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Successive AND Simultaneous Processing

Tom Hildebrandt, Kurt Schulz, Lazar Fleysher, Trevor Griffen, Ashley Heywood, Robyn Sysko
OBJECTIVE: Individuals with eating disorders are theorized to have basic impairments in affective appraisal and social-emotional processing that contribute to pathogenesis of the disease. We aimed to determine if facial electromyography could be used to discriminate between happy and disgust emotions during simultaneous acquisition of an fMRI BOLD sequence in efforts to establish a novel tool for investigating emotion-driven hypotheses about eating pathology. In line with standards for rigor and reproducibility, we provide detailed protocols and code to support each step of this project...
August 18, 2018: International Journal of Eating Disorders
Catherine Pirard, Corinne Charlier
Recent and reliable human biomonitoring data on brominated flame retardants (BFRs), either legacy or new BFRs, are still needed to assess human exposure. The aim of this work was therefore to develop and validate an accurate, fast and user-friendly analytical strategy for the determination of 15 legacy and novel BFRs in human serum namely 8 polybrominated diphenylethers (BDE-28, -47, -99, -100, -153, -154, -183, and -209), 1 hexabromobiphenyl (PBB-153), and 6 novel BFRs (pentabromotoluene, hexabromobenzene, pentabromoethylbenzene, 2-ethylhexy-2,3,4,5-tetrabromobenzoate, 1,2-bis(2,4,6-tribromophenoxy)ethane, and decabromodiphenylethane)...
August 9, 2018: Chemosphere
Y Xiong, A He, C Quan
In this paper, the security of a cryptosystem based on phase-truncated Fourier transforms (PTFTs) and a random amplitude mask (RAM) is evaluated. In the cryptosystem, fake keys used as encryption keys in the second PTFT-based structure are generated by the first PTFT-based structure in which the RAM is encoded by random phase masks (RPMs) used as public keys. Compared to the classical PTFT-based encryption scheme, the security level of the cryptosystem is improved by using cascaded PTFTs to encode the encryption keys and the plaintext simultaneously...
July 20, 2018: Applied Optics
Shiyi Sun, Shaocong Liu, Wensheng Wang, Zhimin Zhang, Cuifang Kuang, Xu Liu
An imaging system combining parallel detection and two-photon excitation is presented in this paper. In the proposed method, seven avalanche photodiodes (APD) are used in the detection path. The light is guided onto the APD sensor by a fiber bundle with seven fibers. The circular arranged fiber end faces together function as a detection array. The outer contour fiber ends deviate from optical axis center and thus obtain higher frequency information. Seven images are acquired simultaneously by the detection array...
July 20, 2018: Applied Optics
Norbert Rácz, Imre Molnár, Arnold Zöldhegyi, Hans-Jürgen Rieger, Róbert Kormány
Chromatographic methods are progressing continuously. Increasing sample complexity and safety expectations lead to higher regulatory demands, hence challenges in liquid chromatography analysis are rising, even today, when faster and faster chromatographic systems are extensively employed and become widely accessible for successful method development. The goal of this study was to investigate the impact of mobile phase influences as important factors of selectivity tuning in method development. This would mitigate mobile phase-related robustness issues throughout the method's lifecycle...
August 2, 2018: Journal of Pharmaceutical and Biomedical Analysis
Xianzhe Liu, Weijing Wu, Weifeng Chen, Honglong Ning, Xiaochen Zhang, Weijian Yuan, Mei Xiong, Xiaofeng Wang, Rihui Yao, Junbiao Peng
In this research, a passivated methodology was proposed for achieving good electrical characteristics for back-channel-etch (BCE) typed amorphous Si-Sn-O thin film transistors (a-STO TFTs). This methodology implied that the thermal annealing (i.e., pre-annealing) should be carried out before deposition of a SiOx passivation layer. The pre-annealing played an important role in affecting device performance, which did get rid of the contamination of the lithography process. Simultaneously, the acceptor-like sub-gap density of states (DOS) of devices was extracted for further understanding the reason for improving device performance...
August 15, 2018: Materials
Mareike Bojer, Isabella R Graf, Erwin Frey
The totally asymmetric simple exclusion process (TASEP) is a paradigmatic stochastic model for nonequilibrium physics, and has been successfully applied to describe active transport of molecular motors along cytoskeletal filaments. Building on this simple model, we consider a two-lane lattice-gas model that couples directed transport (TASEP) to diffusive motion in a semiclosed geometry, and simultaneously accounts for spontaneous growth and particle-induced shrinkage of the system's size. This particular extension of the TASEP is motivated by the question of how active transport and diffusion might influence length regulation in confined systems...
