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https://www.readbyqxmd.com/read/30098097/photo-organocatalytic-enantioselective-radical-cascade-reactions-of-unactivated-olefins
#1
Pablo Bonilla, Yannick Rey, Catherine Holden, Paolo Melchiorre
Radical cascade processes are invaluable for their ability to rapidly construct complex chiral molecules from simple substrates. However, implementing catalytic asymmetric variants is difficult. Herein we report a visible-light-mediated organocatalytic strategy that exploits the excited-state reactivity of chiral iminium ions to trigger radical cascade reactions with high enantioselectivity. By combining two sequential radical-based bond-forming events, the method converts unactivated olefins and α,β-unsaturated aldehydes into chiral adducts in a single step...
August 10, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30014221/structural-effects-of-methylglyoxal-glycation-a-study-on-the-model-protein-mnei
#2
Serena Leone, Jole Fonderico, Chiara Melchiorre, Andrea Carpentieri, Delia Picone
The reaction of free amino groups in proteins with reactive carbonyl species, known as glycation, leads to the formation of mixtures of products, collectively referred to as advanced glycation endproducts (AGEs). These compounds have been implicated in several important diseases, but their role in pathogenesis and clinical symptoms' development is still debated. Particularly, AGEs are often associated to the formation of amyloid deposits in conformational diseases, such as Alzheimer's and Parkinson's disease, and it has been suggested that they might influence the mechanisms and kinetics of protein aggregation...
July 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29987957/deb-tace-a-standard-review
#3
Fabio Melchiorre, Francesca Patella, Lorenzo Pescatori, Filippo Pesapane, Enrico Fumarola, Pierpaolo Biondetti, Pietro Brambillasca, Cristian Monaco, Anna Maria Ierardi, Giuseppe Franceschelli, Gianpaolo Carrafiello
Drug-eluting bead transarterial chemoembolization (DEB-TACE) is a relative new endovascular treatment based on the use of microspheres to release chemotherapeutic agents within a target lesion with controlled pharmacokinetics. This aspect justifies the immediate success of DEB-TACE, that nowadays represents one of the most used treatments for unresectable hepatocellular carcinoma. However, there is no consensus about the choice of the best embolotherapy technique. In this review, we describe the available microspheres and report the results of the main comparative studies, to clarify the role of DEB-TACE in the hepatocellular carcinoma management...
July 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29980405/introduction-of-wt-tp53-into-pancreatic-cancer-cells-alters-sensitivity-to-chemotherapeutic-drugs-targeted-therapeutics-and-nutraceuticals
#4
Stephen L Abrams, Kvin Lertpiriyapong, Li V Yang, Alberto M Martelli, Lucio Cocco, Stefano Ratti, Marco Falasca, Ramiro M Murata, Pedro L Rosalen, Paolo Lombardi, Massimo Libra, Saverio Candido, Giuseppe Montalto, Melchiorre Cervello, Linda S Steelman, James A McCubrey
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10%. Mutations at the TP53 gene are readily detected in pancreatic tumors isolated from PDAC patients. We have investigated the effects of restoration of wild-type (WT) TP53 activity on the sensitivity of pancreatic cancer cells to: chemotherapy, targeted therapy, as well as, nutraceuticals. Upon introduction of the WT-TP53 gene into the MIA-PaCa-2 pancreatic cancer cell line, the sensitivity to drugs used to treat pancreatic cancer cells such as: gemcitabine, fluorouracil (5FU), cisplatin, irinotecan, oxaliplatin, and paclitaxel increased significantly...
June 28, 2018: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29932655/asymmetric-photocatalytic-c-h-functionalization-of-toluene-and-derivatives
#5
Daniele Mazzarella, Giacomo E M Crisenza, Paolo Melchiorre
Reported herein is a visible-light-mediated organocatalytic direct C-H functionalization of toluene derivatives to afford enantioenriched β-benzylated aldehydes from the corresponding enals. The process combines the oxidative power of a chiral excited-state iminium ion and the basic nature of its counteranion to trigger the generation of benzylic radicals by means of a sequential multisite proton-coupled electron transfer mechanism. This study shows that feedstock chemicals generally used as solvents, such as toluene and xylene derivatives, can be used as substrates for making chiral molecules with high enantioselectivity...
