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https://www.readbyqxmd.com/read/28936467/peroxisome-motility-measurement-and-quantification-assay
#1
Jeremy Metz, Inês G Castro, Michael Schrader
Organelle movement, distribution and interaction contribute to the organisation of the eukaryotic cell. Peroxisomes are multifunctional organelles which contribute to cellular lipid metabolism and ROS homeostasis. They distribute uniformly in mammalian cells and move along microtubules via kinesin and dynein motors. Their metabolic cooperation with mitochondria and the endoplasmic reticulum (ER) is essential for the β-oxidation of fatty acids and the synthesis of myelin lipids and polyunsaturated fatty acids...
September 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28935206/tlr7-8-agonists-stimulate-plasmacytoid-dendritic-cells-to-initiate-a-th17-deviated-acute-contact-dermatitis-in-humans
#2
Natalie Garzorz-Stark, Felix Lauffer, Linda Krause, Jenny Thomas, Anne Atenhan, Regina Franz, Sophie Roenneberg, Alexander Boehner, Manja Jargosch, Richa Batra, Nikola S Mueller, Stefan Haak, Christina Groß, Olaf Groß, Claudia Traidl-Hoffmann, Fabian J Theis, Carsten B Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich
BACKGROUND: A standardized human model to study early pathogenic events in psoriasis is missing. Activation of Toll-like receptor 7/8 by topical application of imiquimod is the most commonly used mouse model of psoriasis. OBJECTIVE: To investigate the potential of a human imiquimod patch test model to resemble human psoriasis. METHODS: Imiquimod (Aldara® 5% cream) was applied twice a week onto the back of volunteers (n=18) and the development of skin lesions was monitored over a time period of four weeks...
September 18, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28934541/contact-dermatitis-reaction-to-2-octyl-cyanoacrylate-following-3-orthopedic-procedures
#3
Nicholas H Lake, Brian T Barlow, James E Toledano, Johannah Valentine, Lucas S McDonald
Two-octyl cyanoacrylate is a popular skin adhesive used for closing surgical incisions. Since Food and Drug Administration approval in 1998, the few reports of adverse reactions following its use have primarily been limited to the nonorthopedic literature. The authors present a case series of contact dermatitis associated with 2-octyl cyanoacrylate following orthopedic surgery and a review of the literature on the diagnosis and treatment of this complication. All 3 patients presented with blistering around their incisions within 2 weeks of surgery and responded to treatment involving removal of the offending agent and use of oral diphenhydramine and hydroxyzine and topical triamcinolone...
September 21, 2017: Orthopedics
https://www.readbyqxmd.com/read/28934511/multi-drug-resistant-surgical-site-infection-due-to-mycobacterium-abscessus-complex
#4
Richa Misra, Vidhi Jain, Nidhi Tejan, Aarti Negi, Jyoti Umrao, Tapan Nirodhechand Dhole
M. abscessus complex is notoriously resistant to most antimicrobial agents. The complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. Skin and soft tissue infections due to this organism can be acquired by direct contact with contaminated material through traumatic injury, surgical wound and environmental exposure or by secondary involvement of skin/soft tissue during disseminated disease. We report a case of Mycobacterium abscessus infection recovered from a post-operative mid-line abdominal wound to illustrate the diagnostic and management difficulties encountered in such patients...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934326/the-effect-of-electronic-health-record-software-design-on-resident-documentation-and-compliance-with-evidence-based-medicine
#5
Yasaira Rodriguez Torres, Jordan Huang, Melanie Mihlstin, Mark S Juzych, Heidi Kromrei, Frank S Hwang
This study aimed to determine the role of electronic health record software in resident education by evaluating documentation of 30 elements extracted from the American Academy of Ophthalmology Dry Eye Syndrome Preferred Practice Pattern. The Kresge Eye Institute transitioned to using electronic health record software in June 2013. We evaluated the charts of 331 patients examined in the resident ophthalmology clinic between September 1, 2011, and March 31, 2014, for an initial evaluation for dry eye syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/28934228/knowledge-about-tuberculosis-transmission-and-prevention-and-perceptions-of-health-service-utilization-among-index-cases-and-contacts-in-brazil-understanding-losses-in-the-latent-tuberculosis-cascade-of-care
#6
Flavia Matos Salame, Márcia Danielle Ferreira, Marcia Teresa Belo, Eleny Guimarães Teixeira, Marcelo Cordeiro-Santos, Ricardo Arraes Ximenes, Maria de Fátima Militão de Albuquerque, Philip C Hill, Dick Menzies, Anete Trajman
INTRODUCTION: Tuberculosis contacts are candidates for active and latent tuberculosis infection screening and eventual treatment. However, many losses occur in the different steps of the contacts' cascade of care. Reasons for this are poorly understood. OBJECTIVE: To describe the different steps where losses in the contact cascade occur and to explore knowledge and attitudes regarding tuberculosis transmission/prevention and perceptions about tuberculosis services in order to understand the reasons for losses from the tuberculosis service users' perspective...
