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https://www.readbyqxmd.com/read/29140504/selective-attention-working-memory-and-executive-function-as-potential-independent-sources-of-cognitive-dysfunction-in-schizophrenia
#1
James M Gold, Benjamin Robinson, Carly J Leonard, Britta Hahn, Shuo Chen, Robert P McMahon, Steven J Luck
People with schizophrenia demonstrate impairments in selective attention, working memory, and executive function. Given the overlap in these constructs, it is unclear if these represent distinct impairments or different manifestations of one higher-order impairment. To examine this question, we administered tasks from the basic cognitive neuroscience literature to measure visual selective attention, working memory capacity, and executive function in 126 people with schizophrenia and 122 healthy volunteers. Patients demonstrated deficits on all tasks with the exception of selective attention guided by strong bottom-up inputs...
November 11, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29140500/the-persuasion-network-is-modulated-by-drug-use-risk-and-predicts-anti-drug-message-effectiveness
#2
Richard Huskey, J Michael Mangus, Benjamin O Turner, René Weber
While a persuasion network has been proposed, little is known about how network connections between brain regions contribute to attitude change. Two possible mechanisms have been advanced. One hypothesis predicts that attitude change results from increased connectivity between structures implicated in affective and executive processing in response to increases in argument strength. A second functional perspective suggests that highly arousing messages reduce connectivity between structures implicated in the encoding of sensory information, which disrupts message processing and thereby inhibits attitude change...
November 11, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29140276/clinical-profile-associated-with-adverse-childhood-experiences-the-advent-of-nervous-system-dysregulation
#3
Jorina Elbers, Cynthia R Rovnaghi, Brenda Golianu, Kanwaljeet J S Anand
BACKGROUND: We report the prevalence of children with multiple medical symptoms in a pediatric neurology clinic, describe their symptom profiles, and explore their association with adverse childhood experiences (ACEs). METHODS: We retrospectively reviewed 100 consecutive patients from an outpatient pediatric neurology clinic. Patients were included if they were ≥5 years old and reported ≥4 symptoms that were unexplained for ≥3-months. Symptom profiles across six functional domains were recorded: (1) executive dysfunction, (2) sleep disturbances, (3) autonomic dysregulation, (4) somatization, (5) digestive symptoms, and (6) emotional dysregulation...
November 15, 2017: Children
https://www.readbyqxmd.com/read/29138776/photoelectron-spectroscopy-and-density-functional-theory-studies-of-fructose-h2o-n-n-1-5-anionic-clusters
#4
Zhen Zeng, Elliot R Bernstein
Photoelectron spectroscopy (PES) and density functional theory (DFT) based calculations are executed to characterize gas phase, isolated (fructose + (H2O)n)(-) (n = 1-5) anionic species produced using a matrix assisted laser desorption ionization (MALDI) method. Gas phase, isolated (fructose + (H2O)n)(-) (n = 1-5) cluster anions mainly exist as open chain structures with conformational and positional isomers in the present experiments. Some cyclic structures of (fructose + (H2O)n)(-) (n = 3, 4) are apparently present in the experiments and their VDEs can contribute to the lower energy shoulders of PES features observed for (fructose + (H2O)n)(-) (n = 3, 4)...
November 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29138429/brain-network-correlates-of-emotional-aging
#5
Youngwook Lyoo, Sujung Yoon
Physical and cognitive functions typically decline with aging while emotional stability is relatively conserved. The current proof-of-concept study is the first to report of the brain mechanisms underlying emotional aging from a brain network perspective. Two hundred eighty-six healthy subjects aged 20-65 were classified into three groups of the emotionally young, intermediate-aged, and old (E-young, E-intermediate, and E-old, respectively) based on the cluster analysis of the emotion recognition task data...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137973/exposure-to-polybrominated-diphenyl-ethers-pbdes-and-child-behavior-current-findings-and-future-directions
#6
REVIEW
Ann M Vuong, Kimberly Yolton, Kim N Dietrich, Joseph M Braun, Bruce P Lanphear, Aimin Chen
Polybrominated diphenyl ethers (PBDEs) are recognized neurotoxicants, but the extent to which PBDEs influence various domains of behavior in children is not fully understood. As such, we reviewed epidemiologic studies published to date to provide an overview of the current state of knowledge on PBDEs' potential role in behavioral development. We identified 19 epidemiologic studies reporting on associations of prenatal and childhood concentrations of PBDEs with behaviors assessed in children from 1 to 12years, including executive function, attention, externalizing and internalizing behaviors, adaptive skills, and social behaviors/Autism Spectrum Disorder (ASD)...
November 11, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29137828/differentiating-between-clinical-and-behavioral-phenotypes-in-first-episode-psychosis-during-maintenance-of-visuospatial-working-memory
#7
Maria Jalbrzikowski, Vishnu P Murty, Patricia L Stan, Jusmita Saifullan, Daniel Simmonds, William Foran, Beatriz Luna
INTRODUCTION: We probed the neural basis of working memory in individuals with first episode of psychosis (FEP) and assessed how these neural abnormalities are associated with behavioral performance and/or core to psychosis pathophysiology. METHODS: FEP (N=35) and matched controls (N=25) performed a visuospatial working memory task during fMRI acquisition. We isolated neural activity during the maintenance period and examined neural activity within regions typically engaged during a working memory task...
