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Lymphatic malformation

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https://www.readbyqxmd.com/read/27879620/recurrent-orbital-inflammation-mimicking-orbital-cellulitis-associated-with-orbitopalpebral-venous-lymphatic-malformation
#1
Alicia Galindo-Ferreiro, Hind M Alkatan, Sahar M ElKhamary, Saif AlDosairi, A Augusto V Cruz
An 8-year-old boy initially presented with an orbitopalpebral mass diagnosed clinically and radiologically as a low-flow diffuse venous lymphatic malformation involving the left upper eyelid and orbit. Over 8 months of follow up, he had 2 acute episodes of severe orbital inflammation that warranted hospitalization and treatment with intravenous antibiotic, steroids and surgical debulking. After a third surgical excision, the lesion remained clinically stable.
November 22, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27878447/morbidity-and-healthcare-costs-of-vascular-anomalies-a-national-study
#2
Jina Kim, Zhifei Sun, Harold J Leraas, Uttara P Nag, Ehsan Benrashid, Alexander C Allori, Waleska M Pabon-Ramos, Henry E Rice, Cynthia K Shortell, Elisabeth T Tracy
PURPOSE: This study aimed to define morbidities and costs related to modern-day medical care for children with vascular anomalies. METHODS: We reviewed the 2003-2009 Kids' Inpatient Database for pediatric patients (age < 21 years) hospitalized with hemangioma, arteriovenous malformation (AVM), or lymphatic malformation (LM). Patient characteristics, hospital complications, and hospital charges were compared by vascular anomaly type. Multivariable linear regression modeling was used to determine predictors of increasing hospital costs for patients with AVMs...
November 22, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27846771/an-8-year-population-description-from-a-national-treatment-centre-on-lymphatic-malformations
#3
Jill Josefine Eliasson, Inanna Weiss, Hans Erik Høgevold, Nina Oliver, Rune Andersen, Kirsti Try, Kim Alexander Tønseth
INTRODUCTION: Lymphatic malformations are rare developmental non-malignant abnormalities that present as masses consisting of abnormal growth of fluid filled channels or spaces in the skin or deep tissue that result in abnormalities of lymphatic flow. They may cause symptoms like pain, recurrent lymphorrea, abnormal bone growth, and disturbance of bodily functions. They may also be a cosmetic problem. The study aims to describe the population with lymphatic malformations (LM) treated at a national referral centre...
November 16, 2016: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/27836363/prenatal-growth-characteristics-of-lymphatic-malformations
#4
William H Peranteau, Suzanne D Iyoob, Matthew M Boelig, Nahla Khalek, Julie S Moldenhauer, Mark P Johnson, Holly L Hedrick, Alan W Flake, Beverly G Coleman, N Scott Adzick
PURPOSE: The natural history of prenatally diagnosed lymphatic malformations (LM) remains unknown. The ability to predict growth of a lesion is important to prenatal counseling and any future prenatal intervention. We describe the prenatal growth patterns of LMs as they relate to gestational age, anatomical location, and postnatal management. METHODS: A retrospective review of fetuses prenatally diagnosed with an LM who were followed with serial ultrasounds from 2003 to 2014 was performed with attention to the growth of the lesion as indicated by the lesion volume ratio (LVR)...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27826976/patients-with-klippel-trenaunay-syndrome
#5
M Zavacka, J Pobehova, K Gibarti, M Frankovicova
Klippel-Trenaunay syndrome is the most frequent systemic venous angiodysplasia. It is characterized by cutaneous capillary malformations - naevus flammeus, excessive growth of soft and bone tissue, venous and lymphatic malformations. Investigative methods include: clinical examinations, venography as the evidence of dysplastic changes of superficial and / or deep venous system, the Moyne obstruction and venous insufficiency perforator. Treatment is conservative, related to that of chronic venous disease. The surgery is aimed at removing the varices and insufficient perforators (Fig...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27795797/-cystic-lymphangioma-on-the-floor-of-the-oral-cavity-extending-to-the-submandibular-region-in-adult-patients
#6
Elboukhari Ali, Nador Karim, Attifi Hicham, Zalagh Mohamed
Cystic lymphangiomas are congenital benign lesions occurring predominantly in the head and neck area, especially in the posterior cervical triangle. These malformations involving the lymphatic vessels are frequently diagnosed in children. We report the clinical case of a 28-year-old adult patient with cystic lymphangioma on the floor of the oral cavity extending gradually to the left submandibular region. The clinically suspected tumor was thoroughly explored using tomodensitometry. The treatment consisted of complete resection, endo-orally performed, associated with histological examination confirming the macroscopic diagnosis of cystic lymphangioma...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27790546/bilateral-renal-lymphangiectasia
#7
Vaidehi K Pandya, Maulin K Shah, Shruti P Gandhi, Himanshu V Patel
Renal Lymphangiectasia (RLM) is very rare benign lymphatic malformation. It can be misdiagnosed for other cystic renal masses, most commonly polycystic kidneys. Though incidentally found in most cases, it may be the cause for hypertension and renal failure in undiagnosed patients. Here, we report a case of an adult asymptomatic male with bilateral RLM which was detected as an incidental finding on ultrasound. Confirmation by CT-scan and laboratory diagnosis of aspirated fluid was done, and patient was managed conservatively...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27789267/surgical-excision-with-bleomycin-irrigation-a-better-primary-treatment-choice-for-pediatric-submandibular-lymphatic-malformations
#8
Lei Jin, Jiarui Chen, Xiaoyan Li
PURPOSE: To compare the efficacy of surgical excision combined with intralesional bleomycin irrigation with that of needle aspiration with intralesional bleomycin sclerotherapy (IBS) in pediatric submandibular lymphatic malformations (LMs). MATERIALS AND METHODS: The medical records of 32 patients were analyzed. Clinical response was categorized by improvement in size as determined by imaging studies and calculations of lesion volume. An excellent response was defined as a decrease in volume greater than 90%, a satisfactory response was defined as a decrease greater than 50%, and a poor response was defined as a decrease less than 50%...