July 11, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29883570/cationic-solid-lipid-nanoparticles-as-non-viral-vectors-for-the-inhibition-of-hepatocellular-carcinoma-growth-by-rna-interference
#6
Chiara Botto, Giuseppa Augello, Erika Amore, Maria Rita Emma, Antonina Azzolina, Gennara Cavallaro, Melchiorre Cervello, Maria Luisa Bondì
Hepatocellular carcinoma (HCC) is one of the most important causes of cancer deaths worldwide. Gene therapy is a novel approach for treating HCC. A safe and efficient gene delivery method, using viral or non-viral vectors, is a crucial factor for developing a successful HCC gene therapy. Among non-viral vectors, cationic solid lipid nanoparticles (cSLN) have advantages such as biocompatibility and transfection efficiency. In this study, novel cSLN were prepared, characterized and complexed with a plasmid (shNUPR1) capable of inhibiting the expression of the NUPR1 gene, which is involved in HCC growth and chemoresistance...
May 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29861174/roles-of-p53-nf-%C3%AE%C2%BAb-and-the-androgen-receptor-in-controlling-ngal-expression-in-prostate-cancer-cell-lines
#7
William H Chappell, Saverio Candido, Stephen L Abrams, Suzanne Russo, Roger Ove, Alberto M Martelli, Lucio Cocco, Giulia Ramazzotti, Melchiorre Cervello, Giuseppe Montalto, Linda S Steelman, Xiaohong Leng, Ralph B Arlinghaus, Massimo Libra, James A McCubrey
Neutrophil gelatinase-associated lipocalin (NGAL a.k.a lipocalin 2, lnc2) is a secreted protein which can form a complex with matrix metalloproteinase-9 (MMP9). This MMP9/NGAL complex has been associated with metastasis. MMP9 and NGAL are detected in the urine of patients afflicted with many different types of cancer, including prostate cancer. The effects of p53, NF-κB and the androgen receptor (AR) on the expression of NGAL was examined in four prostate cancer cell lines. Prostate cancer cell lines that are AR negative and expressed either mutant or no p53 (DU145 and PC3) displayed higher levels of NGAL expression compared to the prostate cancer cell lines (LNCaP and 22Rv-1) which are AR positive and express wild type (WT) p53...
May 18, 2018: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29797246/embolization-of-superior-rectal-arteries-for-transfusion-dependent-haemorrhoidal-bleeding-in-severely-cardiopathic-patients-a-new-field-of-application-of-the-emborrhoid-technique
#8
M Venturini, P De Nardi, P Marra, M Panzeri, G Brembilla, F Morelli, F Melchiorre, F De Cobelli, A Del Maschio
No abstract text is available yet for this article.
June 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29777363/high-level-production-of-single-chain-monellin-mutants-with-enhanced-sweetness-and-stability-in-tobacco-chloroplasts
#9
Daniela Castiglia, Serena Leone, Rachele Tamburino, Lorenza Sannino, Jole Fonderico, Chiara Melchiorre, Andrea Carpentieri, Stefania Grillo, Delia Picone, Nunzia Scotti
Plastid-based MNEI protein mutants retain the structure, stability and sweetness of their bacterial counterparts, confirming the attractiveness of the plastid transformation technology for high-yield production of recombinant proteins. The prevalence of obesity and diabetes has dramatically increased the industrial demand for the development and use of alternatives to sugar and traditional sweeteners. Sweet proteins, such as MNEI, a single chain derivative of monellin, are the most promising candidates for industrial applications...
August 2018: Planta
https://www.readbyqxmd.com/read/29685431/corrigendum-to-poly-adp-ribose-polymerase-inhibition-synergizes-with-the-nf-%C3%AE%C2%BAb-inhibitor-dhmeq-to-kill-hepatocellular-carcinoma-cells-biochim-biophys-acta-1853-12-2015-3224-3234
#10
Nadia Lampiasi, Kazuo Umezawa, Giuseppe Montalto, Melchiorre Cervello
No abstract text is available yet for this article.
