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Pemphigus, Pemphigoid

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https://www.readbyqxmd.com/read/30083474/usefulness-of-mirna-338-3p-in-the-diagnosis-of-pemphigus-and-its-correlation-with-disease-severity
#1
Naiyu Lin, Qingxiu Liu, Menglei Wang, Qian Wang, Kang Zeng
Background: Pemphigus is a common life-threatening, autoimmune bullous disease effecting both cutaneous and mucous membranes. Previous diagnosis of pemphigus is based on clinical presentations, histopathology, immunofluorescence and enzyme-linked immunosorbent assay. Furthermore, no laboratory parameters could be used to indicate disease severity. MicroRNAs are endogenous small RNAs, which could be used as diagnostic biomarkers for some autoimmune diseases. Previously, miR-338-3p has been proven significantly up-regulated in pemphigus patients...
2018: PeerJ
https://www.readbyqxmd.com/read/29977929/autoimmune-diseases-and-their-manifestations-on-oral-cavity-diagnosis-and-clinical-management
#2
REVIEW
Matteo Saccucci, Gabriele Di Carlo, Maurizio Bossù, Francesca Giovarruscio, Alessandro Salucci, Antonella Polimeni
Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies. Indeed, an early diagnosis can play a decisive role in improving the quality of treatment strategies as well as quality of life. This can be obtained thanks to specific knowledge of oral manifestations of autoimmune diseases. This review is aimed at describing oral presentations, diagnosis, and treatment strategies for systemic lupus erythematosus, Sjögren syndrome, pemphigus vulgaris, mucous membrane pemphigoid, and Behcet disease...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29948572/thyroid-diseases-and-skin-autoimmunity
#3
REVIEW
Enke Baldini, Teresa Odorisio, Chiara Tuccilli, Severino Persechino, Salvatore Sorrenti, Antonio Catania, Daniele Pironi, Giovanni Carbotta, Laura Giacomelli, Stefano Arcieri, Massimo Vergine, Massimo Monti, Salvatore Ulisse
The skin is the largest organ of the body, at the boundary with the outside environment. Primarily, it provides a physical and chemical barrier against external insults, but it can act also as immune organ because it contains a whole host of immune-competent cells of both the innate and the adaptive immune systems, which cooperate in eliminating invading pathogens following tissue injury. On the other hand, improper skin immune responses lead to autoimmune skin diseases (AISD), such as pemphigus, bullous pemphigoid, vitiligo, and alopecia...
June 15, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29943453/suprabasal-acantholytic-dermatologic-toxicities-associated-checkpoint-inhibitor-therapy-a-spectrum-of-immune-reactions-from-paraneoplastic-pemphigus-like-to-grover-like-lesions
#4
Wei-Shen Chen, Michael T Tetzlaff, Hafeez Diwan, Richard Jahan-Tigh, Adi Diab, Kelly Nelson, Isabella C Glitza, Genevieve J Kaunitz, Daniel Johnson, Carlos Torres-Cabala, Omar Pacha, Janis M Taube, Kudakwashe Maloney, Victor G Prieto, Jonathan L Curry
Checkpoint inhibitors (CPIs) restore the function of effector immunocytes to target and destroy cancer cells. Immune-related adverse events (irAEs) are a consequence of immune reactivation, with unpredictable inflammatory response, loss of self-tolerance, and development of autoimmunity. Adverse events from CPIs that present as dermatologic toxicities have diverse clinical and histopathologic features. CPI-associated dermatologic toxicities may exhibit histopathologic features of lichenoid dermatitis, bullous pemphigoid, and granulomatous/sarcoid-like reactions...
June 25, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29930192/a-case-of-antiepiligrin-cicatricial-pemphigoid-with-extensive-cutaneous-erosions-mimicking-pemphigus-vulgaris
#5
Swastika Suvirya, Sucheta Pathania, Kiran Preet Malhotra, Parul Verma
Cicatricial pemphigoid (CP) is a chronic, autoimmune, subepidermal blistering disease with predominant mucosal involvement. In this article, we report a young patient with mucosal and extensive cutaneous involvement in the form of large erosions mimicking those of pemphigus vulgaris thus leading to diagnostic dilemma. We were unable to find any other previous reports with such extensive cutaneous erosions mimicking those of pemphigus vulgaris. Laminin 5 was the antigen found on knockout substrate testing. Antiepiligrin CP is a distinct subtype of CP with antibodies against laminin 5...
