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Skin to skin contact

Seema Shetty, Shashikiran Umakanth, Bhawani Manandhar, Pankaj Bahadur Nepali
Leprosy and tuberculosis (TB) are endemic to India, however, their coinfection is not frequently encountered in clinical practice. Here, we report a 32-year-old female patient who presented with a history of high-grade intermittent fever, cough and painless skin lesions since a month, along with bilateral claw hand (on examination). The haematological profile was suggestive of anaemia of chronic disease, chest radiograph showed consolidation, sputum smears were positive for Mycobacterium tuberculosis, and skin slit smear confirmed leprosy...
March 15, 2018: BMJ Case Reports
Jianping Cao, Xu Zhang, Yinping Zhang
Dermal exposure to indoor gas-phase semi-volatile organic compounds (SVOCs) has recently received a great deal of attention, and this has included evaluating the role of clothing in this process. Several models have been developed to assess dermal exposure to SVOCs, based on the transient mass transfer of SVOCs from air to dermal capillaries. However, these models assume either that clothing completely retards SVOC transport, or that there is an air gap of constant thickness between the clothing and the surface of the skin, leading to significant errors in the model calculations...
March 15, 2018: Environmental Science & Technology
Pei Huang, Yuanqing Li, Xiao-Guang Yu, Wei-Bin Zhu, Shu-Yan Nie, Hao Zhang, Jin-Rui Liu, Ning Hu, Shao-Yun Fu
The mimicry of human skin to detect both oncoming and physical-contacting object is of great importance in the fields of manufacturing, artificial robots and vehicles, etc. Herein, a novel bio-inspired flexible and highly responsive dual-mode strain/magnetism composite sensor which works via both contact and contactless modes, is first fabricated by incorporating Fe3O4/silicone system into a carbon fiber aerogel. The distance-dependence of magnetic field endorses the CFA/Fe3O4/silicone composite possible for spatial sensing due to the introduction of Fe3O4 magnetic nanoparticles...
March 15, 2018: ACS Applied Materials & Interfaces
Stefanie Kamann, Olivier Aerts, Lutz Heinemann
In the past decade, new diabetes technologies, including continuous glucose monitoring (CGM) systems, support patients with diabetes in their daily struggle with achieving a good glucose control. However, shortly after the first CGM systems appeared on the market, also the first concerns about adverse skin reactions were raised. Most patients claimed to suffer from (sometimes severe) skin irritation, or even allergy, which they related to the (acrylate-based) adhesive part of the device. For a long time the actual substance that caused these skin reactions with, for example, the Flash Glucose Monitoring system (iscCGM; Freestyle® Libre) could not be identified; however, recently Belgian and Swedish dermatologists reported that the majority of their patients that have developed a contact-allergic while using iscCGM react sensitively to a specific acrylate, that is, isobornyl acrylate (IBOA)...
March 1, 2018: Journal of Diabetes Science and Technology
Zhaohua Zhang, Xiangning Tang, Jun Li, Wenyi Yang
PURPOSE: To investigate the effect of cold stimulation (contacting wet fabric) and tactile stimulation (dynamic friction) on skin wetness perception: 1) wetness perception of fabric with different water transfer performance; 2) wetness perception of fabric with different water content; 3) wetness perception of fabric at different friction velocity with skin. METHODS: Twenty participants were screened as reliable assessors using a 7-point wetness rating scale. The dynamic friction between skin and fabric was simulated by a self-made device with adjustable speed controller...
March 14, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
Almut Prkno, Matthias Kaiser, Daniela Goerigk, Martin Pfeffer, Thomas W Vahlenkamp, Donata Hoffmann, Martin Beer, Alexander Starke
Cowpox virus (CPXV) infection is a reportable and potentially zoonotic disease that occurs sporadically in a variety of animals. During the past six decades, CPXV infection has been extensively researched and described in both domestic (cat, dog, horse, cattle) and zoo animals (e. g. elephant, rhinoceros, okapi). Of note, a review of the literature produced only three reports of CPXV in individual or small groups of South American camelids. The goal of this review was to describe the current knowledge as it relates to clinical features of CPXV infection in South American camelids and to compare the clinical manifestations with those described in other animal species...
