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Hayder M Al-Kuraishy, Ali I Al-Gareeb, Huda J Waheed, Thabat J Al-Maiahy
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with abundant adipocytokine changes which may play an important role in the progression of insulin resistance and micro- and macro-vascular complications. Therefore, the objective of this study was to assess the differential effect of metformin alone or in combination with glyburide on apelin serum levels in patients with T2DM. In this case-control study, fifty patients with T2DM in the age range of 45-65 years and twenty-five healthy controls matched for age and body weight were recruited from single endocrinology center, subdivided according to the diabetic pharmacotherapy into: Group I: healthy controls ( n = 25), Group II: T2DM patients on metformin ( n = 15), Group III: T2DM patients on glyburide ( n = 17), and Group IV: T2DM patients on metformin plus glyburide ( n = 28)...
July 2018: Journal of Advanced Pharmaceutical Technology & Research
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
October 11, 2018: Lancet Diabetes & Endocrinology
Nejla Canbulat Sahiner, Ayse Sonay Turkmen, Ayfer Acikgoz, Enver Simsek, Birgul Kirel
BACKGROUND: Repeated injections may prevent children from performing insulin administration (skip dosing) and may cause anxiety. AIMS: To compare the effect of ShotBlocker and the combination of vibration and cold application (Buzzy) in reducing pain during insulin administration in children. METHODS: This research was designed as a randomized controlled experimental study. The study sample consisted of 60 children aged between 6 and 12 years who were diagnosed as having type 1 diabetes and received insulin from the Child Endocrinology Department of the medical faculty in Eskisehir Osmangazi University between May 2015 and June 2017...
October 11, 2018: Worldviews on Evidence-based Nursing
Lingling Xu, Xiaopu Lin, Meiping Guan, Yingshan Liu
INTRODUCTION: Early detection of diabetic peripheral neuropathy (DPN) is critical in patients with type 2 diabetes mellitus (T2DM) due to the lack of targeted therapy for DPN. We have investigated the relationship between different stages of diabetic nephropathy and DPN in an attempt to elucidate whether albuminuria can be used as an early warning signal of DPN progression. METHODS: A total of 217 T2DM patients who met the inclusion criteria were recruited from the Department of Endocrinology, Nanfang Hospital between January 2016 and June 2016...
October 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Stephanie H Chen, Annelise Sprau, Leon Chieng, Simon Buttrick, Elie S Alam, Ali Sheikh, Karthik Madhavan, Zoukaa B Sargi, Ricardo Komotar
INTRODUCTION: With a rapidly expanding elderly population in the United States, the incidence of pituitary adenomas in elderly will continue to rise. In this study, we aim to evaluate the safety and efficacy of transsphenoidal endoscopic endonasal resection for pituitary adenomas in the elderly population. METHODS: A retrospective review was performed of 131 consecutive patients who underwent transsphenoidal endoscopic endonasal resection for pituitary adenomas at the University of Miami Hospital between 2012 and 2016...
October 4, 2018: World Neurosurgery
Michael J Stevenson, Kylie S Uyeda, Nathaniel H O Harder, Marie C Heffern
For over 100 years, there has been an incredible amount of knowledge amassed concerning hormones in the endocrine system and their central role in human health. Hormones represent a diverse group of biomolecules that are released by glands, communicate signals to their target tissue, and are regulated by feedback loops to maintain organism health. Many disease states, such as diabetes and reproductive disorders, stem from misregulation or dysfunction of hormones. Increasing research is illuminating the intricate roles of metal ions in the endocrine system where they may act advantageously in concert with hormones or deleteriously catalyze hormone-associated disease states...
October 1, 2018: Metallomics: Integrated Biometal Science
Mohammed E Al-Sofiani, Michael Quartuccio, Erica Hall, Rita Rastogi Kalyani
PURPOSE OF REVIEW: While there has been a growing utilization of total pancreatectomy with islet autotransplantation (TPIAT) for patients with medically refractory chronic pancreatitis over the past few decades, there remains a lack of consensus clinical guidelines to inform the counseling and management of patients undergoing TPIAT. In this article, we review the current clinical practice and published experience of several TPIAT centers, outline key aspects in managing patients undergoing TPIAT, and discuss the glycemic outcomes of this procedure...
