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Grace risk score

Chantel L Martin, Catherine J Vladutiu, Tarek M Zikry, Matthew R Grace, Anna Maria Siega-Riz
BACKGROUND: The intrauterine environment is critical in the development of child obesity. OBJECTIVE: To investigate the association between maternal lipid levels during pregnancy and child weight status. METHODS: Maternal lipid levels (total cholesterol, high-density and low-density lipoprotein cholesterol, triglycerides) collected from fasting blood samples collected at less than 20 and 24-29 weeks' gestation and child weight status at age 3 were examined prospectively among 183 mother-child dyads enrolled in the Pregnancy, Infection, and Nutrition...
December 4, 2018: Pediatric Obesity
Christian Eick, Patrick Groga-Bada, Kathrin Reinhardt, Martin Duckheim, Lars Mizera, Katharina Böhm, Nina Götz, Meinrad Gawaz, Christine Zürn
Background: Patients with acute coronary syndrome (ACS) are at risk especially in the period shortly after the event. Alterations in respiratory control have been associated with adverse prognosis. The aim of our study was to assess if the nocturnal respiratory rate (NRR) is a predictor of mortality in patients with ACS presenting in the emergency department. Methods: Clinically stable consecutive patients with ACS aged ≥ 18 years were prospectively enrolled. The Global Registry of Acute Coronary Events (GRACE) score and left ventricular ejection fraction (LVEF) were assessed for all patients...
2018: Open Heart
Wen-Hao Li, Li-Fei Hu, Li Yuan, Grace Hao, Zhi-Wei Zhu
PURPOSE: The First Year Inventory (FYI) is a parent-report instrument, and is developed to assess behaviors of 12-month-old infants that could suggest risk for an eventual diagnosis of autism. This study was designed to examine the application of the FYI in the Chinese community. DESIGN AND METHODS: FYIs were completed at a community health center by 541 families during the child's physical examination at 12 months of age from 2013 to 2015. The weighted risk scores used in this study were based on US norms, and compared the FYI differences between China and the U...
November 23, 2018: Journal of Pediatric Nursing
Hailong Song, Hui Zhou, Zhe Qu, Jie Hou, Weilong Chen, Weiwu Cai, Qiong Cheng, Dennis Y Chuang, Shanyan Chen, Shuwei Li, Jilong Li, Jianlin Cheng, C Michael Greenlief, Yuan Lu, Agnes Simonyi, Grace Y Sun, Chenghan Wu, Jiankun Cui, Zezong Gu
Ischemic stroke is a devastating neurological disease that can cause permanent brain damage, but to date, few biomarkers are available to reliably assess the severity of injury during acute onset. In this study, quantitative proteomic analysis of ischemic mouse brain detected the increase in expression levels of clusterin (CLU) and cystatin C (CST3). Since CLU is a secretary protein, serum samples (n = 70) were obtained from acute ischemic stroke (AIS) patients within 24 h of stroke onset and together with 70 matched health controls...
November 21, 2018: Translational Stroke Research
Grace Hernandez, Kimberly Baumann, Susan Knight, Heidi Purrington, Marc Gilgannon, Jennifer Newman, Patricia Tobase, Sheba Mathew, David L Cooper
INTRODUCTION: Limited evidence describes physical activity-associated bleeding risks for people with haemophilia, and risks are usually described only generically. AIM: To assess activity-specific ranges of risk for joint, soft tissue and head bleeds by identifying inherent and modifiable risk factors associated with each activity, based on opinions of expert physical therapists (PTs). METHODS: Physical therapists from US haemophilia treatment centres (HTCs) participated in a survey of 101 physical activities...
