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https://www.readbyqxmd.com/read/30004267/gastroesophageal-reflux-disease-in-obese-patients
#1
Antono C Valezi, Fernando A M Herbella, Francisco Schlottmann, Marco G Patti
Gastroesophageal reflux disease (GERD) and obesity coexist in many patients in the Western population. The association is not coincidental, since GERD pathophysiology is, in part, linked to obesity. Visceral adipose tissue secretes hormones, which increase the risk of GERD. Obesity increases esophageal motor disorders and higher number of transient lower esophageal sphincter relaxations. Central obesity increases abdominal-thoracic pressure gradient and disrupts the gastroesophageal junction by inducing hiatal hernia formation...
August 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28805828/mutations-in-keops-complex-genes-cause-nephrotic-syndrome-with-primary-microcephaly
#2
Daniela A Braun, Jia Rao, Geraldine Mollet, David Schapiro, Marie-Claire Daugeron, Weizhen Tan, Olivier Gribouval, Olivia Boyer, Patrick Revy, Tilman Jobst-Schwan, Johanna Magdalena Schmidt, Jennifer A Lawson, Denny Schanze, Shazia Ashraf, Jeremy F P Ullmann, Charlotte A Hoogstraten, Nathalie Boddaert, Bruno Collinet, Gaëlle Martin, Dominique Liger, Svjetlana Lovric, Monica Furlano, I Chiara Guerrera, Oraly Sanchez-Ferras, Jennifer F Hu, Anne-Claire Boschat, Sylvia Sanquer, Björn Menten, Sarah Vergult, Nina De Rocker, Merlin Airik, Tobias Hermle, Shirlee Shril, Eugen Widmeier, Heon Yung Gee, Won-Il Choi, Carolin E Sadowski, Werner L Pabst, Jillian K Warejko, Ankana Daga, Tamara Basta, Verena Matejas, Karin Scharmann, Sandra D Kienast, Babak Behnam, Brendan Beeson, Amber Begtrup, Malcolm Bruce, Gaik-Siew Ch'ng, Shuan-Pei Lin, Jui-Hsing Chang, Chao-Huei Chen, Megan T Cho, Patrick M Gaffney, Patrick E Gipson, Chyong-Hsin Hsu, Jameela A Kari, Yu-Yuan Ke, Cathy Kiraly-Borri, Wai-Ming Lai, Emmanuelle Lemyre, Rebecca Okashah Littlejohn, Amira Masri, Mastaneh Moghtaderi, Kazuyuki Nakamura, Fatih Ozaltin, Marleen Praet, Chitra Prasad, Agnieszka Prytula, Elizabeth R Roeder, Patrick Rump, Rhonda E Schnur, Takashi Shiihara, Manish D Sinha, Neveen A Soliman, Kenza Soulami, David A Sweetser, Wen-Hui Tsai, Jeng-Daw Tsai, Rezan Topaloglu, Udo Vester, David H Viskochil, Nithiwat Vatanavicharn, Jessica L Waxler, Klaas J Wierenga, Matthias T F Wolf, Sik-Nin Wong, Sebastian A Leidel, Gessica Truglio, Peter C Dedon, Annapurna Poduri, Shrikant Mane, Richard P Lifton, Maxime Bouchard, Peter Kannu, David Chitayat, Daniella Magen, Bert Callewaert, Herman van Tilbeurgh, Martin Zenker, Corinne Antignac, Friedhelm Hildebrandt
Galloway-Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies. Here we identified recessive mutations in OSGEP, TP53RK, TPRKB, and LAGE3, genes encoding the four subunits of the KEOPS complex, in 37 individuals from 32 families with GAMOS. CRISPR-Cas9 knockout in zebrafish and mice recapitulated the human phenotype of primary microcephaly and resulted in early lethality. Knockdown of OSGEP, TP53RK, or TPRKB inhibited cell proliferation, which human mutations did not rescue...
October 2017: Nature Genetics
https://www.readbyqxmd.com/read/28258452/pathophysiology-of-gastroesophageal-reflux-disease
#3
REVIEW
Mariano A Menezes, Fernando A M Herbella
Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastric junction incapable of dealing with a transdiaphragmatic pressure gradient. Antireflux mechanisms include the lower esophageal sphincter and abdominal esophagus, the diaphragm, the angle of His, the Gubaroff valve, and the phrenoesophageal membrane...
