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Anat Vivante, Eugene Brozgol, Irena Bronshtein, Vered Levi, Yuval Garini
During the past three decades, the study of nuclear and chromatin organization has become of great interest. The organization and dynamics of chromatin are directly responsible for many functions including gene regulation, genome replication, and maintenance. In order to better understand the details of these mechanisms, we need to understand the role of specific proteins that take part in these processes. The genome in the nucleus is organized in different length scales, ranging from the bead-like nucleosomes through topological associated domains (TADs) up to chromosome territories...
December 9, 2018: Genes, Chromosomes & Cancer
C-Z Wu, D-Q Ou, L-M Rong, Y-C Xu, J-W Dong, L Fan, Q-Y Wang
OBJECTIVE: This study aimed to evaluate the expression characteristics of lamin A/C proteins in intervertebral disc degeneration (IVD) specimens from patients with different degeneration grades. Lamin A/C proteins have been shown to result in age-related changes in the osteoarticular system. However, the expression characteristics of these nuclear proteins in degenerated human IVD tissues have not been explored previously. PATIENTS AND METHODS: Degenerated human IVD tissues were obtained during spinal surgery...
November 2018: European Review for Medical and Pharmacological Sciences
Mohd Zulkifli Kassim, Siti Nadia Rahimi, Muhamad Asyraf Berhanuddin, Siti Mariam Ab Ghani, Tong Wah Lim
No abstract text is available yet for this article.
October 2018: Journal of Indian Prosthodontic Society
Paolo Cocci, Gilberto Mosconi, Francesco Alessandro Palermo
There is evidence that polycyclic aromatic hydrocarbons (PAHs) are consistently the predominant organic contaminants in concentration found in loggerhead sea turtles (Caretta caretta) from the North and Central Adriatic Sea. Hence this study investigates the PAH toxicity to loggerheads by using a particular set of genes [i.e. CYP1B, CAT, GPX, GSTT1, SOD3, DNMT1, Epoxide hydrolase 1 (EPHX1), Poly (ADP-ribose) polymerase 1 (PARP1), Lamin-A/C isoform 3 (LMNA), Talin 1 (TLN1), Annexin A1 (ANXA1)] whose altered expression is potentially dependent on and specific for the PAH-related mechanism of action...
November 30, 2018: Environmental Pollution
Jakob Trendel, Thomas Schwarzl, Rastislav Horos, Ananth Prakash, Alex Bateman, Matthias W Hentze, Jeroen Krijgsveld
Proteins and RNA functionally and physically intersect in multiple biological processes, however, currently no universal method is available to purify protein-RNA complexes. Here, we introduce XRNAX, a method for the generic purification of protein-crosslinked RNA, and demonstrate its versatility to study the composition and dynamics of protein-RNA interactions by various transcriptomic and proteomic approaches. We show that XRNAX captures all RNA biotypes and use this to characterize the sub-proteomes that interact with coding and non-coding RNAs (ncRNAs) and to identify hundreds of protein-RNA interfaces...
December 1, 2018: Cell
Seitaro Nomura
Cardiomyopathy, a leading cause of death worldwide, is etiologically and phenotypically heterogeneous and is caused by a combination of genetic and non-genetic factors. Major genomic determinants of dilated cardiomyopathy (DCM) are titin truncating mutations and lamin A/C mutations. Patients with these two genotypes show critically different phenotypes, including penetrance, coexistence with a conduction system abnormality, cardiac prognosis, and treatment response. The transcriptomic and epigenomic characteristics of DCM include activation of the DNA damage response, metabolic reprogramming, and dedifferentiation...
December 4, 2018: Journal of Cardiology
Feyza Karasu, Luca Müller, Hassan Ridaoui, Mohammed Ibn ElHaj, Göran Flodberg, Christian Aulin, Lars Axrup, Yves Leterrier
Cellulose nanofibrils (CNF) can be produced in the form of thin, transparent and flexible films. However, the permeability of such materials to oxygen and water vapor is very sensitive to moisture, which limits their potential for a variety of packaging and encapsulation applications. Diffusion barrier coatings were thus developed to reduce the access of water molecules to enzymatically pre-treated and carboxymethylated CNF substrates. The coatings were based on UV curable organic-inorganic hybrids with epoxy, tetraethylorthosilicate (TEOS) and 3-glycidoxypropyltrimethylenesilane (GPTS) precursors and additional vapor formed SiNx layers...
