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https://www.readbyqxmd.com/read/30510145/characterization-of-a-glycyl-radical-enzyme-bacterial-microcompartment-pathway-in-rhodobacter-capsulatus
#1
Heidi S Schindel, Jonathan A Karty, James B McKinlay, Carl E Bauer
Bacterial microcompartments (BMCs) are large (∼100 nm) protein shells that encapsulate enzymes, their substrates, and cofactors for the purposes of increasing metabolic reaction efficiency and protecting cells from toxic intermediates. The best-studied microcompartment is the carbon fixing carboxysome that encapsulates RuBisCO and carbonic anhydrase. Other well-known BMCs include the Pdu and Eut BMCs, which metabolize 1,2-propanediol and ethanolamine, respectively, with B12 -dependent diol dehydratase enzymes...
December 3, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/30509681/serious-adverse-events-attributed-to-remifentanil-patient-controlled-analgesia-during-labour-in-the-netherlands
#2
S L M Logtenberg, M L Vink, M B Godfried, I C M Beenakkers, F G Schellevis, B W Mol, C J Verhoeven
BACKGROUND: During labour, remifentanil patient-controlled analgesia is used as an alternative to neuraxial analgesia. Remifentanil is associated with hypoventilation and respiratory depression but the frequency of serious maternal and neonatal adverse events is unknown. The aim of this study was to estimate the number of serious adverse events attributed to the use of remifentanil patient-controlled analgesia during labour in The Netherlands and to investigate the circumstances (e.g...
November 2, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/30508963/pathologic-and-molecular-studies-of-enterovirus-71-infection-in-a-fatal-case-from-a-recent-epidemic-in-china-a-case-report
#3
Jingjun Xing, Ke Wang, Hua Wei, Dengming Wei
RATIONALE: Enterovirus 71 (EV71) is identified as the primary cause of hand, foot, and mouth disease (HFMD) and mainly infects the young infants. Though some fatal cases have been reported, the underlying mechanisms of EV71 infection remain elusive and more further pathologic and molecular studies of EV71 infection are needed. PATIENT CONCERNS: A 26-month-old girl with a history of fever and lethargy for 3 days and intermittent seizures for 2 hours associated with rash on 4 limbs was brought to a hospital...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30507362/impact-of-stainless-steel-welding-fumes-on-proteins-and-non-coding-rnas-regulating-dna-damage-response-in-the-respiratory-tract-of-sprague-dawley-rats
#4
Jayaraman Krishnaraj, Abdul Basit Baba, Periasamy Viswanathan, Veeran Veeravarmal, Viswalingam Balasubramanian, Siddavaram Nagini
Substantial evidence has established the negative impact of inhalation exposure to welding fumes on respiratory functions. The aim of the present study was to investigate the effect of welding fume inhalation on expression of molecules that function as sensors, transducers and effectors of DNA damage response (DDR) in the respiratory tract of male Sprague-Dawley rats. Animals were exposed to 50 mg/m3 stainless steel welding fumes for 1 h/d for 4, 8, and 12 weeks, respectively. Histological examination demonstrated preneoplastic changes in trachea and bronchi with focal atelectasis and accumulation of chromium (Cr) in the lungs...
December 3, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/30487028/simulation-training-for-in-flight-medical-emergencies-improves-provider-knowledge-and-confidence
#5
Amit Padaki, Waddaa Redha, Todd Clark, Ty Nichols, Leah Jacoby, Rachael Slivka, Claudia Ranniger, Kris Lehnhardt
INTRODUCTION: In-flight medical emergencies require healthcare providers to operate in confined spaces with limited resources and delayed access to definitive care. These emergencies are common, with an estimated frequency of 1 per 100 to 1000 flights. Despite this, training for medical response in these environments is limited. We hypothesize that integrating such education into a pre-existing medical student elective course would improve knowledge and ability to respond appropriately to in-flight medical emergencies...
