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Anna Palau, Alejandro Fernandez-Rodriguez, Juan Carlos Gonzalez Rosillo, Xavier Granados, Mariona Coll, Bernat Bozzo, Rafael Ortega-Hernandez, Jordi Suñé, Narcis Mestres, Xavier Obradors, Teresa Puig
Modulation of carrier concentration in strongly correlated oxides offers the unique opportunity to induce different phases in the same material which dramatically change their physical properties, providing novel concepts in oxide electronic devices with engineered functionalities. This work reports on the electric manipulation of the superconducting to insulator phase transition in YBa2 Cu3 O7-d thin films by electrochemical oxygen doping. Both, the normal state resistance and the superconducting critical temperature can be reversibly manipulated in confined active volumes of the film by gate-tunable oxygen vacancy diffusion...
August 15, 2018: ACS Applied Materials & Interfaces
Yuanying Liang, Mathis Ernst, Fabian Brings, Dmitry Kireev, Vanessa Maybeck, Andreas Offenhäusser, Dirk Mayer
Flexible and transparent electronic devices possess crucial advantages over conventional silicon based systems for bioelectronic applications since they are able to adapt to nonplanar surfaces, cause less chronic immunoreactivity, and facilitate easy optical inspection. Here, organic electrochemical transistors (OECTs) are embedded in a flexible matrix of polyimide to record cardiac action potentials. The wafer-scale fabricated devices exhibit transconductances (12 mS V-1 ) and drain-source on-to-off current ratios (≈105 ) comparable to state of the art nonflexible and superior to other reported flexible OECTs...
August 14, 2018: Advanced Healthcare Materials
Christine L Cain, Stephen D Cole, Charles W Bradley Ii, Michael S Canfield, Elizabeth A Mauldin
BACKGROUND: The Burkholderia cepacia complex (Bcc) is an emerging cause of opportunistic infections. Deep pyoderma associated with Bcc infection has been reported previously in dogs receiving ciclosporin. OBJECTIVE: To report the clinical and histopathological features of four additional cases of Bcc dermatitis in dogs, one of which progressed to septicaemia. ANIMALS: Four dogs with a skin culture yielding growth of Bcc and skin biopsies for histopathological investigation...
August 14, 2018: Veterinary Dermatology
Min Soo Kim, Sumin Shin, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Jong Ho Cho
Background: A method of wound closure using knotless suture material in the chest tube site has been introduced at our center, and is now widely used as the primary method of closing chest tube wounds in video- assisted thoracic surgery (VATS) because it provides cosmetic benefits and causes less pain. Methods: We included 109 patients who underwent VATS pulmonary resection at Samsung Medical Center from October 1 to October 31, 2016. Eighty-five patients underwent VATS pulmonary resection with chest drain wound closure utilizing knotless suture material, and 24 patients underwent VATS pulmonary resection with chest drain wound closure by the conventional method...
August 2018: Korean Journal of Thoracic and Cardiovascular Surgery
Y Xiao
Laparoscopic right colectomy by the rule of complete mesocolic excision is becoming a standard operation for right colon cancer. Intraoperative iatrogenic vascular injuries are rare but disastrous complications. In addition to the dissection along the embryonic plane, reducing iatrogenic bleeding is of crucial importance to safeguard the surgical procedure. Keeping the operative field clear by gentle suction to have a good exposure is essential to identify the origin of bleeding, and then to make decision how to control the bleeding by bipolar coagulation, clipping and transection, suturing or conversion to open surgery...
August 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Katja Obieglo, Martijn J Schuijs, Arifa Ozir-Fazalalikhan, Frank Otto, Yolanda van Wijck, Louis Boon, Bart N Lambrecht, Christian Taube, Hermelijn H Smits
Chronic helminth infection with Schistosoma (S.) mansoni protects against allergic airway inflammation (AAI) in mice and is associated with reduced Th2 responses to inhaled allergens in humans, despite the presence of schistosome-specific Th2 immunity. Schistosome eggs strongly induce type 2 immunity and allow to study the dynamics of Th2 versus regulatory responses in the absence of worms. Treatment with isolated S. mansoni eggs by i.p. injection prior to induction of AAI to ovalbumin (OVA)/alum led to significantly reduced AAI as assessed by less BAL and lung eosinophilia, less cellular influx into lung tissue, less OVA-specific Th2 cytokines in lungs and lung-draining mediastinal lymph nodes, and less circulating allergen-specific IgG1 and IgE antibodies...