September 30, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27784048/efficacy-of-topical-sirolimus-rapamycin-for-the-treatment-of-microcystic-lymphatic-malformations
#9
Marta Ivars, Pedro Redondo
No abstract text is available yet for this article.
October 26, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27776983/doxycycline-sclerotherapy-is-superior-in-the-treatment-of-pediatric-lymphatic-malformations
#10
Debi M Thomas, Minna M Wieck, Christa N Grant, Avafia Dossa, Donna Nowicki, Phillip Stanley, Chadi Zeinati, Lori K Howell, Dean M Anselmo
PURPOSE: To evaluate efficacy of sclerotherapy with doxycycline versus sodium tetradecyl sulfate (STS) for treatment of macrocystic and mixed lymphatic malformations (LMs). MATERIALS AND METHODS: This single-center retrospective review identified 41 children (17 boys; 24 girls; age range, 1 month to 15.4 y) who underwent sclerotherapy with doxycycline (n = 32) or STS (n = 9) for macrocystic (n = 31) or mixed (n = 10) LMs. There were 114 treatments performed, averaging 2...
December 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27775310/-periorbital-lymphatic-malformations-report-of-two-cases
#11
C Lorca-García, B Berenguer, E de Tomás Palacios, C Marín Molina
INTRODUCTION: Periorbital lymphatic malformations are a rare entity in which diagnosis and treatment could be a challenge for surgeons. Management may be conservative, or they can be treated by sclerotherapy, surgery or combination of both. CLINICAL OBSERVATION: We present two cases of periorbital lymphatic malformations treated by sclerotherapy (OK-432 or bleomycin) and surgery in which we achieve good results with minimum morbidity. COMMENTS: Surgery combined with sclerotherapy is a good option of treatment for periorbital lymphatic malformations because surgery can be more conservative and therefore, sequelae are lower...
April 20, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27769582/-orbito-palpebral-vascular-pathology
#12
F Heran Dreyfus, O Galatoire, P Koskas, F Lafitte, E Nau, O Bergès
Orbito-palpebral vascular pathology represents 10% of all the diseases of this area. The lesion may be discovered during a brain CT scan or MRI, or because it causes clinical symptoms such as orbital mass, visual or oculomotor alteration, pain, proptosis, or acute bleeding due to a complication of the lesion (hemorrhage, thrombosis). We present these lesions using an anatomical, clinical, imaging and therapeutic approach. We distinguish four different entities. Vascular tumors have common imaging characteristics (hypersignal on T2 sequence, contrast enhancement, abnormal vascularization well depicted with ultrasound and Doppler, and possible bleeding)...
October 18, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27726421/reply-to-imaging-appearance-of-lymphatic-malformations
#13
Candace L White, Brandon Olivieri, Ricardo Restrepo
No abstract text is available yet for this article.
October 11, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27723921/sirolimus-in-the-treatment-of-vascular-anomalies
#14
Paloma Triana, Mariela Dore, Vanesa Nuñez Cerezo, Manuel Cervantes, Alejandra Vilanova Sánchez, Miriam Miguel Ferrero, Mercedes Díaz González, Juan Carlos Lopez-Gutierrez
Aim of the Study mTOR inhibitors are showing promising results in the management of vascular anomalies. Although current controlled trials remain to be completed, many individual experiences are being published. We present our series of children with complex vascular anomalies treated with sirolimus. Patients and Methods A retrospective review of 41 patients treated with sirolimus between January 2011 and December 2015 was performed: 15% (n = 6) had vascular tumors (4 kaposiform hemangioendotheliomas, 1 PTEN) and 85% (n = 35) had malformations (13 generalized lymphatic anomalies/Gorham-Stout diseases [GSD], 1 kaposiform lymphangiomatosis [KLA], 11 large lymphatic malformations (LMs) in critical areas, 2 lymphedemas, 4 venous malformations, and 4 aggressive arteriovenous malformations [AVM])...
