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Grace risk score

Kwi Hyun Bae, Sung Woo Kim, Yeon Kyung Choi, Jung Beom Seo, Namkyun Kim, Chang Yeon Kim, Won Kee Lee, Sungwoo Lee, Jung Guk Kim, In Kyu Lee, Jang Hoon Lee, Keun Gyu Park
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown. METHODS: From December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study...
May 2, 2018: Diabetes & Metabolism Journal
Amit Kumar Dutta, Grace Rebekah, Sudipta Dhar Chowdhury, Sajith Kattiparambil Gangadharan, Yuvaraj Subramani, Manoj Kumar Sahu, Reuben Thomas Kurien, Deepu David, Ebby George Simon, Anjilivelil Joseph Joseph, Viswanath Reddy Donapati, Ashok Chacko
BACKGROUND: The guidelines for performing endoscopy in dyspeptic patients based on clinical parameters alone have shown variable performance, and there is a need for better prediction tools. AIM: We aimed to prospectively develop and validate a simple clinical-cum-laboratory test-based scoring model to identify dyspeptic patients with high risk of upper gastrointestinal malignancy (UGIM). METHODS: Adult patients with dyspeptic symptoms were prospectively recruited over 5 years...
August 14, 2018: Digestive Diseases and Sciences
Gökhan Çetinkal, Cüneyt Koçaş, Betül Balaban Koçaş, Şükrü Arslan, Okay Abacı, Osman Şükrü Karaca, Yalçın Dalgıç, Özgür Selim Ser, Kudret Keskin, Ahmet Yıldız, Sait Mesut Doğan
OBJECTIVE: This study is designed to evaluate the recently developed AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) risk score (RS), which determines the predisposition to thromboembolic and hemorrhagic events in atrial fibrillation, as a predictor of prognosis in patients having acute myocardial infarction (AMI), and to compare the predictive ability of ATRIA RS with GRACE RS. METHODS: We analyzed 1627 patients having AMI who underwent coronary angiography and/or percutaneous coronary intervention (PCI) between January 2011 and February 2015...
August 2018: Anatolian Journal of Cardiology
S A Berns, E A Shmidt, O A Nagirnyak, A V Klimenkova, M N Litvinova, T Y Sergeeva, O L Barbarash
PURPOSE: to study the role of clinical factors and treatment tactics in the development of adverse outcomes in patients with non-STelevation acute coronary syndrome (NSTEACS) for five years follow up. MATERIALS AND METHODS: The study included 415 patients with NSTEACS observed for 60±4 months from the date of discharge. Adverse events (AE) were unstable angina (UA), myocardial infarction (MI), ischemic stroke or patient's death. The favorable 5-year outcome was identified in 200, adverse outcome - in 178 patients...
July 2018: Kardiologiia
V A Brazhnik, L O Minushkina, M A Evdokimova, A S Galyavich, S N Tereshchenko, N A Koziolova, M G Glezer, A V Yagoda, E V Khorolets, E N Dankovtseva, O I Boeva, V O Konstantinov, D A Zateishchikov
PURPOSE: to analyze possible associations of clinical and genetic factors with development of ischemic stroke after exacerbation of ischemic heart disease (IHD). MATERIALS AND METHODS: The Russian multicenter study aimed at assessment of risk of unfavorable outcomes after exacerbation of IHD "Exacerbation of IHD: logical probabilistic ways to course prognostication for optimization of treatment" (meaning of Cyrillic acronym - oracle) was conducted in 16 centers of 7 cities in Russia...
July 2018: Kardiologiia
Ibrahim Al-Zakwani, Mohammad Zubaid, Alawi A Alsheikh-Ali, Wael Almahmeed, Wafa Rashed
AIM: To evaluate the prevalence and impact of the prescribing of an evidence-based cardiac medication (EBM) combination on 1-month, 6-months and 12-months all-cause mortality in patients with acute coronary syndrome (ACS). METHODS: Data was analyzed from 3681 consecutive patients diagnosed with ACS admitted to 29 hospitals in 4 Middle Eastern countries from January 2012 to January 2013. The EBM combination consisted of concurrent prescribing of an anti-platelet therapy, angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB), β-blocker, and a statin, at hospital discharge...
August 6, 2018: Cardiovascular Therapeutics
Chi-Cheng Huang, Jung-Cheng Hsu, Yen-Wen Wu, Shin-Rong Ke, Jih-Hsin Huang, Kuan-Ming Chiu, Pen-Chih Liao
BACKGROUND: The mortality of patients with ST-segment elevation myocardial infarction (STEMI) and refractory cardiogenic shock (RCS) is high. Extracorporeal membrane oxygenation (ECMO) before percutaneous coronary intervention (PCI) has shown some favorable results, but this may delay door-to-balloon (D2B) time. Whether the benefit surpasses the risk of longer D2B time remains controversial. METHODS: From January 2005 to December 2014, there were 46 patients with STEMI RCS who received ECMO and PCI...