2017: PloS One
https://www.readbyqxmd.com/read/28934124/n-halamine-biocidal-materials-with-superior-antimicrobial-efficacies-for-wound-dressings
#7
Buket Demir, Roy M Broughton, Mingyu Qiao, Tung-Shi Huang, S D Worley
This work demonstrated the successful application of N-halamine technology for wound dressings rendered antimicrobial by facile and inexpensive processes. Four N-halamine compounds, which possess different functional groups and chemistry, were synthesized. The N-halamine compounds, which contained oxidative chlorine, the source of antimicrobial activity, were impregnated into or coated onto standard non-antimicrobial wound dressings. N-halamine-employed wound dressings inactivated about 6 to 7 logs of Staphylococcus aureus and Pseudomonas aeruginosa bacteria in brief periods of contact time...
September 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28932886/immediate-responses-of-the-cockroach-blaptica-dubia-after-the-exposure-to-sulfur-mustard
#8
Tanja Popp, Robin Lüling, Ingrid Boekhoff, Thomas Seeger, Francisco Branoner, Thomas Gudermann, Horst Thiermann, Franz Worek, Dirk Steinritz
The chemical agent sulfur mustard (SM) causes erythema, skin blisters, ulcerations, and delayed wound healing. It is accepted that the underlying molecular toxicology is based on DNA alkylation. With an expected delay, DNA damage causes impairment of protein biosynthesis and disturbance of cell division. However, using the cockroach model Blaptica dubia, the presented results show that alkylating compounds provoke immediate behavior responses along with fast changes in the electrical field potential (EFP) of neurons, suggesting that lesions of DNA are probably not the only effect of alkylating compounds...
September 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28931203/scalpel-versus-electrosurgery-for-major-abdominal-incisions
#9
REVIEW
Kittipat Charoenkwan, Zipporah Iheozor-Ejiofor, Kittipan Rerkasem, Elizabeth Matovinovic
BACKGROUND: Scalpels or electrosurgery can be used to make abdominal incisions. The potential benefits of electrosurgery may include reduced blood loss, dry and rapid separation of tissue, and reduced risk of cutting injury to surgeons. Postsurgery risks possibly associated with electrosurgery may include poor wound healing and complications such as surgical site infection. OBJECTIVES: To assess the effects of electrosurgery compared with scalpel for major abdominal incisions...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28930779/inhibition-of-lymphatic-drainage-with-a-self-designed-surgical-approach-prolongs-the-vascularized-skin-allograft-survival-in-rats
#10
Jiaomiao Pei, Yang Li, Chen Chen, Xi Zhang, Shiping Wang, Yajuan Song, Bei Liu, Yingjun Su, Shuzhong Guo
Vascularized composite allotransplantation (VCA) is an emerging treatment for significant tissue defects. However, VCAs usually consist of multiple highly antigenic skin tissues. Previous studies have shown that the lymphatic system in skin plays important roles in the initiation of immune responses during acute rejection, by transporting T cells and antigen-presenting dendritic cells to regional lymph nodes. Therefore, we designed a new surgical treatment to inhibit lymphatic drainage of skin allografts and investigated whether this approach could promote the survival of allografts and suppress immunological events after transplantation...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28929966/-a-case-with-scalp-pruritus-caused-by-dermanysus-gallinae-order-mesostigmata
#11
Mustafa Şengül, Nida Kaçar, Mehmet Karaca, Sedef Zeliha Öner, Çağrı Ergin
Dermanyssus gallinae is one of the important hematophagous ectoparasite species of poultry like chicken, pigeon and wild bird species. These ectoparasites in the form of nymphs or adults who can not find their hosts are also seen in mammals and even in humans. For this reason, they are considered as important for public health. The ectoparasite causes a clinical condition named gamasoidosis among pet owners and people who live or work close to animal shelters, barns and chicken farms. Pruritus dermatitis is also caused by D...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929511/dermatotoxicology-of-sulfur-mustard-historical-perspectives-from-world-war-i
