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https://www.readbyqxmd.com/read/30532517/risk-factors-for-neovascular-glaucoma-after-vitrectomy-in-eyes-with-proliferative-diabetic-retinopathy
#1
Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Makoto Ubuka, Takatoshi Maeno
Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy. Subjects and methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/30531955/non-gvhd-ocular-complications-after-hematopoietic-cell-transplantation-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-transplant-complications-working-party-of-the-ebmt
#2
REVIEW
Yoshihiro Inamoto, Igor Petriček, Linda Burns, Saurabh Chhabra, Zack DeFilipp, Peiman Hematti, Alicia Rovó, Raquel Schears, Ami Shah, Vaibhav Agrawal, Aisha Ahmed, Ibrahim Ahmed, Asim Ali, Mahmoud Aljurf, Hassan Alkhateeb, Amer Beitinjaneh, Neel Bhatt, Dave Buchbinder, Michael Byrne, Natalie Callander, Kristina Fahnehjelm, Nosha Farhadfar, Robert Peter Gale, Siddhartha Ganguly, Gerhard C Hildebrandt, Erich Horn, Ann Jakubowski, Rammurti T Kamble, Jason Law, Catherine Lee, Sunita Nathan, Olaf Penack, Ravi Pingali, Pinki Prasad, Drazen Pulanic, Seth Rotz, Aditya Shreenivas, Amir Steinberg, Khalid Tabbara, André Tichelli, Baldeep Wirk, Jean Yared, Grzegorz W Basak, Minoo Battiwalla, Rafael Duarte, Bipin N Savani, Mary E D Flowers, Bronwen E Shaw, Nuria Valdés-Sanz
Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation...
December 7, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/30531954/ocular-graft-versus-host-disease-after-hematopoietic-cell-transplantation-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-transplant-complications-working-party-of-the-ebmt
#3
REVIEW
Yoshihiro Inamoto, Nuria Valdés-Sanz, Yoko Ogawa, Monica Alves, Luigi Berchicci, John Galvin, Hildegard Greinix, Gregory A Hale, Biljana Horn, Debra Kelly, Hien Liu, Scott Rowley, Helene Schoemans, Ami Shah, Maria Teresa Lupo Stanghellini, Vaibhav Agrawal, Ibrahim Ahmed, Asim Ali, Neel Bhatt, Michael Byrne, Saurabh Chhabra, Zack DeFilipp, Kristina Fahnehjelm, Nosha Farhadfar, Erich Horn, Catherine Lee, Sunita Nathan, Olaf Penack, Pinki Prasad, Seth Rotz, Alicia Rovó, Jean Yared, Steven Pavletic, Grzegorz W Basak, Minoo Battiwalla, Rafael Duarte, Bipin N Savani, Mary E D Flowers, Bronwen E Shaw, Igor Petriček
Ocular graft-versus-host disease (GVHD) occurs in more than half of patients who develop chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged morbidity, which affects activities of daily living and quality of life. Here we provide an expert review of ocular GVHD in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation...
December 7, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/30521975/non-gvhd-ocular-complications-after-hematopoietic-cell-transplantation-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-transplant-complications-working-party-of-the-ebmt
#4
REVIEW
Yoshihiro Inamoto, Igor Petriček, Linda Burns, Saurabh Chhabra, Zack DeFilipp, Peiman Hematti, Alicia Rovó, Raquel Schears, Ami Shah, Vaibhav Agrawal, Aisha Ahmed, Ibrahim Ahmed, Asim Ali, Mahmoud Aljurf, Hassan Alkhateeb, Amer Beitinjaneh, Neel Bhatt, Dave Buchbinder, Michael Byrne, Natalie Callander, Kristina Fahnehjelm, Nosha Farhadfar, Robert Peter Gale, Siddhartha Ganguly, Gerhard C Hildebrandt, Erich Horn, Ann Jakubowski, Rammurti T Kamble, Jason Law, Catherine Lee, Sunita Nathan, Olaf Penack, Ravi Pingali, Pinki Prasad, Drazen Pulanic, Seth Rotz, Aditya Shreenivas, Amir Steinberg, Khalid Tabbara, André Tichelli, Baldeep Wirk, Jean Yared, Grzegorz W Basak, Minoo Battiwalla, Rafael Duarte, Bipin N Savani, Mary Ed Flowers, Bronwen E Shaw, Nuria Valdés-Sanz
Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation...