September 28, 2018: Current Diabetes Reports
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
October 2018: Lancet Diabetes & Endocrinology
Kathryn E Kyler, Rachel B Kadakia, Hannah L Palac, Soyang Kwon, Adolfo J Ariza, Helen J Binns
Use of metformin for weight loss for children in a clinical setting has not been well described; therefore, we aimed to ide.epsy characteristics of obese patients prescribed metformin in a clinical setting and evaluate changes in anthropometric measures. Records of obese patients aged 10 to 18 years without diabetes attending an academic endocrinology practice from 2009 to 2013 were reviewed. Analyses assessed changes in anthropometric measures (weight, body mass index [BMI], and BMI z-score) over 12 months between those prescribed metformin (n = 49) and those not prescribed metformin (n = 142)...
September 27, 2018: Clinical Pediatrics
Matthieu Wargny, Pierre-Henri Ducluzeau, Jean-Michel Petit, Cédric Le May, Sarra Smati, Lucie Arnaud, Matthieu Pichelin, Benjamin Bouillet, Adrien Lannes, Odile Blanchet, Philippe Lefebvre, Sven Francque, Luc Van Gaal, Bart Staels, Bruno Vergès, Jérôme Boursier, Bertrand Cariou
BACKGROUND AND AIMS: Some studies suggested that proprotein convertase subtilisin kexin type 9 (PCSK9) is linked to liver steatosis severity and non-alcoholic steatohepatitis (NASH). We aimed to assess whether circulating PCSK9 levels are associated with either liver fat content (LFC) or histological markers of NASH in high-risk patients. METHODS: We present results from three cross-sectional studies from two French Hospitals: Dijon and Numevox (departments of Endocrinology) and Angers (department of Hepatology)...
September 13, 2018: Atherosclerosis
Ali Hakan Kaya, Sinem Namdaroğlu, Ömür Kayıkcı, Alparslan Merdin, Hikmettullah Batgi, Dicle İskender, Mehmet Sinan Dal, Merih Kızıl Çakar, Emre Tekgunduz, Fevzi Altuntas
OBJECTIVES: After allogeneic stem cell transplant, patients may experience psychiatric, endocrinologic, pulmonary, and cardiovascular problems, as well as secondary malignancies and chronic graft-versus-host disease over the long-term follow-up. These long-term complications not only increase mortality and morbidity of transplant survivors but also decrease their quality of life. In this study, we shared our experiences with our guideline-driven approach for follow-up of long-term complications...
September 25, 2018: Experimental and Clinical Transplantation
Silvia Martina Ferrari, Poupak Fallahi, Fabio Galetta, Emanuele Citi, Salvatore Benvenga, Alessandro Antonelli
Immune checkpoint inhibitors are drugs that inhibit the "checkpoint molecules". Different types of cancer immune checkpoint inhibitors have been approved recently: CTLA-4 monoclonal antibodies (as ipilimumab); anti-PD-1 monoclonal antibodies (as pembrolizumab and nivolumab); and anti-PD-L1 monoclonal antibodies (as atezolizumab, avelumab, and durmalumab). The increased immune response induced by these agents leads to immune-related adverse events (irAEs), that can vary from mild to fatal, according to the organ system and severity...
September 21, 2018: Reviews in Endocrine & Metabolic Disorders
Alfonso Galderisi, Cosimo Giannini, Ram Weiss, Grace Kim, Veronika Shabanova, Nicola Santoro, Bridget Pierpont, Mary Savoye, Sonia Caprio
BACKGROUND: Type 2 diabetes is preceded by a prediabetic stage of impaired glucose tolerance that affects 10-23% of youth and is expected to double over the next decade. The natural history of impaired glucose tolerance and the determinants of β-cell dynamic response have never been investigated longitudinally in young people. We aimed to investigate the clinical and metabolic determinants of longitudinal glucose tolerance changes and β-cell function in a multiethnic cohort of obese youth...
October 2018: The lancet child & adolescent health
Martin B Whyte, Fariba Shojaee-Moradie, Sharaf E Sharaf, Nicola C Jackson, Barbara Fielding, Roman Hovorka, Jeewaka Mendis, David Russell-Jones, A Margot Umpleby
Context: GLP-1 agonists control postprandial glucose and lipid excursion in type 2 diabetes; however the mechanism(s) are unclear. Objective: To determine the mechanism(s) of postprandial lipid and glucose control with lixisenatide (GLP-1 analogue) in type 2 diabetes. Design: Randomised, double-blind, cross-over study. Setting: Centre for Diabetes, Endocrinology, and Research, Royal Surrey County Hospital, Guildford, UK...
