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https://www.readbyqxmd.com/read/30315283/on-treatment-improvement-of-meld-score-reduces-death-and-hepatic-events-in-patients-with-hepatitis-b-related-cirrhosis
#1
Terry Cheuk-Fung Yip, Henry Lik-Yuen Chan, Yee-Kit Tse, Kelvin Long-Yan Lam, Grace Chung-Yan Lui, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
OBJECTIVES: Antiviral treatment modifies the natural history of chronic hepatitis B (CHB)-related cirrhosis as reflected by improving Model for End-Stage Liver Disease (MELD) score over time. We evaluated the impact of on-treatment change of MELD score on clinical outcomes in patients with CHB-related cirrhosis. METHODS: Cirrhotic CHB patients who received entecavir and/or tenofovir disoproxil fumarate for at least 6 months in Hong Kong between 2005 and 2016 were identified...
October 12, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/30309366/free-triiodothyronine-and-global-registry-of-acute-coronary-events-risk-score-on-predicting-long-term-major-adverse-cardiac-events-in-stemi-patients-undergoing-primary-pci
#2
Xuewei Chang, Shouyan Zhang, Mingming Zhang, Hao Wang, Caifeng Fan, Yunfei Gu, Jinghan Wei, Chunguang Qiu
BACKGROUND: The aim of this study is to investigate the combined value of fT3 and GRACE risk score for cardiovascular prognosis in ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS: Three hundred and thirty eight patients with STEMI who received successful primary PCI were enrolled in our study. All patients underwent (33.5 ± 7.1) month's follow-up. Mace was defined as cardiac death and nonfatal myocardial infarction...
October 12, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30301705/the-effect-of-pelvic-floor-muscle-exercise-on-female-sexual-function-during-pregnancy-and-postpartum-a-systematic-review
#3
REVIEW
Sahar Sadat Sobhgol, Holly Priddis, Caroline A Smith, Hannah Grace Dahlen
INTRODUCTION: Pelvic floor muscle exercise (PFME) is recommended as a first-line treatment for urinary incontinence. However, a review of the literature suggests the effect of PFME on sexual function (SF), particularly during pregnancy and the postpartum period, is understudied. AIM: To assess the effect of PFME on SF during pregnancy and the postpartum period. METHODS: The following databases were searched: CINAHL (EBSCOhost), Health Collection (Informit), PubMed (National Center for Biotechnology Information), Embase (Ovid), MEDLINE, Cochrane, Health Source, Scopus, Wiley, Health & Medical Complete (ProQuest), Joanna Briggs Institute, and Google Scholar...
October 6, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/30290636/blood-homocysteine-levels-could-predict-major-adverse-cardiac-events-in-patients-with-acute-coronary-syndrome-a-strobe-compliant-observational-study
#4
Jianlin Liu, Jianjun Quan, Yanzi Li, Yue Wu, Lin Yang
The Global Registry of Acute Coronary Events (GRACE) risk score independently predicts major adverse cardiac events (MACEs) in patients with acute coronary syndrome (ACS). This study aims to evaluate whether the level of plasma homocysteine in addition to the GRACE score enhances the predictive value for MACEs in patients with acute coronary syndrome.A total of 361 patients with ACS evaluated at our hospital were included in the study and tested for blood homocysteine levels. We recorded 40 (11.1%) instances of MACE during a median follow-up of 43...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30287058/one-year-clinical-outcomes-in-older-patients-with-non-st-elevation-acute-coronary-syndrome-undergoing-coronary-angiography-an-analysis-of-the-icon1-study
#5
Jonathan Batty, Weiliang Qiu, Sophie Gu, Hannah Sinclair, Murugapathy Veerasamy, Benjamin Beska, Dermot Neely, Gary Ford, Vijay Kunadian
AIMS: The aim of this prospective, observational study was to identify predictors of adverse outcome at one year, following invasive care of older patients with non-ST-elevation acute coronary syndrome (NSTEACS) according to frailty status. METHODS: Older patients (aged ≥ 75 years), presenting with NSTEACS, undergoing invasive coronary angiography with a view to revascularisation, underwent assessment of frailty, cognition, functional status and quality of life...