December 3, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30516819/potential-role-of-ocular-microbiome-host-genotype-tear-cytokines-and-environmental-factors-in-corneal-infiltrative-events-in-contact-lens-wearers
#5
Cecilia Chao, Lakshmi Akileswaran, Jessica N Cooke Bailey, Mark Willcox, Russell Van Gelder, Carol Lakkis, Fiona Stapleton, Kathryn Richdale
Purpose: The purpose of this study was to explore differences in genotype, ocular surface microbiome, tear inflammatory markers, and environmental and behavioral exposures in soft contact lens (SCL) wearers with and without a history of corneal infiltrative events (CIEs). Methods: Nine SCL wearers with a recent CIE and nine age-, sex-, and SCL material- and modality-matched controls were enrolled. The Contact Lens Risk Survey, slit-lamp examination data, basal tears, conjunctival microbial cultures, and peripheral blood samples were collected...
December 3, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30505865/a-review-of-antimicrobial-therapy-for-infectious-uveitis-of-the-posterior-segment
#6
REVIEW
Ahmed B Sallam, Kyle A Kirkland, Richard Barry, Mohamed Kamel Soliman, Tayyeba K Ali, Sue Lightman
Treatment of infectious posterior uveitis represents a therapeutic challenge for ophthalmologists. The eye is a privileged site, maintained by blood ocular barriers, which limits penetration of systemic antimicrobials into the posterior segment. In addition, topical and subconjunctival therapies are incapable of producing sufficient drug concentrations, intraocularly. Posterior infectious uveitis can be caused by bacteria, virus, fungi, or protozoa. Mode of treatment varies greatly based on the infectious etiology...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
https://www.readbyqxmd.com/read/30502337/changes-in-ganglion-cell-inner-plexiform-layer-thickness-and-retinal-microvasculature-in-hypertension-an-oct-angiography-study
#7
Hyung Bin Lim, Min Woo Lee, Jae Hyeong Park, Kyeung Min Kim, Young Joon Jo, Jung Yeul Kim
OBJECTIVE: To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness. DESIGN: Retrospective, cross-sectional study. METHODS: A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Hypertensive patients were divided into the two groups according to disease periods (<5 years: hypertension group 1; ≥5 years: hypertension group 2)...
November 28, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30501724/-comparision-of-different-detection-methods-for-blood-flow-infection-with-cryptococcus-neoformans
#8
Xin Tian, Xiang-Ling He, Hua Liu, Run-Ying Zou, Hui Zou, Ya-Lan You, Ke-Ke Chen, Cheng-Guang Zhu
OBJECTIVE: To compare the sensitivity and specificity of real-time fluorescent quanttative PCR(FQ-PCR), blood culture and serum capsular antigen test for the detection of blood flow infection with cryptococcus reoformans, so as to provide the experimental evidence for use of FQ-PCR to detect the blood flow infection with cryptococcus neoformans. METHODS: Sixty male Sprague-Dawley (SD) rats were randomly divided into group A (immune suppression plus infection), group B (immune normal plus infection), group C (immune suppression plus non infection) and group D (normal control)...
December 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30500369/first-report-of-autochthonous-canine-leishmaniasis-caused-by-leishmania-l-mexicana-in-sinaloa-mexico
#9
Hipólito Castillo-Ureta, José Marcial Zazueta-Moreno, José Guadalupe Rendón-Maldonado, José Israel Torres-Avendaño, Héctor Samuel López-Moreno, Vicente Olimón-Andalón, Victor Manuel Salomón-Soto, Fabiola Patricia Pérez-Sánchez, Edith Hilario Torres-Montoya
Leishmaniasis is a neglected tropical disease caused by different species of protozoan parasites of the genus Leishmania. Dogs have been proven as primary hosts of the parasite. Cases of cutaneous leishmaniasis in humans caused by Leishmania mexicana have been reported in Sinaloa; however, the vectors and hosts involved in the epidemiology of the parasite in northwestern Mexico are still unknown. Given the public health implications of this parasite's domestic hosts regarding the permanence and transmission of the disease to humans, the objective of the present study was to detect and determine the species of Leishmania that caused the first three cases of autochthonous canine leishmaniasis in the state of Sinaloa, Mexico...
November 27, 2018: Acta Tropica
https://www.readbyqxmd.com/read/30500332/routes-for-the-delivery-of-insulin-to-the-central-nervous-system-a-comparative-review
#10
REVIEW
Elizabeth M Rhea, Therese S Salameh, William A Banks
Central nervous system (CNS) insulin resistance is a condition in which the cells within the CNS do not respond to insulin appropriately and is often linked to aberrant CNS insulin levels. CNS insulin is primarily derived from the periphery. Aberrant CNS insulin levels can arise due to various factors including i) decreased endogenous insulin transport into the brain, across the blood-brain barrier (BBB), ii) reduced CNS sequestration of insulin, and iii) increased CNS degradation. While the sole route of endogenous insulin transport into the brain is via the BBB, there are multiple therapeutic routes of administration that have been investigated to deliver exogenous insulin to the CNS...
