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premature coronary arterial disease

Tadeusz Osadnik, Natalia Pawlas, Marta Lonnie, Kamila Osadnik, Mateusz Lejawa, Lidia Wądołowska, Kamil Bujak, Martyna Fronczek, Rafał Reguła, Marcin Gawlita, Joanna Katarzyna Strzelczyk, Marta Góral, Marek Gierlotka, Lech Poloński, Mariusz Gąsior
Dietary habits of healthy offspring with a positive family history of premature coronary artery disease (P-CAD) have not been studied so far. The aim of this study was twofold: (1) to identify dietary patterns in a sample of young healthy adults with (cases) and without (controls) family history of P-CAD, and (2) to study the association between dietary patterns and family history of P-CAD. The data came from the MAGNETIC case-control study. The participants were healthy adults aged 18⁻35 years old, with ( n = 351) and without a family history of P-CAD ( n = 338)...
October 12, 2018: Nutrients
Sarah S Pickard, Kimberlee Gauvreau, Michelle Gurvitz, Joshua J Gagne, Alexander R Opotowsky, Kathy J Jenkins, Ashwin Prakash
Adults with repaired coarctation of the aorta (CoA) suffer reduced long-term survival compared with the general population, in part due to coronary artery disease (CAD). There is conflicting evidence as to whether or not CoA is an independent risk factor for CAD. The primary aim was to determine if CoA is independently associated with premature myocardial infarction (MI) in the contemporary era. The secondary aim was to determine if CoA is independently associated with early coronary intervention. In a cross-sectional study using the National Inpatient Sample database from 2005 to 2014, we compared the age at MI and the age at coronary intervention (coronary artery bypass grafting or percutaneous coronary intervention, in the absence of MI diagnosis) in patients with and without CoA using weighted linear regression...
September 21, 2018: American Journal of Cardiology
Rodrigo Alonso, Leopoldo Perez de Isla, Ovidio Muñiz-Grijalvo, Jose Luis Diaz-Diaz, Pedro Mata
Familial hypercholesterolaemia is the most common monogenic disorder associated with premature coronary artery disease. Mutations are most frequently found in the LDL receptor gene. Clinical criteria can be used to make the diagnosis; however, genetic testing will confirm the disorder and is very useful for cascade screening. Early identification and adequate treatment can improve prognosis, reducing negative clinical cardiovascular outcomes. Patients with familial hypercholesterolaemia are considered at high cardiovascular risk and the treatment target is LDL cholesterol <2...
August 2018: European Cardiology
Luis R Macias-Kauffer, Hugo Villamil-Ramírez, Paola León-Mimila, Leonor Jacobo-Albavera, Carlos Posadas-Romero, Rosalinda Posadas-Sánchez, Blanca E López-Contreras, Sofía Morán-Ramos, Sandra Romero-Hidalgo, Víctor Acuña-Alonzo, Blanca E Del-Río-Navarro, Maria-Cátira Bortolini, Carla Gallo, Gabriel Bedoya, Francisco Rothhammer, Rolando González-Jose, Andrés Ruiz-Linares, Christopher R Stephens, Rafael Velazquez-Cruz, Cecilia Fernández Del Valle-Laisequilla, Juan G Reyes-García, Lina M Barranco Garduño, Miriam Del C Carrasco-Portugal, Francisco J Flores-Murrieta, Gilberto Vargas-Alarcón, Carlos A Aguilar-Salinas, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
BACKGROUND: Serum uric acid (SUA) is a heritable trait associated with cardiovascular risk factors and coronary artery disease (CAD). Genome wide association studies (GWAS) have identified several genes associated with SUA, mainly in European populations. However, to date there are few GWAS in Latino populations, and the role of SUA-associated single nucleotide polymorphisms (SNPs) in cardiovascular disease has not been studied in the Mexican population. METHODS: We performed genome-wide SUA association study in 2153 Mexican children and adults, evaluated whether genetic effects were modified by sex and obesity, and used a Mendelian randomization approach in an independent cohort to study the role of SUA modifying genetic variants in premature CAD...
