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Clinical Severity Score Infection

Seline R Goudeketting, Jan Wille, Daniel A F van den Heuvel, Jan-Albert Vos, Jean-Paul P M de Vries
PURPOSE: To review midterm clinical outcomes of EndoAnchor placement during or after endovascular aneurysm repair (EVAR) or chimney EVAR (ch-EVAR). MATERIALS AND METHODS: A retrospective analysis was conducted of 51 consecutive patients [median age 75 years; 38 men] who underwent EVAR/ch-EVAR with EndoAnchor placement between June 2010 and December 2016 to prevent seal failures (31, 61%) or to treat type Ia endoleak and/or migration (20, 39%). Median aortic neck diameter was 27...
December 4, 2018: Journal of Endovascular Therapy
Jian Shen, Qi Zheng, Yi-Fan Wang, Xiao-Zhang Ying
OBJECTIVE: To explore the clinical effects and advantages of percataneous endoscopic focal cleaning and drainage combined with posterior internal fixation in the treatment of tuberculosis of lumbar spine in elderly. METHODS: The clinical data of 32 patients with tuberculosis of lumbar spine received percataneous endoscopic focal cleaning and drainage combined with posterior internal fixation from May 2013 to May 2016 were retrospectively analyzed. There were 13 males and 19 females, aged from 62 to 85 years old with an average of 75 years...
November 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Feyza Hüsrevoğlu-Esen, Yasemin Altuner-Torun, Çiğdem Karakükçü, Seçil Köse, Ahmet Şehriyaroğlu, Dilek Kafadar, Aydın Esen, Mehmet Köse
Hüsrevoğlu-Esen F. Altuner-Torun Y, Karakükçü Ç, Köse S, Şehriyaroğlu A, Kafadar D, Esen A, Köse M. Gelsolin levels in patients with bronchiolitis. Turk J Pediatr 2018; 60: 286-289. Bronchiolitis is the leading cause of hospitalization in infants. Biomarkers can show severity of the disease and help in clinical management. In this study, the aim was to determine the clinical predictiveness of plasma gelsolin levels (pGSN) in acute bronchiolitis. From December 2013 to May 2014, 52 patients with bronchiolitis (aged < 24 months) were included in this study...
2018: Turkish Journal of Pediatrics
Shan Zhang, Xiaoke Dai, Chunbao Guo
Intravenous fluid prescription plays an important role in sepsis management, which may be associated with patient prognosis. The objective of the present study was to determine if the administration of crystalloid fluids is associated with clinical outcome for patients with severe sepsis and septic shock.The medical records of 79 patients with severe sepsis or septic shock at an academic tertiary care hospital between 2011 and 2016 were reviewed retrospectively. The patients were dichotomized based on the median 3-day amount of corrected crystalloid fluids as low (<193 mL/kg) versus high (>193 mL/kg)...
November 2018: Medicine (Baltimore)
Arshi Khanam, Nirupma Trehanpati, Shiv Kumar Sarin
BACKGROUND: Th17 cells mediated immune response is important in chronic hepatitis B (CHB) infection and inflammation associated diseases, however, little is known about their immunopathogenic role in acute-on-chronic liver failure (ACLF). Interleukin-23 receptor (IL-23R) is essential for the generation of pathogenic Th17 cells, therefore, we aimed to evaluate IL-23R expression and its correlation with disease severity in ACLF. METHODS: Forty two patients with ACLF (HBV and alcohol-related), thirty two with CHB and twenty healthy controls (HC) were studied...
December 2, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Ev Christin Heide, Laura Bindila, Julia Maria Post, Dörthe Malzahn, Beat Lutz, Jana Seele, Roland Nau, Sandra Ribes
Easy-to-achieve interventions to promote healthy longevity are desired to diminish the incidence and severity of infections, as well as associated disability upon recovery. The dietary supplement palmitoylethanolamide (PEA) exerts anti-inflammatory and neuroprotective properties. Here, we investigated the effect of prophylactic PEA on the early immune response, clinical course, and survival of old mice after intracerebral E. coli K1 infection. Nineteen-month-old wild type mice were treated intraperitoneally with two doses of either 0...
2018: Frontiers in Immunology
Hussein M Galal, Azza M Tawfek, Mohamed I Abdrabou, Ashgan Mohamed Hessain, Jwaher Haji Alhaaji, Saleh A Kabli, Ayman Elbehiry, Waleed K Alwarhi, Ihab M Moussa
This study was conducted on 100 one-day-old broiler chicks to evaluate the effect of Poulvac E. coli vaccine in reduction of clinical signs and complications after concurrent infectious bronchitis virus (variant 02) and virulent E. coli O78 challenges. The birds were evaluated for clinical signs, mortality for 7 days post-infection, PM lesion score, average body weight and serological evaluation. Re-isolation and RT-PCR for the challenging infectious bronchitis virus (IBV) variant 02 were conducted thereafter...
