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Phototherapy in Neonatal Jaundice

Ibinabo Ibiebele, Jennifer R Bowen, Tanya A Nippita, Jonathan M Morris, Jane B Ford
INTRODUCTION: There is debate about optimal management of pregnancies with a large-for-gestational age baby. A recent randomized controlled trial reported that early term induction of labor reduced cesarean section rates and infant morbidity. However, long term childhood outcomes have not been assessed. The aim of this study was to assess maternal, neonatal and child health and education outcomes for large-for-gestational age babies induced at 37-38 weeks gestation. MATERIAL AND METHODS: Population-based record linkage study of term (37+ weeks), cephalic-presenting singleton pregnancies with a large-for-gestational age baby in New South Wales, Australia, 2002-2006...
December 4, 2018: Acta Obstetricia et Gynecologica Scandinavica
Hare Krishna, Asha Changil, M Srinivas, Tara Sankar Roy, Tony George Jacob
Introduction: Phototherapy is the most common treatment for neonatal jaundice. This study sought to determine ultrastructural changes in testis, at different time-points, after 48 hours of conventional phototherapy was given to newborn rats. Methods: Newborn male Wistar rats ( n = 36) were divided into two groups as follows - group 1 (G1), control (without phototherapy) and group 2 (G2), exposure to conventional phototherapy for 48 h. Six animals from each group were sacrificed on postnatal days (PND) 70, 100 and 130...
October 2018: Journal of microscopy and ultrastructure
Francesco Cavallin, Daniele Trevisanuto, Aye Thein, Amanda Booth, Gaston Arnolda, Danica Kumara, Phyu U, Sandar Myint, Luciano Moccia
AIM: To evaluate the role of pathway to admission for jaundice among the risk factors for exchange transfusion in outborn infants in a low resource setting. METHODS: This retrospective case-control study (1:1 ratio) was carried out at the Yankin Children's Hospital in Yangon (Myanmar). All cases were neonates admitted for treatment of jaundice between March 2013 and February 2014 and who required exchange transfusion. Each control was the next noncase neonate admitted for treatment of jaundice and treated with phototherapy...
November 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
Gaston Arnolda, Tran Dinh Chien, Andrew Hayen, Nguyen Thi Xuan Hoi, Katherine Maningas, Priscilla Joe, Francesco Cavallin, Daniele Trevisanuto, Luciano Moccia
INTRODUCTION: Neonatal jaundice is one of the most common reasons for hospital admission in low resource settings. Treatment is frequently inadequate as conventional phototherapy requires frequent bulb changes. LED phototherapy has comparable efficacy to conventional phototherapy, and the bulbs last over 40,000 hours. This observational study compares the effectiveness of three LED machines, two single-sided and one double-sided in routine use in Vietnam. METHODS: We included all infants weighting ≥1500g and with jaundice diagnosed visually or by Total Serum Bilirubin (TSB) measurement at The Da Nang Hospital for Women and Children (Da Nang, Vietnam)...
2018: PloS One
Jinfu Zhou, Changyi Yang, Wenbin Zhu, Shuwei Chen, Yinglin Zeng, Jing Wang, Hong Zhao, Yao Chen, Feng Lin
To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in Southeastern China. This case-control study aimed to identify the genetic risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China. A total of 286 hyperbilirubinemic newborns were enrolled as a case group, and 250 randomly selected newborns without jaundice or with a bilirubin level that was lower than the threshold required for phototherapy served as controls. The serum levels of total bilirubin, unconjugated bilirubin, and direct bilirubin were measured, and the common genetic loci in UGT1A1, OATP1B1, and HO-1 genes were genotyped...
2018: BioMed Research International
Fabrízia Rennó Sodero Faulhaber, Gustavo Adolpho Moreira Faulhaber, Natália Aydos Marcondes, Renato Soibelmann Procianoy, Rita C Silveira
BACKGROUND: Jaundice due to indirect hyperbilirubinemia affects more than 60% of neonates and phototherapy is the treatment for severe types. There are no previous studies evaluating the effect of phototherapy on the function of neonates neutrophils. The aim of this study was to assess and compare the function of neutrophils by measuring the expression of neutrophils main surface markers in icteric neonates before and after phototherapy. METHODS: Neonates at a gestational age ≥35 weeks and birth weight ≥2,000 g who met the American Academy of Pediatrics criteria for phototherapy were included...
