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premature coronary arterial disease

Kamran Zafar, Nirav Patil
The clinical characteristics and outcomes among patients with inpatient-onset non-ST-segment-elevation acute coronary syndrome have not been fully investigated. Therefore, we conducted a retrospective single-center analysis of patients who were ≥18 years old and diagnosed with acute coronary syndrome at our hospital during 2014. We performed logistic regression analysis to evaluate outcomes and made adjustments for age, race, family history of premature coronary artery disease, and comorbidities. Our search through 31,274 hospital discharge records identified 683 cases of acute coronary syndrome: 32 were inpatient-onset and 651 were outpatient-onset...
June 2018: Texas Heart Institute Journal
Amos Levi, Chava Chezar-Azerrad, David Hasdai, Roy Beigel, Shmuel Gottlieb, Alon Eisen, Nir Shlomo, Ilan Goldenberg, Uri Landes, Ran Kornowski, Zaza Iakobishvili
Family history of premature cardiovascular disease (FHpCVD) is a well-established risk factor for development of coronary artery disease. However, little is known about the impact of FHpCVD on the outcome of patients presenting with acute coronary syndrome (ACS). We therefore aimed to evaluate the outcomes of ACS patients grouped by the presence and/or absence of FHpCVD. All patients ≤65 at admission who had an ACS event and were enrolled in the national ACS Israel Survey registry from 2000 to 2013 were included...
June 25, 2018: American Journal of Cardiology
Max-Paul Winter, Franz Wiesbauer, Hermann Blessberger, Noemi Pavo, Patrick Sulzgruber, Kurt Huber, Johann Wojta, Klaus Distelmaier, Irene M Lang, Georg Goliasch
BACKGROUND: Premature myocardial infarction (≤40 years) represents a rare disease with a distinct risk factor-profile and a lipid phenotype that is characterized by a predominance of elevated triglyceride-rich lipoproteins. So far high-density and low-density lipoproteins remain the primary targets for risk stratification and treatment evaluation in coronary artery disease, but this strategy might be insensitive in patients with premature myocardial infarction. AIM: Aim of the present study was to investigate the predictive value of different lipid fractions on long term cardiovascular outcome in patients with premature myocardial infarction...
July 30, 2018: European Journal of Clinical Investigation
Masoumeh Lotfi-Tokaldany, Abbasali Karimi, Nazila Shahmansouri, Saeed Sadeghian, Seyed Hesameddin Abbasi, Arash Jalali, Farah Ayatollahzade Isfahani, Soheil Saadat
To assess illness perceptions in patients with premature atherosclerotic coronary artery disease (CAD), 717 adults with premature CAD (diagnosis of CAD in men age < 45 years and women age < 55 years) completed sociodemographic indices, the Beck's Depression Inventory-II, Beck Anxiety Inventory and the Brief Illness Perceptions 8 years after the diagnosis. Mean age was 49.59 ± 3.57 years for men and 57.72 ± 4.90 years for women at the time of study. Both sexes were treated through coronary artery bypass graft surgery, percutaneous coronary intervention, or medical treatment...
July 24, 2018: Journal of Clinical Psychology in Medical Settings
Leonardo De Luca, Marcello Arca, Pier Luigi Temporelli, Furio Colivicchi, Lucio Gonzini, Donata Lucci, Biagio Bosco, Mariella Callerame, Giulio Vladimiro Lettica, Andrea Di Lenarda, Michele Massimo Gulizia
INTRODUCTION: Familiar hypercholesterolemia (FH) is an inherited disorder characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) associated with premature cardiovascular disease. METHODS: Using the data from the START (STable Coronary Artery Diseases RegisTry) study, a nationwide, prospective survey on patients with stable coronary artery disease (CAD), we described prevalence and lipid lowering strategies commonly employed in these patients...
July 23, 2018: Clinical Cardiology
Corina Iorgoveanu, Ahmed Zaghloul, Aakash Desai, Anand M Krishnan, Kathir Balakumaran
Cardiovascular diseases, including heart disease and stroke, are the world's largest killers. More than 800,000 people die from cardiovascular disease each year in the United States (US). Heart disease is estimated to cost 200 billion US Dollars (USD) annually. Early identification of an inexpensive marker which allows for early intervention is the need of the hour. We present a case describing one such marker which can be easily appreciated on physical examination. Several studies have shown, not only the association between the presence of the diagonal earlobe crease (DELC) and coronary artery disease (CAD) but also a correlation with the extent and severity of CAD, independent of cardiovascular risk factors...
May 13, 2018: Curēus
Fan Wang, Isabel Z Wang, Stephen Ellis, Stephen Archacki, John Barnard, Carlos Hubbard, Eric J Topol, Qiuyun Chen, Qing K Wang
Apolipoprotein A5 (APOA5) regulates the metabolisms of triglyceride and HDL. APOA5 variants have been linked to coronary artery disease (CAD), but their causal roles are not well studied yet. This study aims to identify the causal effects of APOA5 variants on premature CAD. Sequencing analysis of APOA5 in 128 premature, familiar CAD patients from GeneQuest identified 11 genomic variants, including p.S19W (rs3135506). SKAT analysis showed that all sequenced variants, in aggregate, significantly increased the risk of premature CAD (P-skat = 0...
