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Pulmonary function

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https://www.readbyqxmd.com/read/29156752/early-and-late-effects-of-aspirin-and-naproxen-on-micrornas-in-the-lung-and-blood-of-mice-either-unexposed-or-exposed-to-cigarette-smoke
#1
Alberto Izzotti, Roumen Balansky, Gancho Ganchev, Marietta Iltcheva, Mariagrazia Longobardi, Alessandra Pulliero, Anna Camoirano, Francesco D'Agostini, Marta Geretto, Rosanna T Micale, Sebastiano La Maestra, Mark Steven Miller, Vernon E Steele, Silvio De Flora
We recently showed that nonsteroidal anti-inflammatory drugs (NSAIDs) are able to inhibit the lung tumors induced by cigarette smoke, either mainstream (MCS) or environmental (ECS), in female mice. We used subsets of mice to analyze the expression of 1135 microRNAs in both lung and blood serum, as related to the whole-body exposure to smoke and/or oral administration of either aspirin or naproxen. In a first study, we evaluated early microRNA alterations in A/J mice exposed to ECS for 10 weeks, starting at birth, and/or treated with NSAIDs for 6 weeks, starting after weaning...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156634/an-overview-of-chitosan-nanoparticles-and-its-application-in-non-parenteral-drug-delivery
#2
REVIEW
Munawar A Mohammed, Jaweria T M Syeda, Kishor M Wasan, Ellen K Wasan
The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications...
November 20, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29156550/can-youthful-mesenchymal-stem-cells-from-wharton-s-jelly-bring-a-breath-of-fresh-air-for-copd
#3
REVIEW
Andrzej M Janczewski, Joanna Wojtkiewicz, Ewa Malinowska, Anna Doboszyńska
Chronic obstructive pulmonary disease (COPD) is a major global cause of morbidity and mortality, projected to become the 3rd cause of disease mortality worldwide by 2020. COPD is characterized by persistent and not fully reversible airflow limitation that is usually progressive and is associated with an abnormal chronic inflammatory response of the lung to noxious agents including cigarette smoke. Currently available therapeutic strategies aim to ease COPD symptoms but cannot prevent its progress or regenerate physiological lung structure or function...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156451/impact-of-stressful-life-events-on-patients-with-chronic-obstructive-pulmonary-disease
#4
Tsung Yu, Anja Frei, Gerben Ter Riet, Milo A Puhan
BACKGROUND: There is a general notion that stressful life events may cause mental and physical health problems. OBJECTIVES: We aimed to describe stressful life events reported by patients with chronic obstructive pulmonary disease (COPD) and to assess their impact on health outcomes and behaviors. METHODS: Two hundred and sixty-six primary care patients who participated in the ICE COLD ERIC cohort study were asked to document any stressful life events in the past 3 years...
November 1, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29156356/limax-extract-ameliorates-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease-in-mice
#5
Xue Liang, Jian Wang, Ruijuan Guan, Li Zhao, Defu Li, Zhen Long, Qian Yang, Jingyi Xu, Ziyi Wang, Jinkui Xie, Wenju Lu
Chronic obstructive pulmonary disease (COPD) is a chronic, progressive and lethal lung disease with few treatments. Limax, a mollusk with lung, has been widely used to control phlegm and cough in China, yet whether Limax has a positive effect on COPD is unknown. This study investigated the effects of water-soluble extract from Limax on COPD development and the underlying mechanisms. The results showed that Limax extract improved lung function, relieved emphysema and suppressed the inflammation in the lungs of CS-challenged mice, as evidenced by diminished release of IL-6, KC, TNF-α, IFN-γ, Muc5AC, IL-17 and diminished mRNA expression of Muc5B...