July 2018: Physical Review. E
Suji Choi, Sang Ihn Han, Dongjun Jung, Hye Jin Hwang, Chaehong Lim, Soochan Bae, Ok Kyu Park, Cory M Tschabrunn, Mincheol Lee, Sun Youn Bae, Ji Woong Yu, Ji Ho Ryu, Sang-Woo Lee, Kyungpyo Park, Peter M Kang, Won Bo Lee, Reza Nezafat, Taeghwan Hyeon, Dae-Hyeong Kim
Wearable and implantable devices require conductive, stretchable and biocompatible materials. However, obtaining composites that simultaneously fulfil these requirements is challenging due to a trade-off between conductivity and stretchability. Here, we report on Ag-Au nanocomposites composed of ultralong gold-coated silver nanowires in an elastomeric block-copolymer matrix. Owing to the high aspect ratio and percolation network of the Ag-Au nanowires, the nanocomposites exhibit an optimized conductivity of 41,850 S cm-1 (maximum of 72,600 S cm-1 )...
August 13, 2018: Nature Nanotechnology
Reza Karimi Shervedani, Marzieh Samiei Foroushani, Amirhosein Kefayat, Mostafa Torabi, Fatemeh Rahnemaye Rahsepar
Construction of hybrid systems that combine the cancer treatment and diagnosis agents on a single platform, known as theranostic systems, have received great attentions in the field of nanobiomedicine. Here, construction and characterization of a new multifunctional hybrid theranostic system based on RGO, PDA, BSA, DTPA-Mn(II), and MTX constituents, is presented. Accordingly, GO is partially reduced and simultaneously functionalized by dopamine, leading to reduced graphene oxide/polydopamine, RGO-PDA system; and then, the bovine serum albumin protein (BSA) is grafted onto this system...
October 15, 2018: Biosensors & Bioelectronics
Evgeny A Idelevich, Luise M Storck, Katrin Sparbier, Oliver Drews, Markus Kostrzewa, Karsten Becker
Recently developed direct-on-target microdroplet growth assay (DOT-MGA) allows rapid universal antimicrobial susceptibility testing (AST) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Here, we investigated direct application of this method on positive blood cultures (BC) for acceleration of sepsis diagnostics. Blood samples spiked with meropenem-non-susceptible and meropenem-susceptible Enterobacterales isolates were inoculated into BACTEC Plus Aerobic/F bottles and incubated in the BACTEC automated system...
August 9, 2018: Journal of Clinical Microbiology
Hassan Khorsandi, Mehri Gholizadeh, Ali Ahmad Aghapour
In this study, simultaneous catechol biodegradation and nitrate removal were successfully achieved in a hybrid anoxic biofilter (HAB). The maximum biodegradation concentration of catechol by HAB, was determined 1,000 mg/L. However, optimum conditions of HAB for biodegradation of catechol were determined in catechol and nitrate concentrations of 750 mg/L and 140 mg/L-N, respectively, and a hydraulic retention time of 18 h, which corresponded to organic loading rate of 1.89 kg COD/m3 . d and COD/N of 2.32. The low COD/N ratio is related to nitrogen cycling and reflected N2 O flux within denitrification biofilters...
August 9, 2018: Environmental Technology
Vyacheslav A Trofimov, Svetlana A Varentsova
We discuss an effective time-dependent THz spectroscopy method for the detection and identification of a substance with an inhomogeneous surface using a broadband THz signal reflected from the substance. We show that a successful and reliable identification can be made using the single long-duration THz signal, which contains not only the main reflected pulse, but also several sub-pulses. The method does not use averaging of the measured THz signals over the viewing angles and scanning over the surface area, which significantly increases the signal processing speed...
2018: PloS One
Qinghua Zhou, Zanhui Jin, Jia Li, Bin Wang, Xiuzhen Wei, Jinyuan Chen
In this study, a novel air-assisted liquid-liquid microextraction (AALLME) method was developed for the HPLC determination of bisphenols migration from disposable plastic lunch box to contacting water. The AALLME was carried out in commercially-available medical plastic syringes with low-density extraction solvent (n-octanol), and the reaction of NaHCO3 and HCl was introduced to simultaneously induce the in-situ phase separation and salt effect. After the AALLME processes, the upper organic phase was pushed into the end of syringes (narrow tube) by moving the piston so that it could be readily collected for the HPLC analysis...
November 1, 2018: Talanta
Guido Caluori, Jan Pribyl, Vratislav Cmiel, Martin Pesl, Tomas Potocnak, Ivo Provaznik, Petr Skladal, Vladimir Rotrekl
Calcium ions act like ubiquitous second messengers in a wide amount of cellular processes. In cardiac myocytes, Ca2+ handling regulates the mechanical contraction necessary to the heart pump function. The field of intracellular and intercellular Ca2+ handling, employing in vitro models of cardiomyocytes, has become a cornerstone to understand the role and adaptation of calcium signalling in healthy and diseased hearts. Comprehensive in vitro systems and cell-based biosensors are powerful tools to enrich and speed up cardiac phenotypic and drug response evaluation...