June 21, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29929566/bullous-pemphigoid-in-an-infant-a-case-report
#6
Oscar Thabouillot, Julien Le Coz, Nicolas-Charles Roche
A seven-month-old girl was referred to the emergency department (ED) after a general practitioner suspected Steven-Johnson syndrome. Actually, the diagnosis of bullous pemphigoid (BP) was made based on biopsies; BP is a rare, autoimmune skin disease involving the presence of blisters known as bullae. The child was efficiently treated with topical steroids. This case shows the importance of the ED physician's prior knowledge of BP so that a differential diagnosis with other autoimmune diseases (dermatosis, pemphigus) can be made...
June 22, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29732029/validity-and-reliability-of-the-persian-version-of-the-chronic-oral-mucosal-diseases-questionnaire
#7
Atena Shirzad, Ali Bijani, Mahsa Mehryari, Mina Motallebnejad, Saman Mohsenitavakoli
Background: Chronic oral mucosal disease q uestionnaire (COMDQ) is used to evaluate the quality of life in patients with chronic conditions of the oral mucosa. The aim of the present study was to evaluate the validity and reliability of the Persian version of this questionnaire. Methods: A total of 135 subjects were selected in two groups; group 1 consisted of 95 patients with chronic oral mucosal conditions, including recurrent aphthous stomatitis, oral lichen planus and pemphigus and mucous membrane pemphigoid and group 2 consisted of 40 patients with other oral diseases...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29729120/autoimmune-bullous-diseases-in-non-hiv-kaposi-s-sarcoma-a-retrospective-study-in-a-large-cohort-of-patients
#8
A Tourlaki, G Genovese, E Guanziroli, B M Scoppio, E Berti, L Brambilla
BACKGROUND: Kaposi's sarcoma (KS) is a rare endothelial neoplasm caused by the human herpesvirus 8 (HHV-8). Its risk is increased in immunocompromised patients, including those undergoing immunosuppressive therapy for autoimmune bullous diseases. Conversely, HHV-8 infection has been hypothesized to be a triggering factor of bullous diseases, especially pemphigus. Given the fact that both KS and autoimmune bullous diseases have a low incidence in the general population, it could be expected that the association between these disorders would be exceptional...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29719538/humoral-epitope-spreading-in-autoimmune-bullous-diseases
#9
REVIEW
Dario Didona, Giovanni Di Zenzo
Autoimmune blistering diseases are characterized by autoantibodies against structural adhesion proteins of the skin and mucous membranes. Extensive characterization of their autoantibody targets has improved understanding of pathogenesis and laid the basis for the study of antigens/epitopes diversification, a process termed epitope spreading (ES). In this review, we have reported and discussed ES phenomena in autoimmune bullous diseases and underlined their functional role in disease pathogenesis. A functional ES has been proposed: (1) in bullous pemphigoid patients and correlates with the initial phase of the disease, (2) in pemphigus vulgaris patients with mucosal involvement during the clinical transition to a mucocutaneous form, (3) in endemic pemphigus foliaceus, underlining its role in disease pathogenesis, and (4) in numerous cases of disease transition associated with an intermolecular diversification of immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29678378/desquamative-gingivitis-clinical-findings-and-diseases
#10
REVIEW
Andrea D Maderal, Paul Lee Salisbury, Joseph L Jorizzo
Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Though certain mucosal findings may be suggestive of a particular diagnosis, a thorough history, physical examination, and appropriate dermato- and immunopathologic assessment is necessary for narrowing this broad differential diagnosis...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29630151/paraneoplastic-pemphigus-without-antibodies-to-desmoglein-1-and-3
#11
Kelsey Flood, Christopher Stroud, Zelmira Lazarov, Nadarajah Vigneswaran, Sylvia Hsu
Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions. Herein, we report a patient with paraneoplastic pemphigus whose routine testing led to a diagnosis of pemphigus vulgaris. However, further testing was pursued revealing an antibody profile consistent with paraneoplastic pemphigus...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29626572/t-h-1-t-h-17-cell-recognition-of-desmoglein-3-and-bullous-pemphigoid-antigen-180-in-patients-with-lichen-planus
#12
Thomas Schmidt, Farzan Solimani, Robert Pollmann, Ronja Stein, Ansgar Schmidt, Inna Stulberg, Katja Kühn, Rüdiger Eming, Verena Eubel, Peter Kind, Nicole Arweiler, Cassian Sitaru, Michael Hertl
No abstract text is available yet for this article.