#12
REVIEW
Austin Jiang, Howard Maibach
Sulfur mustard has been used as a chemical warfare agent for the past century. After its introduction by the Germans in World War I, investigators quickly began studying its impact on the human body including its deleterious effects on skin. This review focuses on two groups in particular who conducted experiments from 1917 to 1918: the United States Army at the American University Experiment Station Laboratories and Torald Sollmann at Western Reserve University. Through this work, these researchers proved far ahead of their time by anticipating dermatologic phenomena not described in the literature until later in the twentieth century...
September 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28927887/epidermal-overexpression-of-xenobiotic-receptor-pxr-impairs-the-epidermal-barrier-and-triggers-th2-immune-response
#13
Andreas Elentner, Matthias Schmuth, Nikolaos Yannoutsos, Thomas O Eichmann, Robert Gruber, Franz Pw Radner, Martin Hermann, Barbara Del Frari, Sandrine Dubrac
The skin is in daily contact with environmental pollutants, but the long-term effects of such exposure remain under-investigated. Many of these toxins bind and activate the pregnane x receptor (PXR), a ligand-activated transcription factor that regulates genes central to xenobiotic metabolism. The objective of this work was to investigate the effect of constitutive activation of PXR in the basal layer of the skin to mimic repeated skin exposure to noxious molecules. We designed a transgenic mouse model which overexpresses the human PXR gene linked to the herpes simplex VP16 domain under the control of the keratin 14 promoter...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28922112/effects-of-flexible-dry-electrode-design-on-electrodermal-activity-stimulus-response-detection
#14
Peter A Haddad, Amir Servati, Saeid Soltanian, Frank Ko, Peyman Servati
OBJECTIVE: The focus of this research is to evaluate the effects of design parameters including surface area, distance between and geometry of dry flexible electrodes on electrodermal activity (EDA) stimulus response detection. METHODS: EDA is a result of the autonomic nervous system (ANS) being stimulated, which causes sweat and changes the electrical characteristics of the skin. Standard silver/silver chloride (Ag/AgCl) EDA electrodes are rigid and lack conformability in contact with skin...
September 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28919761/effects-of-bromadiolone-poisoning-on-the-central-nervous-system
#15
Meiling Wang, Yanfeng Yang, Yiwei Hou, Wenbin Ma, Rui Jia, Jinbo Chen
Cases of rodenticide poisoning (second-generation long-acting dicoumarin rodenticide, superwarfarin) have occasionally been reported. The main symptoms of bromadiolone poisoning are skin mucosa hemorrhage, digestive tract hemorrhage, and hematuresis. However, the symptoms of central nervous system toxicity have rarely been reported. Our case reports on a 41-year-old male who had no contact with bromadiolone. His main symptoms were dizziness, unsteady gait, and abnormal behavior. Laboratory test results revealed the presence of bromadiolone in his blood and urine, a longer prothrombin time, activated partial thromboplastin time, and a high international normalized ratio...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28919542/ageing-reduces-light-touch-and-vibrotactile-sensitivity-on-the-anterior-lower-leg-and-foot-dorsum
#16
R L Mildren, M C Yip, C R Lowery, C Harpur, S H M Brown, L R Bent
Cutaneous mechanoreceptors in the anterior lower leg and foot dorsum provide important information about contact with objects and movement at the knee and ankle. This cutaneous feedback contributes to static and dynamic balance control. We conducted experiment 1 to determine the effects of ageing on anterior lower leg cutaneous feedback. We measured light touch (monofilament) perceptual thresholds (MPT) at seven skin sites across the anterior lower leg and foot dorsum in 12 young (5 male, aged 21-28) and 13 older adults (8 male, aged 73-92)...