July 19, 2018: Annals of Human Genetics
Joel G Ray, Tianhua Huang, Wendy S Meschino, Eyal Cohen, Alison L Park
OBJECTIVE: To examine whether abnormal prenatal biochemical screening results are associated with an increased risk of premature cardiovascular disease after pregnancy. DESIGN: Population based cohort study. SETTING: The entire province of Ontario, Canada, where healthcare is universally available. PARTICIPANTS: Women aged 12-55 years, without pre-existing cardiovascular disease, who underwent prenatal screening between 1993 and 2011...
July 11, 2018: BMJ: British Medical Journal
Feng-Jung Yang, Kai-Hsiang Shu, Hung-Yuan Chen, I-Yu Chen, Fang-Yun Lay, Yi-Fang Chuang, Chien-Sheng Wu, Wan-Chuan Tsai, Yu-Sen Peng, Shih-Ping Hsu, Chih-Kang Chiang, George Wang, Yen-Ling Chiu
Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown...
2018: Immunity & Ageing: I & A
Matilde Alique, Rafael Ramírez-Carracedo, Guillermo Bodega, Julia Carracedo, Rafael Ramírez
Atherosclerosis, a chronic inflammatory disease that causes the most heart attacks and strokes in humans, is the leading cause of death in the developing world; its principal clinical manifestation is coronary artery disease. The development of atherosclerosis is attributed to the aging process itself (biological aging) and is also associated with the development of chronic diseases (premature aging). Both aging processes produce an increase in risk factors such as oxidative stress, endothelial dysfunction and proinflammatory cytokines (oxi-inflamm-aging) that might generate endothelial senescence associated with damage in the vascular system...
July 9, 2018: International Journal of Molecular Sciences
Loukianos S Rallidis, Estela Kiouri, Andreas Katsimardos, Christos Kotakos
BACKGROUND AND AIMS: The latest guidelines from the American Association of Clinical Endocrinologists (AACE) and the American College of Endocrinology (ACE) proposed a new "extreme-risk" category of patients, for whom a low-density lipoprotein cholesterol (LDL-C) level <55 mg/dL (1.4 mmol/L) is advised. We aimed to identify the proportion of patients with stable coronary artery disease (CAD), who are at extreme cardiovascular (CV) risk, and explore how achievable is the new LDL-C goal...
June 18, 2018: Atherosclerosis
Elyssa Cannaerts, Marlies Kempers, Alessandra Maugeri, Carlo Marcelis, Thatjana Gardeitchik, Julie Richer, Dimitra Micha, Luc Beauchesne, Janneke Timmermans, Paul Vermeersch, Nathalie Meyten, Sébastien Chénier, Gerarda van de Beek, Nils Peeters, Maaike Alaerts, Dorien Schepers, Lut Van Laer, Aline Verstraeten, Bart Loeys
BACKGROUND: Missense variants in SMAD2 , encoding a key transcriptional regulator of transforming growth factor beta signalling, were recently reported to cause arterial aneurysmal disease. OBJECTIVES: The aims of the study were to identify the genetic disease cause in families with aortic/arterial aneurysmal disease and to further define SMAD2 genotype-phenotype correlations. METHODS AND RESULTS: Using gene panel sequencing, we identified a SMAD2 nonsense variant and four SMAD2 missense variants, all affecting highly conserved amino acids in the MH2 domain...
July 2, 2018: Journal of Medical Genetics
Esther Mm Ooi, Katrina L Ellis, P Hugh R Barrett, GeraldF Watts, Joseph Hung, John P Beilby, Peter L Thompson, Paul Stobie, Brendan M McQuillan
BACKGROUND AND AIMS: Lipoprotein(a) [Lp(a)] is an emerging genetic risk factor for cardiovascular disease (CVD). We examined whether plasma Lp(a) concentration and apolipoprotein(a) [apo(a)] isoform size are associated with extent and severity of coronary artery disease (CAD), and the presence of carotid artery plaque. METHODS: We included in our study male participants (n = 263) from a cohort with angiographically defined premature CAD (Carotid Ultrasound in Patients with Ischemic Heart Disease)...
June 18, 2018: Atherosclerosis
Andriany Qanitha, Cuno S P M Uiterwaal, Jose P S Henriques, Abdul Hakim Alkatiri, Idar Mappangara, Ali Aspar Mappahya, Ilhamjaya Patellongi, Bastianus A J M de Mol
OBJECTIVE: To provide a detailed description of characteristics at hospital admission and clinical outcomes at 30-day and 6-month follow-up in patients hospitalised with coronary artery disease (CAD) in a poor South-East Asian setting. DESIGN: Prospective observational cohort study. SETTING: From February 2013 to December 2014, in Makassar Cardiac Center, Indonesia. PARTICIPANTS: 477 patients with CAD (acute coronary syndrome and stable CAD)...