September 11, 2018: Journal of Clinical Endocrinology and Metabolism
Charlotte Marsot, Philippe Chanson, Françoise Borson-Chazot
Bone is now considered as a particular endocrine organ. Its endocrine function is not yet fully understood and has been the subject of several conferences at the European Society of Endocrinology Congress 2018. Bone regulates phosphate metabolism by secreting fibroblast growth factor 23; it also regulates glucose metabolism via osteocalcin and energy metabolism, thanks to lipocalin 2, a new hormone acting on the brain. In addition, the incidence of diabetes continues to grow, and its impact on bone has been demonstrated, with an increased risk of fractures regardless the type of diabetes...
September 2018: Annales D'endocrinologie
Michaela Katja Stangl, Wolfgang Böcker, Vladimir Chubanov, Uta Ferrari, Michael Fischereder, Thomas Gudermann, Eric Hesse, Peter Meinke, Martin Reincke, Nicole Reisch, Maximilian M Saller, Jochen Seissler, Ralf Schmidmaier, Benedikt Schoser, Cornelia Then, Barbara Thorand, Michael Drey
Sarcopenia in geriatric patients is often associated with or even caused by changes of the endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and additional multimorbidity in geriatric patients makes it difficult to study distinct pathogenic pathways leading to sarcopenia. Patients suffering from diabetes, Cushing's syndrome, chronic kidney disease, Klinefelter's syndrome or motor neuron diseases, such as amyotrophic lateral sclerosis for example are known to have impaired muscle property and reduced physical performance...
September 10, 2018: Experimental and Clinical Endocrinology & Diabetes
A Mantovani, R Rigolon, T Turino, I Pichiri, A Falceri, A Rossi, P L Temporelli, S Bonapace, G Lippi, G Zoppini, E Bonora, C D Byrne, G Targher
AIM: We aimed to assess the association between decreasing estimated glomerular filtration rate (eGFR) or abnormal albuminuria and the risk of certain cardiac conduction defects in patients with type 2 diabetes mellitus (T2DM). METHODS: We examined a hospital-based sample of 923 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Standard electrocardiograms (ECGs) were performed in all patients. eGFR was estimated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, whilst albuminuria was measured by an immuno-nephelometric method on morning spot urine samples...
September 5, 2018: Diabetes & Metabolism
Nida Sajid, Zahid Miyan, Syed Itaat Hussain Zaidi, Syeda Sara Abbas Jaffri, Mariam AbdeAli
Objective: To assess the protein intake and requirement among subject with type 2 diabetes having foot ulcers. Methods: This study was conducted at Baqai Institute of Diabetology & Endocrinology (BIDE), a tertiary care diabetes centre of Karachi, Pakistan among people with type 2 diabetic foot ulcer attending foot clinic from January 2012 to March 2015. The baseline characteristics, dietary intake and laboratory investigations of the study participants were obtained through electronic hospital database "Health Management System" (HMS) based on the 24 hours dietary recall interview...
July 2018: Pakistan Journal of Medical Sciences Quarterly
Mujeeb Ur Rehman Abro, Anum Butt, Kulsoom Baqa, Nazish Waris, Maria Khalid, Asher Fawwad
Objectives: To assess the association of raised serum liver enzyme (ALT) with type 2 diabetic subjects. Methods: This retrospective data was accessed at Baqai Institute of Diabetology and Endocrinology (BIDE) from January 2005 to May 2016. A total of 1966 subjects with type 2 diabetes were included in the study. Subjects were divided into two groups; in group A 1284 subjects had ALT within the normal range (ALT≤35iu/l) and in Group-B 682 subjects had elevated ALT (ALT>35iu/l)...
July 2018: Pakistan Journal of Medical Sciences Quarterly
(no author information available yet)
Dear Readers,It is our - and the publisher's - conviction that a scientific journal's mission is not only to provide its readers with the most relevant and interesting papers available, but also to further scientific research and to reward and honour those whose contributions to the advancement of science are truly remarkable. We are thus especially delighted to announce that from this year onward, we - the Editors-in-Chief together with the publisher Georg Thieme Verlag- will again officially award the most innovative paper published in Experimental and Clinical Endocrinology & Diabetes ...
September 2018: Experimental and Clinical Endocrinology & Diabetes
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