December 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/30482137/intensive-care-implications-of-epidemic-thunderstorm-asthma
#6
Jai N Darvall, Matthew Durie, David Pilcher, Geoffrey Wigmore, Craig French, Dharshi Karalapillai, Forbes McGain, Edward Newbigin, Timothy Byrne, Vineet Sarode, Ben Gelbart, Andrew Casamento, John Dyett, Ashley Crosswell, Joseph Vetro, Joseph McCaffrey, Gopal Taori, Ashwin Subramaniam, Christopher MacIsaac, Anthony Cross, David Ku, Rinaldo Bellomo
OBJECTIVE: To investigate the environmental precipitants, treatment and outcome of critically ill patients affected by the largest and most lethal reported epidemic of thunderstorm asthma. DESIGN, SETTING AND PARTICIPANTS: Retrospective multicentre observational study. Meteorological, airborne particulate and pollen data, and a case series of 35 patients admitted to 15 intensive care units (ICUs) due to the thunderstorm asthma event of 21-22 November 2016, in Victoria, Australia, were analysed and compared with 1062 total ICU-admitted Australian patients with asthma in 2016...
December 2018: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/30477628/-reye-syndrome-and-sudden-death-symptoms-after-oral-administration-of-nimesulide-due-to-upper-respiratory-tract-infection-in-a-boy
#7
Li-Fang Feng, Xiao-Hong Chen, Dong-Xiao Li, Xi-Yuan Li, Jin-Qing Song, Ying Jin, Yan-Ling Yang
A boy aged 6 years and 3 months developed upper respiratory tract infection and pyrexia 2 months ago and was given oral administration of nimesulide by his parents according to directions. Half an hour later, the boy experienced convulsions and cardiopulmonary arrest, and emergency examination found hypoketotic hypoglycemia, metabolic acidosis, significant increases in serum aminotransferases and creatine kinase, and renal damage. Recovery of consciousness and vital signs was achieved after cardiopulmonary resuscitation, but severe mental and movement regression was observed...
November 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30470651/acute-necrotizing-encephalopathy-and-a-carnitine-palmitoyltransferase-2-variant-in-an-adult
#8
Yuya Kobayashi, Hiroki Kanazawa, Ai Hoshino, Ryota Takamatsu, Rie Watanabe, Kenichi Hoshi, Wataru Ishii, Hiroyuki Yahikozawa, Masashi Mizuguchi, Shunichi Sato
A 54-year-old Japanese man had a fever of over 40 °C for 7 days and developed unconsciousness, seizure and respiratory arrest. T2-weighted imaging magnetic resonance imaging revealed high-intensity signals on bilateral thalamus and it gradually extended to the brain white matter. Moreover, the lesion progressed to the spinal gray matter. The patient was diagnosed with acute necrotizing encephalopathy. CPT2 variants have been reported to be associated with acute necrotizing encephalopathy particularly in children and spinal cord lesions are extremely rare...
November 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30470643/nurses-recognition-and-response-to-clinical-deterioration-in-the-cardiac-catheterisation-laboratory
#9
Kevin White, Julie Considine, Judy Currey
BACKGROUND: Patients presenting to the cardiac catheter laboratory for treatment of unstable acute coronary syndromes (ACS) experience a mismatch in myocardial oxygen supply and demand, causing vital sign abnormalities prior to neurological, cardiac and respiratory deterioration. Delays in detecting clinical deterioration and escalating care increases risk of adverse events, unplanned intensive care (ICU) admission, cardiac arrest, and in-hospital mortality. OBJECTIVES: The objective of the study was to explore how nurses in the cardiac catheter laboratory (CCL) recognise and respond to clinical deterioration in patients with unstable ACS undergoing primary percutaneous coronary intervention (PCI)...
November 20, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/30466470/ecmo-improves-survival-following-cardiogenic-shock-due-to-carbon-monoxide-poisoning-an-experimental-porcine-model
#10
Carsten Simonsen, Sigridur O Magnusdottir, Jan J Andreasen, Marianne Cathrine Rohde, Benedict Kjærgaard
BACKGROUND: Severe intoxication with carbon monoxide (CO) is extremely lethal and causes numerous deaths due to cardiac or respiratory failure. Conventional intensive treatment may not be sufficient. The aim of this study was to investigate the treatment effect of extracorporeal veno-arterial extracorporeal membrane oxygenation (ECMO) following severe CO poisoning in an experimental porcine model. METHODS: A total of twelve pigs were anaesthetized, routinely monitored and intoxicated by inhalation of CO until the beginning of cardiac failure and randomized to a treatment (ventilator using an FiO2 of 100% or ECMO)...
