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Oleic acid

Moazameh Peyrovi, Mohammadreza Hadjmohammadi, Iman Saeidi
In the present study, a novel and efficient adsorbent constructed of molecularly imprinted polymer on the surface of modified magnetic nanoparticles with oleic acid (MNPs) was applied for the selective extraction of ezetimibe. The magnetic molecularly imprinted polymer (MMIP) was polymerized at the surface of modified MNPs using methacrylic acid (MAA) as functional monomer, ezetimibe as template and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The resulting MMIP showed high adsorption capacity, good selectivity and fast kinetic binding for the template molecule...
October 12, 2018: Biomedical Chromatography: BMC
Qi Liu, Yuying Guo, Mengtian Shan, Chao Lan, Rongchang Chen
OBJECTIVE: To explore the effect of lung strain on breathing mechanics in dogs with acute respiratory distress syndrome (ARDS). METHODS: Twenty-four healthy male Beagle dogs were recruited to reproduce medium ARDS models with venous injection of 0.18 mL/kg oleic acid, and they were randomly assigned to five groups with random numbers table method. In lung protective ventilation (LPV) group (n = 4), the ventilation was supported for 24 hours with tidal volume (VT) at 6-8 mL/kg, and in lung strain 1...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Olga Otrubova, Monika Jerigova, Sona Halaszova, Ladislav Turecky, Jana Muchova, Dusan Velic
This work provides complex characterisation of cirrhotic rat liver tissue induced by carbon tetrachloride using biochemical and histopathological analyses, and also presents a novel approach, secondary ion mass spectrometry (SIMS). According to our knowledge, this is the first report that compares these three different approaches in study of liver damage. We observed increased levels of triacylglycerols and total cholesterol in the liver and decreased levels of those parameters in the plasma. Histopathological observations include fat accumulation in the cells and changes in internal configuration of cells such as shift of position of organelles from the centre to the edge...
September 2018: General Physiology and Biophysics
Eva Gesteiro, Jesús Galera-Gordo, Marcela González-Gross
Palm oil is obtained from Elaeis guineensis, E. oleifera or the hybrid OxG palm fruits. When crude, it contains high carotenoid concentrations (responsible for the red color), tocopherols and tocotrienols, but most of them are eliminated during its refining. Palm oil main components are palmitic and oleic acids, both near 50%, but their proportion changes depending on the fraction used. Fatty acids absorption and the effect on blood lipid profile depend on the position in the triacylglycerol, especially in the sn-2 position...
October 8, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Bin Lou, Qi Liu, Jiahui Hou, Inamul Kabir, Peipei Liu, Tingbo Ding, Jibin Dong, Mingguang Mo, Deyong Ye, Yang Chen, Hai H Bui, Kenneth Roth, Yu Cao, Xian-Cheng Jiang
2-Hydroxy-oleic acid (2OHOA) is a potent anticancer drug that induces cancer cell cycle arrest and apoptosis. We have previously proposed that 2OHOA-mediated inhibition of sphingomyelin synthase (SMS), especially of SMS2, could be a potential therapeutic approach to manage metabolic diseases. However, other studies have suggested that 2OHOA's anticancer effect is mediated by SMS activation in cancer cells, including A549 and U118 cells. To resolve this apparent discrepancy, in this study, we treated both A549 and U118 cells with 2OHOA and measured SMS activity...
October 10, 2018: Journal of Biological Chemistry
Olena Myronycheva, Olov Karlsson, Margot Sehlstedt-Persson, Micael Öhman, Dick Sandberg
During industrial wood drying, extractives migrate towards the wood surfaces and make the material more susceptible to photo/biodegradation. The present work provides information about the distribution, quantity and nature of lipophilic substances beneath the surface in air- and kiln-dried Scots pine (Pinus sylvestris L.) sapwood boards. Samples were taken from knot-free sapwood surfaces and the composition of lipophilic extractives, phenols and low-molecular fatty/resin acids layers at different nominal depths below the surface was studied gravimetrically, by UV-spectrometry and by gas chromatography-mass spectrometry (GC-MS)...
2018: PloS One
Violaine Dubois, Albertus Viljoen, Laura Laencina, Vincent Le Moigne, Audrey Bernut, Faustine Dubar, Mickaël Blaise, Jean-Louis Gaillard, Yann Guérardel, Laurent Kremer, Jean-Louis Herrmann, Fabienne Girard-Misguich
Mycobacterium abscessus is a peculiar rapid-growing Mycobacterium (RGM) capable of surviving within eukaryotic cells thanks to an arsenal of virulence genes also found in slow-growing mycobacteria (SGM), such as Mycobacterium tuberculosis A screen based on the intracellular survival in amoebae and macrophages (MΦ) of an M. abscessus transposon mutant library revealed the important role of MAB_0855, a yet uncharacterized Mycobacterial membrane protein Large (MmpL). Large-scale comparisons with SGM and RGM genomes uncovered MmpL12 proteins as putative orthologs of MAB_0855 and a locus-scale synteny between the MAB_0855 and Mycobacterium chelonae mmpL8 loci...