2018: Frontiers in Chemistry
Elizabeth R Smith, Callinice D Capo-Chichi, Xiang-Xi Xu
Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer. In high-grade serous ovarian cancer, the only common gene aberration is the p53 point mutation, though extensive genomic perturbation is common due to severe aneuploidy, which presents as a deviant karyotype. Several mechanisms for the development of aneuploidy in cancer cells have been recognized, including chromosomal non-disjunction during mitosis, centrosome amplification, and more recently, nuclear envelope rupture at interphase...
2018: Frontiers in Oncology
D Pollard, C E Wylie, J R Newton, K L P Verheyen
BACKGROUND: Previous robust epidemiological studies of equine laminitis have utilised only veterinary-diagnosed episodes of disease, potentially underestimating true disease frequency. OBJECTIVES: To estimate the incidence of, and describe clinical signs associated with, owner-reported active laminitis in horses/ponies, using both veterinary-diagnosed and non-veterinary-diagnosed episodes. STUDY DESIGN: Prospective cohort. METHODS: Data were collected from horse/pony owners in Great Britain between August 2014 and December 2016 using a web-based application...
December 5, 2018: Equine Veterinary Journal
Shanshan Liu, Zhaoliang Guo, Xiongfeng Zeng, Xianguang Meng, Haina Sun, Yizao Wan, Guifu Zuo
The original version of this article unfortunately contained a mistake. In the Abstract section the sentence "Furthermore, the drug release mechanism was investigated by kinetic models and a first-order relationship was concluded, which indicated that the drug release is a simple diffusion process cohydroxyapatite/methotrexate complexntrolled by gradient drug concentration." was wrong. It should read as "Furthermore, the drug release mechanism was investigated by kinetic models and a first-order relationship was concluded, which indicated that the drug release is a simple diffusion process controlled by gradient drug concentration...
December 4, 2018: Journal of Materials Science. Materials in Medicine
Vanesa Baño, Daniel Godoy, Diego Figueredo, Abel Vega
The main objective of this work was to study the structural viability of using small-diameter logs of Uruguayan Loblolly/Slash pine, mainly from thinning operations, to design cross-laminated timber (CLT) panels. A visual grade named "CTH" (coniferous thinning) was proposed, and 45 specimens of sawn timber boards were tested, resulting in 51% lower bending strength than that of the minimum strength class C14. Subsequently, 20 CLT panels were manufactured and experimentally tested, the results showed that the bending strength of the CLT panels was 43% above that of the individual layers...
November 30, 2018: Materials
Chen-Yang Zhao, Na Su, Yu-Xin Jiang, Meng Yang
Aggressive angiomyxoma (AAM) is a rare tumour that often occurs in soft tissues of the female genital tract. Eight cases of AAM are reported in this article, and the clinical features and ultrasound and magnetic resonance imaging (MRI) results of the eight cases are reviewed and summarized. The main complaints of all the patients were palpable and painless masses in the vulva or scrotum. The lesions were mainly located in the vulva, pelvis, and perineal region, with a large scope of involvement. The sonographic features of AAM were characteristic...
November 26, 2018: World Journal of Clinical Cases
Qiang Liao, Man He, Yuming Zhou, Shuangxi Nie, Yongjuan Wang, Beibei Wang, Xiaoming Yang, Xiaohai Bu, Ruili Wang
The lightweight and compatible metal-organic framework (MOF)-derived carbon-based composites are widely used in electromagnetic (EM) absorption field. Their combination with laminated TiO2-C (derived from Ti3C2Tx) is expected to further strengthen the EM attenuation ability. Herein, novel laminated Co/TiO2-C hybrids were derived from Ti3C2Tx/Co-MOF using heat treatment. Compared with pristine MOF-derived carbon-based composites, the EM absorption ability of Co/TiO2-C was improved by multiple reflections between multilayered microstructures and the improved polarization loss (due to the heterogeneous interfaces, residual defects and dipole polarization) and the strengthened conductivity loss caused by the carbon layers...
