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Türker Şahin, Murat Tezer, Levent Cerit
OBJECTIVE: To report the results of four mock femoral venous cannulas and the hydrodynamical superiority of one of them, which is the completely punched (CP) model, upon the other three. METHODS: Four simulated femoral venous cannulas (single-stage, two-stage, multi-stage, and CP model) were designed from a 1/4" x 1/16" x 68 cm polyvinyl chloride (PVC) tubing line for testing. Holes on the PVC tubes were opened by a 5 mm aortic punch. In order to evaluate the cannulas' drainage performance, gelofusine was used as fluid...
September 2018: Brazilian Journal of Cardiovascular Surgery
Elias Domínguez-Comesaña, Iria Tojo-Artos, Rubén Domínguez-Fernández, Sergio Tojo-Ramallo, Agata Rial-Durán, Sergio M Estévez-Fernández
AIM: The aim of this study was to evaluate the results of laparoscopic cholecystectomy (LC) in patients with xanthogranulomatous cholecystitis (XGC) compared with patients without XGC. METHODS: A retrospective study was performed including patients who had undergone elective LC between January 2003 and November 2017. Results of patients with XGC (25) were compared with those of patients without XGC (2181) with respect to operative time, conversion rate, drain use, postoperative complications, and postoperative stay...
December 3, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Susan M Goobie, David Zurakowski, Michael P Glotzbecker, Mary E McCann, Daniel Hedequist, Robert M Brustowicz, Navil F Sethna, Lawerence I Karlin, John B Emans, M Timothy Hresko
BACKGROUND: Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss. Evidence supporting its efficacy in surgery for adolescent idiopathic scoliosis is not robust. This trial was designed to validate the clinical efficacy of TXA in surgery for adolescent idiopathic scoliosis. METHODS: This institutional review board-approved prospective double-blinded trial involved 111 patients with adolescent idiopathic scoliosis who were randomized to receive either a placebo or TXA (50-mg/kg loading dose and 10-mg/kg/h infusion)...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
Valentina Lancellotta, Sara Chierchini, Elisabetta Perrucci, Simonetta Saldi, Lorenzo Falcinelli, Martina Iacco, Claudio Zucchetti, Isabella Palumbo, Vittorio Bini, Cynthia Aristei
INTRODUCTION: To evaluate the incidence of toxicity in breast cancer with helical tomotherapy (HT). MATERIALS AND METHODS: 51 patients with breast cancer were assigned to postoperative radiotherapy by means of HT to the chest wall/breast plus draining nodes. During HT treatment, toxicity was monitored and were assessed using the Common Terminology Criteria for Adverse Events 4.0 scale. RESULTS: Acute skin G3 toxicity observed in 1.9% cases...
December 5, 2018: Cancer Investigation
Xavier Dauchy, Virginie Boiteux, Adeline Colin, Cristina Bach, Christophe Rosin, Jean-François Munoz
Per- and polyfluoroalkyl substances (PFASs) are key ingredients of firefighting foams designed to suppress fires involving flammable and combustible liquids. Such foams are used by firefighters during fire training at dedicated sites. Because PFASs are very persistent chemicals, substantial soil and groundwater contamination has been observed in the vicinity of firefighter training areas. However, very few data are available on PFAS contamination of wastewater and runoff water on such sites. The purpose of this study was to evaluate the occurrence of more than 50 PFASs in 43 water samples (effluent from a wastewater treatment plant (WWTP), lagoon, runoff water, and wastewater drained from firefighter training areas) collected from a large firefighter training site, using target and suspect screening...
December 4, 2018: Archives of Environmental Contamination and Toxicology
Paul Lohan, Nick Murphy, Oliver Treacy, Kevin Lynch, Maurice Morcos, Bingling Chen, Aideen E Ryan, Matthew D Griffin, Thomas Ritter
High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. In this study, a rat model of pre-existing anti-donor immunity was developed in which corneal allografts were rejected earlier than in non-pre-sensitized recipients. In this model, third-party (non-donor, non-recipient strain) allogeneic mesenchymal stromal cells (allo-MSC) were administered intravenously 7 and 1 days prior to transplantation...
2018: Frontiers in Immunology
Tomoya Hayashi, Masatoshi Momota, Etsushi Kuroda, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S J Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J Ishii, Hidetoshi Arima
Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host-derived damage-associated molecular patterns (DAMPs). However, like most other DAMP-inducing adjuvants such as aluminum hydroxide (Alum), HP-β-CyD may not be sufficient for the induction of protective type-1 (cellular) immune responses, thereby leaving room for improvement...