October 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
Oh Yoen Kim, Su Mi Lee, Won Suk An
Fatty acids (FAs) are essential nutrients and main constituents of cell membranes that are involved in the signaling pathway and associated with health conditions. We investigated if blood or erythrocyte membrane FAs can predict the risk of cardiovascular disease (CVD), chronic kidney disease (CKD), and related complications. Omega-3 ( n -3) FAs are important predictors for metabolic syndrome, diabetes, CVD, and CKD risks, and the n -3 index is also a good biomarker for sudden cardiac death in coronary artery disease...
October 7, 2018: Nutrients
Shahram Seidi, Negar Sabahi Moosavi, Maryam Shanehsaz, Marzieh Abdolhosseini, Seyed Jamal Sadeghi
This study describes an ultrasonic assisted magnetic dispersive solid phase extraction based on oleic acid functionalized magnetic graphene oxide followed by HPLC-UV. The method was applied for simultaneous determination of ibuprofen, diclofenac, naproxen and mefenamic acid in urine. Applying of sonication led to well-dispersion of the sorbent and consequently, significant shortening of the extraction time. The sorbent was successfully characterized by different instrumental analysis. The influence of adsorption parameters were optimized using a rotational central composite design...
October 9, 2018: Journal of Separation Science
Paweł Górnaś, Magdalena Rudzińska, Anna Grygier, Gunārs Lācis
BACKGROUND: The seeds of Vitis vinifera grape are well studied, while the knowledge about the interspecific crosses of other Vitis species (e.g. V. vinifera, V. amurensis, V. rupestris, V. riparia, V. labruska) is very limited. RESULTS: Oil yield recovered from the grape seeds ranged between 7-160 g kg-1 dw. The main fatty acids were linoleic (72.5-83.1%), oleic (6.2-15.5%), and palmitic (5.4-13.2%), containing 92.8-97.1% of total detected fatty acids. The total concentration of tocopherol (T) and tocotrienol (T3) homologues was between 0...
October 9, 2018: Journal of the Science of Food and Agriculture
Xiujuan Yan, Yingxiu Li, Yun Ho Choi, Chongyang Wang, Yihua Piao, Jing Ye, Jingzhi Jiang, Liangchang Li, Huixian Xu, Qingsong Cui, Guanghai Yan, Minggen Jin
BACKGROUND This study investigated the role and mechanism of alprostadil in acute respiratory distress syndrome (ARDS) induced by oleic acid (OA) in rats. MATERIAL AND METHODS Sprague-Dawley rats were randomly divided into control, OA model, and OA + Alprostadil (2.5, 5, and 10 μg/kg, respectively) groups. The ARDS model was induced by femoral vein injection of OA, and alprostadil was administrated immediately. Lung injury was evaluated by lung wet-dry weight ratio (W/D) and histological analyses. Expressions of ACE, inflammatory mediators, apoptotic-related proteins, and proteins in the MAPKs and NF-κB signaling pathways were determined by Western blot or immunohistochemical staining...
October 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Weihua Long, Maolong Hu, Jianqin Gao, Song Chen, Jiefu Zhang, Li Cheng, Huiming Pu
Rapeseed ( Brassica napus L.) is a vital oil crop worldwide. High oleic acid content is a desirable quality trait for rapeseed oil, which makes it more beneficial to human health. However, many germplasm resources with high oleic acid content in rapeseed have not been evaluated with regard to their genotypes, making it difficult to select the best strains with this trait for the breeding of high oleic acid rapeseed variety. This work was to explore the gene-regulation mechanism of this trait using a new super-high oleic acid content (∼85%) line N1379T as genetic material...
2018: Frontiers in Genetics
Noha Nafee, Shaimaa Makled, Nabila Boraie
With the non-selective vasodilating action, short half-life and first-pass metabolism of sildenafil (SC), local application in the lung for pulmonary arterial hypertension is of high demand. Although several nanosystems have been lately investigated, nanostructured lipid carriers (NLCs) give promises of potential safety, biodegradability and controlled drug release. In the current study, NLCs comprising either precirol, stearic acid or beeswax as solid lipid in presence of oleic acid as liquid lipid and PVA or poloxamer as emulsifier were prepared...
October 4, 2018: European Journal of Pharmaceutical Sciences
Ellen Denise Prado Almeida, Lívia Vieira Dipieri, Fábia Cristina Rosseti, Juliana Maldonado Marchetti, Maria Vitória Lopes Badra Bentley, Rogéria de Souza Nunes, Víctor Hugo Vitorino Sarmento, Mário Ernesto Giroldo Valério, José Joatan Rodrigues, Monalisa Martins Montalvão, Cristiane Bani Correa, Ana Amélia Moreira Lira
The objective of this study was to develop and characterize lipid nanoparticles (LNs) containing chloroaluminum phthalocyanine (ClAlPc) to reduce the aggregation of the drug and improve its skin penetration and its antitumor effect. LNs were prepared and characterized by using stearic acid (SA) as solid lipid and oleic acid (OA) as liquid lipid in different proportions. In vitro and in vivo skin penetration was evaluated using modified Franz diffusion cells and fluorescence microscopy, respectively. In vitro biocompatibility and Photodynamic Therapy (PDT) were performed using L929-fibroblasts cell line and A549 cancer cell line and melanoma BF16-F10, respectively...