July 7, 2018: International Journal of Cardiology
Tang-Meng Guo, Bei Cheng, Li Ke, Si-Ming Guan, Ben-Ling Qi, Wen-Zhu Li, Bin Yang
Coronary artery disease (CAD) is a multifactorial disease in which inflammation plays a central role. This study aimed to investigate the association of inflammatory markers such as the neutrophil to lymphocyte ratio (NLR), the Global Registry of Acute Coronary Events (GRACE) score with in-hospital mortality of elderly patients with acute myocardial infarction (AMI) in an attempt to explore the prognostic value of these indices for elderly AMI patients. One thousand consecutive CAD patients were divided into two groups based on age 60...
April 2018: Current medical science
Marcin Ojrzanowski, Łukasz Figiel, Jan Z Peruga, Sonu Sahni, Jarosław D Kasprzak
BACKGROUND: The Global Registry of Acute Coronary Events (GRACE) study produced a scale for risk stratification in acute coronary syndromes (ACSs). Pregnancy-associated plasma protein A (PAPP-A) serum concentration was implicated as a marker of unstable atherosclerotic plaques. OBJECTIVES: We hypothesized that the measurement of the concentration of PAPP-A on admission may improve the stratification of cardiovascular risk in suspected ACS patients. MATERIAL AND METHODS: We studied 70 patients with chest pain suggesting ACS diagnosis on admission...
July 30, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
M van Toorenburg, V J van den Berg, T van der Ploeg, A A Heestermans, M T Dirksen, R W Hautvast, O Drexhage, E Boersma, I Kardys, V A W M Umans
AIM: To investigate whether blood biomarkers measured routinely at hospital admission in myocardial infarction (MI) patients can improve the admission GRACE score for the composite endpoint of all-cause mortality and non-fatal MI at 6 months. METHODS: 2055 patients treated for MI in the Northwest clinics, the Netherlands, between 2013 and 2016 were examined. As part of the prevailing MI treatment protocol, 19 biomarkers were measured and the GRACE score was ascertained...
July 21, 2018: International Journal of Cardiology
D Bock, J Senges, C Pohlmann, M Hochadel, T Münzel, E Giannitsis, C Schmitt, G Heusch, T Voigtländer, H Mudra, B Schumacher, H Darius, L S Maier, B Hailer, M Haude, H Gohlke, U Hink
BACKGROUND: Chest pain is a major reason for admission to an internal emergency department, and smoking is a well-known risk factor for coronary artery disease (CAD) and acute coronary syndrome (ACS). The aim of this analysis is to illustrate the differences between smokers and nonsmokers presenting to German chest pain units (CPU) in regard to patient characteristics, CAD manifestation, treatment strategy, and prognosis. METHODS: From December 2008 to March 2014, 13,902 patients who had a complete 3‑month follow-up were enrolled in the German CPU registry...
July 27, 2018: Herz
Jessika González-D'Gregorio, Gema Miñana, Julio Núñez, Eduardo Núñez, Vicente Ruiz, Sergio García-Blas, Clara Bonanad, Anna Mollar, Ernesto Valero, Martina Amiguet, Clara Sastre, Juan Sanchis
AIM: We evaluated the relationship between iron deficiency (ID) and long-term mortality risk in elderly patients with acute coronary syndrome (ACS). METHODS: In this prospective observational study, we included 252 patients older than 65 years with ACS. Transferrin saturation (TSAT) and ferritin were collected before discharge. RESULTS: Mean age, hemoglobin and GRACE score were 78 ± 7 years, 12.4 ± 1.8 g/dl and 138.8 ± 25.3, respectively, 112(44...
July 25, 2018: Biomarkers in Medicine
Anthony Ming-Yu Chuang, David G Hancock, Amera Halabi, Matthew Horsfall, Julian Vaile, Carmine De Pasquale, Ajay Sinhal, Dylan Jones, Richard Brogan, Derek P Chew
BACKGROUND: The aim of this study was to characterise the interaction between ACS- and non-ACS-risk on the benefits of invasive management in patients presenting with acute coronary syndrome (ACS). METHODS: Consecutive patients admitted to a tertiary hospital's Cardiac Care Unit in the months of July-December, 2003-2011 with troponin elevation (>30 ng/L) were included. "ACS-specific-risk" was estimated using the GRACE score and "non-ACS-risk" was estimated using the Charlson-Comorbidity-Index (CCI)...