November 2018: Saudi Journal of Biological Sciences
Ying P Tabak, Anita H Sung, Gang Ye, Latha Vankeepuram, Vikas Gupta, Eilish McCann
BACKGROUND: Gram-negative complicated urinary tract infections (cUTIs) can have serious consequences for patients and hospitals. AIM: We examined the clinical and economic burden attributable to Gram-negative carbapenem-nonsusceptible (C-NS; resistant/intermediate) versus carbapenem-susceptible (C-S) infections in 78 United States (US) hospitals. METHODS: All nonduplicate C-NS and C-S urine source isolates were analyzed. A subset had principal diagnosis ICD-9-CM codes denoting cUTI...
November 29, 2018: Journal of Hospital Infection
Camilla Björkman, Claudia von Brömssen, Karin Troell, Catarina Svensson
Diarrhea is common in young calves and is often caused by Cryptosporidium parvum infection. The aim of this study was to investigate if disinfection of calf pens with hydrated lime would reduce contamination of C. parvum oocysts and improve calf health in herds with C. parvum associated diarrhea problems. Four dairy herds with ongoing C. parvum associated calf diarrhea problems each participated in the study over six to seven months. During the study period, all pens/huts for young calves were cleaned according to the usual farm routine before a new calf entered...
December 15, 2018: Veterinary Parasitology
Jason C Gallagher, Michael J Satlin, Abdulrahman Elabor, Nidhi Saraiya, Erin K McCreary, Esther Molnar, Claudine El-Beyrouty, Bruce M Jones, Deepali Dixit, Emily L Heil, Kimberly C Claeys, Jon Hiles, Nikunj M Vyas, Christopher M Bland, Jin Suh, Kenneth Biason, Dorothy McCoy, Madeline A King, Lynette Richards, Nicole Harrington, Yi Guo, Saira Chaudhry, Xiaoning Lu, Daohai Yu
Background: Multidrug-resistant Pseudomonas aeruginosa infections remain common in hospitals worldwide. We investigated the outcomes associated with the use of ceftolozane-tazobactam for the treatment of these infections. Methods: Data were collected retrospectively from 20 hospitals across the United States about adults who received ceftolozane-tazobactam for the treatment of multidrug-resistant P aeruginosa infections of any source for at least 24 hours. The primary outcome was a composite of 30-day and inpatient mortality, and secondary outcomes were clinical success and microbiological cure...
November 2018: Open Forum Infectious Diseases
Ming-Te Kuo, Tsung-Hui Hu, Chao-Hung Hung, Jing-Houng Wang, Sheng-Nan Lu, Kai-Lung Tsai, Chien-Hung Chen
BACKGROUND: Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are first-line long-term monotherapy for treatment of chronic hepatitis B (CHB) infection. High virological relapse rates are found after cessation of either ETV or TDF in CHB patients. AIM: To compare hepatitis B virus (HBV) relapse rates in CHB patients without cirrhosis who discontinued ETV or TDF. METHODS: A retrospective-prospective study was conducted in 342 CHB patients (108 hepatitis B e antigen (HBeAg)-positive and 234 HBeAg-negative) who received ETV and 165 (46 HBeAg-positive, 119 HBeAg-negative) who received TDF were recruited...
November 28, 2018: Alimentary Pharmacology & Therapeutics
Aamer Imdad, Maribeth R Nicholson, Emily E Tanner-Smith, Joseph P Zackular, Oscar G Gomez-Duarte, Dawn B Beaulieu, Sari Acra
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, relapsing disease of the gastrointestinal tract that is thought to be associated with a complex interplay between microbes and the immune system, leading to an abnormal inflammatory response in genetically susceptible individuals. Dysbiosis, characterized by the alteration of the composition of the resident commensal bacteria in a host compared to healthy individuals, is thought to play a major role in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD), two subtypes of IBD...
November 13, 2018: Cochrane Database of Systematic Reviews
Jacqueline S Womersley, Georgina Spies, Soraya Seedat, Sian M J Hemmings
HIV-associated neurocognitive disorder (HAND) describes a spectrum of behavioural, motor and cognitive disturbances that can occur secondary to HIV infection. Less severe forms of the disorder persist despite advances in antiretroviral medication efficacy and availability. Childhood trauma (CT) may predispose individuals to developing HAND. As genetic variation in human apolipoprotein E (ApoE) has been implicated in cognitive decline and may mediate the development of long-term health outcomes following CT, we investigated the influence of ApoE and CT on cognitive function in the context of HIV...
November 26, 2018: Journal of Neurovirology
Chao Liu, Yue Zhou
OBJECTIVES: To compare the clinical outcomes of patients with massive lumbar disc disease undergoing percutaneous endoscopic lumbar discectomy and minimally invasive transforaminal lumbar interbody fusion at a single clinic. PATIENTS AND METHODS: From January 2008 to January 2014, 360 consecutive patients with massive lumbar disc herniation were treated with PELD(184 patients) or MIS-TLIF(176 patients). Data collected prospectively for analysis included clinical and radiographic results after revision surgery and complications...