October 8, 2018: Cytometry. Part B, Clinical Cytometry
T M Slusher, L T Day, T Ogundele, N Woolfield, J A Owa
No abstract text is available yet for this article.
October 3, 2018: Early Human Development
Ridhimaa Jain, Ashish Jain, Veena Devgan, Jerin Sekhar
OBJECTIVE: To determine the effect of alternative positions (relative to placenta) of normal term neonates, prior to the recommended delayed cord clamping, on placental transfusion and short-term neonatal outcome. METHODS: Normal term neonates born vaginally were randomly assigned to be placed either on mother's abdomen (Group AL, n = 97) or 20 cm below the introitus (Group BL, n = 102) for 90 seconds after delivery. Subsequently the cord was clamped...
September 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
Shalin Lee Wan Fei, Keng Sheng Chew, Saloma Pawi, Li Tsu Chong, Khatijah Lim Abdullah, Lik Thai Lim, Feryante Rintika
OBJECTIVE: To identify the efficacy and safety of the use of various cost-effective reflective materials around phototherapy units to reduce the duration of phototherapy and hasten the reduction of bilirubin among neonates with physiologic jaundice. DATA SOURCES: A systematic review of randomized controlled trials identified from searches in the Cumulative Index to Nursing and Allied Health Literature, ScienceDirect, Embase, and the Cochrane Library with the use of keywords, MeSH terms, operators, and the review of reference lists of retrieved articles...
November 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Tim Colbourn, Charles Mwansambo
No abstract text is available yet for this article.
October 2018: Lancet Global Health
Masayoshi Zaitsu, Tatsuya Yoshihara, Hiromitsu Nakai, Shiro Kubota
BACKGROUND: Neonatal jaundice is strongly attributable to excess body-weight loss as a result of insufficient calorific intake. OBJECTIVES: To examine the incidence of neonatal jaundice (defined by use of phototherapy) and body-weight loss, as well as their association, among neonates under optimal thermal control with sufficient nutrition, a local protocol for temperature and nutritional regulation. METHODS: We retrospectively identified a cohort of 10,544 neonates (birth weight ≥2,500 g) placed in thermo-controlled incubators for 2 h immediately after birth...
2018: Neonatology
Yan Jiao, Yuting Jin, Huanhuan Meng, Meizhang Wen
This study aimed to discuss and evaluate the clinical effect of blue light phototherapy combined with bifico in treating neonatal hemolytic jaundice. One hundred and twenty cases with neonatal hemolytic jaundice were randomly divided into treatment group and control group, 60 cases in each group. Neonatal patients in the control group were treated with traditional treatment, including administration of enzyme inducer phenobarbital and blue light phototherapy for 8 consecutive hours every day. Neonatal patients in the treatment group received bifico orally based on traditional treatment...
August 2018: Experimental and Therapeutic Medicine
Fabrízia R S Faulhaber, Renato S Procianoy, Rita C Silveira
Phototherapy in neonates for treatment of pathological jaundice is an effective therapeutic tool that is widely used in neonatal units. Over the past years, a greater concern has emerged about the effects on the immune and inflammatory system and its potential genotoxic and side effects, especially the late ones, possibly associated with childhood diseases, showing that this treatment is not as harmless as previously believed. Numerous studies assessing these possible adverse effects of phototherapy on neonates have been published over the past years...
August 6, 2018: American Journal of Perinatology
Ruo-Han Wu, Shuo Feng, Mei Han, Patrina Caldwell, Shi-Gang Liu, Jing Zhang, Jian-Ping Liu
BACKGROUND: Neonatal jaundice affects at least 481,000 newborns every year. Phototherapy is recommended but it's effects are limited and adverse reactions can occur. In China, phototherapy combined with Yinzhihuang oral liquid is also used for this condition. This systematic review evaluated the effectiveness and safety of combination therapy with Yinzhihuang oral liquid and phototherapy compared to phototherapy alone for treating neonatal jaundice. METHOD: A comprehensive literature search was performed in four Chinese databases, two English language databases and two trial registries from inception to June 2017...