July 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29685110/wirsung-atraumatic-rupture-in-patient-with-pancreatic-pseudocysts-a-case-presentation
#11
Martino Gerosa, Marco Chiarelli, Angelo Guttadauro, Matilde De Simone, Fulvio Tagliabue, Melchiorre Costa, Sabina Terragni, Ugo Cioffi
BACKGROUND: Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, walled-off necrosis, pancreatic fistulas, ascites, pleural and pericardial effusions. Pseudocyst formation is the most frequent outcome of a pancreatic duct leak. CASE PRESENTATION: We describe a case of a 64-year old man with large multiple pancreatic cysts discovered for progressive jaundice and significant weight loss in the absence of a previous episode of acute pancreatitis...
April 23, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29584564/association-between-mica-gene-variants-and-the-risk-of-hepatitis-c-virus-induced-hepatocellular-cancer-in-a-sicilian-population-sample
#12
Giuseppa Augello, Daniele Balasus, Caterina Fusilli, Tommaso Mazza, Maria Rita Emma, Lydia Giannitrapani, Rosalia Agliastro, Melchiorre Cervello, Giuseppe Montalto
There are currently no biomarkers that predict hepatocellular carcinoma (HCC) risk in patients with hepatitis C virus (HCV)-related cirrhosis. We investigated the relationships among major histocompatibility complex (MHC) class I chain-related gene A (MICA) polymorphisms, plasma levels of soluble MICA (sMICA), and HCC risk in patients with HCV-related HCC. One hundred fifty-four HCV-related HCC patients, 93 HCV-related liver cirrhosis (LC) cases, and 244 healthy controls, all sampled from the native Sicilian population, were genotyped using the KASP™ single-nucleotide polymorphism genotyping method...
April 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29562448/-clinical-application-and-optimization-of-head-us-quantitative-ultrasound-assessment-scale-for-hemophilic-arthropathy
#13
J Li, X J Guo, X L Ding, B M Lyu, J Xiao, Q L Sun, D S Li, W F Zhang, J C Zhou, C P Li, R C Yang
Objective: To assess the feasibility of HEAD-US scale in the clinical application of hemophilic arthropathy (HA) and propose an optimized ultrasound scoring system. Methods: From July 2015 to August 2017, 1 035 joints ultrasonographic examinations were performed in 91 patients. Melchiorre, HEAD-US (Hemophilic Early Arthropathy Detection with UltraSound) and HEAD-US-C (HEAD-US in China) scale scores were used respectively to analyze the results. The correlations between three ultrasound scales and Hemophilia Joint Health Scores (HJHS) were evaluated...
February 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29483504/sodium-enhances-indium-gallium-interdiffusion-in-copper-indium-gallium-diselenide-photovoltaic-absorbers
#14
Diego Colombara, Florian Werner, Torsten Schwarz, Ingrid Cañero Infante, Yves Fleming, Nathalie Valle, Conrad Spindler, Erica Vacchieri, Germain Rey, Mael Guennou, Muriel Bouttemy, Alba Garzón Manjón, Inmaculada Peral Alonso, Michele Melchiorre, Brahime El Adib, Baptiste Gault, Dierk Raabe, Phillip J Dale, Susanne Siebentritt
Copper indium gallium diselenide-based technology provides the most efficient solar energy conversion among all thin-film photovoltaic devices. This is possible due to engineered gallium depth gradients and alkali extrinsic doping. Sodium is well known to impede interdiffusion of indium and gallium in polycrystalline Cu(In,Ga)Se2 films, thus influencing the gallium depth distribution. Here, however, sodium is shown to have the opposite effect in monocrystalline gallium-free CuInSe2 grown on GaAs substrates...