November 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29156256/effects-of-ambient-temperature-on-lung-function-in-patients-with-chronic-obstructive-pulmonary-disease-a-time-series-panel-study
#6
Zhijing Lin, Yutong Gu, Cong Liu, Yuanlin Song, Chunxue Bai, Renjie Chen, Shujing Chen, Haidong Kan
BACKGROUND: Limited evidence concerns the associations between ambient temperature and lung function and the results are mixed. OBJECTIVE: To evaluate the associations between temperature variations and daily fluctuations in pulmonary function in chronic obstructive pulmonary disease (COPD) patients. METHODS: We designed a time-series panel study of 28 male urban COPD patients with repeated daily lung function measurements from December 2012 to May 2013 in Shanghai, China...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156011/pulmonary-resection-for-patients-with-multidrug-resistant-tuberculosis-based-on-survival-outcomes-a-systematic-review-and-meta-analysis
#7
Hyunsuk Frank Roh, Jihoon Kim, Seung Hyuk Nam, Jung Mogg Kim
We investigated the survival benefit of pulmonary resection for patients with multidrug-resistant tuberculosis. To weigh the survival benefit of pulmonary resection for patients with multidrug-resistant tuberculosis who have undergone surgical treatment combined with medical chemotherapy compared with medical chemotherapy alone, we did a meta-analysis of available studies containing a hazard ratio for pulmonary resection. Among 1726 articles, 6 clinical reports, with a mean sample size of 47 patients per report, met the inclusion criteria...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155942/detergent-based-decellularization-strategy-preserves-macro-and-microstructure-of-heart-valves
#8
Jessica Haupt, Georg Lutter, Stanislav N Gorb, Dan T Simionescu, Derk Frank, Jette Seiler, Alina Paur, Irma Haben
OBJECTIVES: Biological tissue has great potential to function as bioprostheses in patients for heart valve replacement. As these matrices are mainly xenogenic, the immunogenicity needs to be reduced by decellularization steps. Reseeding of bioscaffolds has tremendous potential to prevent calcification upon implantation, so intact microstructure of the material is mandatory. An optimal decellularization protocol of heart valves resulting in adequate preservation of the extracellular architecture has still not been developed...
October 9, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29155483/modeling-persistent-mycoplasma-pneumoniae-infection-of-human-airway-epithelium
#9
Oliver A Prince, Thomas M Krunkosky, Edward S Sheppard, Duncan C Krause
Mycoplasma pneumoniae is a human respiratory tract pathogen causing acute and chronic airway disease states that can include long-term carriage and extra-pulmonary spread. The mechanisms of persistence and migration beyond the conducting airways, however, remain poorly understood. We previously described an acute exposure model using normal human bronchial epithelium (NHBE) in air-liquid interface culture, showing that M. pneumoniae gliding motility is essential for initial colonization and subsequent spread, including localization to epithelial cell junctions...
November 20, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29155385/local-low-dose-urokinase-thrombolysis-for-the-management-of-hemodynamically-stable-pulmonary-embolism-with-right-ventricular-dysfunction
#10
Sara Alcántara Carmona, Marina Pérez Redondo, Luis Nombela Franco, Rocío González Costero, Bárbara Balandín Moreno, Miguel Valdivia de la Fuente, Santiago Méndez Alonso, Agustín García Suárez, Ana Royuela
AIMS: To evaluate the effectiveness of local low-dose urokinase thrombolysis (LLDUT) in hemodynamically stable pulmonary embolism with right ventricular dysfunction (RVD). METHODS AND RESULTS: Prospective study. LLDUT with a 200,000 IU bolus followed by a 100,000 IU/h infusion. Treatment duration was determined through radiological control performed 48-72h into treatment. Follow-up echocardiogram was performed within seven days after LLDUT completion. Evolution of thrombus burden, pulmonary artery pressures (PAP) and RVD were studied, and hemorrhagic complications and mortality were recorded...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29155298/mechanisms-of-l-alpha-lysophosphatidylinositol-induced-relaxation-in-human-pulmonary-arteries
#11
Olga Karpińska, Marta Baranowska-Kuczko, Barbara Malinowska, Monika Kloza, Magdalena Kusaczuk, Agnieszka Gęgotek, Paweł Golec, Irena Kasacka, Hanna Kozłowska
AIMS: l-Alpha-lysophosphatidylinositol (LPI) is an endogenous agonist of G protein-coupled receptor 55 (GPR55) which relaxes mesenteric arteries on activation. The aim of the present study was to determine the influence and underlying mechanisms of LPI-induced relaxation in human pulmonary arteries (hPAs). MAIN METHODS: Functional studies were performed in isolated hPAs using organ bath technique. The expression of GPR55 in hPAs and bronchioles was determined by real-time qPCR, Western blot analysis, and immunohistochemistry...
