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https://www.readbyqxmd.com/read/29556122/phenolic-compounds-from-viscum-album-tinctures-enhanced-antitumor-activity-in-melanoma-murine-cancer-cells
#1
Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Adalgisa Felippe Wiecikowski, Renato Sampaio Carvalho, Juliana de Lima Castro, Felipe Alves Gomes de Oliveira, Henrique Marcelo Gualberto Pereira, Venicio Feo da Veiga, Marcia Marques Alves Capella, Leandro Rocha, Carla Holandino
Cancer is one of the biggest problems in public health worldwide. Plants have been shown important role in anticancer research. Viscum album L. (Santalaceae), commonly known as mistletoe, is a semi-parasitic plant that grows on different host trees. In complementary medicine, extracts from European mistletoe ( Viscum album L.) have been used in the treatment of cancer. The study was conducted to identify chemical composition and antitumor potential of Viscum album tinctures. Chemical analysis performed by high resolution chromatography equipped with high resolution mass spectrometer identified caffeic acid, chlorogenic acid, sakuranetin, isosakuranetin, syringenin 4-O-glucoside, syringenin 4-O-apiosyl-glucoside, alangilignoside C and ligalbumoside A compounds...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29549352/health-promoting-potential-of-herbal-teas-and-tinctures-from-artemisia-campestris-subsp-maritima-from-traditional-remedies-to-prospective-products
#2
Catarina Guerreiro Pereira, Luísa Barreira, Sebastiaan Bijttebier, Luc Pieters, Cátia Marques, Tamára F Santos, Maria João Rodrigues, João Varela, Luísa Custódio
This work explored the biotechnological potential of the medicinal halophyte Artemisia campestris subsp. maritima (dune wormwood) as a source of health promoting commodities. For that purpose, infusions, decoctions and tinctures were prepared from roots and aerial-organs and evaluated for in vitro antioxidant, anti-diabetic and tyrosinase-inhibitory potential, and also for polyphenolic and mineral contents and toxicity. The dune wormwood extracts had high polyphenolic content and several phenolics were identified by ultra-high performance liquid chromatography-photodiode array-mass-spectrometry (UHPLC-PDA-MS)...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29512736/development-of-podophyllotoxin%C3%A2-loaded-nanostructured-lipid-carriers-for-the-treatment-of-condyloma-acuminatum
#3
Yan Gao, Kai Han, Qi Wang, Zhili Hu, Qingxiu Liu, Lishi Liu, Kang Zeng
Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papillomavirus (HPV). Podophyllotoxin (POD), a cytotoxic compound, is able to effectively treat HPV; however, the severe irritation side effects of POD restrict its use as a treatment for CA. The aim of the present study was to construct novel POD‑loaded nanostructured nanolipid carriers (POD‑NLCs) and evaluate their physicochemical characteristics and cytotoxicity. POD‑NLCs (0.5%) were prepared using emulsion‑evaporation and low temperature‑solidification methods with optimized conditions and preparations...
March 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29484986/characterization-of-biologically-active-substances-from-calendula-officinalis
#4
Petra Lovecka, Jan Lipov, Kamila Thumova, Anna Macurkova
BACKGROUND: The aim of this work was to compare water and organic extracts, infusions and tinctures from flowers and leaves of Calendula officinalis in terms of their biological activity and composition. The purpose of work was investigation whether the leaves and stems are really the waste or they contain interesting substances which could be utilized. Antimicrobial, antifungal, antioxidant and anti-inflammatory activities were studied. Then the ability to inhibit collagenase was studied as well...
February 26, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29438634/regulating-cannabis-manufacturing-applying-public-health-best-practices-from-tobacco-control
#5
Daniel G Orenstein, Stanton A Glantz
State legalization and regulation of cannabis, despite continued federal illegality, is a massive shift in regulatory approach. Manufactured cannabis, including concentrates, extracts, edibles, tinctures, topicals and other products, has received less attention than more commonly used dried flower, but represents emerging regulatory challenges due to additives, potency, consumption methods, and abuse and misuse potential. In November 2017, the California Department of Public Health (CDPH) released initial cannabis manufacturing regulations as part of a new state regulatory structure...