November 22, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/30464849/concepts-for-augmented-reality-visualisation-to-support-needle-guidance-inside-the-mri
#11
André Mewes, Florian Heinrich, Bennet Hensen, Frank Wacker, Kai Lawonn, Christian Hansen
During MRI-guided interventions, navigation support is often separated from the operating field on displays, which impedes the interpretation of positions and orientations of instruments inside the patient's body as well as hand-eye coordination. To overcome these issues projector-based augmented reality can be used to support needle guidance inside the MRI bore directly in the operating field. The authors present two visualisation concepts for needle navigation aids which were compared in an accuracy and usability study with eight participants, four of whom were experienced radiologists...
October 2018: Healthcare Technology Letters
https://www.readbyqxmd.com/read/30464519/the-clinical-feasibility-of-flexible-bronchoscopy-interventional-therapy-in-patients-with-central-airway-stenosis-and-respiratory-failure-caused-by-malignancy
#12
Jiwang Wang, Yang Yang, Wangjian Zha, Xiuwei Zhang
Objective: The aim of this study was to investigate the clinical effects and feasibility of using flexible bronchoscopy intervention in cases of malignancy that causes central airway stenosis and respiratory failure. Methods: The clinical data of patients who were admitted to the Department of Respiratory Medicine at the First Affiliated Hospital of Nanjing Medical University and underwent treatment of a malignant tumor with central airway stenosis and respiratory failure by flexible bronchos-copy from February 2010 to May 2013 were analyzed using a retrospective method...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30459824/multi-organ-protection-of-ulinastatin-in-traumatic-cardiac-arrest-model
#13
Shaoyun Liu, Jiefeng Xu, Yuzhi Gao, Peng Shen, Senlin Xia, Zilong Li, Mao Zhang
Background: Post-cardiac arrest syndrome, which has no specific curative treatment, contributes to the high mortality rate of victims who suffer traumatic cardiac arrest (TCA) and initially can be resuscitated. In the present study, we investigated the potential of ulinastatin to mitigate multiple organ injury after resuscitation in a swine TCA model. Methods: Twenty-one male pigs were subjected to hemodynamic shock (40% estimated blood loss in 20 min) followed by cardiac arrest (electrically induced ventricular fibrillation) and respiratory suspension for 5 min, and finally manual resuscitation...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/30455855/pharmacoinformatic-approach-to-explore-the-antidote-potential-of-phytochemicals-on-bungarotoxin-from-indian-krait-bungarus-caeruleus
#14
Barani Kumar Rajendran, M Xavier Suresh, Shanmuga Priya Bhaskaran, Yarradoddi Harshitha, Uma Gaur, Hang Fai Kwok
Venomous reptiles especially serpents are well known for their adverse effects after accidental conflicts with humans. Upon biting humans these serpents transmit arrays of detrimental toxins with diverse physiological activities that may either lead to minor symptoms such as dermatitis and allergic response or highly severe symptoms such as blood coagulation, disseminated intravascular coagulation, tissue injury, and hemorrhage. Other complications like respiratory arrest and necrosis may also occur. Bungarotoxins are a group of closely related neurotoxic proteins derived from the venom of kraits ( Bungarus caeruleus ) one of the six most poisonous snakes in India whose bite causes respiratory paralysis and mortality without showing any local symptoms...
2018: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/30450829/functional-analysis-of-salmonella-typhi-adaptation-to-survival-in-water
#15
Robert A Kingsley, Gemma Langridge, Sarah E Smith, Carine Makendi, Maria Fookes, Tom M Wileman, Moataz Abd El Ghany, A Keith Turner, Zoe A Dyson, Sushmita Sridhar, Derek Pickard, Sally Kay, Nicholas Feasey, Vanessa Wong, Lars Barquist, Gordon Dougan
Contaminated water is a major risk factor associated with the transmission of Salmonella enterica serovar Typhi (S. Typhi), the aetiological agent of human typhoid. However, little is known about how this pathogen adapts to living in the aqueous environment. We used transcriptome analysis (RNA-seq) and transposon mutagenesis (TraDIS) to characterize these adaptive changes and identify multiple genes that contribute to survival. Over half of the genes in the S. Typhi genome altered expression level within the first 24 h following transfer from broth culture to water, although relatively few did so in the first 30 min...