November 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
Barbara Marjorie Nanteza, David Serwadda, Edward Nelson Kankaka, Grace Bua Mongo, Ronald Gray, Frederick Edward Makumbi
BACKGROUND: Free VMMC services have been available in Uganda since 2010. However, uptake in Northern Uganda remains disproportionately low. We aimed to determine if this is due to men's insufficient knowledge on VMMC, and if women's knowledge on VMMC has any association with VMMC status of their male sexual partners. METHODS: In this cross sectional study, participants were asked their circumcision status (or that of their male sexual partner for female respondents) and presented with 14 questions on VMMC benefits, procedure, risk, and misconceptions...
November 20, 2018: BMC Public Health
Abha Shah, Matthew Wyatt, Bethany Gourneau, Grace Shih, Martin De Ruyter
Burnout is characterized by three components: emotional exhaustion, depersonalization, and low personal accomplishment. Burnout in health professionals results in reduced job satisfaction, decreased mental health and decreased quality of care, with rates ranging from 30-65% across medical specialties. The purpose of this study was to evaluate the prevalence of burnout components and identify factors associated with these components in physicians, residents, and certified nurse anesthetists (CRNAs) in a large academic anesthesiology department...
November 19, 2018: Psychology, Health & Medicine
João Filipe Carvalho, Adriana Belo, Kisa Congo, David Neves, Ana Rita Santos, Bruno Piçarra, Ana Filipa Damásio, José Aguiar
INTRODUCTION: A low-risk GRACE score identifies patients with a lower incidence of major cardiac events, however it can erroneously classify patients with severe coronary artery disease as low-risk. We assessed the prevalence, clinical outcomes and predictors of left main and/or three-vessel disease (LM/3VD) in non-ST-elevation acute myocardial infarction (NSTEMI) patients with a GRACE score of ≤108 at admission. METHODS: Using data from the Portuguese Registry on Acute Coronary Syndromes, 1196 patients with NSTEMI and a GRACE score of ≤108 who underwent coronary angiography were studied...
November 15, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Grace E McMahon, Megan M Spencer-Smith, Carmen C Pace, Alicia J Spittle, Paulina Stedall, Kate Richardson, Jeanie L Y Cheong, Lex W Doyle, Peter J Anderson, Karli Treyvaud
OBJECTIVES: To examine factors associated with fathers' early parenting behaviors (including very preterm [VPT] birth, familial social risk, child sex, and child medical risk), and the relationship between fathers' early parenting behaviors and later child development. STUDY DESIGN: Participants were 81 VPT (born <30 weeks of gestation) and 39 full-term father-child dyads. Parenting behaviors (sensitivity, structuring, nonintrusiveness, nonhostility) were assessed at 12 months of corrected age using the Emotional Availability Scales, with scores ranging from 1 (low) to 7 (high)...
November 14, 2018: Journal of Pediatrics
A Morrow, F Ahmad, C Steele, M McEntegart, D Murdoch
BACKGROUND AND AIMS: Anti-platelet and anti-thrombotic therapy are well-established treatments in acute coronary syndromes. Highly sensitive assays have diminished the positive predictive value of troponin in acute coronary syndromes and increased the importance of the clinical assessment in interpreting positive results. This cohort study sought to investigate over-treatment of non-coronary troponin rises and associated adverse outcomes. METHODS AND RESULTS: We reviewed 223 consecutive patients presenting to Queen Elizabeth University Hospital, Glasgow, with suspected acute coronary syndromes over a six-week period...
November 14, 2018: Scottish Medical Journal
Grace H Lo, Jing Song, Timothy E McAlindon, Gillian A Hawker, Jeffrey B Driban, Lori Lyn Price, Charles B Eaton, Marc C Hochberg, Rebecca D Jackson, C Kent Kwoh, Michael C Nevitt, Dorothy D Dunlop
OBJECTIVE: Validation of a symptom measure for early knee OA may help identify new treatments and modifiable risk factors. Symptom measures that consider pain in the context of activity level may provide better discrimination than pain alone. Therefore, we aimed to compare sensitivity to change for radiographic progression between Ambulation Adjusted Score for Knee pain (AASK), which accounts for self-reported ambulation, and Western Ontario McMaster Osteoarthritis (WOMAC) knee pain score...
