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https://www.readbyqxmd.com/read/30320624/simultaneous-quantification-of-nine-antimicrobials-by-lc-ms-ms-for-therapeutic-drug-monitoring-in-critically-ill-patients
#1
Sophie Neugebauer, Christina Wichmann, Sibylle Bremer-Streck, Stefan Hagel, Michael Kiehntopf
BACKGROUND: Adequate antibiotic treatment is a prerequisite for the successful treatment of systemic infections. Based on accumulating scientific evidence, a fixed dosage regimen can lead to insufficient and ineffective antibiotic therapy. Thus, the aim of this study was to develop and validate a simplified, but sensitive method for the simultaneous quantification of antimicrobials by using liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the development of personalized therapy regimens using therapeutic drug monitoring (TDM)...
October 12, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/30318651/direct-laser-writing-of-crystallized-tio-2-and-tio-2-carbon-microstructures-with-tunable-conductive-properties
#2
Shang-Yu Yu, Gautier Schrodj, Karine Mougin, Joseph Dentzer, Jean-Pierre Malval, Hsiao-Wen Zan, Olivier Soppera, Arnaud Spangenberg
Metal oxides are an important class of materials for optoelectronic applications. In this context, developing simple and versatile processes for integrating these materials at the microscale and nanoscale has become increasingly important. One of the major remaining challenges is to control the microstructuration and electro-optical properties in a single step. It is shown here that near-infrared femtosecond laser irradiation can be successfully used to prepare amorphous or crystallized TiO2 microstructures in a single step using a direct laser writing (DLW) approach from a TiO2 precursor thin film doped with a suitable dye...
October 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30317715/type-b-aortic-dissection-with-retrograde-intramural-hematoma-and-pulmonary-embolism
#3
Kisa Hyde Congo, António Tomás, Álvaro Laranjeira, Daniela Afonso, José Fragata
We report the case of 67-year old male patient who was admitted with a 2-week history of progressively worsening chest pain and dyspnea. Diagnostic investigation showed a type B aortic dissection with a retrograde intramural hematoma and bilateral pulmonary embolism. These simultaneous findings highly complicated patient management. Patient was started on anticoagulation therapy with partial resolution of pulmonary embolism after which surgical correction was performed. The patient was successfully submitted to a modified Frozen Elephant Trunk technique with a 3-branched customized Dacron tube and aortic arch replacement with E-Vita Open Plus...
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/30315994/enhanced-removal-of-arsenite-and-arsenate-by-a-multifunctional-fe-ti-mn-composite-oxide-photooxidation-oxidation-and-adsorption
#4
Wei Zhang, Gaosheng Zhang, Caihong Liu, Juan Li, Tong Zheng, Jun Ma, Lu Wang, Jin Jiang, Xuedong Zhai
In order to attain a high-efficiency and low-cost adsorbent for both arsenate (As(V)) and arsenite (As(III)) removal from As-contaminated water, a novel nanostructured Fe-Ti-Mn composite oxide (FTMO) was fabricated through a one-step simultaneous oxidation and co-precipitation method. Batch control experiments and series of spectroscopy detection technologies were carried out to investigate the surface change of the FTMO adsorbent and the respective role of Fe, Ti and Mn content in the arsenic adsorption process...
October 5, 2018: Water Research
https://www.readbyqxmd.com/read/30307887/identifying-key-opinion-leaders-in-social-media-via-modality-consistent-harmonized-discriminant-embedding
#5
Yang Liu, Zhonglei Gu, Tobey H Ko, Jiming Liu
The digital age has empowered brands with new and more effective targeted marketing tools in the form of key opinion leaders (KOLs). Because of the KOLs' unique capability to draw specific types of audience and cultivate long-term relationship with them, correctly identifying the most suitable KOLs within a social network is of great importance, and sometimes could govern the success or failure of a brand's online marketing campaigns. However, given the high dimensionality of social media data, conducting effective KOL identification by means of data mining is especially challenging...
October 9, 2018: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/30307101/simultaneous-determination-of-savaside-a-acteoside-and-isoacteoside-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-comparative-pharmacokinetic-and-bioavailability-characteristics-of-monochasma-savatieri-via-different
#6
Bingwei Feng, Yonggui Song, Qiongming Xu, Pengfei Xu, Qiang Zeng, Baixi Shan, Kuangyi Liu, Dan Su
Phenylethanoid glycosides were the bioactive components in Monochasma savatieri which primarily contains savaside A, acteoside, and isoacteoside. Pharmacological researches were comprehensive, but there are few studies on pharmacokinetics, especially about Savaside A. An ultra-high performance liquid chromatography-tandem mass spectrometry with multiple reaction monitoring mode had been developed and validated for the simultaneous determination of the three compounds from Monochasma savatieri. Meanwhile, this method was fully validated and successfully applied to compare the pharmacokinetics and bioavailability following four different routes included intravenous injection, intraperitoneal injection, muscle injection and oral administration...