June 27, 2018: BMJ Open
Latha Palaniappan, Arun Garg, Enas Enas, Henrietta Lewis, Sehrish Bari, Martha Gulati, Cristina Flores, Ashish Mathur, Cesar Molina, Jagat Narula, Shahid Rahman, Jennifer Leng, Francesca Gany
South Asians (SAs) are at heightened risk for cardiovascular disease as compared to other ethnic groups, facing premature and more severe coronary artery disease, and decreased insulin sensitivity. This disease burden can only be partially explained by conventional risk factors, suggesting the need for a specific cardiovascular risk profile for SAs. Current research, as explored through a comprehensive literature review, suggests the existence of population specific genetic risk factors such as lipoprotein(a), as well as population specific gene modulating factors...
June 12, 2018: Journal of Community Health
A J Scheen
Cardiovascular disease still represents, together with cancer, a major cause of morbidity and mortality. Atherosclerosis is a silent progressive process, which can start in early life and usually progresses with advancing age. Besides genetic predisposition, atherosclerosis is accelerated by the presence of several modifiable risk factors such as smoking, dyslipidaemia, arterial hypertension and diabetes mellitus. Asymptomatic atherosclerosis may lead to an acute event, mostly due to plaque rupture and secondary thrombosis...
May 2018: Revue Médicale de Liège
Michael C Honigberg, Amy A Sarma
PURPOSE OF REVIEW: To educate clinicians on cardiovascular considerations and management strategies surrounding pregnancy in childhood cancer survivors. RECENT FINDINGS: With advances in oncologic treatment, growing numbers of childhood cancer survivors are now able to consider pregnancy. A significant proportion of survivors have received cardiotoxic therapy, particularly anthracyclines, and/or chest radiation. Cardiomyopathy is the most common cardiac complication of cancer-directed therapy; pericardial disease, valvular disease, premature coronary artery disease, and conduction abnormalities are other potential sequelae...
June 19, 2018: Current Treatment Options in Cardiovascular Medicine
David M Herrington, Chunhong Mao, Sarah J Parker, Zongming Fu, Guoqiang Yu, Lulu Chen, Vidya Venkatraman, Yi Fu, Yizhi Wang, Timothy D Howard, Goo Jun, Caroline F Zhao, Yongmei Liu, Georgia Saylor, Weston R Spivia, Grace B Athas, Dana Troxclair, James E Hixson, Richard S Vander Heide, Yue Wang, Jennifer E Van Eyk
BACKGOUND: The inability to detect premature atherosclerosis significantly hinders implementation of personalized therapy to prevent coronary heart disease. A comprehensive understanding of arterial protein networks and how they change in early atherosclerosis could identify new biomarkers for disease detection and improved therapeutic targets. METHODS: Here we describe the human arterial proteome and proteomic features strongly associated with early atherosclerosis based on mass spectrometry analysis of coronary artery and aortic specimens from 100 autopsied young adults (200 arterial specimens)...
June 19, 2018: Circulation
Ozan M Demir, Luciano Candilio, Daniel Fuster, Robert Muga, Giuseppe Barbaro, Antonio Colombo, Lorenzo Azzalini
Human Immunodeficiency Virus (HIV) infection affects 36.7 million people worldwide, it accounted for 1.1 million deaths in 2015. The advent of combined antiretroviral therapy (cART) has been associated with a decrease in HIV-related morbidity and mortality. However, there are increasing concerns about long-lasting effects of chronic inflammation and immune activation, leading to premature aging and HIV-related mortality. Cardiovascular diseases, especially coronary artery disease, are among the leading causes of death in HIV-infected patients, accounting for up to 15% of total deaths in high income countries...
August 15, 2018: International Journal of Cardiology
Mariko Harada-Shiba, Hidenori Arai, Yasushi Ishigaki, Shun Ishibashi, Tomonori Okamura, Masatsune Ogura, Kazushige Dobashi, Atsushi Nohara, Hideaki Bujo, Katsumi Miyauchi, Shizuya Yamashita, Koutaro Yokote
Statement1. Familial hypercholesterolemia (FH) is an autosomal hereditary disease with the 3 major clinical features of hyper-LDL-cholesterolemia, premature coronary artery disease and tendon and skin xanthomas. As there is a considerably high risk of coronary artery disease, in addition to early diagnosis and intensive treatment, family screening (cascade screening) is required (Recommendation level A)2.For a diagnosis of FH, at least 2 of the following criteria should be satisfied:① LDL-C ≥180 mg/dL, ② Tendon/skin xanthomas, ③ History of FH or premature coronary artery disease (CAD) within 2nd degree blood relatives (Recommendation level A)3...
June 7, 2018: Journal of Atherosclerosis and Thrombosis
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