October 2, 2018: Photodiagnosis and Photodynamic Therapy
K S Sharma, R S Ningthoujam, A K Dubey, A Chattopadhyay, S Phapale, R R Juluri, S Mukherjee, R Tewari, Neena G Shetake, B N Pandey, R K Vatsa
Monodispersed Fe3 O4 magnetic nanoparticles (MNPs) having size of 7 nm have been prepared from iron oleate and made water dispersible by functionalization for biomedical applications. Three different reactions employing thioglycolic acid, aspartic acid and aminophosphonate were performed on oleic acid coated Fe3 O4 . In order to achieve a control on particle size, the pristine nanoparticles were heated in presence of ferric oleate which led to increase in size from 7 to 11 nm. Reaction parameters such as rate of heating, reaction temperature and duration of heating have been studied...
October 3, 2018: Scientific Reports
Mmahiine Molepo, Ademola Ayeleso, Trevor Nyakudya, Kennedy Erlwanger, Emmanuel Mukwevho
Metabolic syndrome, a cluster of different disorders which include diabetes, obesity and cardiovascular diseases, is a global epidemic that is growing at an alarming rate. The origins of disease can be traced back to early developmental stages of life. This has increased mortalities and continues to reduce life expectancies of individuals across the globe. The aim of this study was to investigate the sub-acute and long term effects of neonatal oral administration of oleanolic acid and metformin on lipids (free fatty acids, FFAs) and genes associated with lipid metabolism and glucose transport using a neonatal rat experimental model...
October 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Qiuhong Min, Lei Zhao, Yushuang Qi, Jing Lei, Wenbo Chen, Xuhui Xu, Dacheng Zhou, Jianbei Qiu, Xue Yu
An amorphous layer acting as a quenching center at the surface of oleic acid-capped NaGdF4:Yb3+/Tm3+ nanoparticles is observed directly, which can be reconstructed via a novel post-chemical annealing process. The amorphous phase of the surface layer of NaGdF4:Yb3+/Tm3+ nanoparticles gradually crystallizes as the post-chemical annealing temperature increases; meanwhile, the good dispersibility of the as-obtained nanoparticles is maintained. The reduction of surface defects and higher local symmetry of the crystal field environment around the doped rare-earth ions contribute to drastically increased up-conversion (UC) emission intensity of the NaGdF4:Yb3+/Tm3+ nanoparticles...
October 3, 2018: Nanoscale
Junko Yamaguchi, Midori Nagase, Yorihiro Yamamoto, Atsushi Sakurai, Airi Kubo, Hikaru Mitsuhashi, Masaru Matsuoka, Shingo Ihara, Kosaku Kinoshita
Sepsis remains one of the leading causes of death in intensive care units. The early phase of sepsis is characterized by a massive formation of reactive oxygen and nitrogen species such as superoxide and nitric oxide. However, few comprehensive studies on plasma antioxidants have been reported. Increased oxidative stress was confirmed in sepsis patients ( n  = 18) at the time of hospitalization by a significant decrease in plasma ascorbic acid and a significant increase in the percentage of oxidized form of coenzyme Q10 in total coenzyme Q10 compared to age-matched healthy controls ( n  = 62)...
September 2018: Journal of Clinical Biochemistry and Nutrition
Yuji Matsui, Hideo Iwahashi
This study examines oxidizability in individual aqueous solutions of oleic acid, linoleic acid, α-linolenic acid, γ-linolenic acid and arachidonic acid, and in their mixtures. We used electron spin resonance (ESR), high performance liquid chromatography-electron spin resonance (HPLC-ESR) and high performance liquid chromatography-electron spin resonance-mass spectrometries (HPLC-ESR-MS). We detected 4-carboxybutyl radical derived from γ-linolenic acid, ethyl and 7-carboxyheptyl radicals derived from α-linolenic acid, and pentyl and 7-carboxyheptyl radicals derived from linoleic acid...
September 2018: Journal of Clinical Biochemistry and Nutrition
Anita Jerković, Sandra Abou-Ahmed, Paul Ertl, Barbara Stoeßl, Vanessa Lengauer, Anchalee Samphao, Kurt Kalcher, Gerd Leitinger, Stefan Wernitznig, Astrid Ortner
In this work the development of an electrochemical sensor for the determination of polyunsaturated fatty acids (PUFAs), in particular linoleic acid, in commercially available safflower oil as complex matrix is described. The sensor consists of a carbon paste electrode with cobalt(II) phthalocyanine, Co(II)Pc, as mediator and multiwalled carbon-nanotubes (MWCNT) as nanomaterial. As carrier medium a sodium borate buffer (0.1 M, pH 9) was used. PUFAs were detected at a working voltage of 0.35-0.45 V (vs. Ag/AgCl)...
December 14, 2018: Analytica Chimica Acta
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