September 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28918339/interference-of-dibutylphthalate-on-human-prostate-cell-viability
#17
Mariana Di Lorenzo, Maurizio Forte, Salvatore Valiante, Vincenza Laforgia, Maria De Falco
Dibutylphthalate (DBP) is an environmental pollutant widely used as plasticizer in a variety of industrial applications worldwide. This agent can be found in personal-care products, children's toy, pharmaceuticals, food products. Exposure to DBP can occur via ingestion and inhalation as well as intravenous or skin contact. DBP belongs to the family of endocrine disrupting chemicals (EDCs) and its effects on reproductive system were demonstrated both in vivo and in vitro. In the present study we evaluated the effects of DBP on human prostate adenocarcinoma epithelial cells (LNCaP) in order to highlight xenoestrogens influence on human prostate...
September 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28918228/primary-photosensitization-and-contact-dermatitis-caused-by-malachra-fasciata-jacq-n-v-malvaceae-in-sheep
#18
Valber Onofre de Araújo, Temístocles Soares Oliveira Neto, Sara Vilar Dantas Simões, Thatyana Kelly Ferreira da Silva, Franklin Riet-Correa, Ricardo Barbosa Lucena
Farmers from Paraiba state, Northeast Brazil, claim that Malachra fasciata causes cutaneous lesions in sheep. To test its toxicity the plant was harvested daily and fed ad libitum for 21 days to 3 sheep as the sole food source (# 1-3). An additional sheep (# 4) was maintained as a control. Cutaneous lesions of photosensitization initiated after 7 days and increased continuously over the next 21 days. The dose ingested varied between 129 g/kg to 175 g/kg. Alopecia, hyperemia and crusting were observed in the animals...
September 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28915955/implications-of-bisphosphonate-calcium-ion-depletion-interfering-with-desmosome-epithelial-seal-in-osseointegrated-implants-and-pressure-ulcers
#19
Louis Z G Touyz, Kelvin I Afrashtehfar
Osteoporosis (OP) is a global bone disease prevalent in aging in humans, especially in older women. Bisphosphonates (BPs) are commonly used as therapy for OP as it influences hard and soft tissues calcium metabolism. Mucosal and dermal ulceration with exposure of underlying bone arises from incomplete epithelial recovery due to reduced desmosome formation deriving from lack of available calcium. Pathological situations such as bisphosphonate-related osteonecrosis of the jaw have been described. This hypothesis states other situations which demand intact functional desmosomes such as healing skin over chronic pressure points leading to pressure ulcers (as well-known as bedsores, pressure sores, pressure injuries, decubitus ulcers), and hemidesmosomes such as epithelial seals in contact with titanium surfaces will have a higher prevalence of breakdown among patients being treated with BPs...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915129/atypical-exit-wound-in-high-voltage-electrocution
#20
Jamshid Parakkattil, Shanmugam Kandasamy, Siddhartha Das, Gerard Pradeep Devnath, Vinod Ashok Chaudhari, Kusa Kumar Shaha
Electrocution fatality cases are difficult to investigate. High-voltage electrocution burns resemble burns caused by other sources, especially if the person survives for few days. In that case, circumstantial evidence if correlated with the autopsy findings helps in determining the cause and manner of death. In addition, the crime scene findings also help to explain the pattern of injuries observed at autopsy. A farmer came in contact with a high-voltage transmission wire and sustained superficial to deep burns over his body...
September 14, 2017: American Journal of Forensic Medicine and Pathology
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