October 1, 2018: International Journal of Cardiology
Elizabeth Blair Solow, Wanpen Vongpatanasin, Brian Skaug, David R Karp, Colby Ayers, James A de Lemos
OBJECTIVES: Patients with clinically evident autoimmune disease are at increased risk for premature cardiovascular disease (CVD). Markers of serological autoimmunity such as anti-nuclear antibodies (ANA) are found in approximately 25% of the general population. Yet, the vast majority will not develop clinical autoimmune disease. Serological autoimmunity is a risk factor for CVD death in individuals without autoimmune disease; however, the mechanisms mediating this excess CVD risk have not been elucidated...
September 17, 2018: Clinical and Experimental Rheumatology
Perry Wengrofsky, Ghassan Mubarak, Ahmed Shim, Pramod Theetha Kariyanna, Adam Buzidkowski, Jacob Schwartz, Samy I McFarlane
Marijuana abuse is rapidly growing and currently it is the most coimnon drug of abuse in the United States due to increased legalization for recreational and medicinal use. Delta 9-tetrahydrocannibol, the main psychoactive compound in marijuana, acts via the endocannabinoid system to elicit various cardiovascular physiological effects, and has been associated with many adverse cardiovascular effects such as acute coronary syndrome, arrhythmias, and sudden cardiac death that have previously been reported by our group and others...
2018: American journal of medical case reports
Amalia Peix, Diana Paez
Cardiovascular diseases (CVDs) constitute the main cause of death in Latin America (LA), with ischemic heart disease (IHD) as the principal cause in most countries. Women are particularly at risk of premature death by CVDs. Nevertheless, in LA, as in other parts of the world, there is a misconception at public level of the importance of CVDs in women; thus, CVDs do not get as much coverage as breast cancer campaigns. Women frequently have atypical symptoms and nonobstructive coronary artery disease as well as inequity in medical and interventional treatments; therefore, care should be built upon these differences...
October 5, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
P Chemaly, O Nallet, N Delarche, C Legagneur, R Boulestreau, I Reibel, C Palette, A Grenier, H Courtade, G Beaune, L Belle, J-L Georges
BACKGROUND: Familial hypercholesterolemia (FH) is a frequent genetic disorder that leads to premature atherosclerosis and coronary artery disease. However, knowledge of FH by cardiologists is weak, and FH remains underdiagnosed in France. FH should be suspected when low-density lipoprotein cholesterol (LDLc) levels exceed 1.9g/L (4.9mmol/L) without lipid lowering therapy. PURPOSE: This multicenter retro- and prospective observational study aimed at estimating the prevalence of high LDLc levels in patients admitted in coronary care units, and the impact for the personal and familial follow-up for lipid status...
October 2, 2018: Annales de Cardiologie et D'angéiologie
Olivier S Descamps, Olivier Van Caenegem, Michel P Hermans, Jean-Luc Balligand, Christophe Beauloye, Antoine Bondue, Stéphane Carlier, Emilie Castermans, Fabien Chenot, Marc Claeys, Christophe De Block, Anne de Leener, Antoine De Meester, Fabian Demeure, Herbert De Raedt, Walter Desmet, Ivan Elegeert, Michel Guillaume, Etienne Hoffer, Raymond Kacenelenbogen, Patrizio Lancellotti, Michel Langlois, Attilio Leone, Ann Mertens, Nicolas Paquot, Olivier Vanakker, Jean-Louis Vanoverschelde, Ann Verhaegen, Pieter Vermeersch, Caroline Wallemacq, Ernst Rietzschel
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) is an autosomal dominant lipoprotein disorder characterized by significant elevation of low-density lipoprotein cholesterol (LDL-C) and markedly increased risk of premature cardiovascular disease (CVD). Because of the very high coronary artery disease risk associated with this condition, the prevalence of FH among patients admitted for CVD outmatches many times the prevalence in the general population. Awareness of this disease is crucial for recognizing FH in the aftermath of a hospitalization of a patient with CVD, and also represents a unique opportunity to identify relatives of the index patient, who are unaware they have FH...
