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Caustic Esophageal Burns

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https://www.readbyqxmd.com/read/30086993/effects-of-topical-application-of-platelet-rich-plasma-on-esophageal-stricture-and-oxidative-stress-after-caustic-burn-in-rats-is-autologous-treatment-possible
#1
Mustafa Onur Oztan, Fatma Demet Arslan, Sule Oztan, Gulden Diniz, Gokhan Koyluoglu
BACKGROUND: Caustic esophageal burn is still an important health problem in pediatric surgery. Although there are a number of experimental and clinical studies to increase the recovery of the esophagus and reduce the stenosis rate, there is no consensus on the treatment protocol. Platelet-rich plasma (PRP) is an autologous blood product, which has positive effects on wound healing, reepithelization and scar prevention. The aim of our study was to investigate the effects of PRP on stricture formation and oxidative status after caustic esophageal injury in rats...
August 1, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29992379/barrett-s-esophagus-in-children-what-is-the-evidence
#2
REVIEW
Maja Raicevic, Amulya K Saxena
BACKGROUND: This study systematically reviewed etiology, prevalence, treatment and outcome of Barrett's esophagus (BE) in the pediatric population. METHODS: PubMed® was searched for terms "Barrett's esophagus" and "children". End points were age of patients, etiology, association with other syndromes, treatment, incidence of carcinoma and outcome. This review was conducted according to the PRISMA guidelines. Data were collected, entered and analyzed into a Microsoft Excel® spreadsheet database...
July 10, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29951983/the-effect-of-platelet-rich-plasma-on-motility-changes-in-experimental-caustic-esophageal-burn
#3
Mustafa Onur Oztan, Sule Oztan, Neslihan Duzenli, Murat Olukman, Gokhan Koyluoglu
BACKGROUND: Besides stricture formation, diminished esophageal motility after caustic esophageal burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of caustic burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes. METHODS: Twenty-one Wistar albino rats were divided into three groups [Sham operation (n = 8), caustic esophageal burn with NaOH (n = 6), PRP treatment after caustic burn (n = 7)]...
July 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29892928/halofuginone-improves-caustic-induced-oxidative-injury-of-esophagus-in-rats
#4
Kıvılcım Karadeniz Cerit, Berna Karakoyun, Elif Bahadır, Meral Yüksel, Nurdan Bülbül, Feriha Ercan, E Tolga Dağlı, Berrak Ç Yeğen
BACKGROUND: The aim of this study is to evaluate the anti-inflammatory and anti-fibrotic effects of halofuginone in caustic esophageal burn injury in rats. MATERIALS AND METHODS: Corrosive esophageal injury (CEI) was produced in male Wistar albino rats by instilling NaOH solution (1 ml, 37.5%) into the distal esophagus. Rats were decapitated on the 3rd day (early group) or 28th day (late group), and treated daily with either saline or halofuginone (100 µg/kg/day; i...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29286326/role-of-rdw-in-prediction-of-burn-after-caustic-substance-ingestion
#5
Emrah Aydin, Omer Faruk Beser, Soner Sazak, Ensar Duras
A quantifiable, quick, inexpensive and reproducible predictor is needed to decide if caustic substance ingestion results in burn regardless of the symptoms. A multicenter cohort study was conducted to investigate the predictive value of red cell distribution width (RDW) in detecting the esophageal burns. The data of 174 patients were retrospectively analyzed. Eleven patients were excluded due to inability to define the substance ingested. Complete blood count (CBC) was taken at admission, and an esophagogastroduodenoscopy was performed within the first 12-24 h in all patients, regardless of their symptoms...
December 29, 2017: Children
https://www.readbyqxmd.com/read/28881910/effect-of-polaprezinc-on-experimental-corrosive-esophageal-burns-in-rats
#6
A Ozbayoglu, K Sonmez, R Karabulut, Z Turkyilmaz, A Poyraz, O Gulbahar, A C Basaklar
Unconsciously caustic ingestion is one of the most common causes of serious esophageal strictures in children. The aim of this study is to determine the efficiency of polaprezinc in preventing stricture formation after corrosive esophageal burns (CEB); this was the first time it has been used to treat experimental CEB in rats. Twenty-four rats were divided into four groups, three of which received CEB by the instillation of 1 mL of 10% NaOH solution into their isolated esophageal segments for three minutes...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28502435/caustic-ingestions-and-foreign-bodies-ingestions-in-pediatric-patients
#7
REVIEW
Jacob A Kurowski, Marsha Kay
Children inevitably swallow foreign material accidentally or intentionally. Each type of ingestion carries their own set of risks and complications, short and long term, some requiring immediate attention while others close monitoring. Alkalotic household cleaning products and lithium button batteries are increasingly common and damage the esophagus quickly. While many toys with rare-earth metals are banned, they are already present in many households and can cause necrosis of bowel that is between the magnets...