September 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30276820/recovery-in-the-first-six-months-after-hand-and-upper-limb-burns-a-prospective-cohort-study
#6
Grace Ghalayini, Lisa O'Brien, Helen M Bourke-Taylor
BACKGROUND/AIM: Hands are commonly involved in burn trauma. Occupational therapy in the acute phase aims to reduce the risk of deformities and facilitate return to usual occupations. This study aimed to describe usual occupational therapy care at a major adult burns service, and measure recovery from hand burns in the first six months post-acute hospital discharge. METHOD: To describe usual occupational therapy care, an audit of patient contact statistics over six months was undertaken, and occupational therapy staff were interviewed...
October 1, 2018: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/30252932/comparative-effectiveness-of-radical-prostatectomy-with-adjuvant-radiotherapy-versus-radiotherapy-plus-androgen-deprivation-therapy-for-men-with-advanced-prostate-cancer
#7
Thomas L Jang, Neal Patel, Izak Faiena, Kushan D Radadia, Dirk F Moore, Sammy E Elsamra, Eric A Singer, Mark N Stein, James A Eastham, Peter T Scardino, Yong Lin, Isaac Y Kim, Grace L Lu-Yao
BACKGROUND: Men with locally advanced prostate cancer (LAPCa) or regionally advanced prostate cancer (RAPCa) are at high risk for death from their disease. Clinical guidelines support multimodal approaches, which include radical prostatectomy (RP) followed by radiotherapy (XRT) and XRT plus androgen deprivation therapy (ADT). However, there are limited data comparing these substantially different treatment approaches. Using Surveillance, Epidemiology, and End Results (SEER)-Medicare data, this study compared survival outcomes and adverse effects associated with RP plus XRT versus XRT plus ADT in these men...
September 25, 2018: Cancer
https://www.readbyqxmd.com/read/30249416/randomized-controlled-trial-of-transcranial-magnetic-stimulation-in-pregnant-women-with-major-depressive-disorder
#8
Deborah R Kim, Eileen Wang, Brendan McGeehan, Jessica Snell, Grace Ewing, Claudia Iannelli, John P O'Reardon, Mary D Sammel, C Neill Epperson
BACKGROUND: Major depressive disorder (MDD) affects 10% of pregnancies. Because transcranial magnetic stimulation (TMS) is a nonmedication option, psychiatric patients who do not tolerate or prefer to avoid antidepressants are good candidates for TMS. METHOD: In a randomized controlled trial of twenty-two women with MDD in the second or third trimester of pregnancy, subjects were randomized to active TMS (n=11) or sham TMS (n=11). This study took place at a single academic center...
September 14, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/30245882/can-obstetric-risk-factors-predict-fetal-acidaemia-at-birth-a-retrospective-case-control-study
#9
Habiba Kapaya, Roslyn Williams, Grace Elton, Dilly Anumba
Background: Despite major advances in perinatal medicine, intrapartum asphyxia remains a leading and potentially preventable cause of perinatal mortality and long-term morbidity. The umbilical cord pH is considered an essential criteria for the diagnosis of acute intrapartum hypoxic events. The purpose of this study was to evaluate whether obstetric risk factors are associated with fetal acidaemia at delivery. Methodology: In a case-control study, 294 women with term singleton pregnancies complicated by an umbilical artery cord pH < 7...
2018: Journal of Pregnancy
https://www.readbyqxmd.com/read/30232680/obstructive-sleep-apnea-in-pregnancy-performance-of-a-rapid-screening-tool
#10
Bilgay Izci Balserak, Bingqian Zhu, Michael A Grandner, Nicholas Jackson, Grace W Pien
PURPOSE: The Sleep Apnea Symptom Score (SASS) has been commonly used to assess obstructive sleep apnea (OSA). The aim of this study was to examine the psychometric properties of the SASS and the predictive value of SASS incorporating bedpartner-reported information in identifying OSA in pregnant women. METHODS: A cohort of healthy pregnant women completed the SASS and Pittsburgh Sleep Quality Index. Participants underwent overnight laboratory polysomnography (PSG) monitoring...