November 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29136949/minocycline-improves-cardiac-function-after-myocardial-infarction-in-rats-by-inhibiting-activation-of-parp-1
#8
Hua Zhao, Jianjun Zhang, Gang Hong
To investigate whether Minocycline can protect myocardial cells after myocardial infarction and improve myocardial remodeling through inhibiting PARP-1 activity, thus improving cardiac function. 50 male Wistar rats aged 4 months were used to establish the myocardial infarction model. The experimental rats underwent the echocardiography at 3d, 14d and 28d after operation. After 28days, the rats were executed and the myocardial tissues in the infarct-related zone were treated with immumohistochemical staining and molecular biology detection...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136542/cognition-and-behaviour-in-children-with-congenital-abdominal-wall-defects
#9
Alice C Burnett, Julia K Gunn, Esther A Hutchinson, Margaret M Moran, Lisa M Kelly, Ursula C Sevil, Peter J Anderson, Rod W Hunt
AIM: To characterise neurodevelopment at age two years and cognition and behaviour at age five years in children born with abdominal wall defects (gastroschisis or exomphalos). STUDY DESIGN: Participants were treated as neonates for gastroschisis or exomphalos and invited for routine clinical follow-up at ages two and five years. Thirty-nine two year-olds and 20 five year-olds with gastroschisis and 20 two year-olds and 10 five year-olds with exomphalos returned for age-appropriate assessments of development (two years) and intellectual functioning (IQ), executive function, and behavioural problems...
November 11, 2017: Early Human Development
https://www.readbyqxmd.com/read/29136310/brain-networks-of-the-imaginative-mind-dynamic-functional-connectivity-of-default-and-cognitive-control-networks-relates-to-openness-to-experience
#10
Roger E Beaty, Qunlin Chen, Alexander P Christensen, Jiang Qiu, Paul J Silvia, Daniel L Schacter
Imagination and creative cognition are often associated with the brain's default network (DN). Recent evidence has also linked cognitive control systems to performance on tasks involving imagination and creativity, with a growing number of studies reporting functional interactions between cognitive control and DN regions. We sought to extend the emerging literature on brain dynamics supporting imagination by examining individual differences in large-scale network connectivity in relation to Openness to Experience, a personality trait typified by imagination and creativity...
November 14, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29136305/neural-basis-of-exertional-fatigue-in-the-heat-a-review-of-magnetic-resonance-imaging-methods
#11
REVIEW
X R Tan, Ivan C C Low, Mary C Stephenson, T W Soong, Jason K W Lee
The central nervous system, specifically the brain, is implicated in the development of exertional fatigue under a hot environment. Diverse neuroimaging techniques have been used to visualize the brain activity during or after exercise. Notably, the use of magnetic resonance imaging (MRI) has become prevalent due to its excellent spatial resolution and versatility. This review evaluates the significance and limitations of various brain MRI techniques in exercise studies - brain volumetric analysis, functional MRI, functional connectivity MRI and arterial spin labelling...
November 14, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29136215/multitaskprotdb-ii-an-update-of-a-database-of-multitasking-moonlighting-proteins
#12
Luís Franco-Serrano, Sergio Hernández, Alejandra Calvo, María A Severi, Gabriela Ferragut, JosepAntoni Pérez-Pons, Jaume Piñol, Òscar Pich, Ángel Mozo-Villarias, Isaac Amela, Enrique Querol, Juan Cedano
Multitasking, or moonlighting, is the capability of some proteins to execute two or more biological functions. MultitaskProtDB-II is a database of multifunctional proteins that has been updated. In the previous version, the information contained was: NCBI and UniProt accession numbers, canonical and additional biological functions, organism, monomeric/oligomeric states, PDB codes and bibliographic references. In the present update, the number of entries has been increased from 288 to 694 moonlighting proteins...
November 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29135934/ultrapse-a-universal-and-extensible-software-platform-for-representing-biological-sequences
#13
Pu-Feng Du, Wei Zhao, Yang-Yang Miao, Le-Yi Wei, Likun Wang
With the avalanche of biological sequences in public databases, one of the most challenging problems in computational biology is to predict their biological functions and cellular attributes. Most of the existing prediction algorithms can only handle fixed-length numerical vectors. Therefore, it is important to be able to represent biological sequences with various lengths using fixed-length numerical vectors. Although several algorithms, as well as software implementations, have been developed to address this problem, these existing programs can only provide a fixed number of representation modes...
November 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29135816/dopaminergic-genetic-variants-and-voluntary-externally-paced-exercise-behavior
#14
Denise J van der Mee, Iryna O Fedko, Jouke-Jan Hottenga, Erik A Ehli, Matthijs D van der Zee, Lannie Ligthart, Toos C E M van Beijsterveldt, Gareth E Davies, Meike Bartels, Joseph G Landers, Eco J C de Geus
PURPOSE: Most candidate gene studies on the neurobiology of voluntary exercise behavior have focused on the dopaminergic signaling pathway and its role in the mesolimbic reward system. We hypothesized that dopaminergic candidate genes may influence exercise behavior through additional effects on executive functioning and that these effects are only detected when the types of exercise activity are taken into account. METHODS: Data on voluntary exercise behavior and at least one SNP/VNTR were available for 12,929 participants of the Netherlands Twin Registry...