November 27, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/30498576/concussion-in-adolescent-rugby-union-players-comprehensive-acute-assessment-protocol-and-development-of-the-ssc-concussion-passport-to-monitor-long-term-health
#11
REVIEW
Ciaran Cosgrave, Colm Fuller, Andy Franklyn-Miller, Eanna Falvey, Cliff Beirne, John Ryan, Paul McCrory
Introduction: Sports-related concussion (SRC) can be challenging to diagnose, assess and manage. Much of the SRC research is conducted on adults. The assessment of SRC should aim to identify deficits using a detailed multimodal assessment; however, most studies investigating the effects of SRC use diagnostic tools in isolation. It is likely that a combination of diagnostic tests will improve diagnostic accuracy. In this study, we aim to investigate how concussion affects adolescent rugby players and how a variety of diagnostic tools interact with each other as participants recover from their injury...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/30487781/biofilm-formation-by-ica-negative-ocular-isolates-of-staphylococcus-haemolyticus
#12
Sasmita Panda, Durg Vijai Singh
Staphylococcus haemolyticus is the second most frequently isolated CoNS from ocular infections and human blood cultures. In this study, we examined 18 ocular S. haemolyticus isolates for their capacity to form biofilm and conducted detachment assay to determine the composition of the biofilm matrix and involvement of various elements in cell lysis. PCR identified the presence of biofilm-associated genes, and ica operon and CLSM visualized the components of the biofilm matrix. We found that PIA-independent biofilm formation is the characteristic feature of S...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30487281/unique-type-i-interferon-expansion-survival-cytokines-and-jak-stat-gene-signatures-of-multi-functional-hsv-specific-effector-memory-cd8-t-em-cells-are-associated-with-asymptomatic-ocular-herpes-in-humans
#13
Hawa Vahed, Anshu Agrawal, Ruchi Srivastava, Swayam Prakash, Pierre-Gregoire A Coulon, Soumyabrata Roy, Lbachir BenMohamed
A large proportion of the world population harbors herpes simplex virus type 1 (HSV-1) a major cause of infectious corneal blindness. HSV-specific CD8+ T cells protect from herpes infection and disease. However, the genomic, phenotypic and functional characteristics of CD8+ T cells associated with the protection seen in asymptomatic (ASYMP) individuals, who despite being infected, never experienced any recurrent herpetic disease, remains to be fully elucidated. In this investigation, we compared the phenotype, function, and level of expression of a comprehensive panel of 579 immune genes of memory CD8+ T cells, sharing the same HSV-1 epitope-specificities, and freshly isolated peripheral blood from well-characterized cohorts of protected ASYMP and non-protected symptomatic (SYMP) individuals, with a history of numerous episodes of recurrent herpetic disease using high throughput digital NanoString nCounter™ system and Flow Cytometry...
November 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30487103/measuring-mental-workload-using-physiological-measures-a-systematic-review
#14
REVIEW
Rebecca L Charles, Jim Nixon
Technological advances have led to physiological measurement being increasingly used to measure and predict operator states. Mental workload (MWL) in particular has been characterised using a variety of physiological sensor data. This systematic review contributes a synthesis of the literature summarising key findings to assist practitioners to select measures for use in evaluation of MWL. We also describe limitations of the methods to assist selection when being deployed in applied or laboratory settings. We detail fifty-eight peer reviewed journal articles which present original data using physiological measures to include electrocardiographic, respiratory, dermal, blood pressure and ocular...
January 2019: Applied Ergonomics
https://www.readbyqxmd.com/read/30485331/evaluation-of-flicker-induced-hyperemia-in-the-retina-and-optic-nerve-head-measured-by-laser-speckle-flowgraphy
#15
Klemens Fondi, Ahmed M Bata, Nikolaus Luft, Katarzyna J Witkowska, René M Werkmeister, Doreen Schmidl, Matthias Bolz, Leopold Schmetterer, Gerhard Garhöfer
PURPOSE: The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a commercially available technique for measuring blood flow, is capable to assess flicker-induced haemodynamic changes in the retinal and optic nerve head (ONH) circulation. METHODS: Twenty healthy subjects were included in this cross sectional study...
