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Bun Kim, Byung Chang Kim, Jeongseon Kim, Hyun Jin Oh, Kum Hei Ryu, Bum Joon Park, Dae Kyung Sohn, Chang Won Hong, Kyung Su Han
PURPOSE: Prior abdomino-pelvic (AP) surgery makes colonoscopy difficult and can affect bowel preparation quality. However, bowel preparation quality has been found to vary according to prior AP surgery type. We examined the relationship of prior AP surgery type with bowel preparation quality in a large-scale retrospective cohort. MATERIALS AND METHODS: In the health screening cohort of the National Cancer Center, 12881 participants who underwent screening or surveillance colonoscopy between June 2007 and December 2014 were included...
January 2019: Yonsei Medical Journal
Carla Felice, Pietro Leccese, Luigia Scudeller, Ennio Lubrano, Fabrizio Cantini, Fabiana Castiglione, Paolo Gionchetti, Ambrogio Orlando, Carlo Salvarani, Raffaele Scarpa, Maurizio Vecchi, Ignazio Olivieri, Alessandro Armuzzi
Collaboration between gastroenterologists and rheumatologists is recommended for correct management of patients with associated spondyloarthritis (SpA) and inflammatory bowel disease (IBD). We aimed to establish the appropriateness of several red flags for a prompt specialist referral. A systematic review of the literature was performed using the GRADE method to describe the prevalence of coexisting IBD-SpA and the diagnostic accuracy of red flags proposed by a steering committee. Then, a consensus among expert gastroenterologists and rheumatologists (10 in the steering committee and 13 in the expert panel) was obtained using the RAND method to confirm the appropriateness of each red flag as "major" (1 sufficient for patient referral) or "minor" (at least 3 needed for patient referral) criteria for specialist referral...
December 15, 2018: Clinical and Experimental Immunology
Yahel Segal, Miri Blank, Yehuda Shoenfeld
The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadly studied for its attenuating effects on the human immune system. In an attempt to develop a novel therapeutic small molecule for the treatment of autoimmune conditions, we have conjugated PC with tuftsin, a natural immunomodulatory tetrapeptide, to create TPC...
December 15, 2018: Immunologic Research
Katsuhiko Mitsuzaki, Gen Iinuma, Tsuyoshi Morimoto, Mototaka Miyake, Hideto Tomimatsu
PURPOSE: To test the tagging efficacy, patient acceptability, and accuracy of computed tomographic colonography (CTC) with a reduced dose of laxative using a novel barium sulfate (BaSO4 ) contrast agent. MATERIALS AND METHODS: CTC followed by optical colonoscopy (OC) was performed on 73 patients with positive results in fecal occult blood tests. They were administrated a BaSO4 suspension and a magnesium citrate solution for bowel preparation. Patients completed a questionnaire about the acceptability of bowel preparation...
December 15, 2018: Japanese Journal of Radiology
Shunji Ishihara, Kousaku Kawashima, Nobuhiko Fukuba, Yasumasa Tada, Satoshi Kotani, Yoshiyuki Mishima, Naoki Oshima, Yoshikazu Kinoshita
Ulcerative colitis (UC) patients in clinical remission often experience irritable bowel syndrome (IBS)-like symptoms. The prevalence rate of UC patients meeting the definition of IBS, such as shown by the Rome criteria, is significantly higher in those without ongoing clinical activity as compared to healthy controls. Several studies have investigated residual low-grade inflammation found in colonic mucosa of quiescent UC patients and its association with development of IBS-like symptoms. In these patients, residual colonic inflammation was evaluated using endoscopy and histology findings, as well as fecal calprotectin level and shown to not be simply associated with the presence of IBS-like symptoms in UC patients in clinical remission...
December 14, 2018: Digestion
Katsuyoshi Ando, Mikihiro Fujiya, Yoshiki Nomura, Yuhei Inaba, Yuya Sugiyama, Yu Kobayashi, Takuya Iwama, Masami Ijiri, Keitaro Takahashi, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Yusuke Mizukami, Kazumi Akasaka, Satoshi Fujii, Satoshi Yamada, Hiroshi Nakase, Toshikatsu Okumura
BACKGROUND: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than in the general population in Western studies. However, the actual state of VTE in Asian IBD remains poorly understood. AIMS: To reveal the incidence of VTE in IBD patients in Japan. METHODS: Eighty-five patients admitted to 3 gastroenterology centers were registered from 2013 to 2018. The incidence of VTE in patients with IBD (n = 42) was prospectively compared to that among patients with other digestive diseases (n = 43)...
