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İrfan Çelebi, Gülpembe Bozkurt, Abdullah Soydan Mahmutoğlu, Umman Guliyev
OBJECTIVES: To describe and quantify computed tomography (CT) findings of auto-evacuated (spontaneously drained) secondary acquired cholesteatoma (SAC). MATERIALS AND METHODS: This multicenter retrospective study included 69 patients with intermittent ear discharge diagnosed with SAC by autoscopy or automicroscopy who were surgically treated. Three independent radiologists measured the medial and lateral attic distance on coronal and axial planes using multidetector computed tomography (MDCT) in 75 ear CTs from 69 patients with intraoperatively verified diagnoses of pars flaccida cholesteatoma (n=36), pars tensa cholesteatoma (n=24), and auto-atticotomy or automastoidectomy (n=15) and compared them with contralateral healthy ears...
October 13, 2018: Journal of International Advanced Otology
Roy S Hwang, Vishad Sukul, Claire Collison, Julia Prusik, Julie G Pilitsis
BACKGROUND: Intrathecal (IT) Baclofen is beneficial for spasticity, but if pumps become infected necessitating removal, baclofen withdrawal is difficult to manage and life-threatening. Furthermore there is no consistency between dosing and severity of withdrawal. Case reports detail full baclofen withdrawal at dosages of 260 μg/day. OBJECTIVE: To demonstrate that in patients on stable IT baclofen for prolonged periods, externalizing a patient's original IT pump is a safe, effective way to wean IT doses...
October 16, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Olufunsho Awodele, Rebecca Aliu, Ibrahim Ali, Yetunde Oni, Christianah Mojisola Adeyeye
Adverse drug reactions (ADRs) are expected to be associated with an economic drain on the healthcare systems. The study was carried out to determine the occurrence of ADRs reported to NAFDAC Pharmacovigilance from January to June 2015, to illustrate the pattern of organ system affected by ADRs, to assess the completeness of ADR report, to determine the relationship between the occurrence of ADRs with suspect drugs and the use of concomitant drugs as well as to generate possible signals from the reported ADRs...
October 2018: Pharmacology Research & Perspectives
Maxim Behaeghe, Patrick Seynaeve, Koenraad Verstraete
We present a case of a 54-year-old woman with a left-sided complete duplication of the ureter. The upper moiety drains in the proximal third of the vagina, which results in an ureterocele and urinary incontinence. The ureteral orifice of lower moiety ureter was normal. Duplication of the ureters with distal, infra-sphincteric, vaginal implantation is an uncommon congenital anomaly and a rarely seen entity in adulthood as a cause of urinary incontinence. MR colpocystodefecography showed an ureterocele in between the bladder and the rectum...
October 3, 2018: Journal of the Belgian Society of Radiology
Hiroki Umezawa, Takeshi Matsutani, Kazuhiko Yokoshima, Munenaga Nakamizo, Rei Ogawa
Background: Patients with head and neck or esophageal cancer who undergo resection and reconstructive surgery sometimes develop fistulae that exhibit delayed wound healing. We developed a novel negative pressure wound therapy (NPWT) that employs a Penrose drain. This case series report describes its effect on the wound healing and treatment duration of cancer patients with postoperative fistulae. Methods: This consecutive case series consisted of all patients from February 2014 to February 2017 who underwent resection and reconstruction for head and neck or esophageal cancer and who then developed a fistula that was treated with either NPWT or a second flap that did not resolve the fistula or led to fistula recurrence and was then treated with NPWT...
August 2018: Plastic and Reconstructive Surgery. Global Open
Allen Gabriel, Steven Sigalove, Noemi Sigalove, Toni Storm-Dickerson, Jami Rice, Patrick Maxwell, Leah Griffin
Background: Studies report that incision management with closed incision negative pressure therapy (ciNPT) may provide clinical benefits, including protecting surgical incisions, for postsurgical closed incisions (eg, orthopedic, sternotomy, and colorectal). This retrospective analysis compared postoperative outcomes in patients who received ciNPT versus standard of care (SOC) for incision management after breast reconstruction postmastectomy. Methods: Patient demographics, chemotherapy exposure, surgical technique, ciNPT use, number of drains, time to drain removal, and 90-day postoperative complication rates were analyzed from records of 356 patients (ciNPT = 177, SOC = 179) with 665 closed breast incisions (ciNPT = 331, SOC = 334)...