August 14, 2018: Parasite Immunology
R Ray, J Basu, W A Gazi, N Samanta, K Bhattacharyya, C Roy Chaudhuri
Recently, graphene nanogrid sensor has been reported to be capable of sub-femtomolar sensing of Hepatitis B (Hep-B) surface antigen in buffer. However, for such low concentration of Hep-B in serum, it has been observed during real time operation, that there is an overlap of around 50% in the drain-source current sensitivity values between different concentrations of the target biomolecule, in the range of 0.1 fM to 100 fM. This has been attributed to the fact that the concentration of non-specific antigen in serum being significantly higher than that of the target antigen, there is a considerable deviation in the number of captured target antigen for the same concentration...
August 6, 2018: IEEE Transactions on Nanobioscience
Jie Jiao, Shaozhuang Liu, Cheng Chen, A Maimaiti, Qingsi He, Sanyuan Hu, Wenbin Yu
Introduction: At present, the main treatment of gastric cancer is surgical resection combined with radiotherapy and chemotherapy, the most important part of which is radical gastrectomy. Laparoscopic radical gastrectomy for advanced gastric cancer is difficult to operate, and whether it can achieve the same curative effect with the laparotomy is still controversial. Materials and Methods: This study retrospectively analysed the clinical data of 269 gastric cancer patients surgically treated by our medical team from May 2011 to December 2015 for comparative analysis of the clinical efficacy of laparoscopic-assisted radical gastrectomy and traditional open radical gastrectomy...
August 7, 2018: Journal of Minimal Access Surgery
Wandi Zhu, Song Li, Chao Wang, Guoying Yu, Mark R Prausnitz, Bao-Zhong Wang
Skin vaccination using biodegradable microneedle patch (MNP) technology in vaccine delivery is a promising strategy showing significant advantages over conventional flu shots. In this study, we developed an MNP encapsulating a 4M2e-tFliC fusion protein and two types of whole inactivated influenza virus vaccines (H1N1 and H3N2) as a universal vaccine candidate. We demonstrated that mice receiving this tri-component influenza vaccine via MNP acquired improved IgG1 antibody responses with more balanced IgG1/IgG2a antibody responses and enhanced cellular immune responses, including increased populations of IL-4 and IFN-γ producing cells and higher frequencies of antigen-specific plasma cells compared with intramuscular injection...
2018: Frontiers in Immunology
Vishwas Malik, Usha Kiran, Sandeep Chauhan, Neeti Makhija
Background and Aims: In patients undergoing open heart surgery, chest tubes are removed postoperatively when patients are well awake and stable. Pain during chest tube removal can be moderate to severe and can be the worst experience of hospitalization. Various modalities of pain relief during chest tube removal have been tried with variable results. We sought to examine the effect of transcutaneous electrical nerve stimulation (TENS) as an intervention for pain relief during chest tube removal after cardiac surgery...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Keisuke Yoshida, Ayaka Hara, Kazunori Sugiura, Yuki Fukaya, Toru Hisabori
Thiol-based redox regulation is central to adjusting chloroplast functions under varying light conditions. A redox cascade via the ferredoxin-thioredoxin reductase (FTR)/thioredoxin (Trx) pathway has been well recognized to mediate the light-responsive reductive control of target proteins; however, the molecular basis for reoxidizing its targets in the dark remains unidentified. Here, we report a mechanism of oxidative thiol modulation in chloroplasts. We biochemically characterized a chloroplast stroma-localized atypical Trx from Arabidopsis , designated as Trx-like2 (TrxL2)...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Yan Liu, Zenghui Pu, Maomao Zhao
A 70-year-old woman was adimittetd with subarachnoid haemorrhage. The patient underwent cerebral aneurysm embolization. On hospital day 14, the patient underwent a lumbar subarachnoid continuous drain insertion because of fever and enlarged ventricles were showed on the head computed tomography. On hospital day 19, the patient presented with remittent fever (peak at 39.1 °C) associated with altered mental status. Cerebro-Spinal Fluid (CSF) revealed white blood cell (WBC) count of 53484/mm3 (polymorphonucleocytes,75...
August 13, 2018: Antimicrobial Agents and Chemotherapy
(no author information available yet)
Conventional free-draining bioretention systems promote nitrate production and continual 23 leaching to receiving waters. In this study, laboratory tests demonstrated the efficacy of an 24 internal water storage zone (IWSZ) to target nitrate removal via denitrification. Experimental 25 results confirmed that the carbon substrate characteristics (Willow Oak woodchip media) and the 26 hydraulic retention time of nitrified stormwater affected nitrate removal performance. A 2.6-day 27 batch treatment time reduced 3...