July 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/27429032/esophageal-adenocarcinoma-impact-of-a-large-hiatal-hernia-on-outcomes-after-surgery
#4
Anne Gandon, Caroline Gronnier, Florence Renaud, Paul Borde, Marguerite Vanderbeken, Flora Hec, Guillaume Piessen, Antoine Adenis, Xavier Mirabel, Christophe Mariette
OBJECTIVE: To evaluate complete tumor resection rate (primary objective), 30-day postoperative outcomes, and survival (secondary objectives) in patients with a hiatal hernia (HH) ≥5 cm (HH group) compared with those who did not have a HH or presented with a HH <5 cm (control group). BACKGROUND: HH is a risk factor for esophageal and junctional adenocarcinoma (EGJA). Its impact on the outcomes after EGJA surgery is unknown. METHODS: Among 367 patients who underwent surgery for EGJA, a HH was searched for on computerized tomography scan and barium swallow, with comparison between the HH (n = 42) and control (n = 325) groups...
November 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27174889/hiatal-hernia-on-thoracic-computed-tomography-in-pulmonary-fibrosis
#5
Céline Tossier, Clairelyne Dupin, Laurent Plantier, Julie Leger, Thomas Flament, Olivier Favelle, Thierry Lecomte, Patrice Diot, Sylvain Marchand-Adam
Gastro-oesophageal reflux has long been suspected of implication in the genesis and progression of idiopathic pulmonary fibrosis (IPF). We hypothesised that hiatal hernia may be more frequent in IPF than in other interstitial lung disease (ILD), and that hiatal hernia may be associated with more severe clinical characteristics in IPF.We retrospectively compared the prevalence of hiatal hernia on computed tomographic (CT) scans in 79 patients with IPF and 103 patients with other ILD (17 scleroderma, 54 other connective tissue diseases and 32 chronic hypersensitivity pneumonitis)...
September 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/26469286/use-of-mesh-in-laparoscopic-paraesophageal-hernia-repair-a-meta-analysis-and-risk-benefit-analysis
#6
REVIEW
Beat P Müller-Stich, Hannes G Kenngott, Matthias Gondan, Christian Stock, Georg R Linke, Franziska Fritz, Felix Nickel, Markus K Diener, Carsten N Gutt, Moritz Wente, Markus W Büchler, Lars Fischer
INTRODUCTION: Mesh augmentation seems to reduce recurrences following laparoscopic paraesophageal hernia repair (LPHR). However, there is an uncertain risk of mesh-associated complications. Risk-benefit analysis might solve the dilemma. MATERIALS AND METHODS: A systematic literature search was performed to identify randomized controlled trials (RCTs) and observational clinical studies (OCSs) comparing laparoscopic mesh-augmented hiatoplasty (LMAH) with laparoscopic mesh-free hiatoplasty (LH) with regard to recurrences and complications...
2015: PloS One
https://www.readbyqxmd.com/read/26275540/the-threatened-stomach-management-of-the-acute-gastric-volvulus
#7
D Light, D Links, M Griffin
INTRODUCTION: Acute presentation of gastric volvulus is a rare condition with a high mortality for acute ischaemia. This study was undertaken to investigate the acute management, diagnosis, and long-term outcomes of patients presenting with acute gastric volvulus. METHODS: Cases were reviewed retrospectively from 2004 to 2014. Patients presenting as an emergency admission with acute gastric volvulus were included. RESULTS: Thirty-six patients were included, five of whom had previous surgery...
May 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/25868406/repair-of-paraesophageal-hiatal-hernias%C3%A2-is-a-fundoplication-needed-a-randomized-controlled-pilot-trial
#8
RANDOMIZED CONTROLLED TRIAL
Beat P Müller-Stich, Verena Achtstätter, Markus K Diener, Matthias Gondan, René Warschkow, Francesco Marra, Andreas Zerz, Carsten N Gutt, Markus W Büchler, Georg R Linke
BACKGROUND: The need for a fundoplication during repair of paraesophageal hiatal hernias (PEH) remains unclear. Prevention of gastroesophageal reflux represents a trade-off against the risk of fundoplication-related side effects. The aim of this trial was to compare laparoscopic mesh-augmented hiatoplasty with simple cardiophrenicopexy (LMAH-C) with laparoscopic mesh-augmented hiatoplasty with fundoplication (LMAH-F) in patients with PEH. STUDY DESIGN: The study was designed as a patient- and assessor-blinded randomized controlled pilot trial, registration number: DRKS00004492 (www...