August 6, 2018: Journal of Molecular Recognition: JMR
Sijia Huang, Feng Li, Huifang Liu, Pei Ye, Xiaochuan Fan, Xinqiu Yuan, Zhidan Wu, Jin Chen, Chunyang Jin, Beifen Shen, Jiannan Feng, Boyan Zhang
MBS301, a glyco-engineered bispecific anti-human epidermal growth factor receptor 2 (HER2) antibody with a typical IgG1 monoclonal antibody structure, was developed through dual-cell expression and in vitro assembling process. MBS301 consists of two half antibodies engineered from trastuzumab and pertuzumab, respectively. Integrity and purity profiles of MB301 indicated that the heterodimerization of the two half antibodies was successful. The high and similar melting temperatures (Tm1,72.0°C and Tm2, 84.8°C) of MBS301 compared with those of its parental monoclonal antibodies trastuzumab and pertuzumab (in-house made T-mab and P-mab, respectively) revealed its structural compactness...
August 6, 2018: MAbs
Joanna Kroehnke, Justyna Szadzińska, Marcin Stasiak, Elżbieta Radziejewska-Kubzdela, Róża Biegańska-Marecik, Grzegorz Musielak
The aim of these studies was to investigate the influence of airborne ultrasound-assisted convective drying and microwave-assisted convective drying, as well as their combination, on process kinetics, total color change, water activity, content of carotenoids, polyphenols and antioxidant activity of carrots (Daucus carota L.). The global model of drying kinetics based on coupled ordinary differential equations was used to describe the moisture and material temperature profiles during drying. Application of ultrasound and microwave in convective drying reduced drying time in the range of 9-81%, but the shortest drying time was observed for simultaneous action of convection, ultrasound and microwave...
November 2018: Ultrasonics Sonochemistry
Linchen He, Xing Lucy Liu, Junfeng Jim Zhang
Oxidative stress is involved in the pathophysiology of many diseases and natural aging. Urinary 8‑hydroxy‑2'‑deoxyguanosine (8‑OHdG), a stable product of DNA oxidative damage, has been widely used as an oxidative stress biomarker. However, only reporting 8‑OHdG level, as commonly done previously, does not take into account of damaged DNA molecules that have not been repaired and excreted in urine. Melatonin is known to help with DNA repairs and hence can modify 8‑OHdG levels. 6‑sulfatoxymelatonin (aMT6s) is a major metabolite of melatonin excreted in urine...
July 29, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Yuanyuan Yao, Ji Ji, Hongding Zhang, Kun Zhang, Baohong Liu, Pengyuan Yang
Single-cell analysis provides an important strategy to evaluate cellular heterogeneity. Although surface-enhanced Raman scattering (SERS) has been considered as a promising label-free technique for single-cell analysis, it remains at the early stage for characterizing the extracellular metabolites of single cells. Herein, we developed a convenient, flexible, and straightforward three-dimensional (3D) plasmonic trap array for simultaneously compartmentalizing and sensitively detecting single-cell metabolites...
August 14, 2018: Analytical Chemistry
Diana L N Jere, Chimwemwe K Banda, Lily C Kumbani, Li Liu, Linda L McCreary, Chang Gi Park, Crystal L Patil, Kathleen F Norr
BACKGROUND: Scaling-up evidence-based behavior change interventions can make a major contribution to meeting the UNAIDS goal of no new HIV infections by 2030. We developed an evidence-based peer group intervention for HIV prevention and testing in Malawi that is ready for wider dissemination. Our innovative approach turns over ownership of implementation to rural communities. We adapted a 3-Step Implementation Model (prepare, roll-out and sustain) for communities to use. Using a hybrid design, we simultaneously evaluate community implementation processes and program effectiveness...
August 2, 2018: BMC Public Health
Chunxiong Bao, Jie Yang, Sai Bai, Weidong Xu, Zhibo Yan, Qingyu Xu, Junming Liu, Wenjing Zhang, Feng Gao
Photodetectors are critical parts of an optical communication system for achieving efficient photoelectronic conversion of signals, and the response speed directly determines the bandwidth of the whole system. Metal halide perovskites, an emerging class of low-cost solution-processed semiconductors, exhibiting strong optical absorption, low trap states, and high carrier mobility, are widely investigated in photodetection applications. Herein, through optimizing the device engineering and film quality, high-performance photodetectors based on all-inorganic cesium lead halide perovskite (CsPbIx Br3- x ), which simultaneously possess high sensitivity and fast response, are demonstrated...
July 31, 2018: Advanced Materials
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