October 2018: Atherosclerosis
Mariko Harada-Shiba, Junya Ako, Hidenori Arai, Atsushi Hirayama, Yoshitaka Murakami, Atsushi Nohara, Asuka Ozaki, Kiyoko Uno, Masato Nakamura
BACKGROUND AND AIMS: Prevalence of familial hypercholesterolemia (FH), a common genetic disorder with a high risk for coronary artery disease (CAD), is high among CAD patients; however, data on FH prevalence among acute coronary syndrome (ACS) patients are limited. EXPLORE-J is the largest registry to diagnose FH among Japanese ACS patients using the 2012 Japan Atherosclerosis Society guidelines. METHODS: This prospective study consecutively recruited patients between April 2015 and August 2016 at 59 sites...
October 2018: Atherosclerosis
Andreea Dumitrescu, Svetlana Mosteoru, Dragos Vinereanu, Gheorghe A Dan, Laura Gaita, Dan Gaita
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is one of the most frequent monogenic cholesterol disorders. Its prevalence varies in adults between 1/500-1/217 individuals in the heterozygous form. The objective of this study was to uncover the FH prevalence in Romania to perform an adequate prevention for high risk individuals. METHODS: We have conducted an epidemiological study between January 2015 and January 2018 by recruiting patients from the CardioPrevent Foundation based on their FH score (taking into account their low density lipoprotein cholesterol (LDLc) levels, clinical characteristics such as premature coronary artery disease (CAD), and their family history of premature cardiovascular disease)...
October 2018: Atherosclerosis
Lamija Pojskic, Belma Pojskic
BACKGROUND AND AIMS: We aimed to estimate the frequency of cardiovascular diseases in familial hypercholesterolemia (FH) patients in Bosnia and Herzegovina. METHODS: We screened lipid profiles in the hospital system during the period March 2008-November 2016, and included 307 patients with LDL>4.5 mmol/L. FH was diagnosed according to the Dutch Lipid Clinic Network (DLCN) criteria. Followed parameters were: the presence of coronary artery disease (CAD), premature CAD (defined as men<55yrs,women<65yrs), cerebral vascular disease (CVD)...
October 2018: Atherosclerosis
Ayman Jubran, Anna Zetser, Barak Zafrir
BACKGROUND: Elevated lipoprotein(a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD). However, its role in real-world practice and implications for clinical care remains limited. Under investigation herein, are the clinical characteristics associated with increased Lp(a) levels in patients presenting with acute coronary syndrome (ACS). METHODS: Lp(a) was measured at admission in patients ≤ 65 years of age presenting with ACS in a single center...
September 20, 2018: Cardiology Journal
Micaela Iantorno, Sahar Soleimanifard, Michael Schär, Todd T Brown, Gabriele Bonanno, Patricia Barditch-Crovo, Lena Mathews, Shenghan Lai, Gary Gerstenblith, Robert G Weiss, Allison G Hays
BACKGROUND AND AIMS: Coronary artery disease (CAD) is now an important cause of premature death in people with HIV but the causes of accelerated CAD are poorly understood. Epicardial adipose tissue (EAT) is metabolically-active and thought to contribute to CAD development. We tested the hypothesis that abnormal coronary endothelial function (CEF), an early marker and mediator of atherosclerosis, is related to the amount of local pericoronary EAT in HIV. METHODS: We studied 36 participants with HIV and no CAD (HIV+ CAD-), 15 participants with HIV and known CAD (HIV+ CAD+), and 14 age-matched, healthy participants without HIV (HIV-CAD-)...
August 17, 2018: Atherosclerosis
J F Argacha, T Mizukami, T Bourdrel, M-A Bind
An integrated exposomic view of the relation between environment and cardiovascular health should consider the effects of both air and non-air related environmental stressors. Cardiovascular impacts of ambient air temperature, indoor and outdoor air pollution were recently reviewed. We aim, in this second part, to address the cardiovascular effects of noise, food pollutants, radiation, and some other emerging environmental factors. Road traffic noise exposure is associated with increased risk of premature arteriosclerosis, coronary artery disease, and stroke...