2018: PloS One
https://www.readbyqxmd.com/read/30481594/ocular-graft-versus-host-disease-after-hematopoietic-cell-transplantation-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-transplant-complications-working-party-of-the-ebmt
#16
REVIEW
Yoshihiro Inamoto, Nuria Valdés-Sanz, Yoko Ogawa, Monica Alves, Luigi Berchicci, John Galvin, Hildegard Greinix, Gregory A Hale, Biljana Horn, Debra Kelly, Hien Liu, Scott Rowley, Helene Schoemans, Ami Shah, Maria Teresa Lupo Stanghellini, Vaibhav Agrawal, Ibrahim Ahmed, Asim Ali, Neel Bhatt, Michael Byrne, Saurabh Chhabra, Zack DeFilipp, Kristina Fahnehjelm, Nosha Farhadfar, Erich Horn, Catherine Lee, Sunita Nathan, Olaf Penack, Pinki Prasad, Seth Rotz, Alicia Rovó, Jean Yared, Steven Pavletic, Grzegorz W Basak, Minoo Battiwalla, Rafael Duarte, Bipin N Savani, Mary Ed Flowers, Bronwen E Shaw, Igor Petriček
Ocular graft-versus-host disease (GVHD) occurs in more than half of patients who develop chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged morbidity which affects activities of daily living and quality of life. Here we provide an expert review of ocular GVHD in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation...
November 24, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30479897/family-based-whole-exome-sequencing-identifies-novel-loss-of-function-mutations-of-fbn1-for-marfan-syndrome
#17
Zhening Pu, Haoliang Sun, Junjie Du, Yue Cheng, Keshuai He, Buqing Ni, Weidong Gu, Juncheng Dai, Yongfeng Shao
Background: Marfan syndrome (MFS) is an inherited connective tissue disorder affecting the ocular, skeletal and cardiovascular systems. Previous studies of MFS have demonstrated the association between genetic defects and clinical manifestations. Our purpose was to investigate the role of novel genetic variants in determining MFS clinical phenotypes. Methods: We sequenced the whole exome of 19 individuals derived from three Han Chinese families. The sequencing data were analyzed by a standard pipeline...
2018: PeerJ
https://www.readbyqxmd.com/read/30479719/negative-regulators-of-angiogenesis-ocular-vascular-homeostasis-and-pathogenesis-and-treatment-of-exudative-amd
#18
REVIEW
Mitra Farnoodian, Christine M Sorenson, Nader Sheibani
Angiogenesis, the formation of new blood vessels from pre-existing capillaries, is very tightly regulated and normally does not occur except during developmental and reparative processes. This tight regulation is maintained by a balanced production of positive and negative regulators, and alterations under pathological conditions such as retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration can lead to growth of new and abnormal blood vessels. Although the role of proangiogenic factors such as vascular endothelial growth factor has been extensively studied, little is known about the roles of negative regulators of angiogenesis in the pathogenesis of these diseases...
October 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/30474717/effects-of-ripasudil-a-rho-kinase-inhibitor-on-blood-flow-in-the-optic-nerve-head-of-normal-rats
#19
Yasushi Wada, Tomomi Higashide, Atsushi Nagata, Kazuhisa Sugiyama
PURPOSE: To evaluate the effect of topically administrated ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head (ONH) of normal rats. METHODS: Ripasudil (0.4%) or placebo was administered in the right eye of normal Brown Norway rats in a double-blind manner. Laser speckle flowgraphy was measured in the ONH of the right eye 20 or 40 min after a single instillation and before and after 7 or 14 days of twice daily instillation. Mean blur rate was evaluated in the total area (MA), the vessel region (MV), and the tissue region (MT)...
November 24, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30470798/modeling-diabetic-corneal-neuropathy-in-a-3d-in-vitro-cornea-system
#20
Phillip M Deardorff, Tina B McKay, Siran Wang, Chiara E Ghezzi, Dana M Cairns, Rosalyn D Abbott, James L Funderburgh, Kenneth R Kenyon, David L Kaplan
Diabetes mellitus is a disease caused by innate or acquired insulin deficiency, resulting in altered glucose metabolism and high blood glucose levels. Chronic hyperglycemia is linked to development of several ocular pathologies affecting the anterior segment, including diabetic corneal neuropathy and keratopathy, neovascular glaucoma, edema, and cataracts leading to significant visual defects. Due to increasing disease prevalence, related medical care costs, and visual impairment resulting from diabetes, a need has arisen to devise alternative systems to study molecular mechanisms involved in disease onset and progression...
November 23, 2018: Scientific Reports
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