November 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29135068/contribution-of-genes-in-the-gabaergic-pathway-to-bipolar-disorder-and-its-executive-function-deficit-in-the-chinese-han-population
#15
Hongyan Ren, Lijie Guan, Liansheng Zhao, Yin Lin, Yincheng Wang, Zhenxing Yang, Xuan Li, Xiaohong Ma, Xiongchao Cheng, Wenhao Deng, Katherine J Aitchison, Liping Cao, Tao Li
In this study, we investigated the association between bipolar I disorder (BDI) and between cognitive deficits therein and SNPs in GABAergic receptor genes. The sample comprised 477 patients with BDI and 438 healthy controls, with three neurocognitive tests being administered in 123 patients and 164 controls. For three SNPs, rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, their allele frequencies were significantly different between patients and controls (Bonferroni-adjusted p = values 3...
November 14, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29135021/diagnostic-accuracy-of-the-chinese-version-of-the-trail-making-test-for-screening-cognitive-impairment
#16
Mingqing Wei, Jing Shi, Ting Li, Jingnian Ni, Xuekai Zhang, Yumeng Li, Shenghua Kang, Fuyun Ma, Hengge Xie, Bin Qin, Dongsheng Fan, Liping Zhang, Yongyan Wang, Jinzhou Tian
BACKGROUND/OBJECTIVES: The Trail-Making Test (TMT), which is commonly used to measure executive function, consists of two components (TMT-A and TMTB). There is a lack of normative TMT data for Chinese elderly adults. This study aimed to evaluate the validity of the TMT in screening for cognitive impairment. DESIGN: 2,294 Chinese-speaking adults aged 50 to 85: 1,026 with normal cognition (NC), 462 with mild cognitive impairment (MCI), 108 with Alzheimer's disease (AD), 113 with vascular mild cognitive impairment (VaMCI), 121 with vascular dementia (VaD), 282 with uncertain types of dementia, and 15 with mixed dementia...
November 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29133926/genetic-programs-can-be-compressed-and-autonomously-decompressed-in-live-cells
#17
Nicolas Lapique, Yaakov Benenson
Fundamental computer science concepts have inspired novel information-processing molecular systems in test tubes (1-13) and genetically encoded circuits in live cells (14-21) . Recent research has shown that digital information storage in DNA, implemented using deep sequencing and conventional software, can approach the maximum Shannon information capacity (22) of two bits per nucleotide (23) . In nature, DNA is used to store genetic programs, but the information content of the encoding rarely approaches this maximum (24) ...
November 13, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/29132388/a-composite-robotic-based-measure-of-upper-limb-proprioception
#18
Jeffrey M Kenzie, Jennifer A Semrau, Michael D Hill, Stephen H Scott, Sean P Dukelow
BACKGROUND: Proprioception is the sense of the position and movement of our limbs, and is vital for executing coordinated movements. Proprioceptive disorders are common following stroke, but clinical tests for measuring impairments in proprioception are simple ordinal scales that are unreliable and relatively crude. We developed and validated specific kinematic parameters to quantify proprioception and compared two common metrics, Euclidean and Mahalanobis distances, to combine these parameters into an overall summary score of proprioception...
November 13, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29132265/time-based-prospective-memory-in-children-and-adolescents-with-22q11-2-deletion-syndrome
#19
Céline Souchay, Lydia Dubourg, Nicola Ballhausen, Maude Schneider, Charline Cerf, Katharina Schnitzspahn, Laurence Faivre, Matthias Kliegel, Stephan Eliez
OBJECTIVE: 22q11.2 deletion syndrome, also known as velo-cardio-facial syndrome (VCFS) is a genetic disorder caused by a microdeletion on chromosome 22q11.2 and characterized by marked impairment in visual attention and executive function. The present study examined if this cognitive deficit extends to prospective memory (the type of memory involved in remembering to perform actions in the future). METHOD: 20 participants with 22q11.2DS aged between 6 and 14 were included in the study as well as 22 typically developing individuals (TDC) aged 6-12...
November 14, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29131826/an-interactive-sports-video-game-as-an-intervention-for-rehabilitation-of-community-living-patients-with-schizophrenia-a-controlled-single-blind-crossover-study
#20
Nobuko Shimizu, Tomohiro Umemura, Masahiro Matsunaga, Takayoshi Hirai
Hypofrontality is a state of decreased cerebral blood flow in the prefrontal cortex during executive function performance; it is commonly observed in patients with schizophrenia. Cognitive dysfunction, as well as the psychological symptoms of schizophrenia, influences the ability of patients to reintegrate into society. The current study investigated the effects of an interactive sports video game (IVG; Nintendo Wii™ Sports Resort) on frontal lobe function of patients with schizophrenia. A sample of eight patients (6 male and 2 female; mean age = 46...
2017: PloS One
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