September 8, 2018: Trends in Cardiovascular Medicine
Stephen A Freitas, Ross MacKenzie, David N Wylde, Jason Von Bergen, J Carl Holowaty, Margaret Beckman, Steven J Rigatti, Stacy Gill
OBJECTIVE: -To determine the all-cause mortality of life insurance applicants having a family history of coronary artery disease (CAD) before age 60. BACKGROUND: -Epidemiological studies have shown that a family history of premature CAD is an independent risk factor for CAD events. The strength of the association between family history and CAD is greatest with earlier age of presentation of CAD in the family member and when multiple family members are affected. Despite earlier insurance studies on this relationship, there is sparse current data on the association between family history of CAD and all-cause mortality in life insurance applicants...
January 2018: Journal of Insurance Medicine
Joanna Iwanicka, Tomasz Iwanicki, Paweł Niemiec, Anna Balcerzyk, Jolanta Krauze, Sylwia Górczyńska-Kosiorz, Anna Ochalska-Tyka, Władysław Grzeszczak, Iwona Żak
The cholesteryl ester transfer protein (CETP) gene encodes a hydrophobic glycoprotein that plays a crucial role in the reverse transport of cholesterol. The aim of the present study was to determine whether CETP polymorphisms (rs1532624, rs247616 and rs708272) are associated with coronary artery disease (CAD) in a Polish population. Serum lipid levels and single nucleotide polymorphisms of CETP genes were determined in 494 subjects: 248 patients with premature CAD and 246 blood donors as controls. Selected polymorphisms were examined using TaqMan PCR analysis...
September 3, 2018: Molecular Biology Reports
Sai Lv, Wei Liu, Yujie Zhou, Yuyang Liu, Dongmei Shi, Yingxin Zhao, Xiaoli Liu
BACKGROUND: Coronary artery disease (CAD) is showing an increasing trend in young adults. Cigarette smoking has been shown to be a major cause of premature CAD. Previous studies have also shown that hyperuricemia (HUA) is associated with CAD; however, the interaction effect between HUA and smoking on CAD is uncertain. Therefore, this study was designed to determine the relationship and interactive effects of HUA and smoking on the risk of CAD in young adults ≤ 35 years of age. METHODS: In this observational study we consecutively included adults (18-35 years of age) with suspected CAD who underwent coronary angiography for the first time in our institution from January 2005 to December 2015...
August 31, 2018: BMC Cardiovascular Disorders
Jin-Sheng Wang, Yi-Gen Shen, Ri-Peng Yin, Saroj Thapa, Yang-Pei Peng, Kang-Ting Ji, Lian-Ming Liao, Jia-Feng Lin, Yang-Jing Xue
BACKGROUND: Patients with frequent premature ventricular contractions (PVCs) are often symptomatic. Catheter ablation was usually indicated to eliminate symptoms in patients with PVCs-induced cardiomyopathy. Currently, PVCs-ablation is also applied for patients with PVCs and no structural heart diseases (SHD); however, the safety and efficacy of ablation in these patients remains unclear. METHODS: In this retrospective study, data from patients who underwent ablation for PVCs from January 2010 to December 2016 at our hospital was retrieved...
August 31, 2018: BMC Cardiovascular Disorders
Laust Dupont Rasmussen, Morten Bøttcher, Per Ivarsen, Hanne Skou Jørgensen, Mette Nyegaard, Henriette Buttenschøn, Camilla Gustafsen, Simon Glerup, Hans Erik Bøtker, My Svensson, Simon Winther
Background: Chronic kidney disease is a risk factor for premature development of coronary atherosclerosis and mortality. A high level of proprotein convertase subtilisin/kexin type 9 (PCSK9) is a recently recognized cardiovascular risk factor and has become the target of effective inhibitory treatment. In 167 kidney transplantation candidates, we aimed to: (i) compare levels of PCSK9 with those of healthy controls, (ii) examine the association between levels of PCSK9 and low-density lipoprotein cholesterol (LDL-c) and the degree of coronary artery disease (CAD) and (iii) evaluate if levels of PCSK9 predict major adverse cardiac events (MACE) and mortality...
August 22, 2018: Nephrology, Dialysis, Transplantation
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