2018: Frontiers in Immunology
Jonatan Mendez, Donglei Sun, Wenbin Tuo, Zhengguo Xiao
Ostertagia ostertagi (OO) is a widespread parasite that causes chronic infection in cattle and leads to annual losses of billions of dollars in the cattle industry. It remains unclear why cattle are unable to mount an effective immune response despite a large influx of immune cells to the infected abomasal mucosa and draining lymph nodes. Neutrophils, the immune system's first responders, have the capacity to release neutrophil extracellular traps (NETs) to contain various pathogens, including some parasites...
December 4, 2018: Scientific Reports
Alexandra Frazao, Meriem Messaoudene, Nicolas Núñez, Nicolas Dulphy, France Roussin, Christine Sedlik, Laurence Zitvogel, Eliane Piaggio, Antoine Toubert, Anne Caignard
Tumor-draining lymph nodes (TD-LNs) are the first site of metastasis of breast cancer (BC). Natural killer (NK) cells that infiltrate TD-LNs (including non-invaded (NI) or metastatic (M)-LNs from BC patients) and NK cells from healthy donor (HD)-LN were characterized, and their phenotype analyzed by flow cytometry. Low percentages of tumor cells invaded M-LNs, and these cells expressed ULBP2 and HLA class I molecules. Although NK cells from paired NI and M-LNs were similar, they expressed different markers compared to HD-LN NK cells...
December 4, 2018: Cancer Immunology Research
Paul E Clavijo, Jay Friedman, Yvette Robbins, Ellen C Moore, Ernest S Smith, Maurice Zauderer, Elizabeth E Evans, Clint T Allen
Tumor infiltration by immunosuppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs), causes resistance to immunotherapy. Semaphorin4D, originally characterized for its axonal guidance properties, also contributes to endothelial cell migration and survival and modulates global immune cytokine profiles and myeloid cell polarization within the tumor microenvironment. Here, we show how a therapeutic murine Sema4D mAb improves responses to immune checkpoint blockade in two murine carcinoma models...
December 4, 2018: Cancer Immunology Research
Stephen D Cole, Darko Stefanovski, Simon Towl, Ashley G Boyle
Abstract There is a lack of epidemiological studies about equine subsolar (hoof) abscesses even though they are among one of the most common causes of acute, severe lameness. The goals of this study were to (1) describe the equine subsolar abscess patient population of the University of Pennsylvania's New Bolton Center's Field Service and (2) to determine the factors that are associated with increased veterinary visits, prolonged treatment and complications. Descriptive statistics were performed on data collected from 160 cases of equine subsolar abscess...
December 4, 2018: Veterinary Record
Kimiko Nakajima, Sayo Kataoka, Kenji Sato, Mikiro Takaishi, Mayuko Yamamoto, Hideki Nakajima, Shigetoshi Sano
BACKGROUND: Psoriasis is an inflammatory disease associated with aberrant crosstalk between the epidermis and immune system. However, the role of Langerhans cells (LCs) in psoriasis remains controversial. OBJECTIVES: To elucidate whether LCs are functionally involved in the development of psoriasis using a mouse model. METHODS: Two lines of transgenic mice were used and crossed. They included K5.Stat3C, the psoriasis-model mouse and langerin DTR knock-in (KI) mouse...
November 23, 2018: Journal of Dermatological Science
Christina Popovic, Pankaj Saxena
No abstract text is available yet for this article.
December 4, 2018: ANZ Journal of Surgery
Ding-Hong Wu, Miao-Miao Zhang, Ning Li, Xiong Li, Quan-Wei Cai, Wan-Lin Yu, Li-Ping Liu, Wei Zhu, Chuan-Jian Lu
The IL-17-producing CD4+ T cell and γδT cells play critical roles in the pathogenesis of psoriasis (PS). PSORI-CM02 is a representative herbal formula for the treatment for PS in South China. It was confirmed to improve PS without obvious side effects in the clinic. Here we sought to clarify whether and how PSORI-CM02 regulates T cell differentiation and functions in IMQ-induced psoriasis-like BALB/c mouse model. Mice pre-treated 3 days with PSORI-CM02 significantly alleviated skin inflammation, as reduced in PASI score and classic psoriatic characteristics in pathological sections...