November 12, 2018: Clinical Rheumatology
Louis Arnould, Charles Guenancia, Arthur Azemar, Guillaume Alan, Stéphane Pitois, Florence Bichat, Marianne Zeller, Pierre-Henry Gabrielle, Alain M Bron, Catherine Creuzot-Garcher, Yves Cottin
Purpose: To evaluate the association between retinal microvasculature (vascular density) on optical coherence tomography-angiography (OCT-A) and the cardiovascular profile of patients hospitalized for acute coronary syndrome (ACS). Methods: EYE-Myocardial Infarction (EYE-MI) study is a prospective cross-sectional study in the Cardiology Intensive Care Unit of Dijon University Hospital. Retinal OCT-A was performed for each patient within 2 days after admission. Superficial retinal capillary plexus (SCP) vascular density was measured...
August 1, 2018: Investigative Ophthalmology & Visual Science
Victor J van den Berg, Majorie van Toorenburg, Olivier Drexhage, Eric Boersma, Isabella Kardys, Victor A W M Umans
The GRACE score is currently the most widely used model to assess patient prognosis after myocardial infarction (MI). We have demonstrated that the prognostic performance of the GRACE score can be improved by adding blood biomarkers measured routinely at hospital admission in our study recently published in the International Journal of Cardiology: "Addition of routinely measured blood biomarkers significantly improves GRACE risk stratification in patients with myocardial infarction". In this Data-in-Brief article we present additional original data from our dataset...
December 2018: Data in Brief
L I Malinova, N V Furman, P V Dolotovskaya, L A Chernousova, T P Denisova
PURPOSE: to assess the possibility of the use of ADP induced blood-clotting time measurement in clinical practice prognostication of the course of acute coronary syndrome (ACS) and assessment of effectiveness of antiplatelet therapy (APT). MATERIALS AND METHODS: We enrolled in the study 163 male patients admitted to the coronary unit for acute coronary syndrome (ACS) and 38 male practically healthy volunteers (PHV). ADP induced blood-clotting time (ADP BCT) was measured as time (sec) between addition of ADP (10 μcmol) to recalcificated sample of citrate blood and clot formation...
June 2018: Kardiologiia
Slayman Obeid, Antonio H Frangieh, Lorenz Räber, Nooraldaem Yousif, Thomas Gilhofer, Kyohei Yamaji, Milosz Jaguszewski, Soheila Aghlmandi, James Adams, Yannik Bockhorn, Christian Templin, Barbara E Stähli, Peter Jüni, Nicolas Rodondi, François Mach, Marco Roffi, Stephan Windecker, Willibald Maier, Fabian Nietlispach, Christian M Matter, Roland Klingenberg, Thomas F Lüscher
Aims: To assess the incremental prognostic value of SYNTAX score II (SxSII) as compared to anatomical SYNTAX Score (SxS) and GRACE risk score in patients with acute coronary syndromes who underwent percutaneous coronary intervention. Methods and results: SxSII and SxS were determined in 734 ACS patients. Patients were enrolled in the prospective Special Program University Medicine ACS and the COMFORTABLE AMI cohorts and later on stratified according to tertiles of SxSII (SxSIILow ≤21...
2018: Cardiology Research and Practice
Andrew R Chapman, Kerrick Hesse, Jack Andrews, Kuan Ken Lee, Atul Anand, Anoop S V Shah, Dennis Sandeman, Amy V Ferry, Jack Jameson, Simran Piya, Stacey Stewart, Lucy Marshall, Fiona E Strachan, Alasdair Gray, David E Newby, Nicholas L Mills
BACKGROUND: High-sensitivity cardiac troponin assays can help to identify patients who are at low risk of myocardial infarction in the emergency department. We aimed to determine whether the addition of clinical risk scores would improve the safety of early rule-out pathways for myocardial infarction. METHODS: In 1935 patients with suspected acute coronary syndrome, we evaluated the safety and efficacy of 2 rule-out pathways alone or in conjunction with low-risk TIMI (Thrombolysis In Myocardial Infarction) (0 or 1), GRACE (Global Registry of Acute Coronary Events) (≤108), EDACS (Emergency Department Assessment of Chest Pain Score) (<16), or HEART (History, ECG, Age, Risk factors, Troponin) (≤3) scores...