December 3, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Abdelrahman Ahmed, Emmanuel Akintoye, Oluwole Adegbala, Ahmed Yassin, Ahmed Subahi, Lamin Bangura, Hossam Abubakar, Mahir Elder, Mohamed Shokr, Luis Afonso
BACKGROUND: Periprocedural outcomes of transcatheter mitral valve repair (TMVR) with Mitraclip in patients with pulmonary hypertension (PH) are not well studied. METHODS: Patients who underwent TMVR with Mitraclip between 2011 and 2015 were identified using the National Inpatient Sample (NIS). All missing variables were excluded from the analysis and therefore, complete case analysis was performed. RESULTS: A total of 1,037 patients underwent TMVR with Mitraclip between 2011 and 2015...
December 2, 2018: Catheterization and Cardiovascular Interventions
Yasuharu Takamori, Yukie Hirahara, Taketoshi Wakabayashi, Tetsuji Mori, Taro Koike, Yosky Kataoka, Yasuhisa Tamura, Shuji Kurebayashi, Kiyoshi Kurokawa, Hisao Yamada
Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate somatic lamins A and C. Mutations in lamin genes have been linked to many human hereditary diseases, including neurodegenerative disorders. Knowledge about lamins in the nervous system has been accumulated recently, but a precise analysis of lamin subtypes in glial cells has not yet been reported...
December 2018: IBRO Reports
S A Durward-Akhurst, N E Schultz, E M Norton, A K Rendahl, H Besselink, P A Behnisch, A Brouwer, R J Geor, J R Mickelson, M E McCue
Equine Metabolic Syndrome (EMS) is characterized by abnormalities in insulin regulation, increased adiposity and laminitis, and has several similarities to human metabolic syndrome. A large amount of environmental variability in the EMS phenotype is not explained by commonly measured factors (diet, exercise, and season), suggesting that other environmental factors play a role in EMS development. Endocrine disrupting chemicals (EDCs) are associated with metabolic syndrome and other endocrine abnormalities in humans...
November 26, 2018: Chemosphere
Alexandre Chojnowski, Radoslaw M Sobota, Peh Fern Ong, Wei Xie, Xianrong Wong, Oliver Dreesen, Brian Burke, Colin L Stewart
The modulation of protein-protein interactions (PPIs) is an essential regulatory activity defining diverse cell functions in development and disease. BioID is an unbiased proximity-dependent biotinylation method making use of a biotin-protein ligase fused to a protein of interest and has become an important tool for mapping of PPIs within cellular contexts. We devised an advanced method, 2C-BioID, in which the biotin-protein ligase is kept separate from the protein of interest, until the two are induced to associate by the addition of a dimerizing agent...
November 15, 2018: iScience
Siyang Liu, Yong Wu, Linfei Yang, Xiaohua Li, Lihua Huang, Xiaowei Xing
Lamin B1 is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects (NDTs), adult-onset autosomal dominant leukodystrophy (ADLD)] and tumors (e.g. pancreatic cancer)...
November 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
Morgana Souza Marques, Κarine Modolon Zepon, Julia Maia Heckler, Fernando Dal Pont Morisso, Marcos Marques da Silva Paula, Luiz Alberto Κanis
In this study, polysaccharide-based hydrogel wound dressings containing in situ synthesized gold nanoparticles (AuNPs) were prepared by using a simple, fast and green protocol. The prepared hydrogels were characterized with UV-vis and infrared spectroscopy (FT-IR), and dynamic light scattering (DLS). The rheological and swelling properties and the feasibility to scale-up the wound dressing production from the lamination of the prepared hydrogel on non-woven fabric were also investigated. UV-vis spectra confirmed the AuNPs synthesis and the DLS results exhibited an increase in the size of AuNPs with increasing the initial Au3+ concentration...
November 26, 2018: International Journal of Biological Macromolecules
Deborah McGott, Michael D Kempe, Stephen Glynn, Nick Bosco, Teresa M Barnes, Nancy M Haegel, Colin A Wolden, Matthew O Reese
Controlled delamination of thin-film photovoltaics (PV) post-growth can reveal interfaces that are critical to device performance, yet are poorly understood due to their inaccessibility within the device stack. In this work, we demonstrate a technique to lift off thin-film solar cells from their glass substrates in a clean, reproducible manner by first laminating a polymeric backsheet to the device, then thermally shocking the system at low temperatures (T ≤ -30˚C). To enable clean delamination of diverse thin-film architectures, a theoretical framework is developed and key process control parameters are identified...
November 29, 2018: ACS Applied Materials & Interfaces
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