August 1, 2018: Water Environment Research: a Research Publication of the Water Environment Federation
Yoonjoong Kim, Doohyeok Lim, Jinsun Cho, Sangsig Kim
In this paper, we describe the feedback and tunneling operations of a dual top gate field-effect transistor (FET) with a p+-i-n+ doped silicon nanowire channel. The transistor functions selectively in either a feedback FET (FBFET) or a tunneling FET (TFET) mode by modulating the source-to-drain voltage, and it features an outstanding subthreshold swing characteristic of 6.15 mV/dec with an on/off current ratio (Ion/Ioff) of approximately 10^6 in the feedback operating mode and of 41.3 mV/dec with Ion/Ioff of ~10^7 in the tunneling operating mode...
August 13, 2018: Nanotechnology
Qiaoli Ma, Lothar C Dieterich, Kristian Ikenberg, Samia B Bachmann, Johanna Mangana, Steven T Proulx, Valerie C Amann, Mitchell P Levesque, Reinhard Dummer, Peter Baluk, Donald M McDonald, Michael Detmar
Tumor lymphangiogenesis is accompanied by a higher incidence of sentinel lymph node metastasis and shorter overall survival in several types of cancer. We asked whether tumor lymphangiogenesis might also occur in distant organs with established metastases and whether it might promote further metastatic spread of those metastases to other organs. Using mouse metastasis models, we found that lymphangiogenesis occurred in distant lung metastases and that some metastatic tumor cells were located in lymphatic vessels and draining lymph nodes...
August 2018: Science Advances
Deepali Savargaonkar, Swati Sinha, Bina Srivastava, B N Nagpal, Abhinav Sinha, Arshad Shamim, Ram Das, Veena Pande, Anupkumar R Anvikar, Neena Valecha
OBJECTIVES: To study the epidemiology of dengue with reference to serological, demographic profile, spatio-temporal distribution, vectors, circulating serotypes and coinfections. METHODS: Demographic data and presenting symptoms of fever cases reporting to the clinic were recorded. Suspected patients were tested for dengue, chikungunya and malaria. Dengue specific RT-PCR was performed to detect circulating DENV serotypes. Vector surveys were carried out to detect Aedes breeding...
July 2, 2018: International Journal of Infectious Diseases: IJID
Vijay Agarwal, Daniel L Barrow
We present 2 illustrative cases of interhemispheric approaches to right sided arteriovenous malformations (AVMs). The first patient is a healthy 54-yr-old female who presented with left-sided hearing loss and pulsatile tinnitus, and was neurologically intact. Imaging demonstrated a right sided interhemispheric AVM, fed by the anterior cerebral artery with superficial venous drainage to the superior sagittal sinus. The AVM was thought to be asymptomatic and the patient chose to have her AVM treated surgically to eliminate future risk of hemorrhage...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
David L Penn, Kyle C Wu, Kayla R Presswood, Coleman P Riordan, R Michael Scott, Edward R Smith
Children with arteriovenous malformations (AVMs) are at cumulative, life-long risk of debilitating and fatal intracranial hemorrhage, especially with syndromes such as hereditary hemorrhagic telangiectasia. Cerebral angiography is the gold standard for diagnosis and allows simultaneous adjunctive embolization limiting radiation and contrast exposure and intraoperative blood loss, important in pediatric patients with low blood volume. Microsurgical resection of low-grade AVMs offers cure with minimal morbidity...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
Matteo Gregori, Diletta Cassini, Norma Depalma, Michelangelo Miccini, Farshad Manoochehri, Gianandrea A Baldazzi
The surgical treatment for patients with generalized peritonitis complicating sigmoid diverticulitis is currently debated; particularly in case of diffuse purulent contamination (Hinchey 3). Laparoscopic lavage and drainage (LLD) has been proposed by some authors as a safe and effective alternative to single- or multi-stage resective surgery. However, among all the different studies on LLD, there is no uniformity in terms of surgical technique adopted and data show significant differences in postoperative outcomes...
August 10, 2018: Updates in Surgery
Zoltan Czigany, Marcus N Scherer, Johann Pratschke, Markus Guba, Silvio Nadalin, Arianeb Mehrabi, Gabriela Berlakovich, Xavier Rogiers, Jacques Pirenne, Jan Lerut, Zoltan Mathe, Philipp Dutkowski, Bo-Göran Ericzon, Massimo Malagó, Nigel Heaton, Wenzel Schöning, Jan Bednarsch, Ulf Peter Neumann, Georg Lurje
BACKGROUND: Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage liver disease. However, technical aspects of OLT are still subject of ongoing debate and are widely based on personal experience and local institutional protocols. METHODS: An international online survey was sent out to all liver transplant centers (n = 52) within the Eurotransplant, Swisstransplant, Scandiatransplant, and British Transplant Society networks...
August 10, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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