November 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/29155102/targeting-of-rac1-prevents-bronchoconstriction-and-airway-hyperresponsiveness
#12
Gwennan André-Grégoire, Florian Dilasser, Julie Chesné, Faouzi Braza, Antoine Magnan, Gervaise Loirand, Vincent Sauzeau
BACKGROUND: The molecular mechanisms responsible for airway smooth muscle cells (aSMC) contraction and proliferation in airway hyperresponsiveness (AHR) associated with asthma are still largely unknown. The small GTPases of the Rho family (RhoA, Rac1 and Cdc42) play a central role in SMC functions including migration, proliferation and contraction. OBJECTIVE: The objective of this study is to identify the role of Rac1 in aSMC contraction and to investigate its involvement in AHR associated with allergic asthma...
November 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29154530/atg101-single-stranded-antisense-rna-loaded-triangular-dna-nanoparticles-control-human-pulmonary-endothelial-growth-via-regulation-of-cell-macroautophagy
#13
Juan Du, Zhi Xu, Qian Liu, Yu Yang, Hang Qian, Mingdong Hu, Ye Fan, Qi Li, Wei Yao, Hongli Li, Guisheng Qian, Binfeng He, Deshan Zhou, Chengde Mao, Guansong Wang
Autophagy plays a key role in pulmonary vascular remodeling (PVR) via regulation of apoptosis and hyperproliferation of pulmonary arterial endothelial cells (PAECs), which are the subject of increased attention. ATG101 is an essential gene for the initiation of autophagy. While the structure of ATG101 has been well characterized, its exact biological function in autophagy is still unknown. In this study, an ATG101 single-stranded antisense RNA-loaded DNA triangular nanoparticle (ssATG101-TNP) is constructed to knock down ATG101 gene expression...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29154434/right-ventricular-involvement-in-cardiac-sarcoidosis-demonstrated-with-cardiac-magnetic-resonance
#14
Jan-Peter Smedema, Robert-Jan van Geuns, Gillian Ainslie, Joris Ector, Hein Heidbuchel, Harry J G M Crijns
AIMS: Cardiac involvement in sarcoidosis is reported in up to 30% of patients. Left ventricular involvement demonstrated by contrast-enhanced cardiac magnetic resonance has been well validated. We sought to determine the prevalence and distribution of right ventricular late gadolinium enhancement in patients diagnosed with pulmonary sarcoidosis. METHODS AND RESULTS: We prospectively evaluated 87 patients diagnosed with pulmonary sarcoidosis with contrast-enhanced cardiac magnetic resonance for right ventricular involvement...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29154202/polymorphisms-in-inflammasome-genes-and-risk-of-asthma-in-brazilian-children
#15
Vinicius Nunes Cordeiro Leal, Isabel Rugue Genov, Márcia C Mallozi, Dirceu Solé, Alessandra Pontillo
Considering its role in inflammation and recently described "alternative" roles in epithelial homeostasis and Th1/Th2 balance, we hypothesize that inflammasome genetics could contribute to the development of asthma. Selected functional polymorphisms in inflammasome genes are evaluated in a cohort of asthmatic children and their families. Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children...