August 2015: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/25834453/risk-factors-for-osteoporosis-in-japan-is-it-associated-with-helicobacter-pylori
#9
Daisuke Asaoka, Akihito Nagahara, Yuji Shimada, Kenshi Matsumoto, Hiroya Ueyama, Kohei Matsumoto, Yuta Nakagawa, Tsutomu Takeda, Ippei Tanaka, Hitoshi Sasaki, Taro Osada, Mariko Hojo, Sumio Watanabe
BACKGROUND: A number of diseases and drugs may influence bone mineral density; however, there are few reports concerning the relationship between lifestyle-related diseases and osteoporosis in Japan as determined by multivariate analysis. The aim of this study was to investigate the risk factors for osteoporosis and whether infection by or eradication of Helicobacter pylori is associated with osteoporosis. METHODS: Between February 2008 and November 2014, using a cross-sectional study design, we investigated patient profile (age, sex, BMI, alcohol, smoking), H...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/25738433/-assessment-of-bovine-pericardium-tutomesh%C3%A2-and-coated-polypropylene-proceed%C3%A2-in-the-para-oesophageal-position-in-a-pig-model
#10
COMPARATIVE STUDY
H Scheuerlein, T El-Asfar, Y Dittmar, A Tannapfel, U Settmacher, F Rauchfuss
BACKGROUND: Hiatal hernias are nowadays increasingly treated with meshes. Often, biological implants are being used for this application. Oesophageal perforations have been reported as rare but serious complications from the application of synthetic meshes at the oesophageal hiatus. The role of the different mesh types has not been clearly established by experimental research so far. In the present large animal model, we investigated two implant types (Tutomesh® and Proceed®) with respect to their biocompatibility and mechanical stability...
April 2015: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/25256373/impact-of-crural-relaxing-incisions-collis-gastroplasty-and-non-cross-linked-human-dermal-mesh-crural-reinforcement-on-early-hiatal-hernia-recurrence-rates
#11
Evan T Alicuben, Stephanie G Worrell, Steven R DeMeester
BACKGROUND: Hernia recurrence is the leading form of failure after antireflux surgery and may be secondary to unrecognized tension on the crural repair or from a foreshortened esophagus. Mesh reinforcement has proven beneficial for repair of hernias at other sites, but the use of mesh at the hiatus remains controversial. The aim of this study was to evaluate the outcomes of hiatal hernia repair with human dermal mesh reinforcement of the crural closure in combination with tension reduction techniques when necessary...
November 2014: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/25194179/gastro-oesophageal-reflux-disease-and-obesity-pathogenesis-and-response-to-treatment
#12
REVIEW
François Mion, Jérôme Dargent
The link between obesity and GERD is clear on all measures of the disease: clinical symptoms, erosive oesophagitis, acid esophageal exposure, and complications. The pathogenesis of this link may be due to general factors such as visceral adiposity, oestrogen levels, or decrease of Helicobacter pylori infection with increased gastric acid secretion. Increased abdominal pressure leads to disruption of the esophago-gastric junction and hiatal hernia, and esophageal motility may be modified by obesity. Weight loss does improve GERD, but lifestyle modifications and diet are usually insufficient in the long-term for morbid obesity...
August 2014: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/25071357/atrial-fibrillation-in-patients-with-gastroesophageal-reflux-disease-a-comprehensive-review
#13
REVIEW
Crina Roman, Stanislas Bruley des Varannes, Lucian Muresan, Alina Picos, Dan L Dumitrascu
AIM: To analyze the potential relationship between gastroesophageal reflux disease (GERD) and the development of atrial fibrillation (AF). METHODS: Using the key words "atrial fibrillation and gastroesophageal reflux", "atrial fibrillation and esophagitis, peptic", "atrial fibrillation and hernia, hiatal" the PubMed, EMBASE, Cochrane Library, OVIDSP, WILEY databases were screened for relevant publications on GERD and AF in adults between January 1972-December 2013...
July 28, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25048181/endoscopic-assessment-of-reflux-esophagitis-concurrent-with-hiatal-hernia-in-male-japanese-patients-with-obstructive-sleep-apnea
#14
Takahiro Zenda, Kei Hamazaki, Rie Oka, Tomomi Hagishita, Susumu Miyamoto, Junzo Shimizu, Hidekuni Inadera
OBJECTIVE: The pathogenetic relationship underlying the high prevalence of gastroesophageal reflux disease (GERD) in patients with obstructive sleep apnea (OSA) remains unclear. In addition, GERD has not been adequately assessed by endoscopy in patients with OSA. The purpose of this study was to use endoscopy to investigate potential interactions among reflux esophagitis, hiatal hernia (HH) and OSA. MATERIAL AND METHODS: A total of 243 consecutive male Japanese participants who underwent both overnight ambulatory polygraphic monitoring and esophagogastroduodenoscopy were retrospectively evaluated in a cross-sectional study...
September 2014: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/24784925/influence-of-weight-and-structure-on-biological-behavior-of-polypropylene-mesh-prostheses-placed-at-the-esophageal-hiatus
#15
Jonas Senft, Tobias Gehrig, Felix Lasitschka, Georg R Linke, Maxym Shevchenko, Thomas Bruckner, Hannes G Kenngott, Lars Fischer, Beat P Müller-Stich
BACKGROUND: Experimental knowledge about mesh behavior at the esophageal hiatus is rare, but such information is essential in order to find a safe and effective method of mesh reinforcement. This study aimed to investigate the influence of mesh structure on the biological behavior of polypropylene prostheses placed at the hiatus. MATERIALS AND METHODS: Twenty-four pigs in three groups of eight underwent implantation of heavyweight small-porous (HW-SP), heavyweight large-porous (HW-LP), or lightweight large-porous (LW-LP) circular polypropylene mesh at the hiatus...