September 19, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30216925/neuraxial-morphine-after-unintentional-dural-puncture-is-not-associated-with-reduced-postdural-puncture-headache-in-obstetric-patients
#11
Molly E Brinser, David L Seng, Gordon L Mandell, Jonathan Waters, Patricia L Dalby, Grace Lim
STUDY OBJECTIVE: To examine the relationship between neuraxial morphine exposure after unintentional dural puncture and the risk for postdural puncture headache in obstetric patients. DESIGN: Retrospective cohort study. SETTING: Obstetrical unit at a tertiary care referral center. PATIENTS: Parturients receiving labor epidural analgesia with recognized unintentional dural puncture. INTERVENTIONS: Cases in which neuraxial morphine was given for any reason were compared to cases in which it was not for the outcome of postdural puncture headache...
September 11, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/30212983/prodromal-angina-and-risk-of-2-year-cardiac-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-intervention
#12
Gabriele Ghetti, Maria Letizia Bacchi Reggiani, Claudia Rosetti, Paola Battistini, Gianluca Lanati, Maria Teresa Di Dio, Anna Corsini, Matteo Bruno, Diego Della Riva, Antonio Giulio Bruno, Miriam Compagnone, Riccardo Narducci, Francesco Saia, Claudio Rapezzi, Nevio Taglieri
We sought to investigate the prognostic significance of prodromal angina (PA) in unselected patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) and its additive predictive value to the GRACE score.We prospectively enrolled 3015 consecutive STEMI patients undergoing PPCI. Patients were divided in 2 groups according to the presence or absence of PA. Multivariable Cox regression was used to establish the relation to 2-year cardiac mortality of PA...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30193195/combination-of-the-cyp2c19-metabolizer-and-the-grace-risk-score-better-predicts-the-long-term-major-adverse-cardiac-events-in-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#13
Xiao-Fang Bai, Ya-Ping Zhang, Juan Zhou, Yue Wu, Rui-Feng Li, Li-Zhe Sun, Qiang-Qiang Ma, Bo-Wen Lou, Bo-Wen Zhai, Meng-Ping Liu, Le-Le Cheng, Xiao-Ning Tong, Zu-Yi Yuan
INTRODUCTION: Both Global Registry of Acute Coronary Events (GRACE) risk score and CYP2C19 metabolizer status can independently predict major adverse cardiac events (MACEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). We investigated whether their combination could better predict MACE occurrence in patients with ACS undergoing PCI. MATERIALS AND METHODS: This retrospective cohort study included 548 consecutive patients with ACS undergoing PCI...
October 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30172845/gut-microbiome-correlates-with-altered-striatal-dopamine-receptor-expression-in-a-model-of-compulsive-alcohol-seeking
#14
Kshitij S Jadhav, Veronica L Peterson, Olivier Halfon, Grace Ahern, Fiona Fouhy, Catherine Stanton, Timothy G Dinan, John F Cryan, Benjamin Boutrel
Identifying biological markers predicting vulnerability to develop excessive alcohol consumption may lead to a real improvement of clinical care. With converging evidence suggesting that gut microbiome is capable of influencing brain and behavior, this study aimed at investigating whether changes in gut microbiome composition is associated with conditioned responses to alcohol. We trained Wistar rats to self-administer alcohol for a prolonged period before screening those exhibiting uncontrolled alcohol seeking and taking by modeling diagnostic criteria for AUD: inability to abstain during a signaled period of reward unavailability, increased motivation assessed in a progressive effortful task and persistent alcohol intake despite aversive foot shocks...
October 2018: Neuropharmacology
https://www.readbyqxmd.com/read/30158473/a-risk-assessment-of-aflatoxin-m1-exposure-in-low-and-mid-income-dairy-consumers-in-kenya
#15
Sara Ahlberg, Delia Grace, Gideon Kiarie, Yumi Kirino, Johanna Lindahl
Aflatoxin M₁ (AFM₁), a human carcinogen, is found in milk products and may have potentially severe health impacts on milk consumers. We assessed the risk of cancer and stunting as a result of AFM₁ consumption in Nairobi, Kenya, using worst case assumptions of toxicity and data from previous studies. Almost all (99.5%) milk was contaminated with AFM₁. Cancer risk caused by AFM₁ was lower among consumers purchasing from formal markets (0.003 cases per 100,000) than for low-income consumers (0.006 cases per 100,000) purchasing from informal markets...