February 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29482945/metformin-influences-drug-sensitivity-in-pancreatic-cancer-cells
#15
Saverio Candido, Stephen L Abrams, Linda Steelman, Kvin Lertpiriyapong, Alberto M Martelli, Lucio Cocco, Stefano Ratti, Matilde Y Follo, Ramiro M Murata, Pedro L Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Pann-Gill Suh, Massimo Libra, James A McCubrey
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Metformin is a very frequently prescribed drug used to treat type II diabetes...
May 2018: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29388950/enhancing-the-potential-of-enantioselective-organocatalysis-with-light
#16
REVIEW
Mattia Silvi, Paolo Melchiorre
Organocatalysis-catalysis mediated by small chiral organic molecules-is a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previously inaccessible reaction pathways, thereby creating new synthetic opportunities. Here we describe the historical context, scientific reasoning and landmark discoveries that were essential in expanding the functions of organocatalysis to include one-electron-mediated chemistry and excited-state reactivity...
January 31, 2018: Nature
https://www.readbyqxmd.com/read/29351036/crouzon-with-acanthosis-nigricans-and-odontogenic-tumors-a-rare-form-of-syndromic-craniosynostosis
#17
Wen Xu, Donna M McDonald-McGinn, Alexandra J Melchiorre, Elaine H Zackai, Scott P Bartlett, Jesse A Taylor
Crouzon syndrome with acanthosis nigricans (CAN) is caused by a mutation in the fibroblast growth factor receptor ( FGFR) 3 gene that presents clinically as Crouzonoid craniofacial features in association with other anomalies such as acanthosis nigricans and benign odontogenic tumors. Diagnosis through the use of genetic mutational analysis is critical, as it alerts the surgeon to the need for careful screening for jaw tumors so that timely treatment in the form of curettage or segmental resection can be provided...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29348495/preclinical-evaluation-of-antitumor-activity-of-the-proteasome-inhibitor-mln2238-ixazomib-in-hepatocellular-carcinoma-cells
#18
Giuseppa Augello, Martina Modica, Antonina Azzolina, Roberto Puleio, Giovanni Cassata, Maria Rita Emma, Caterina Di Sano, Antonella Cusimano, Giuseppe Montalto, Melchiorre Cervello
Hepatocellular carcinoma (HCC) is one of the common malignancies and is an increasingly important cause of cancer death worldwide. Surgery, chemotherapy, and radiation therapy extend the 5-year survival limit in HCC patients by only 6%. Therefore, there is a need to develop new therapeutic approaches for the treatment of this disease. The orally bioavailable proteasome inhibitor MLN2238 (ixazomib) has been demonstrated to have anticancer activity. In the present study, we investigated the preclinical therapeutic efficacy of MLN2238 in HCC cells through in vitro and in vivo models, and examined its molecular mechanisms of action...
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29331149/correction-to-entrapment-of-an-egfr-inhibitor-into-nanostructured-lipid-carriers-nlc-improves-its-antitumor-activity-against-human-hepatocarcinoma-cells
#19
Roberto Di Gesù, Maria Luisa Bondì, Antonina Azzolina, Emanuela Fabiola Craparo, Chiara Botto, Erika Amore, Gaetano Giammona, Melchiorre Cervello
Following publication of our article [1], we became aware that Roberto Di Gesù had been omitted from the list of authors. The corrected author list and authors' contribution statement appear below. We apologize for any inconvenience this may have caused.
January 13, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29320197/synthesis-of-thelepamide-via-catalyst-controlled-1-4-addition-of-cysteine-derivatives-and-structure-revision-of-thelepamide
#20
Tobias Seitz, Ramón E Millán, Dieter Lentz, Carlos Jiménez, Jaime Rodríguez, Mathias Christmann
The first enantioselective total synthesis and structural reassignment of (-)-thelepamide, a cytotoxic tetraketide-amino acid from the marine worm Thelepus crispus, is reported. A convergent approach provides access to all thelepamide diastereomers in six steps from four simple building blocks. Key features of the synthesis include the application of Melchiorre's organocatalytic thia-Michael reaction and a sonication-assisted assembly of an unprecedented N,O-acetal-hemiacetal moiety. The corrected structure was confirmed by NMR-DFT analysis...
February 2, 2018: Organic Letters
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