October 16, 2018: Circulation
Christian Widera, Evangelos Giannitsis, Matthias Mueller-Hennessen, Ines Reimann, Anja Guba-Quint, Ivonne Marquardt, Kerstin Bethmann, Sven Meyer
INTRODUCTION: Sex- and age-specifichigh-sensitivity Troponin T (hs-cTnT) cutpoints for the diagnosis and prognosis in acute coronary syndromes are not well established. We evaluated the use of such dichotomous thresholds for calculation of the GRACE score. METHODS: We analyzed a retrospective cohort study of 1146 patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Sex-dependenths-cTnT cutpoints comprised 15.5ng/L for men and 9.0ng/L for women, while the sex-/age-specific cutpoints comprised 17ng/L for 50-64-year-old men and ≥65-year-old women, 31ng/L for ≥65-year-old men and 14ng/L for the remainder of patients...
October 11, 2018: International Journal of Cardiology
Julie E Davis, Robert J Ward, James W MacKay, Bing Lu, Lori Lyn Price, Timothy E McAlindon, Charles B Eaton, Mary F Barbe, Grace H Lo, Matthew S Harkey, Jeffrey B Driban
Objectives: To determine whether greater effusion-synovitis volume and infrapatellar fat pad (IFP) signal intensity alteration differentiate incident accelerated knee OA (KOA) from a gradual onset of KOA or no KOA. Methods: We classified three sex-matched groups of participants in the Osteoarthritis Initiative who had a knee with no radiographic KOA at baseline (recruited 2004-06; Kellgren-Lawrence <2; n = 125/group): accelerated KOA: ⩾1 knee progressed to Kellgren-Lawrence grade ⩾3 within 48 months; common KOA: ⩾1 knee increased in radiographic scoring within 48 months; and no KOA: both knees had the same Kellgren-Lawrence grade at baseline and 48 months...
October 20, 2018: Rheumatology
Suceena Alexander, George T John, Anila Korula, T S Vijayakumar, Vinoi George David, Anjali Mohapatra, Anna T Valson, Shibu Jacob, Pradeep Mathew Koshy, Gautam Rajan, Elenjickal Elias John, Smita Mary Matthai, L Jeyaseelan, Babu Ponnusamy, Terence Cook, Charles Pusey, Mohamed R Daha, John Feehally, Jonathan Barratt, Santosh Varughese
Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis and an important cause of end-stage kidney disease. Unlike the slowly progressive course seen among Caucasian and East Asian subjects (actuarial survival 80-85% over 10 years), in India about 30-40% of patients have nephrotic syndrome and renal dysfunction at presentation and a 10-year renal survival of 35%, as reported from a retrospective registry. These observations cannot be entirely attributed to a lack of uniform screening protocols or late referral and attest to the probability that IgAN may not be the same disease in different parts of the world...
2018: Wellcome Open Research
Terry Cheuk-Fung Yip, Henry Lik-Yuen Chan, Yee-Kit Tse, Kelvin Long-Yan Lam, Grace Chung-Yan Lui, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
OBJECTIVES: Antiviral treatment modifies the natural history of chronic hepatitis B (CHB)-related cirrhosis as reflected by improving Model for End-Stage Liver Disease (MELD) score over time. We evaluated the impact of on-treatment change of MELD score on clinical outcomes in patients with CHB-related cirrhosis. METHODS: Cirrhotic CHB patients who received entecavir and/or tenofovir disoproxil fumarate for at least 6 months in Hong Kong between 2005 and 2016 were identified...
October 12, 2018: American Journal of Gastroenterology
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