August 29, 2018: Toxins
https://www.readbyqxmd.com/read/30143454/neural-correlates-of-compulsive-alcohol-seeking-in-heavy-drinkers
#16
Erica N Grodin, Lauren Sussman, Kelsey Sundby, Grace M Brennan, Nancy Diazgranados, Markus Heilig, Reza Momenan
BACKGROUND: Compulsive alcohol use, the tendency to continue alcohol seeking and taking despite negative consequences, is a hallmark of alcohol use disorder. Preclinical rodent studies have suggested a role for the medial prefrontal cortex, anterior insula, and nucleus accumbens in compulsive alcohol seeking. It is presently unknown whether these findings translate to humans. We used a novel functional magnetic resonance imaging paradigm and tested the hypothesis that heavy drinkers would compulsively seek alcohol despite the risk of an aversive consequence, and that this behavior would be associated with the activity of frontostriatal circuitry...
July 9, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/30125952/chronic-kidney-disease-progression-in-patients-with-chronic-hepatitis-b-on-tenofovir-entecavir-or-no-treatment
#17
Grace Lai-Hung Wong, Henry Lik-Yuen Chan, Yee-Kit Tse, Terry Cheuk-Fung Yip, Kelvin Long-Yan Lam, Grace Chung-Yan Lui, Cheuk-Chun Szeto, Vincent Wai-Sun Wong
BACKGROUND: In clinical trials involving patients with preserved renal function, tenofovir disoproxil fumarate (TDF) use was associated with mild renal impairment in 1% of patients. AIM: To compare serial renal function of entecavir (ETV)-treated, TDF-treated, and untreated patients with chronic hepatitis B. METHODS: We studied the risk of chronic kidney disease (CKD) progression in a territory-wide cohort of patients with chronic hepatitis B without treatment and of those on ETV or TDF treatment...
August 20, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30121176/the-risk-treatment-paradox-in-non-st-elevation-myocardial-infarction-patients-according-to-their-estimated-grace-risk
#18
Aet Saar, Toomas Marandi, Tiia Ainla, Krista Fischer, Mai Blöndal, Jaan Eha
BACKGROUND: The purpose was to describe the treatment and outcomes of non-ST-elevation myocardial infarction (NSTEMI) in Estonia according to patients' estimated mortality risk by the Global Registry of Acute Coronary Events (GRACE) score and investigate if inequalities in treatment had an impact on prognosis. METHODS: We performed a linkage between Estonian Myocardial Infarction Registry, Population Registry and Estonian Health Insurance Fund. All NSTEMI patients 2012-2014 were stratified into low (<4%), intermediate (4-12%), or high (>12%) mortality risk according to GRACE...
December 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30112872/serum-levels-of-pcsk9-are-associated-with-coronary-angiographic-severity-in-patients-with-acute-coronary-syndrome
#19
Kwi Hyun Bae, Sung Woo Kim, Yeon Kyung Choi, Jung Beom Seo, Namkyun Kim, Chang Yeon Kim, Won Kee Lee, Sungwoo Lee, Jung Guk Kim, In Kyu Lee, Jang Hoon Lee, Keun Gyu Park
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown. METHODS: From December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study...
May 2, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30109577/a-simple-pre-endoscopy-score-for-predicting-risk-of-malignancy-in-patients-with-dyspepsia-a-5-year-prospective-study
#20
Amit Kumar Dutta, Grace Rebekah, Sudipta Dhar Chowdhury, Sajith Kattiparambil Gangadharan, Yuvaraj Subramani, Manoj Kumar Sahu, Reuben Thomas Kurien, Deepu David, Ebby George Simon, Anjilivelil Joseph Joseph, Viswanath Reddy Donapati, Ashok Chacko
BACKGROUND: The guidelines for performing endoscopy in dyspeptic patients based on clinical parameters alone have shown variable performance, and there is a need for better prediction tools. AIM: We aimed to prospectively develop and validate a simple clinical-cum-laboratory test-based scoring model to identify dyspeptic patients with high risk of upper gastrointestinal malignancy (UGIM). METHODS: Adult patients with dyspeptic symptoms were prospectively recruited over 5 years...
August 14, 2018: Digestive Diseases and Sciences
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