October 10, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27708135/hobnail-hemangioma-with-an-unusual-clinical-presentation-case-report
#15
María Librada Porriño-Bustamante, José Aneiros-Fernández, Juan Antonio Retámero, María Antonia Fernández-Pugnaire
Hobnail hemangioma, also known as targetoid hemosiderotic hemangioma, is an uncommon vascular proliferation that clinically presents as a small solitary red to purple papule or macule, located on the limbs or trunk. Multiple lesions and atypical locations have been described. Histopathologically, it exhibits a biphasic pattern, with dilated vessels in the superficial dermis and angulated vessels in the deeper dermis, with endothelial cells that show a hobnail appearance. There is controversy about the histogenetic origin of hobnail hemangioma, although recent studies support that it is a lymphatic malformation...
October 5, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27707871/sclerotherapy-for-lymphatic-malformations-of-the-head-and-neck-in-the-pediatric-population
#16
Joanna H Tu, Huy M Do, Viraat Patel, Kristen W Yeom, Joyce M C Teng
BACKGROUND: Sclerotherapy is one of the most commonly used minimally invasive interventions in the treatment of macrocystic lymphatic malformations (LMs). Several different sclerosing agents and injection protocols have been reported in the literature, each with varying degrees of success. The safety and efficacy of the treatments have not been evaluated comparatively in the pediatric population. METHODS: Chart review of pediatric patients with macrocystic/mixed head and neck LMs who underwent sclerotherapy using OK-432, doxycycline, or ethanolamine oleate at Lucile Packard Children's Hospital at Stanford during 2000-2014...
October 5, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27631231/treatment-of-deep-seated-facial-microcystic-lymphatic-malformations-with-intralesional-injection-of-pingyangmycin
#17
Hai Wei Wu, Xuan Wang, Jia Wei Zheng, Hai Guang Zhao, Jing Ge, Ling Zhang, Yan An Wang, Li Xin Su, Xin Dong Fan
Treatment of microcystic lymphatic malformations (LMs) is still a great challenge to physicians in the field of managing vascular anomalies. Several kinds of treatment have been proposed for microcystic LMs, but the responses to these treatment modalities vary considerably among individuals. The aim of the study was to investigate the safety and efficacy of intralesional injection of pingyangmycin for microcystic LMs located in the deep facial region.Twenty-one consecutive patients with deep-seated facial microcystic LMs were treated with intralesional injection of pingyangmycin between March 2010 and April 2015...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27607327/medical-management-of-vascular-anomalies
#18
Cameron C Trenor
We have entered an exciting era in the care of patients with vascular anomalies. These disorders require multidisciplinary care and coordination and dedicated centers have emerged to address this need. Vascular tumors have been treated with medical therapies for many years, while malformations have been historically treated with endovascular and operative procedures. The recent serendipitous discoveries of propranolol and sirolimus for vascular anomalies have revolutionized this field. In particular, sirolimus responses are challenging the dogma that vascular malformations are not biologically active...
September 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27607321/genetic-basis-for-vascular-anomalies
#19
A Yasmine Kirkorian, Anna L Grossberg, Katherine B Püttgen
The fundamental genetics of many isolated vascular anomalies and syndromes associated with vascular anomalies have been elucidated. The rate of discovery continues to increase, expanding our understanding of the underlying interconnected molecular pathways. This review summarizes genetic and clinical information on the following diagnoses: capillary malformation, venous malformation, lymphatic malformation, arteriovenous malformation, PIK3CA-related overgrowth spectrum (PROS), Proteus syndrome, SOLAMEN syndrome, Sturge-Weber syndrome, phakomatosis pigmentovascularis, congenital hemangioma, verrucous venous malformation, cutaneomucosal venous malformation, blue rubber bleb nevus syndrome, capillary malformation-arteriovenous malformation syndrome, Parkes-Weber syndrome, and Maffucci syndrome...
September 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27601828/venolymphatic-vascular-malformation-of-the-parotid-gland-extending-into-the-parapharyngeal-space-a-rare-presentation
#20
Yasmeen Khatib, Madhura Dande, Richa D Patel, Vinod Gite
Vascular malformations (VMs) are structural malformations of vascular development causing soft tissue abnormality with functional and esthetic impairment. They are named by their predominant vessel type as arterial, venous, lymphatic or mixed types. VMs of the parotid gland are extremely rare and constitute a distinct entity of parotid pathology that requires specific diagnostic tools and management. Till 2013, only fifty cases of VMs of the parotid have been described in the literature. We present a case of a venolymphatic malformation of the parotid gland extending into the parapharyngeal space in a 21-year-old male who presented with a swelling on the left side of the face extending into the neck...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
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