February 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
Carsten Goebel, Thomas L Diepgen, Brunhilde Blömeke, Anthony A Gaspari, Axel Schnuch, Anne Fuchs, Kordula Schlotmann, Maya Krasteva, Ian Kimber
Occupational exposure of hairdressers to hair dyes has been associated with the development of allergic contact dermatitis (ACD) involving the hands. p-Phenylenediamine (PPD) and toluene-2,5-diamine (PTD) have been implicated as important occupational contact allergens. To conduct a quantitative risk assessment for the induction of contact sensitization to hair dyes in hairdressers, available data from hand rinsing studies following typical occupational exposure conditions to PPD, PTD and resorcinol were assessed...
March 9, 2018: Regulatory Toxicology and Pharmacology: RTP
Christoph Skudlik, Marcella Markthaler, Swen M John
No abstract text is available yet for this article.
April 2018: Contact Dermatitis
David A Rafei-Shamsabadi, Saskia van de Poel, Britta Dorn, Stefanie Kunz, Stefan F Martin, Christoph S N Klose, Sebastian J Arnold, Yakup Tanriver, Karolina Ebert, Andreas Diefenbach, Timotheus Y F Halim, Andrew N J McKenzie, Thilo Jakob
Allergic contact dermatitis and its animal model, contact hypersensitivity (CHS), are T cell-mediated inflammatory skin diseases that require activation of the innate immune system. Here we investigate the role of innate lymphoid cells (ILCs) during the elicitation phase of TNCB-induced CHS using EomesGfp/+ x Rorc(γt)-CreTg x Rosa26RYfp/+ reporter mice. Ear swelling responses, cutaneous ILC numbers and cytokine production were determined at different time points. Functional analyses were performed in a CD90...
March 8, 2018: Journal of Investigative Dermatology
B Diczig, I Németh, Gy Pónyai, M Sárdy
Rosacea is a chronic skin disease characterized by inflammatory processes affecting mainly the center of the face. The pathophysiology is complex, environmental factors seem to play an important role in the exacerbation and worsening of the lesions. The barrier-dysfunction theory in atopic dermatitis has been well described in the literature. This article is protected by copyright. All rights reserved.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Hajime Suto, Aya Nambu, Hideaki Morita, Sachiko Yamaguchi, Takafumi Numata, Takamichi Yoshizaki, Eri Shimura, Ken Arae, Yousuke Asada, Kenichiro Motomura, Mari Kaneko, Takaya Abe, Akira Matsuda, Yoichiro Iwakura, Ko Okumura, Hirohisa Saito, Kenji Matsumoto, Katsuko Sudo, Susumu Nakae
BACKGROUND: As well as thymic stromal lymphopoietin (TSLP) and IL-33, IL-25 is known to induce Th2 cytokine production by various cell types-including Th2 cells, Th9 cells, invariant NKT cells and group 2 innate lymphoid cells-involved in Th2-type immune responses. Since both Th2-type and Th17-type cells/cytokines are crucial for contact hypersensitivity (CHS), IL-25 may contribute to this by enhancing Th2-type immune responses. However, the precise role of IL-25 in the pathogenesis of FITC-induced CHS is poorly understood...
March 6, 2018: Journal of Allergy and Clinical Immunology
Luz Fonacier, Irum Noor
OBJECTIVE: Contact dermatitis (CD) is a common disease seen by allergists. Although underutilized, patch testing (PT) remains the gold standard in the diagnosis of allergic CD. It is not difficult to perform, however, the interpretation of the PT, proper classification of the results and determination of their relevance, need an appropriate level of expertise. The objective of this article is to provide a review of CD and its key allergens and provide updates and recommendations for the practicing allergist...
March 6, 2018: Annals of Allergy, Asthma & Immunology
Anne-Claire Pierrefeu-Lagrange, Karine Mari, Caroline Hoss, Breda Cullen, Lorraine Nisbet
INTRODUCTION: Dressings are a mainstay for wound management; however, dressing adherence to the wound or periwound area can cause pain and trauma at removal. Dressing-related trauma includes skin reactions, adherence to the wound, and skin stripping. The development of atraumatic wound contact layer dressings has been a major advancement in reducing trauma. OBJECTIVE: This study compares the benefits of a cellulose acetate mesh (CAM) coated with soft silicone versus a flexible polyamide net (FPN) coated with soft silicone...