June 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28451845/reflux-esophagitis-and-its-role-in-the-pathogenesis-of-barrett-s-metaplasia
#8
REVIEW
Rhonda Frances Souza
Reflux esophagitis damages the squamous epithelium that normally lines the esophagus, and promotes replacement of the damaged squamous lining by the intestinal metaplasia of Barrett's esophagus, the precursor of esophageal adenocarcinoma. Therefore, to prevent the development of Barrett's metaplasia and esophageal adenocarcinoma, the pathogenesis of reflux esophagitis must be understood. We have reported that reflux esophagitis, both in a rat model and in humans, develops as a cytokine-mediated inflammatory injury (i...
July 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28375474/minimally-invasive-substernal-colonic-transposition-for-corrosive-strictures-of-the-upper-aerodigestive-tract
#9
J K Banerjee, R Saranga Bharathi
Corrosive upper aerodigestive tract strictures are conventionally treated by open surgery. Surgical advancements permit these strictures to be addressed with minimal invasion. Corrosive strictures treated minimally invasively over a 2-year period (2014-2015) were audited. Colonic mobilization and retrosternal tunneling were performed laparoscopically. The left colic vessel-based isoperistaltic colonic/ileocolonic segment was transposed substernally into the neck, aided by miniceliotomy. Proximal anastomosis was side-to-side esophagocolic in all patients except those who underwent pharyngolaryngectomy or partial laryngectomy, where pharyngocolic/pyriform fossa-ileal anastomosis was employed...
April 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28340493/conservative-treatment-with-octreotide-to-provide-early-recovery-of-children-with-esophageal-perforation
#10
Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez, Abdullah Can Basaklar
BACKGROUND: The effectiveness of nonoperative treatment of esophageal perforation (EP) in children with octreotide is highlighted. METHODS: Records of nine patients (seven boys and two girls with an average age of 5.83 ± 5.35 years) with EP were reviewed. RESULTS: EP developed in six patients during dilation of esophageal stenosis (five of six caused by caustic burns). In the other three patients, EP developed after nasogastric placement, after endotracheal intubation, and during endoscopy for foreign body...
August 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28333543/corrosive-induced-carcinoma-of-esophagus-esophagographic-and-ct-findings
#11
Seung Yeon Noh, Hyun Jin Kim, Hyun Joo Lee, Seong Ho Park, Jong Seok Lee, Ah Young Kim, Hyun Kwon Ha
OBJECTIVE: The purpose of this study was to evaluate the esophagographic and CT findings of corrosive esophageal cancer. MATERIALS AND METHODS: The records of all patients who presented with corrosive esophageal strictures at one institution between June 1989 and April 2015 were retrospectively identified. The search yielded the records of 15 patients with histopathologically proven esophageal cancer. Esophagograms (13 patients) and chest CT images (14 patients) were interpreted independently by two reviewers...
June 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28318189/evaluation-of-esophageal-injuries-secondary-to-ingestion-of-unlabeled-corrosive-substances-pediatric-case-series
#12
Gonul Kucuk, Gulnur Gollu, Ufuk Ates, Zeynep A Cakmak, Meltem Kologlu, Aydın Yagmurlu, Tanju Aktug, Huseyin Dindar, Ahmet M Cakmak
Esophageal or gastric injuries secondary to caustic substance ingestion is still an important issue in developing countries. Its clinical spectrum can vary from absence of mucosal injury to complications such as severe burns, strictures and perforation. Physical examination and first endoscopic evaluation are very important in the diagnosis. The objective of this study is to present 154 children who were undergone upper gastrointestinal endoscopy because of caustic substance ingestion including descaler, degreaser, unlabeled bleach, drain opener, surface cleaner, dishwasher rinse aid, hydrochloric acid...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28281403/effectiveness-of-endoscopic-balloon-dilatation-in-grade-2a-and-2b-esophageal-burns-in-children
#13
Hakan Taşkinlar, Gökhan Berktuğ Bahadir, Doğakan Yiğit, Cankat Erdoğan, Dinçer Avlan, Ali Nayci
PURPOSE: To evaluate the predictability of the initial endoscopic evaluation of the effectiveness of endoscopic balloon dilatation (EBD) in childhood esophageal strictures caused by corrosive ingestion. MATERIAL AND METHODS: Medical records of 635 endoscopies caused by corrosive ingestion between January 2000 and December 2015 in children between the ages of 0 and 18 years were retrospectively analyzed. Among them, five children with grade 2a and 15 with grade 2 b who developed esophageal strictures were evaluated for the effectiveness of endoscopic balloon dilatation...