July 28, 2018: BMC Complementary and Alternative Medicine
Garima Agrawal, Kapil Garg, Sadasivan Sitaraman, Anurag Sarna
OBJECTIVE: To evaluate correlation of transcutaneous bilirubin (TcB) measured at different body sites with serum total bilirubin (TSB) in early preterm infants. METHODS: This hospital based prospective comparative study was carried out in the Department of Pediatrics, SMS Medical College, Jaipur between April 2015 to March 2016. Early preterm infants with gestational age ≤ 34 weeks in whom clinical jaundice was significant mandating TSB measurement were included in the study...
July 18, 2018: Indian Journal of Pediatrics
Min-Sho Ku
BACKGROUND: Preventing the development of allergic skin disease in children is the best way to treat the disease. OBJECTIVES: Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children. METHODS: We randomly recruited 117,041 children from an insurance research database. Those with neonatal jaundice and receiving neonatal phototherapy were classified as the icteric-phototherapy group (n = 4,744), those with neonatal jaundice and not receiving phototherapy were classified as the icteric-non-phototherapy group (n = 5,003), and those without jaundice were classified as the non-icteric group (n = 107,294)...
2018: Neonatology
Emily Shepherd, Rehana A Salam, Philippa Middleton, Shanshan Han, Maria Makrides, Sarah McIntyre, Nadia Badawi, Caroline A Crowther
BACKGROUND: Cerebral palsy is an umbrella term that encompasses disorders of movement and posture attributed to non-progressive disturbances occurring in the developing foetal or infant brain. As there are diverse risk factors and aetiologies, no one strategy will prevent cerebral palsy. Therefore, there is a need to systematically consider all potentially relevant interventions for prevention. OBJECTIVES: PrimaryTo summarise the evidence from Cochrane Systematic Reviews regarding effects of neonatal interventions for preventing cerebral palsy (reducing cerebral palsy risk)...
June 20, 2018: Cochrane Database of Systematic Reviews
Hitoshi Okada, Susumu Itoh, Kohichiroh Nii, Masashiro Sugino, Noriko Fuke, Kosuke Koyano, Saneyuki Yasuda, Takashi Kusaka
As rhesus monkeys exhibit physiological jaundice during the neonatal period, we used rhesus monkey serum to examine changes in bilirubin photoisomers. Bilirubin-rhesus monkey serum solution was irradiated with blue light-emitting diode, and changes in the absorbance and bilirubin fraction were compared with those in bilirubin- human serum albumin (HSA) and bilirubin-rat albumin solutions. The λmax decreased with light irradiation. The mean production rate of cyclobilirubin IXα was 1.98, 199 and 0.76 × 10-2 /min in rhesus monkey serum, HSA and rat albumin, respectively...
August 2018: Journal of Photochemistry and Photobiology. B, Biology
Juan Sebastián Peinado-Acevedo, Estephanía Chacón-Valenzuela, Laura Liliana Rodríguez-Moncada
The bronze baby syndrome is an infrequent dyschromia resulting from phototherapy in newborn babies with neonatal jaundice. Even though the common phenotype has been described in patients with direct neonatal hyperbilirubinemia secondary to cholestasis, several cases of patients with indirect neonatal hyperbilirubinemia who have managed to reverse it have been reported, as well as patients with isolated hyperbilirubinemia.Currently, the physiopathology of this condition is still a subject of controversy and, therefore, there is a lack of clear conducts for its correct diagnosis and treatment...
May 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
Jayasree Nair, Vasantha H S Kumar
Neonatal liver failure (NLF) is a rare diagnosis but carries with it significant risks of mortality and morbidity. Common etiologies for NLF include metabolic causes, gestational alloimmune liver disease (GALD or neonatal hemochromatosis), and viral infections. We report a case of liver failure in a premature infant with abnormal iron profile within 48 hours of birth. Lack of accepted guidelines for the initial management of severe jaundice with a high direct component in the first week after birth made treatment challenging...
April 2018: American Journal of Perinatology Reports
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