June 2014: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/24117632/outcomes-of-esophageal-surgery-especially-of-the-lower-esophageal-sphincter
#16
REVIEW
Luigi Bonavina, Stefano Siboni, Greta I Saino, Demetrio Cavadas, Italo Braghetto, Attila Csendes, Owen Korn, Edgar J Figueredo, Lee L Swanstrom, Eelco Wassenaar
This paper includes commentaries on outcomes of esophageal surgery, including the mechanisms by which fundoduplication improves lower esophageal sphincter (LES) pressure; the efficacy of the Linx™ management system in improving LES function; the utility of radiologic characterization of antireflux valves following surgery; the correlation between endoscopic findings and reported symptoms following antireflux surgery; the links between laparoscopic sleeve gastrectomy and decreased LES pressure, endoscopic esophagitis, and gastroesophageal reflux disease (GERD); the less favorable outcomes following fundoduplication among obese patients; the application of bioprosthetic meshes to reinforce hiatal repair and decrease the incidence of paraesophageal hernia; the efficacy of endoluminal antireflux procedures, and the limited efficacy of revisional antireflux operations, underscoring the importance of good primary surgery and diligent work-up to prevent the necessity of revisional procedures...
October 2013: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/23670038/laparoscopic-mesh-augmented-hiatoplasty-without-fundoplication-as-a-method-to-treat-large-hiatal-hernias
#17
Georg R Linke, Tobias Gehrig, Lena V Hogg, Anna Göhl, Hannes Kenngott, Fritz Schäfer, Lars Fischer, Carsten N Gutt, Beat P Müller-Stich
PURPOSE: Laparoscopic hiatal hernia repair with additional fundoplication is a commonly recommended standard surgical treatment for symptomatic large hiatal hernias with paraesophageal involvement (PEH). However, due to the risk of persistent side effects, this method remains controversial. Laparoscopic mesh-augmented hiatoplasty without fundoplication (LMAH), which combines hiatal repair and mesh reinforcement, might therefore be an alternative. METHODS: In this retrospective study of 55 (25 male, 30 female) consecutive PEH patients, the perioperative course and symptomatic outcomes were analyzed after a mean follow-up of 72 months...
May 2014: Surgery Today
https://www.readbyqxmd.com/read/23317443/cardiaplication-as-a-novel-antireflux-procedure-for-infants-a-proof-of-concept-in-an-infant-porcine-model
#18
Sarah J Hill, Mark L Wulkan
INTRODUCTION: Current surgical techniques for gastroesophageal reflux in infants involve gastric fundoplication and crural repair. These operations are complicated by a high recurrence rate in the infant population. The primary cause of failure is generally related to recurrent hiatal hernia. Minimal dissection of the gastroesophageal junction has been linked to reduced hiatal hernia formation. We propose an alternative plication technique for modifying the gastroesophageal junction called cardiaplication...
January 2013: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/22876792/full-incorporation-of-strattice%C3%A2-reconstructive-tissue-matrix-in-a-reinforced-hiatal-hernia-repair-a-case-report
#19
Bruce E Freedman
INTRODUCTION: A non-cross-linked porcine acellular dermal matrix was used to reinforce an esophageal hiatal hernia repair. A second surgery was required 11 months later to repair a slipped Nissen; this allowed for examination of the hiatal hernia repair and showed the graft to be well vascularized and fully incorporated. CASE PRESENTATION: A 71-year-old Caucasian woman presented with substernal burning and significant dysphagia. An upper gastrointestinal series revealed a type III complex paraesophageal hiatal hernia...
2012: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/22419182/transthoracic-repair-of-an-incarcerated-diaphragmatic-hernia-using-hexamethylene-diisocyanate-cross-linked-porcine-dermal-collagen-permacol
#20
Benn Gooch, Neil Smart, Saj Wajed
It is the general surgeon who commonly repairs paraesophageal hernias nowadays, and they are repaired laparoscopically, making the performance of thoracotomy relatively rare. Whether to use prosthetic materials to repair the hiatus is still under debate, as is the question of which material to use, if any. We report a case of a 38-year-old man who had a large, incarcerated paraesophageal hernia. He had a past history of extensive abdominal surgery for exomphalos, which rendered any abdominal surgical approach a high-risk procedure...
March 2012: General Thoracic and Cardiovascular Surgery
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