December 14, 2018: Digestion
Lee Na Tan, Ka Wang Cheung, Isaac Philip, Stephen Ong, Mark David Kilby
BACKGROUND/PURPOSE: We report a case study of jejunal atresia and the results of a systematic literature review of all reported cases of bowel complications occurring after fetoscopic laser ablation (FLA) for the treatment of twin-to-twin transfusion syndrome (TTTS). METHODS: A systematic literature review was performed of bowel complications after FLA for TTTS according to PRISMA guidelines. RESULTS: There are 11 published cases of small bowel atresia, 5 cases of necrotising enterocolitis (NEC), and 2 cases with foetal bowel perforations...
December 14, 2018: Fetal Diagnosis and Therapy
Satoshi Kinoshita, Toshihiro Nishizawa, Naohisa Yahagi, Toshio Uraoka
Patients with ulcerative colitis have an increased risk of developing colorectal cancer. This risk has been estimated to reach about 7% at 20 years of disease, 7-14% at 25 years, and as high as 30% after 35 years. The guidelines for the management of inflammatory bowel disease recommend endoscopic resection of circumscribed dysplasia and ongoing colonoscopic surveillance as a reasonable strategy in patients with ulcerative colitis. Submucosal fibrosis due to background inflammation could hamper adequate lifting and endoscopic treatment...
December 14, 2018: Digestion
Amy Downing, Adam W Glaser, Paul J Finan, Penny Wright, James D Thomas, Alexandra Gilbert, Jessica Corner, Mike Richards, Eva Ja Morris, David Sebag-Montefiore
BACKGROUND: There is a growing population of cancer survivors at risk of treatment-related morbidity. This study investigates how potentially curative rectal cancer treatment influences subsequent function and health-related quality of life (HRQL) using data from a large-scale survey of patient-reported outcomes. METHODS: All individuals 12-36 months post-diagnosis of colorectal cancer in England were sent a survey in January 2013. The survey responses were linked with cancer registration, hospital admissions and radiotherapy data through the National Cancer Registration and Analysis Service...
December 13, 2018: International Journal of Radiation Oncology, Biology, Physics
Patrick C Blaufuss, T Gibson Gaylord, Wendy M Sealey, Madison S Powell
The current study examines expression of S100 genes, a group of calcium-sensing proteins poorly characterized in fishes. In mammals, these proteins are known to play roles beyond calcium-signaling, including mediation of inflammatory processes. Some S100 proteins also serve as biomarkers for a variety of autoinflammatory conditions. It is well known that salmonids exhibit varying degrees of intestinal enteritis when exposed to alternative feed ingredients containing antinutritional factors, with soybean meal (SBM) being one of the best characterized...
December 13, 2018: Fish & Shellfish Immunology
Sasha Jardine, Neel Dhingani, Aleixo M Muise
The rising incidence of paediatric inflammatory bowel disease (IBD), coupled with the efficiency of whole exome sequencing, has led to the identification of Tetratricopeptide Repeat Domain 7A (TTC7A) as a steward of intestinal health. TTC7A-deficiency is an autosomal recessively inherited disease. In five years since the original description more than 50 patients with >20 distinct disease-causing TTC7A mutations have been identified. Patients exhibit heterogenous intestinal and immunological disease manifestations, including but not limited to multiple intestinal atresias, very early-onset inflammatory bowel disease, loss of intestinal architecture, apoptotic enterocolitis, combined immunodeficiency, and various extraintestinal features related to the skin and/or hair...
December 13, 2018: Cellular and Molecular Gastroenterology and Hepatology
Marco Gentili, Simona Ronchetti, Erika Ricci, Rosanna Di Paola, Enrico Gugliandolo, Salvatore Cuzzocrea, Oxana Bereshchenko, Graziella Migliorati, Carlo Riccardi
Cannabinoids are known to possess anti-inflammatory and immunomodulatory properties, but the mechanisms involved are not fully understood. CB2 is the cannabinoid receptor that is expressed primarily on hematopoietic cells and mediates the immunoregulatory functions of cannabinoids. In order to study the effect of JTE907, a selective/inverse agonist of CB2 with anti-inflammatory properties, on the differentiation of T cell subtypes, we used an in vitro system of Th lineage-specific differentiation of naïve CD4+ T lymphocytes isolated from the mouse spleen...
December 12, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Leonardo Zorron Cheng Tao Pu, Kevin Lu, Amanda Ovenden, Khizar Rana, Gurfarmaan Singh, Sudarshan Krishnamurthi, Suzanne Edwards, Bill Wilson, Masanao Nakamura, Takeshi Yamamura, Andrew Ruszkiewicz, Yoshiki Hirooka, Alastair D Burt, Rajvinder Singh
BACKGROUND AND AIM: Adenoma detection rate (ADR) is an important quality metric in colonoscopy. However, there is conflicting evidence around factors that influence ADR. This study aims to investigate the effect of time of day and endoscopist background on ADR and sessile serrated adenoma/polyp detection rate (SSA/P-DR) for screening colonoscopies. METHODS: Consecutive patients undergoing colonoscopy in 2016 were retrospectively evaluated. Primary outcome was the effect of time of day and endoscopist speciality on screening ADR...