July 19, 2018: International Journal of Cardiology
E M Grace, C Shaw, A Lalji, K Mohammed, H J N Andreyev, K Whelan
BACKGROUND: Patients with oesophago-gastric (OG) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (GI) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to assess (i) nutritional status and how it evolved over the first year; (ii) the association between nutritional status scores and GI symptom scores; and (iii) the nutrient and food group intake pattern...
July 22, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
Ehsan Khan, David Brieger, John Amerena, John J Atherton, Derek P Chew, Ahmad Farshid, Marcus Ilton, Craig P Juergens, Nadarajah Kangaharan, Rohan Rajaratnam, Amy Sweeny, Darren L Walters, Clara K Chow
OBJECTIVE: To examine whether there are sex differences in the characteristics, management, and clinical outcomes of patients with an ST-elevation myocardial infarction (STEMI). Design, setting: Cohort study; analysis of data collected prospectively by the CONCORDANCE acute coronary syndrome registry from 41 Australian hospitals between February 2009 and May 2016. PARTICIPANTS: 2898 patients (2183 men, 715 women) with STEMI. MAIN OUTCOME MEASURES: Rates of revascularisation (percutaneous coronary intervention [PCI], thrombolysis, coronary artery bypass grafting [CABG]), adjusted for GRACE risk score quartile...
August 6, 2018: Medical Journal of Australia
Carla Araújo, Olga Laszczyńska, Marta Viana, Paula Dias, Maria Júlia Maciel, Ilídio Moreira, Ana Azevedo
INTRODUCTION AND OBJECTIVES: Despite increased awareness of sex disparities in care and outcomes of acute myocardial infarction (AMI), there appears to have been no consistent attenuation of these differences over the last decade. We investigated differences by sex in management and 30-day mortality using the European Society of Cardiology Acute Cardiovascular Care Association quality indicators (QIs) for AMI. METHODS: Proportions and standard errors of the 20 Acute Cardiovascular Care Association QIs were calculated for 771 patients with AMI who were admitted to the cardiology departments of 2 tertiary hospitals in Portugal between August 2013 and December 2014...
July 3, 2018: Revista Española de Cardiología
Wei Xia, Xiao-Yan Feng
BACKGROUND ST-segment elevation myocardial infarction (STEMI) is an acute and life-threatening disease. Adverse cardiac events (ACEs) are defined as cardiovascular death or worsening congestive heart failure in STEMI patients. The present study investigated the predictive role of fragmented QRS complex (fQRS) in risks of ACEs in STEMI. MATERIAL AND METHODS This study was a retrospective analysis involving patients who underwent percutaneous coronary intervention (PCI) or thrombolysis. STEMI patients were divided into the fQRS group (259 cases) and the non-fQRS group (161 cases)...
July 5, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Grace Campbell, Rachel A Wolfe, Mary Lou Klem
PURPOSE: The aim of the study was to identify risk factors for falls among cancer survivors. DESIGN: Integrative literature review. METHODS: We searched PubMed, Embase, CINAHL, Cochrane Central Register of Controlled Trials, and PEDro for studies investigating fall risk in cancer. Reports of randomized controlled trials, descriptive studies (quantitative and qualitative), and theoretical papers meeting predetermined criteria were included...
July 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Jiachen Luo, Liming Dai, Jianming Li, Jinlong Zhao, Zhiqiang Li, Xiaoming Qin, Hongqiang Li, Baoxin Liu, Yidong Wei
Purpose: New-onset atrial fibrillation (NOAF) is a common finding in patients with myocardial infarction (MI), but few studies are available regarding the prediction model for its risk estimation. Although Global Registry of Acute Coronary Events (GRACE) risk score (RS) has been recognized as an effective tool for the risk evaluation of clinical outcomes in patients with MI, its usefulness in the prediction of post-MI NOAF remains unclear. In this study, we sought to validate the discrimination performance of GRACE RS in the prediction of post-MI NOAF and to make a comparison with that of the CHA2 DS2 -VASc score in patients with ST-segment elevation myocardial infarction (STEMI)...
2018: Clinical Interventions in Aging
Vanessa El Kamari, Corrilynn O Hileman, Pierre M Gholam, Manjusha Kulkarni, Nicholas Funderburg, Grace A McComsey
BACKGROUND & AIMS: Therapies are needed to limit progression of fatty liver diseases in patients with HIV infection. We analyzed data from a prospective study of the effects of rosuvastatin (a statin) on hepatic steatosis in HIV-positive adults. METHODS: We performed secondary analysis of data from a double-blind trial of adult patients with HIV infection (78% male; 68% African American; mean age, 46 years; body mass index, 29 kg/m2 ; HIV1 RNA<1000 copies/mL; LDL-cholesterol <130 mg/dL) receiving antiretroviral therapy...
June 13, 2018: Clinical Gastroenterology and Hepatology
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