February 13, 2018: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29428930/managing-hashimoto-s-thyroiditis-through-personalized-care-a-case-report
#6
Keren Dolan, Heather Finley, Margo Gasta, Sasha Houseman
Hashimoto's thyroiditis (HT) affects more than 14 million individuals in the United States, most of them women. Thyroid replacement therapy has long been the foundation of medical treatment for HT; however, recent research supports a role for nutritional approaches. This case report describes the management of a 34-y-old female with HT who declined thyroid replacement therapy and was successfully managed for a period of 5 mo. The patient was advised to follow a phytonutrient rich diet (eg, berries); avoid sensitive foods (gluten and soy); and consume quality fats, fermented foods, and filtered water...
February 10, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29409377/the-role-of-artichoke-leaf-tincture-cynara-scolymus-in-the-suppression-of-dna-damage-and-atherosclerosis-in-rats-fed-an-atherogenic-diet
#7
Natasa Bogavac-Stanojevic, Jelena Kotur Stevuljevic, Darko Cerne, Janja Zupan, Janja Marc, Zorica Vujic, Milkica Crevar-Sakac, Miron Sopic, Jelena Munjas, Miroslav Radenkovic, Zorana Jelic-Ivanovic
CONTEXT: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. OBJECTIVES: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. MATERIALS AND METHODS: Eighteen male Wistar albino rats were divided into three groups (n = 6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29404050/chemical-and-microbiological-characterization-of-tinctures-and-microcapsules-loaded-with-brazilian-red-propolis-extract
#8
Erika Tayse da Cruz Almeida, Maria Cristina Delgado da Silva, José Marcos Dos Santos Oliveira, Regianne Umeko Kamiya, Rodolfo Elleson Dos Santos Arruda, Danilo Abreu Vieira, Valdemir da Costa Silva, Pierre Barnabé Escodro, Irinaldo Diniz Basílio-Júnior, Ticiano Gomes do Nascimento
The aim of this study was to characterize tinctures and microcapsules loaded with an ethanol extract of red propolis through chemical, physicochemical and microbiological assays in order to establish quality control tools for nutraceutical preparations of red propolis. The markers (isoflavonoids, chalcones, pterocarpans, flavones, phenolic acids, terpenes and guttiferones) present in the tinctures A and B were identified and confirmed using LC/ESI/FTMS/Orbitrap. Four compositions (A, B, C and D) were prepared to contain B tincture of the red propolis with some pharmaceutical excipients and submitted to two drying processes, i...
October 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29352696/safety-and-efficacy-of-prostatic-artery-chemoembolization-for-prostate-cancer-initial-experience
#9
João Pisco, Tiago Bilhim, Nuno V Costa, Manuel Pinto Ribeiro, Lucia Fernandes, António G Oliveira
PURPOSE: To evaluate outcome of prostatic artery chemoembolization for patients with prostate cancer (PCa). MATERIALS AND METHODS: This single-center prospective cohort study was conducted between August 2013 and July 2016 in 20 patients with PCa who underwent chemoembolization. Mean patient age was 67.5 years ± 6.4. Gleason score was 6-10, and staging was T2N0M0. Fifteen patients refused prostatectomy and 5 wanted to stop hormonal therapy because of side effects...
March 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29338650/stoicism-and-alchemy-in-late-antiquity-zosimus-and-the-concept-of-pneuma
#10
Athanasios Rinotas
At the beginning of the twentieth century, historians associated the alchemy of the third-century alchemist Zosimus of Panopolis with Platonism and Aristotelianism, explicating his theory of alchemical transmutation under the intellectual umbrella of these philosophical traditions. More recently, scholars of alchemy such as Christina Viano and William Newman have suggested a connection between Zosimean alchemy and Stoicism. Through a close reading of texts in Zosimus's corpus, this paper posits a Stoic interpretation of several aspects of Zosimean alchemy, focusing on the concepts of pneuma and tension...