December 14, 2018: Journal of Gastroenterology and Hepatology
Julie Woodfield, Ingrid Hoeritzauer, Aimun A B Jamjoom, Savva Pronin, Nisaharan Srikandarajah, Michael Poon, Holly Roy, Andreas K Demetriades, Philip Sell, Niall Eames, Patrick F X Statham
INTRODUCTION: Cauda equina syndrome (CES) is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness and pain. CES occurs infrequently, but has serious potential morbidity and medicolegal consequences. This study aims to identify and describe the presentation and management of patients with CES in the UK. METHODS AND ANALYSIS: Understanding Cauda Equina Syndrome (UCES) is a prospective and collaborative multicentre cohort study of adult patients with confirmed CES managed at specialist spinal centres in the UK...
December 14, 2018: BMJ Open
Jim G Castellanos, Viola Woo, Monica Viladomiu, Gregory Putzel, Svetlana Lima, Gretchen E Diehl, Andrew R Marderstein, Jorge Gandara, Alexendar R Perez, David R Withers, Stephan R Targan, David Q Shih, Ellen J Scherl, Randy S Longman
Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that adherent IBD-associated microbiota induced TL1A release from CX3CR1+ mononuclear phagocytes (MNPs). Using cell-specific genetic deletion models, we identified an essential role for CX3CR1+ MNP-derived TL1A in driving group 3 innate lymphoid cell (ILC3) production of interleukin-22 and mucosal healing during acute colitis...
December 5, 2018: Immunity
Farzaneh Lotfi, Fariborz Bahrehmand, Asad Vaisi-Raygani, Reza Khodarahmi, Maryam Tanhapour, Amir Kiani, Zohreh Rahimi, Tayebeh Pourmotabbed
BACKGROUND: Discovering the association between genetic variations of metabolizing enzymes with idiopathic diseases such as ulcerative colitis (UC) may not only be an auxiliary agent in diagnosis but also could be an effective pharmacotherapy for inflammatory bowel disease (IBD). The aim of the present case-control study was to determine the association of cytochrome P450 2D6 (CYP2D6 *4), N-acteyltransferase-2 (NAT2*7) and multidrug resistance 1 (MDR1) 3435 C/T genotypes with UC susceptibility and thiopurine methyltransferase (TPMT) enzyme activity...
November 1, 2018: Archives of Iranian Medicine
Marie Skov Kristensen, Thora Majlund Kjærulff, Annette Kjær Ersbøll, Anders Green, Jesper Hallas, Lau Caspar Thygesen
Background: Psychiatric comorbidity might modify the disease course adversely in patients with inflammatory bowel disease (IBD). Treatment options include antidepressants, which, apart from improving mood, have anti-inflammatory properties that might modify the disease course. This nationwide study aimed to examine the influence of antidepressants on the disease course among patients with ulcerative colitis (UC) and Crohn's disease (CD). Methods: Patients registered with an incident diagnosis of CD or UC in the Danish National Patient Register (2000-2017) were included...
December 14, 2018: Inflammatory Bowel Diseases
Jennifer C C deBruyn, Ing Shian Soon, Kevin Fonseca, Sharon Feng, Melanie Purtzki, Caitlin Goedhart, Susan Kuhn, Otto G Vanderkooi, Iwona Wrobel
Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD. Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD...
December 14, 2018: Inflammatory Bowel Diseases
Åsa H Everhov, Hamed Khalili, Johan Askling, Pär Myrelid, Jonas F Ludvigsson, Jonas Halfvarson, Caroline Nordenvall, Martin Neovius, Jonas Söderling, Ola Olén
Background: The aim of this study was to examine work loss in patients with Crohn's disease. Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015)...
December 14, 2018: Inflammatory Bowel Diseases
Marissa N Baudino, Kaitlyn L Gamwell, Caroline M Roberts, John E Grunow, Noel J Jacobs, Stephen R Gillaspy, Clayton S Edwards, Larry L Mullins, John M Chaney
Objective: The objective of this study is to examine parent and youth appraisals of illness uncertainty as potential serial mediators in the relation between disease severity and youth depressive symptoms in adolescents with inflammatory bowel disease (IBD). Methods: Participants were 85 adolescents 13-18 years of age (Mage = 15.75, SD =1.51) with a confirmed diagnosis of IBD (Crohn's disease, 59%; ulcerative colitis, 41%) and a primary caregiver. At a scheduled outpatient visit, caregivers completed a measure of illness uncertainty, while adolescents completed measures of illness uncertainty and depressive symptoms...
December 14, 2018: Journal of Pediatric Psychology
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