August 2018: Plastic and Reconstructive Surgery. Global Open
Gamaliel López-Leal, Fernanda Cornejo-Granados, Juan Manuel Hurtado-Ramírez, Alfredo Mendoza-Vargas, Adrian Ochoa-Leyva
Microbiome sequencing has become the standard procedure in the study of new ecological and human-constructed niches. To our knowledge, this is the first report of a metagenome from the water of a greenhouse drain. We found that the greenhouse is not a diverse niche, mainly dominated by Rhizobiales and Rodobacterales. The analysis of the functions encoded in the metagenome showed enrichment of characteristic features of soil and root-associated bacteria such as ABC-transporters and hydrolase enzymes. Additionally, we found antibiotic resistances genes principally for spectinomycin, tetracycline, and aminoglycosides...
2018: Standards in Genomic Sciences
Bin Wang, Chong Sun, Sijia Wang, Na Shang, Junjie Shangguan, Matteo Figini, Liang Pan, Kang Zhou, Quanhong Ma, Daniele Procissi, Yury Velichko, Vahid Yaghmai, Guoxin Li, Zhuoli Zhang
Dendritic cell (DC) based immunotherapy is a promising approach for cancer treatment and has been approved in clinical settings for decades. Clinical trials have demonstrated relatively poor therapeutic efficacy. The efficacy of DC immunotherapy is strongly influenced by their ability to migrate to the draining lymph nodes (LNs). Therefore, it is critical to deliver DCs and monitor the in vivo biodistributions of DCs after administration. The purpose of this study is to determine whether a novel injection route of DCs improves DC migration to LNs, tissues, organs and lymphatics...
2018: American Journal of Translational Research
Marguerite E Matherne, Kasey Cockerill, Yiyang Zhou, Mihir Bellamkonda, David L Hu
The swinging of a mammal's tail has long been thought to deter biting insects, which, in cows, can drain up to 0.3 liters of blood per day. How effective is a mammal's tail at repelling insects? In this combined experimental and theoretical study, we filmed horses, zebras, elephants, giraffes and dogs swinging their tails. The tail swings at triple the frequency of a gravity-driven pendulum, and requires 27 times more power input. Tails can also be used like a whip to directly strike at insects. This whip-like effect requires substantial torques from the base of the tail on the order of 101 -102  N m, comparable to the torque of a sedan, but still within the physical limits of the mammal...
October 15, 2018: Journal of Experimental Biology
Hanne Vos, Ann Smeets, Patrick Neven, Annouschka Laenen, Lienke Vandezande, Ines Nevelsteen
PURPOSE: The use of suction drains after breast cancer surgery (BCS) is common practice. However, the optimal time to remove drains is not clear yet and limited research has been conducted so far to assess the impact of their use on patient comfort. The goal of this study was to investigate the effect of early drain removal after BCS on quality of life (QoL) and clinical outcome. METHOD: A randomised controlled trial was conducted in 99 patients scheduled for BCS including placement of suction drains...
October 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Sebastian Stange, Zsolt Sziklavari
BACKGROUND: Chylothorax is a multifactorial complication, usually caused by surgery or traumatic injury, and more rarely by malignant disease. Because of the lack of prospective, randomised trials, the evidence-based treatment rests upon personal experience, but ideally taking into account retrospective analysis. MATERIAL AND METHODS: The aim of this review is to provide a comprehensive overview of the currently available modern treatment options. Another aspect is to show their advantages and disadvantages...
October 15, 2018: Zentralblatt Für Chirurgie
James J Zhou, Michael A Mooney, S Harrison Farber, Michael A Bohl, Andrew S Little, Peter Nakaji
OBJECTIVE: Patients with hydrocephalus secondary to third ventricular colloid cysts may require bilateral external ventricular drain (EVD) placement while awaiting surgery. However, some patients may develop auto-fenestration of the septum pellucidum (AFSP) and only require 1 EVD. We evaluated our experience with bedside iohexol ventriculography and staged EVD placement for patients with obstructive hydrocephalus. METHODS: We retrospectively identified 34 patients treated for third ventricular colloid cysts (2013-2016)...
October 12, 2018: World Neurosurgery
Shelanah A Fernando, Thuy Phan, Christine Parker, Tina Cai, Thomas Gottlieb
Wet surface biofilms are a potential reservoir for multidrug-resistant Gram-negative organisms, including carbapenamase-producing Enterobacteriaceae (CPE). Recognition of environmental sources is important in reducing secondary patient transmission. We report the increased detection of bla-IMP-4+ CPE in environmental samples from floor drains in Burns Unit shower rooms, when collected following cleaning as compared to pre-cleaning. We propose that disruption of biofilms during cleaning may account for the increased detection of multi-resistant organisms...
