic factors in receiving major surgical treatment in patients with lung cancer in England. METHODS: Our study comprised 31 351 patients diagnosed with non-small cell lung cancer in England in 2012. Data from the national population-based cancer registry were linked to Hospital Episode Statistics and National Lung Cancer Audit data to obtain information on stage, performance status and comorbidities, and to identify patients receiving major surgical treatment...
August 12, 2018: Thorax
https://www.readbyqxmd.com/read/30100056/expression-of-phosphatase-and-tensin-homolog-and-programmed-cell-death-ligand-1-in-adenosquamous-carcinoma-of-the-lung
#16
Aung Myo Hlaing, Bungo Furusato, Emiko Udo, Yuka Kitamura, Masakazu Souda, Mitsuko Masutani, Junya Fukuoka
BACKGROUND: Lung adenosquamous carcinoma (ASC) is a rare variant of non-small cell lung cancer (NSCLC) with poor prognosis. Certain biological differences may exist between these tumors and other common histological types of NSCLC, including adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The phosphoinositide 3-kinase (PI3K) pathway, which links oncogenes and multiple receptor classes to essential cellular functions, is activated by phosphatase and tensin homolog (PTEN) loss. The PTEN loss has been suggested to induce programmed cell death ligand 1 (PD-L1) expression in various cancer types...
August 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30099496/artificial-oocyte-activation-with-srcl2-or-calcimycin-after-icsi-improves-clinical-and-embryological-outcomes-compared-with-icsi-alone-results-of-a-randomized-clinical-trial
#17
Mohamed Fawzy, Mai Emad, Ali Mahran, Mohamed Sabry, Ahmed N Fetih, Hazem Abdelghafar, Salah Rasheed
STUDY QUESTION: Are pregnancy and birth rates affected by artificial oocyte activation (AOA) with SrCl2 or calcimycin after ICSI for couples with male-factor infertility linked to abnormal sperm morphology or for couples with previous ICSI cycles of unexplained low fertilization or inadequate fertilization associated with impaired oocyte morphology? SUMMARY ANSWER: AOA with either SrCl2 or calcimycin can improve the rates of clinical pregnancy, ongoing pregnancy and live birth compared with ICSI alone, and the two agents have diverse effects for different subgroups of patients...
August 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30097997/therapeutic-implications-of-how-tnf-links-apoe-p-tau-%C3%AE-synuclein-%C3%AE-amyloid-and-insulin-resistance-in-neurodegenerative-diseases
#18
REVIEW
I A Clark, B Vissel
While cytokines such as tumour necrosis factor (TNF) are long recognised as essential to normal cerebral physiology, the implications of their chronic excessive production within the brain are now also increasingly appreciated. Syndromes as diverse malaria and lead poisoning, as well as the non-infectious neurodegenerative diseases illustrate this. These cytokines also orchestrate changes in tau, α-synuclein, β-amyloid levels and degree of insulin resistance in most neurodegenerative states. New data on the effects of salbutamol, an anti-TNF agent, on α-synuclein and Parkinson's disease, APOE4 and tau add considerably to the rationale of the anti-TNF approach to understanding, and treating, these diseases...
August 10, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/30097685/-the-s2k-guideline-indications-for-knee-endoprosthesis-evidence-and-consent-based-indications-for-total-knee-arthroplasty
#19
REVIEW
J Lützner, T Lange, J Schmitt, C Kopkow, M Aringer, E Böhle, H Bork, K Dreinhöfer, N Friederich, S Gravius, K-D Heller, R Hube, E Gromnica-Ihle, S Kirschner, B Kladny, M Kremer, M Linke, J Malzahn, R Sabatowski, H-P Scharf, J Stöve, R Wagner, K-P Günther
Total knee arthroplasty (TKA) is one of the most frequent surgical procedures in orthopaedic surgery. Until now there have not been any standardized indication criteria, which might contribute to the large geographical differences in the frequency of TKA. This guideline aims to consent minimal requirements (main criteria), additional important aspects (minor criteria), as well as relative and absolute contraindications for TKA. The following main criteria have been consented: knee pain, radiological confirmation of osteoarthritis or osteonecrosis, inadequate response to conservative treatment, adverse impact of knee disease on the patient's quality of life and the burden of suffering due to the knee disease...
August 10, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/30097409/hydroxyapatite-calvaria-graft-repair-in-experimental-diabetes-mellitus-in-rats
#20
Davi da Silva Barbirato, Mariana Fampa Fogacci, Heloisa Gusman, Christina Maeda Takiya, Denise Pires de Carvalho, Carmelo Samsone
Among the systemic conditions that impact negatively on the planning and execution of surgical procedures, diabetes mellitus (DM) is the primary clinical condition responsible for complications. This study investigated bone formation in critical defects surgically filled with hydroxyapatite (HA) in diabetic rats. A descriptive, randomized sample and blinded analysis were conducted to test bone regeneration in critical bone defects surgically performed in rat calvaria. Twenty adult male Wistar rats were randomly divided into two groups: control, normoglycemic animals (CG); and test, streptozotocin-induced hyperglycemic animals (TG)...
April 19, 2018: Journal of Cranio-maxillo-facial Surgery
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