October 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28191325/management-of-esophageal-burns-caused-by-caustic-ingestion-a-case-report
#14
Bita Shahbazzadegan, Mehdi Samadzadeh, Iraj Feizi, Yousef Shafaiee
INTRODUCTION: Domestic and industrial swallowing of caustic substances can cause acute and chronic injuries. In the acute phase of care, focus is on the immediate control of tissue damage and perforation, and in the chronic phase, the focus is on the treatment of pharyngeal narrowing and impaired swallowing. CASE PRESENTATION: The patients of this report were an 18-year-old man and a 20-year-old woman, who had esophageal burns after ingesting chemicals, and for solving their nutritional problems, such as difficulty in swallowing, they had underwent surgery...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27955797/acute-esophageal-injury-and-strictures-following-corrosive-ingestions-in-a-27year-cohort
#15
Timothy Cowan, Robert Foster, Geoffrey K Isbister
PURPOSE: We aimed to determine the incidence of esophageal strictures in corrosive ingestions and potential predictors of severe injury. BASIC PROCEDURES: This was a retrospective cohort study of corrosive ingestions from a toxicology unit (1987-2013) with telephone follow-up at least 1 y post-ingestion. Clinical data and investigations were obtained from a toxicology admission database. The primary outcome was esophageal stricture. Other outcomes included in-hospital mortality, endoscopy grade and early complications...
March 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27872426/gastric-tube-esophageal-reconstruction-in-children-with-esophageal-atresia-and-caustic-stricture-study-of-clinical-value-based-on-25-single-center-centre-experience
#16
Maja Milickovic, Djordje Savic, Blagoje Grujic, Aleksandar Vlahovic, Miroslav Vukadin, Mila Stajevic, Vladimir Kojovic
AIM: The aim of this study was estimation of clinical value of gastric tube esophagoplasty in children based on one single center experience. METHODS: Forty-nine patients with diagnosis of EA (n=22) and caustic esophageal injury (n=27) had undergone reverse gastric tube esophagoplasty during 25 years at our institution. Almost all EA patients received initially gastrostomy and cervical esophagostomy. Majority of CS patients had initially repeated dilatation therapy...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27859311/basic-mechanism-of-button-battery-ingestion-injuries-and-novel-mitigation-strategies-after-diagnosis-and-removal
#17
Kris R Jatana, Keith Rhoades, Scott Milkovich, Ian N Jacobs
OBJECTIVES/HYPOTHESIS: Button battery (BB) injuries continue to be a significant source of morbidity and mortality, and there is a need to confirm the mechanism of injury for development of additional mitigation strategies. STUDY DESIGN: Cadaveric piglet esophageal model. METHODS: Lithium, silver oxide, alkaline, and zinc-air BBs were placed in thawed sections of cadaveric piglet esophagus, bathed in normal saline. Severity of gross visual burn, pH, and temperature were recorded every 30 minutes for 6 hours...
June 2017: Laryngoscope
https://www.readbyqxmd.com/read/27424019/caustic-agent-ingestion-by-a-1-5-year-old-boy
#18
Behdad Gharib, Masoud Mohammadpour, Bahareh Yaghmaie, Meisam Sharifzadeh, Mehrzad Mehdizadeh, Fatemeh Zamani, Rouhollah Edalatkhah, Reihaneh Mohsenipour
We present a case of caustic ingestion by a 1.5-year-old boy. The caustic agent was drain opener which is a strong alkaline substance. Children in Iran and many other countries are still exposed to not "child proof" (child resistant packaging) toxic substance containers. Ingestion of caustic agents may lead to necrosis, perforation, and strictures. Substances that are ingested more frequently are liquid alkali material which causes severe, deep liquefaction necrosis. Common signs and symptoms of caustic agents are vomiting, drooling, refusal to drink, oral burns, stridor, hematemesis, dyspnea, dysphagia and abdominal pain...
July 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/26687065/conservative-management-of-severe-caustic-injuries-during-acute-phase-leads-to-superior-long-term-nutritional-and-quality-of-life-qol-outcome
#19
K Raynaud, D Seguy, M Rogosnitzky, F Saulnier, F R Pruvot, Philippe Zerbib
PURPOSE: Best clinical management of severe caustic injury is still a subject of debate. Most surgical teams consider severe caustic injury as an indication for emergency surgery. But, under certain circumstances, conservative management is feasible, avoids the need for gastrectomy, and has a low mortality rate. Postponed reconstructive surgery is usually performed several months after caustic ingestion to restore intestinal continuity or to treat stricture sequelae. This study aimed to investigate long-term nutritional and quality of life (QoL) outcomes after reconstructive surgery for high-grade esophageal and gastric caustic injury...
February 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/26587125/colon-bypass-with-a-colon-flap-augmentation-pharyngoesophagoplasty
#20
Mark Tettey, Frank Edwin, Ernest Aniteye, Martin Tamatey, Ekow Entsua-Mensah, Ernest Offosu-Appiah, Innocent Adzamli
Extensive caustic stricture of the upper aero-digestive system (oro- and hypo-pharynx) is a severe injury with limited surgical options. We adopted augmentation of the cicatrized upper aero-digestive tract with colon as our preferred management option. The aim of this report is to describe our initial experience with the technique of colon-flap augmentation pharyngo-esophagoplasty (CFAP) for selected patients with severe pharyngo-esophageal stricture. Between October 2011 and June 2013, three male patients (aged 16, 4 and 18 years respectively) underwent CFAP following extensive pharyngo-esophageal stricture...
2015: Pan African Medical Journal
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