October 12, 2018: Journal of Hospital Infection
Joana C Branco, Mariana F Cardoso, Luís Carvalho Lourenço, Liliana Santos, David Valadas Horta, Élia Coimbra, Jorge A Reis
Introduction: Walled-off necrosis (WON) is a potentially lethal late complication of acute pancreatitis (AP) and occurs in less than 10% of AP cases. It can be located in or outside the pancreas. When infected, the mortality rate increases and can reach 100% if the collection is not drained. Its treatment is complex and includes, at the beginning, intravenous antibiotics, which permit sepsis control and a delay in the therapeutic intervention, like drainage. Nowadays, a minimally invasive approach is advised...
September 2018: GE Portuguese Journal of Gastroenterology
Darren de Sa, Jayson Lian, Andrew J Sheean, Kathleen Inman, Nicholas Drain, Olufemi Ayeni, Craig Mauro
Background: There is a rapidly growing body of literature on the topic of hip arthroscopic surgery. Purpose: To provide an overall summary of systematic reviews published on the indications, complications, techniques, outcomes, and information related to hip arthroscopic surgery. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of all hip arthroscopic surgery-related systematic reviews published between January 2000 and May 2018 was performed using PubMed, MEDLINE, and the Cochrane Library...
September 2018: Orthopaedic Journal of Sports Medicine
Antigoni Poultsidi, Yiannis Dimopoulos, Ting-Fang He, Triantafyllos Chavakis, Emmanouil Saloustros, Peter P Lee, Constantinos Petrovas
Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population, provide critical help for the development of antigen-specific B cell responses within the germinal center. Throughout the past decade, numerous studies have revealed the important role of Tfh cells in Human Immunodeficiency Virus (HIV) pathogenesis as well as in the development of neutralizing antibodies post-infection and post-vaccination. It has also been established that tumors influence various immune cell subsets not only in their proximity, but also in draining lymph nodes...
2018: Frontiers in Immunology
Weiwei Liu, Yajie Zhang, Weina Zhu, Chunhua Ma, Jie Ruan, Hongyan Long, Yue Wang
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthropathy associated with articular damage and attendant comorbidities. Even although RA treatment has advanced remarkably over the last decade, a significant proportion of patients still do not achieve sustained remission. The cause of RA is not yet known despite the many potential mechanisms proposed. It has been confirmed that RA is associated with dysregulated immune system and persistent inflammation. Therefore, management of inflammation is always the target of therapy...
2018: Frontiers in Immunology
Jatin Sethi, Miikka Visanko, Monika Österberg, Juho Antti Sirviö
This study covers a green method to prepare hybrid lignocellulosic nanopapers by combining wood nanofibres (WNFs) and cellulose nanofibres (CNFs). The WNFs and CNFs behave synergistically to compensate for the drawbacks of each other resulting in enhanced hybrid nanopapers. The draining time of hybrid nanopapers was improved by up to 75% over CNF nanopaper, and the mechanical properties, modulus, strength and elongation, were respectively improved up to 35%, 90% and 180% over WNF nanopaper. Additionally, the water resistance of hybrid nanopapers was considerably improved with a water contact angle of 95°; the neat CNF nanopaper had a contact angle of 52°...
January 1, 2019: Carbohydrate Polymers
Vera Frazão Vieira, Catarina Faria, Maria do Rosário Barroso, Fernando Mota Tavares
The authors present the case of an elderly woman with multiple comorbidities hospitalized with the diagnosis of community- acquired pneumonia with pleural effusion. However, there was a history of fall with chest trauma 1 week before, coinciding with the onset of symptoms. The patient had a massive hemothorax that could not be drained. There was a progressive worsening of the patient clinical status with sustained fever and arising of inflammatory parameters, despite broad-spectrum antibiotic therapy and antipyretics...
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Muhammad Sohail Ajmal Ghouri, Aamna Hassan
Vulvar cancer typically spreads through the inguinofemoral lymph nodes and traditionally en bloc resection of these nodes is performed as their status is an important prognostic factor. Sentinel lymph node (SLN) mapping in vulvar carcinoma directs the surgeon to the first draining node from the tumour. Hypothesis of sentinel node(SLN) biopsy is that, if these nodes are negative for malignancy, the remaining regional lymph nodes will also be negative. This technique spares SLN-negative women the morbidity of unnecessary regional lymphadenectomy...
October 2018: JPMA. the Journal of the Pakistan Medical Association
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