January 26, 2018: Wounds: a Compendium of Clinical Research and Practice
Mathieu Garand, Martin Goodier, Olumuyiwa Owolabi, Simon Donkor, Beate Kampmann, Jayne S Sutherland
Tuberculosis (TB) is still a global health concern, especially in resource-poor countries such as The Gambia. Defining protective immunity to TB is challenging: its pathogenesis is complex and involves several cellular components of the immune system. Recent works in vaccine development suggest important roles of the innate immunity in natural protection to TB, including natural killer (NK) cells. NK cells mediate cellular cytotoxicity and cytokine signaling in response to Mycobacterium tuberculosis (Mtb). NK cells can display specific memory-type markers to previous antigen exposure; thus, bridging innate and adaptive immunity...
2018: Frontiers in Immunology
S Daens, D Grossin, T Hermanns-Lê, D Peeters, D Manicourt
We report the history of a 15-year old patient with a hypermobile Ehlers-Danlos syndrome (hEDS) (his mother, his two brothers and his sister have the same phenotype as him). He suffers mainly from a severe mast cell activation syndrome (MCAS) with an overreaction of the skin to any kind of contact (water of the shower, clothes, bed sheets) but he has also fatigue, headaches, and rash. This impressive rash is exacerbated after the shower and he has the urge to rest («shower's sign»). We describe the MCAS and its easy, fast and very effective medication management, without any significant side effects as well as its frequent association with the hEDS...
February 2018: Revue Médicale de Liège
Louiza Sophocleous, Inez Frerichs, Martijn Miedema, Merja Kallio, Thalia Papadouri, Christina Karaoli, Tobias Becher, David G Tingay, Anton van Kaam, Richard H Bayford, Andreas Daniel Waldmann
OBJECTIVE: Critically ill neonates and infants might particularly benefit from continuous chest electrical impedance tomography (EIT) monitoring at the bedside. In this study a textile 32-electrode interface for neonatal EIT examination has been developed and tested to validate its clinical performance. The objectives were to assess ease of use in a clinical setting, stability of contact impedance at the electrode-skin interface and possible adverse effects. APPROACH: Thirty preterm infants (gestational age: 30...
March 8, 2018: Physiological Measurement
Valentina Galbiati, Sue Gibbs, Erwin Roggen, Emanuela Corsini
Recently, an in vitro procedure, which combines the epidermal equivalent potency assay with assessment of IL-18 to provide a single test for identification and classification of skin sensitizers, was developed and validated. This unit will describe a simple in vitro method for estimation of the expected sensitization induction level interpolating in vitro EC50 and IL-18 SI2 values to predict LLNA EC3 and/or human NOEL from standards curves generated using reference contact allergens, based on the use of Reconstituted human Epidermis (RhE)...
February 21, 2018: Current Protocols in Toxicology
Devika Iddawela, Sanura Malinda Pallegoda Vithana, Dhilma Atapattu, Lanka Wijekoon
BACKGROUND: Leishmaniasis, a vector borne tropical/subtropical disease caused by the protozoan Leishmania is transmitted to humans by sandfly vectors Phlebotomus and Lutzomyia. The principal form found in Sri Lanka is cutaneous leishmaniasis (CL) and is caused by Leishmania donovani. A rising trend in disease prevalence has been observed recently in Sri Lanka and the island is in fact the newest endemic focus in South Asia. Determining the prevalence of smear positivity among clinically suspected CL patients, identifying risk factors and specific clinical presentations of CL in order to implement preventive and early treatment strategies were the objectives of this study...
March 6, 2018: BMC Infectious Diseases
Muhammad Yunusa, Guillermo J Amador, Dirk M Drotlef, Metin Sitti
The wrinkling and interfacial adhesion mechanics of a gallium oxide nanofilm encapsulating a liquid gallium droplet are presented. Such native oxide nanofilm provides mechanical stability by preventing the flow of the liquid metal. We show how such few nanometers-thick, crumpled oxide skin behaves akin to a highly bendable elastic nanofilm under ambient conditions. Upon compression, a wrinkling instability emerges at the contact interface to relieve the applied stress. As the load is further increased, radial wrinkles evolve and, eventually, the oxide nanofilm ruptures...
March 6, 2018: Nano Letters
Mark H Ebell, Thuy Nhu Thai, Kyle J Royalty
Background: Recommendations regarding cancer screening vary from country to country, and may also vary within countries depending on the organization making the recommendations. The goal of this study was to summarize the cancer screening recommendations from the 21 countries with the highest per capita spending on healthcare. Main body: Cancer screening guidelines were identified for each country based on a review of the medical literature, internet searches, and contact with key informants in most countries...
2018: Public Health Reviews
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