December 1, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Antoine Lerat-Hardy, Alexandra Coynel, Lionel Dutruch, Clément Pereto, Cécile Bossy, Teba Gil-Diaz, Marion-Justine Capdeville, Gérard Blanc, Jörg Schäfer
New and rapidly developing technologies imply the emission of emerging potentially toxic contaminants such as Rare Earth Elements (REEs). Yet, the lithology-derived quantities and anthropogenic contributions, especially from urban areas, to annual REE fluxes into fluvial-estuarine systems remain widely unknown. The Garonne River drains water from ~20% of the French land surface hosting about 5,200,000 inhabitants and two large cities. Based on long-term monitoring (2003-2017) of water discharges and dissolved REEs concentrations at the outlet of the Garonne Watershed upstream from Bordeaux, this study aims at assessing REE anomalies and evaluating temporal evolution of annual dissolved REE fluxes into the Gironde Estuary...
November 24, 2018: Science of the Total Environment
Osamu Hachiya, Tamie Sato, Makoto Toda, Wataru Kimura
BACKGROUND: For safe laparoscopic gastrectomy, it is essential to secure a good visual field by employing liver retraction. We have developed a safe and easy method for liver retraction using a silicone disc, and evaluated its feasibility. METHODS: We analyzed retrospectively 36 patients with gastric cancer, who underwent laparoscopic distal gastrectomy employing liver retraction by a silicone disc and needle forceps (Silicone group) or by the Penrose drain method (Penrose group) between January 2013 and July 2016...
December 4, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Risto Uusitalo, Riitta Lemola, Eila Turtola
No-till as a water protection measure is highly efficient in controlling erosion and particulate P (PP) loss but tends to increase dissolved reactive P (DRP) concentrations in runoff water. In a 9-yr field study on a clay soil in Southwest Finland, the effects of no-till and autumn plowing on surface runoff and subsurface drainage water quality were compared. The site had a 2% slope and was under spring cereal cropping, with approximately replacement fertilizer P rates. Vertical stratification of soil-test P that had developed during a preceding 6-yr grass ley was undone by plowing but continued to develop under no-till...
November 2018: Journal of Environmental Quality
Caroline Shams Hakimi, Sukhi Singh, Camilla Hesse, Anders Jeppsson
BACKGROUND: Excessive bleeding is a significant problem in cardiac surgery. Fibrinogen and platelet concentrate transfusion are used clinically to improve haemostasis and reduce bleeding but little is known about their functional effects on coagulation and platelet function in patients with ongoing bleeding. METHODS: Forty-two patients with ongoing bleeding after cardiac surgery were included in an observational study. Patients received either fibrinogen concentrate (n = 16), platelet concentrate (n = 12), or both fibrinogen and platelets (n = 14), median doses 2 g fibrinogen and 2 units platelets given at one occasion...
December 3, 2018: Acta Anaesthesiologica Scandinavica
Xiuyun Liu, Lara L Zimmermann, Nhi Ho, Paul Vespa, Xiaoling Liao, Xiao Hu
OBJECTIVES: Intracranial pressure (ICP) monitoring is a common practice when treating intracranial pathology with risk of elevated ICP. External ventricular drain (EVD) insertion is a standard approach for both monitoring ICP and draining cerebrospinal fluid (CSF). However, the conventional EVD cannot serve these two purposes simultaneously because it cannot accurately measure ICP and its pulsatile waveform while the EVD is open to CSF drainage. A new Integra® Camino® FLEX Ventricular Catheter (Integra Lifesciences, County Offaly, Ireland) with a double-lumen construction has been recently introduced into the market, and it can monitor ICP waveforms even during CSF drainage...
December 3, 2018: Neurocritical Care
Mingzhe Zhang, Raynald Liu, Hongli Xing, Huixuan Luo, Leiting Cui, Zhaosheng Sun
We present a patient with pontine hemorrhage. On admission, the patient was in a comatose state (Glasgow coma scale, 3). Due to rapid deterioration of his breathing, we immediately performed a direct puncture to the hematoma site. We present a simple and rapid puncture method for drainage of hematomas. The method is described and discussed in detail in this article. The described technique may be beneficial in emergency situations where the condition of the patient, particularly their respiration is declining rapidly...
2018: Frontiers in Neurology
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