October 29, 2018: Clinical Neurology and Neurosurgery
James A Russell, Hugh Wellman, Keith R Walley
Purpose: It is not clear whether vasopressin versus norepinephrine changed mortality in clinical practice in the Vasopressin and Septic Shock Trial (VASST) coordinating center hospital after VASST was published. We tested the hypothesis that vasopressin changed mortality compared to norepinephrine using propensity matching of vasopressin to norepinephrine-treated patients in the VASST coordinating center hospital before (SPH1) and after (SPH2) VASST was published. Methods: Vasopressin-treated patients were propensity score matched to norepinephrine-treated patients based on age, APACHE II, respiratory, renal, and hematologic dysfunction, mechanical ventilation status, medical/surgical status, infection site, and norepinephrine dose...
2018: Journal of Intensive Care
Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Taka-Aki Nakada, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-Ichiro Shiraishi, Kiyotsugu Takuma, Ryosuke Tsuruta, Akiyoshi Hagiwara, Kazuma Yamakawa, Tomohiko Masuno, Naoshi Takeyama, Norio Yamashita, Hiroto Ikeda, Masashi Ueyama, Satoshi Fujimi, Satoshi Gando
BACKGROUND: Sepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical characteristics, and evolving management of sepsis is important. Thus, this study aimed to evaluate the characteristics, management, and outcomes of patients with severe sepsis in Japan. METHODS: This is a cohort study of the Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis, and Trauma (FORECAST) study, which was a multicenter, prospective cohort study conducted at 59 intensive care units (ICUs) from January 2016 to March 2017...
November 22, 2018: Critical Care: the Official Journal of the Critical Care Forum
Peter G Passias, Cheongeun Oh, Samantha R Horn, Han Jo Kim, D Kojo Hamilton, Daniel M Sciubba, Brian J Neuman, Aaron J Buckland, Gregory W Poorman, Frank A Segreto, Cole A Bortz, Avery E Brown, Themistocles S Protopsaltis, Eric O Klineberg, Christopher Ames, Justin S Smith, Virginie Lafage
We developed a predictive model to describe risk factors for complications in cervical deformity surgeries. Cervical deformity (CD) surgical patients are growing in number, but remain under-studied in the literature. CD was defined as at least one of the following: C2-C7 Cobb >10°, CL >10°, cSVA >4 cm, CBVA >25°. Patient demographics and clinical data were assessed as risk factors for medical/surgical complications using multivariate regression models. 123 patients underwent CD surgery (60...
November 17, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Matthew Cooper, Tracy Cheng, Tracy Truong, Maragatha Kuchibhatla, Ralph Abi Hachem, David W Jang
OBJECTIVE: Although balloon sinuplasty (BSP) is increasing in popularity, little is known about which patients are the ideal candidates. The objective of this study is to investigate factors that may be associated with BSP failure. STUDY DESIGN: Retrospective review. SETTING: Academic center. SUBJECTS AND METHODS: This is a 6-year (July 2011-June 2017) retrospective review of patients who underwent BSP or revision endoscopic sinus surgery (rESS) after BSP within a single tertiary health system...
November 20, 2018: Otolaryngology—Head and Neck Surgery
Cole A Bortz, Peter G Passias, Frank A Segreto, Samantha R Horn, Renaud Lafage, Justin S Smith, Breton G Line, Gregory M Mundis, Michael P Kelly, Paul Park, Daniel M Sciubba, D Kojo Hamilton, Jeffrey L Gum, Douglas C Burton, Robert A Hart, Frank J Schwab, Shay Bess, Christopher Shaffrey, Eric O Klineberg
STUDY DESIGN: This is a retrospective review of prospective multicenter cervical deformity (CD) database. OBJECTIVE: Assess the impact of complication type and Clavien complication (Cc) grade on clinical outcomes of surgical CD patients BACKGROUND:: Validated for general surgery, the Clavien-Dindo complication classification system allows for broad comparison of postoperative complications; however, the applicability of this system is unclear in CD-specific populations...
November 16, 2018: Clinical Spine Surgery
Fei Teng, Xin Liu, Shu-Bin Guo, Zhuo Li, Wen-Qing Ji, Fang Zhang, Xiao-Mei Zhu
BACKGROUND: Influenza is frequently complicated by bacterial co-infection, causing additional hospitalization and mortality. We determined the incidence, risk factors and outcomes of patients with influenza-associated community-acquired bacterial co-infection. METHOD: This was a retrospective, observational study. Influenza was diagnosed using the polymerase chain reaction. Co-infection had to be confirmed using standard bacteriological tests. The primary endpoint was presence of community-acquired co-infection, and the secondary endpoint was in-hospital mortality...
November 15, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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