November 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/30440128/-role-of-signaling-pathway-of-long-non-coding-rna-growth-arrest-specific-transcript-5-microrna-200c-3p-angiotensin-converting-enzyme-2-in-the-apoptosis-of-human-lung-epithelial-cell-a549-in-acute-respiratory-distress-syndrome
#16
H B Li, P P Zi, H J Shi, M Gao, R Q Sun
Objective: To investigate whether long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5)/microRNA-200c-3p/angiotensin converting enzyme 2(ACE2) involved in the regulation of the apoptosis of human lung epithelial cell A549 in acute respiratory distress syndrome (ARDS). Methods: ARDS rat models were established and were divided into control, ARDS, ARDS+ pcDNA and ARDS+ pcDNA-GAS5 groups. Six hours after the establishment of ARDS rat model, arterial blood and lung tissues of the rats from the four groups were collected...
November 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/30429747/emergent-airway-management-in-a-patient-with-in-situ-tracheal-stent-a-lesson-learned
#17
Jose R Navas-Blanco, Junior Uduman, Javier Diaz-Mendoza
The prevalence of in situ tracheal stents has increased in the past two decades for the management of malignant and benign central airway diseases for either palliation or definitive therapy. Recent placement of a tracheal stent has been associated with edema of the upper airway; therefore, these patients are at a great risk for airway collapse, especially within the days most recent to the procedure. The authors present the case of a morbidly obese patient with a tracheal stent admitted to the Intensive Care Unit who developed acute respiratory failure and was found to be "unable to ventilate, unable to intubate...
October 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/30417244/practical-guide-for-the-management-of-systemic-toxicity-caused-by-local-anesthetics
#18
REVIEW
(no author information available yet)
Systemic toxicity from local anesthetics can occur in any of the wide range of situations in which these agents are used. This practical guide is created to generate a shared awareness of the prevention, diagnosis, and treatment of local anesthetic systemic toxicity among all medical professionals who perform nerve blocks. Systemic toxicity of local anesthetic is induced by an increase of its protein-unbound plasma concentration. Initial symptoms are characterized by central nervous system signs such as excitation, convulsions, followed by loss of consciousness and respiratory arrest...
November 11, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/30415788/severe-limb-girdle-muscular-dystrophy-2a-in-two-young-siblings-from-guinea-bissau-associated-with-a-novel-null-homozygous-mutation-in-capn3-gene
#19
Miguel Oliveira Santos, Pedro Ninitas, Isabel Conceição
Limb-girdle muscular dystrophy 2A (LGMD2A) or calpainopathy is the most common type of LGMD worldwide, representing about 30-40% of all described cases. Nevertheless, its prevalence in sub-Saharan African countries is unknown. We report two young siblings from Guinea-Bissau with recessive calpainopathy due to novel null homozygous c.1702Gdup mutation in CAPN3 gene. Their phenotype was quite aggressive concerning limb-girdle atrophy and muscle weakness as well as respiratory involvement. The proband needed nocturnal non-invasive ventilation at the age of 32, and his 33-year-old affected sister succumbed to an acute respiratory arrest after an intercurrent infection...
October 9, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/30411302/the-full-outline-of-unresponsiveness-four-score-and-its-use-in-outcome-prediction-a-scoping-systematic-review-of-the-adult-literature
#20
REVIEW
A Almojuela, M Hasen, F A Zeiler
BACKGROUND: The Full Outline of UnResponsivness (FOUR) score is a neurological assessment score. Its theoretical benefit over preexisting scores is its evaluation of brainstem reflexes and respiratory pattern which may allow better assessment of patients with severe neurologic impairment. OBJECTIVE: Our goal was to perform a scoping systematic review on the available literature for FOUR score and outcome prediction in critically ill patients. The primary outcome of interest was patient global outcome, as assessed by any of: mortality, modified Rankin Score, Glasgow Outcome Score, or any other functional or neuropsychiatric outcome...
November 8, 2018: Neurocritical Care
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