August 2017: Ambix
https://www.readbyqxmd.com/read/29329207/arnica-tincture-cures-cutaneous-leishmaniasis-in-golden-hamsters
#11
Sara M Robledo, Ivan D Vélez, Thomas J Schmidt
In search for potential therapeutic alternatives to existing treatments for cutaneous Leishmaniasis, we have investigated the effect of Arnica tincture Ph. Eur. (a 70% hydroethanolic tincture prepared from flowerheads of Arnica montana L.) on the lesions caused by infection with Leishmania braziliensis in a model with golden hamsters. The animals were treated topically with a daily single dose of the preparation for 28 days. Subsequently, the healing process was monitored by recording the lesion size in intervals of 15 days up to day 90...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29317910/impact-of-choice-of-skin-preparation-solution-in-cardiac-surgery-on-rate-of-surgical-site-infection-a-propensity-score-matched-analysis
#12
Shahzad G Raja, Melissa Rochon, Clair Mullins, Carlos Morais, Antonios Kourliouros, Ellie Wishart, Anthony De Souza, Sunil Bhudia
Background: Antiseptic skin preparations containing chlorhexidine gluconate and povidone iodine are routinely used to reduce the risk of surgical site infection (SSI). This study assesses the efficacy of two alcohol-based solutions, 2% chlorhexidine-alcohol and 10% povidone iodine-alcohol, on the incidence of cardiac SSI. Methods: A total of 738 consecutive patients undergoing cardiac surgery had skin preparation with 2% chlorhexidine gluconate in 70% isopropanol (ChloraPrep, BD Ltd, UK) were propensity matched to 738 patients with skin prepared with 10% povidone-iodine in 30% industrial methylated spirit (Videne Alcoholic Tincture, Ecolab Ltd, UK)...
January 2018: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29259645/-in-vivo-evaluation-of-galla-chinensis-solution-in-the-topical-treatment-of-dermatophytosis
#13
Kai Sun, Xu Song, RenYong Jia, Zhongqiong Yin, Yuanfeng Zou, Lixia Li, Lizi Yin, Changliang He, Xiaoxia Liang, Gang Ye, Guizhou Yue, Xinghong Zhao, Jiankang Yu
Aim: Dermatophytosis is one of the main fungal diseases in humans and animals all over the world. Galla chinensis , a traditional medicine, has various pharmacological effects. The goal of this study was to evaluate the treatment effect of Galla chinensis solution (GCS) on dermatophytosis-infected dogs ( Microsporum canis , Microsporum gypseum , and Trichophyton mentagrophytes , resp.). Methods: The treatment effects of GCS were evaluated by mycological cure rates and clinical score comprised of three indices, including inflammation, hair loss, and lesion scale...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29237032/the-development-and-pilot-testing-of-the-marijuana-retail-surveillance-tool-mrst-assessing-marketing-and-point-of-sale-practices-among-recreational-marijuana-retailers
#14
Carla J Berg, Lisa Henriksen, Patricia Cavazos-Rehg, Gillian L Schauer, Bridget Freisthler
As recreational marijuana expands, it is critical to develop standardized surveillance measures to study the retail environment. To this end, our research team developed and piloted a tool assessing recreational marijuana retailers in a convenience sample of 20 Denver retailers in 2016. The tool assesses: (i) compliance and security (e.g. age-of-sale signage, ID checks, security cameras); (ii) marketing (i.e. promotions, product availability and price) and (iii) contextual and neighborhood features (i.e. retailer type, facilities nearby)...
December 1, 2017: Health Education Research
https://www.readbyqxmd.com/read/29214642/allergic-contact-dermatitis-caused-by-topical-herbal-remedies-importance-of-patch-testing-with-the-patients-own-products
#15
Liesbeth Gilissen, Sara Huygens, An Goossens
BACKGROUND: Natural ingredients have variable compositions, so their allergenic potencies may differ. OBJECTIVES: To retrospectively analyse subjects reacting to herbal remedies over the past 27 years, with the aim of (i) evaluating demographic characteristics and lesion locations, (ii) describing the frequencies of positive patch test reactions, (iii) identifing sensitization sources, and (iv) studying concomitant sensitivity. PATIENTS AND METHODS: In total, 15980 patients were patch tested between 1990 and 2016 with the European baseline series and/or other series, product(s) used, and, whenever possible, the respective ingredients...