April 4, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29575350/regulatory-t-cells-in-autoimmune-skin-diseases
#13
Hideyuki Ujiie
CD4+ Foxp3+ regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and functions of Tregs, changes in cytokine and chemokine levels related to Tregs and the differences in genetic background regarding Tregs in autoimmune skin disorders. Recent studies have extended our knowledge of certain properties of Tregs, especially skin-resident Tregs...
March 25, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29575160/association-of-serious-infections-with-pemphigus-and-pemphigoid-analysis-of-the-nationwide-inpatient-sample
#14
Z Ren, S Narla, D Y Hsu, J I Silverberg
BACKGROUND: Pemphigus and pemphigoid are blistering disorders associated with barrier disruption, immune dysregulation and use of immunosuppressing systemic therapy, all of which may predispose towards serious infections. OBJECTIVES: To determine whether pemphigus and pemphigoid are associated with increased likelihood of serious infections and the impact of such infections on mortality and cost of care. METHODS: We analysed data from the 2002 to 2012 Nationwide Inpatient Sample, including a representative 20% sample of all hospitalizations in the US (total n = 72 108 077 adults)...
March 25, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29569809/commentary-on-changing-prevalence-of-diabetes-mellitus-in-bullous-pemphigoid-it-is-the-dipeptidyl-peptidase-4-inhibitors
#15
LETTER
L Fania, G Di Zenzo, C Mazzanti, D Abeni
No abstract text is available yet for this article.
March 23, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29569760/changing-prevalence-of-diabetes-mellitus-in-bullous-pemphigoid-it-is-the-dipeptidyl-peptidase-4-inhibitors
#16
LETTER
A Gravani, G Gaitanis, T Tsironi, S Tigas, I D Bassukas
No abstract text is available yet for this article.
March 23, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29566927/blistering-diseases-in-the-mature-patient
#17
Ines Lakoš Jukić, Sandra Jerković Gulin, Branka Marinović
Autoimmune blistering diseases (AIBD) are a group of chronic diseases affecting the skin and mucous membranes, with different presentation, clinical course, histologic and immunopathologic findings, and different therapeutic approach. Blisters develop as a result of autoantibodies directed against distinct adhesion structures within desmosomes or within the basement membrane zone. The most common AIBD that develops in the elderly is bullous pemphigoid (previously also named "pemphigoid senilis"), but mature patients can also present with other AIBD as mucous membrane pemphigoid, epidermolysis bullosa acquisita, paraneoplastic pemphigus, pemphigus vulgaris, pemphigus foliaceus, linear IgA dermatosis, and dermatitis herpetiformis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29520266/effectiveness-and-safety-of-rituximab-in-recalcitrant-pemphigoid-diseases
#18
Aniek Lamberts, H Ilona Euverman, Jorrit B Terra, Marcel F Jonkman, Barbara Horváth
Introduction: Rituximab (RTX) is a monoclonal antibody targeting CD20, a transmembrane protein expressed on B cells, causing B cell depletion. RTX has shown great efficacy in studies of pemphigus vulgaris, but data of pemphigoid diseases are limited. Objective: To assess the effectiveness and safety of RTX in pemphigoid diseases. Methods: The medical records of 28 patients with pemphigoid diseases that were treated with RTX were reviewed retrospectively...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29392620/treatment-of-autoimmune-bullous-disorders-in-pregnancy
#19
REVIEW
Carolyn J Kushner, Josef Symon S Concha, Victoria P Werth
Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety and efficacy of therapeutic interventions during the perinatal period are lacking because randomized controlled trials are typically not performed in this setting. However, many of the treatments for AIBD are also used in other diseases, so data can be extrapolated from studies or case reports in these other patient populations...
June 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29341355/reflectance-confocal-microscopy-and-optical-coherence-tomography-for-the-diagnosis-of-bullous-pemphigoid-and-pemphigus-and-surrounding-sub-clinical-lesions
#20
V D Mandel, E Cinotti, E Benati, B Labeille, S Ciardo, C Vaschieri, F Cambazard, J L Perrot, G Pellacani
BACKGROUND: Diagnosis of bullous pemphigoid (BP) and pemphigus is based on clinical features, histology, immunofluorescence and laboratory data. OBJECTIVES: To evaluate features of BP and pemphigus at reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in order to provide a rapid non-invasive bed-side diagnosis. Secondary objective was to evaluate the detectability of clinically non-visible lesions. METHODS: This was an observational, retrospective, multicentre study in which patients with suspicious lesions for BP or pemphigus underwent clinical assessment, RCM, OCT, blood tests and skin biopsy for histological and direct immunofluorescence examinations from January 2014 to December 2015...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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