November 15, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29153881/relationship-of-blood-eosinophil-count-to-exacerbations-in-chronic-obstructive-pulmonary-disease
#16
Robert S Zeiger, Trung N Tran, Rebecca K Butler, Michael Schatz, Qiaowu Li, Deepak B Khatry, Ubaldo Martin, Aniket A Kawatkar, Wansu Chen
BACKGROUND: Eosinophilic airway inflammation characterizes a chronic obstructive pulmonary disease (COPD) phenotype that requires more study. OBJECTIVE: To investigate the relationship of blood eosinophil count to exacerbations in COPD. METHODS: Using administrative pharmacy and health care utilization data from 2009 to 2012, we retrospectively identified patients 40 years or older with a COPD diagnosis, postbronchodilator FEV1/forced vital capacity ratio of less than 0...
November 15, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29153727/lifetime-exposure-to-particulate-air-pollutants-is-negatively-associated-with-lung-function-in-non-asthmatic-children
#17
Hung-Chang Tsui, Chi-Hsien Chen, Ying-Hsuan Wu, Hung-Che Chiang, Bing-Yu Chen, Yue Leon Guo
BACKGROUND: Pulmonary function is known to be affected by acute and subacute exposure to ambient air pollution. However, the impacts of lifetime exposure to air pollution on the pulmonary function of children have been inconsistent. The present study investigated the impact of lifetime residential exposure to intermediate levels of air pollution on the pulmonary function of schoolchildren. METHODS: In 2011, a survey of children aged 6-15 years was conducted in 44 schools in Taiwan...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29153638/%C3%AE-1-anti-trypsin-improves-function-of-porcine-donor-lungs-during-ex-vivo-lung-perfusion
#18
Huiqing Lin, Manyin Chen, Feng Tian, Jussi Tikkanen, Lei Ding, Hei Yu Andrew Cheung, Daisuke Nakajima, Zhe Wang, Andrea Mariscal, David Hwang, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu
BACKGROUND: Ex-vivo lung perfusion (EVLP), a technique for donor lung assessment, also represents a platform for donor lung repair and immunomodulation. α1-Anti-trypsin (A1AT), a medication used to treat emphysema in A1AT-deficient patients, has anti-inflammatory properties and has been shown to attenuate ischemia-reperfusion injury in rat and pig lung transplants. The objective of this study was to determine whether administration of A1AT during EVLP can improve donor lung quality after prolonged hypothermic preservation...
October 2, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29153415/comparison-of-the-rapid-effects-of-single-inhalations-of-formoterol-and-tiotropium-bromide-on-respiratory-function-and-copd-symptoms-in-a-randomized-crossover-study
#19
Hiroyuki Ohbayashi
BACKGROUND: This study aimed to compare rapid improvements in respiratory function and symptoms following single inhalation of formoterol (FOM) dry power inhaler (DPI) or tiotropium bromide (TIO) DPI in patients with chronic obstructive pulmonary disease (COPD). METHODS: Fifty-two outpatients with COPD (GOLD stage 2 or 3) received either a single inhalation of FOM DPI (9 μg via a Turbuhaler(®)) or TIO DPI (18μg via a HandiHaler(®)) in a randomized crossover manner...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29153331/reduced-mortality-risk-in-the-recent-era-in-early-stage-hodgkin-lymphoma-patients-treated-with-radiation-therapy-with-or-without-chemotherapy
#20
Chirayu G Patel, Evan Michaelson, Yu-Hui Chen, Barbara Silver, Karen J Marcus, Mary Ann Stevenson, Peter M Mauch, Andrea K Ng
PURPOSE: To determine the effect of treatment changes over time on all-cause mortality risk in patients with early-stage Hodgkin lymphoma (HL) after radiation therapy. The long-term survivorship of those with HL necessitates quantification of the late risk of mortality from HL and other causes. METHODS AND MATERIALS: An institutional review board-approved retrospective study was conducted using a multi-institutional database of 1541 stage I and II HL patients treated from 1968 to 2007 with radiation therapy alone or combined-modality treatment...
October 5, 2017: International Journal of Radiation Oncology, Biology, Physics
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