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29175499/visualization-of-porcine-eye-anatomy-by-x-ray-microtomography
#16
Bartosz Leszczyński, Paulina Sojka-Leszczyńska, Dorota Wojtysiak, Andrzej Wróbel, Roman Pędrys
The aim of our study is to obtain, as accurately as possible, porcine ocular tissue visualization using microtomography (micro-CT) method. We propose image contrast enhancement by different staining procedures with combination of micro-CT scanning. Porcine eye globes were investigated with Bruker-SkyScan 1172 micro-CT. We used 4F1G and Bouin's as sample fixation solutions and tincture of iodine, 100% Lugol, phosphotungstic acid and 1% osmium tetroxide solutions for staining. Quantitative and qualitative analysis was performed based on micro-CT reconstruction images histograms and 3D volume rendering models of investigated samples...
February 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29151068/crataegus-special-extract-ws-1442-up-to-date-review-of-experimental-and-clinical-experiences
#17
M Zorniak, B Szydlo, T F Krzeminski
Extracts and tinctures made from Crataegus spp. (Hawthorn) have been used as cardioprotective remedies since ancient times. WS 1442 special extract, manufactured by Dr. W. Schwabe Pharmaceuticals©, made from Crataegus spp. Leaves and flowers is one of the most studied and popular of preparations received from Hawthorn. It is integral, and most important active component of such herbal drugs as Crataegutt® novo 450, and CardioMax®. This standardized extract contains 18.75% oligomeric procyanidins (OPC), which have beneficial cardioprotective values and play a role as free-radicals scavengers, that protect the ischemic heart tissue from neutrophile elastase action successions...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29119763/-systematic-review-of-safeness-and-therapeutic-efficacy-of-cannabis-in-patients-with-multiple-sclerosis-neuropathic-pain-and-in-oncological-patients-treated-with-chemotherapy
#18
REVIEW
Laura Amato, Silvia Minozzi, Zuzana Mitrova, Elena Parmelli, Rosella Saulle, Fabio Cruciani, Simona Vecchi, Marina Davoli
BACKGROUND: medical cannabis refers to the use of cannabis or cannabinoids as medical therapy to treat disease or alleviate symptoms. In the United States, 23 states and Washington DC (May 2015) have introduced laws to permit the medical use of cannabis. Within the European Union, medicinal cannabis laws and praxis vary wildly between Countries. OBJECTIVES: to provide evidence for benefits and harms of cannabis (including extracts and tinctures) treatment for adults in the following indications: control of spasticity and pain in patients with multiple sclerosis; control of pain in patients with chronic neuropathic pain; control of nausea and vomiting in adults with cancer receiving chemotherapy...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29116293/antioxidant-effect-of-morus-nigra-on-chagas-disease-progression
#19
Michelly Cristina Montenote, Vithor Zuccaro Wajsman, Yoichi Takaki Konno, Paulo César Ferreira, Regildo Márcio Gonçalves Silva, Altino Luiz Silva Therezo, Luciana Pereira Silva, Luciamáre Perinetti Alves Martins
Considering the widespread popular use of Morus nigra and the amount of scientific information on its antioxidant and anti-inflammatory activity, the effectiveness of this phytotherapeutic compound in the parasitemia progression during the acute phase of Chagas disease and its role in the development of the inflammatory process as well as its effects on the oxidative damage in the chronic phase of infection were evaluated. Thus, 96 male Swiss mice were randomly divided into eight groups, four groups were uninfected controls, and four groups were intraperitoneally infected with 5...
November 6, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29058303/transmucosal-delivery-of-nicotine-in-combination-with-tincture-of-benzoin-inhibits-apoptosis
#20
Alex Battaglia, Thanh Nguyen
BACKGROUND AND OBJECTIVE: The aim of this study was to test the hypothesis that tincture of benzoin (TOB) facilitates immediate transmucosal nicotine absorption while simultaneously promoting a safe and sustained delivery of the nicotine. METHODS: In combination with TOB, nicotine toxicity and diffusion across human mucosal cells were measured using a 3-D human mucosal tissue model. RESULTS: Nicotine was delivered 2.1 times more quickly in combination with TOB than in combination with saline (p < 0...
December 2017: Drugs in R&D
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