October 11, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/30305019/genome-wide-transcriptome-profiling-of-transgenic-hop-humulus-lupulus-l-constitutively-overexpressing-hlwrky1-and-hlwdr1-transcription-factors
#7
Ajay Kumar Mishra, Ganesh Selvaraj Duraisamy, Mudra Khare, Tomáš Kocábek, Jernej Jakse, Jindřich Bříza, Josef Patzak, Teruo Sano, Jaroslav Matoušek
BACKGROUND: The hop plant (Humulus lupulus L.) is a valuable source of several secondary metabolites, such as flavonoids, bitter acids, and essential oils. These compounds are widely implicated in the beer brewing industry and are having potential biomedical applications. Several independent breeding programs around the world have been initiated to develop new cultivars with enriched lupulin and secondary metabolite contents but met with limited success due to several constraints. In the present work, a pioneering attempt has been made to overexpress master regulator binary transcription factor complex formed by HlWRKY1 and HlWDR1 using a plant expression vector to enhance the level of prenylflavonoid and bitter acid content in the hop...
October 11, 2018: BMC Genomics
https://www.readbyqxmd.com/read/30303785/running-a-radiology-residency-program-strategies-for-success
#8
David S Sarkany, Anuradha S Shenoy-Bhangle, Tara M Catanzano, Tabitha A Fineberg, Ronald L Eisenberg, Priscilla J Slanetz
Running a successful radiology residency program requires departments to navigate the evolving educational landscape at the departmental, institutional, and national levels. To attract the best applicants, departments must invest time and money to support the leadership of the program and its faculty to provide innovative educational opportunities in a positive learning environment while simultaneously complying with all of the requirements of the Accreditation Council for Graduate Medical Education. The key administrative requirements of a successful radiology residency program are described and can be grouped into (a) essential administrative components, (b) the clinical learning environment review and self-study process, and (c) resident recruitment...
October 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/30294265/when-does-oxytocin-affect-human-memory-encoding-the-role-of-social-context-and-individual-attachment-style
#9
Ullrich Wagner, Gerald Echterhoff
The neuropeptide oxytocin plays an essential role in regulating social behavior and has been implicated in a variety of human cognitive processes in the social domain, including memory processes. The present study investigates the influence of oxytocin on human memory encoding, taking into account social context and personality, which have previously been neglected as moderators for how oxytocin affects memory encoding. To examine the role of social context of encoding, we employed an established experimental paradigm in which participants perform a word-categorization task in either a joint (social) or individual (non-social) setting...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/30289159/antagonistic-recursivities-and-successive-cover-ups-the-case-of-private-nuclear-proliferation
#10
Grégoire Mallard
"Legal recursivity" is a concept introduced by socio-legal scholars to capture the progressive elaboration of transnational rules through policy linkages at the international and domestic levels, and the associated jurisdictional expansion of international institutions to new policy areas. Recursivity can take many forms, and this article introduces the concept of "antagonistic recursivity" to capture a dual process of recursive legal innovation and antagonistic obstruction by the same policy actors...
October 5, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/30285295/5-12-diaminotetracenes-the-impact-of-orbital-interactions-between-the-acene-%C3%AF-system-and-amino-groups-on-their-electronic-states
#11
Masashi Uebe, Kenji Kawashima, Akihiro Ito
5,12-Diamino-substituted tetracenes with various N-substituents have been prepared, and their molecular structural changes upon oxidation have been evaluated in association with their electronic structures. The N-substituents influence both the electronic and molecular structures of the oxidized species of 5,12-diaminotetracenes. The tetracene moiety of 5,12-bis(N,N-dianisylamino)tetracene retained its planarity during the course of two successive one-electron oxidations, whereas 5,12-bis(N,N-dimethylamino)tetracene and 5,12-bis(N-anisyl-N-methylamino)tetracene underwent substantial structural changes into butterfly like structures through a simultaneous two-electron oxidation process...
October 4, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30280381/multiple-density-dependent-processes-shape-the-dynamics-of-a-spatially-structured-amphibian-population
#12
Hugo Cayuela, Benedikt R Schmidt, Avril Weinbach, Aurélien Besnard, Pierre Joly
1.Understanding the mechanisms that regulate the dynamics of spatially structured populations (SSP) is a critical challenge for ecologists and conservation managers. Internal population processes such as births and deaths occur at a local level, while external processes such as dispersal take place at an inter-population level. At both levels, density dependence is expected to play a critical role. At a patch scale, demographic traits (e.g. survival, breeding success) and the population growth rate can be influenced by density either negatively (e...
October 2, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/30278772/calibration-methods-for-the-simultaneous-measurement-of-the-impulse-mass-loss-and-average-thrust-of-a-pulsed-plasma-thruster
#13
T Yoshikawa, R Tsukizaki, H Kuninaka
This paper presents calibration devices and methods for the measurement of electric thruster performance parameters using a seesaw-type thrust stand to measure the mass loss of solid propellant in a vacuum. In previous studies, impact hammers and electrostatic combs have been manufactured for the calibration of the thrust and impulse using seesaw-type thrust stands. However, these conventional devices rely on self-calibration, which means that the input delivered by the device in unknown, and must undergo a calibration process themselves...
September 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/30274667/hide-and-seek-directing-top-down-attention-is-not-sufficient-for-accelerating-conscious-access
#14
Surya Gayet, Iris Douw, Vera van der Burg, Stefan Van der Stigchel, Chris L E Paffen
At any moment in time, we have a single conscious visual experience representing a minute part of our visual world. As such, the visual input stimulating our retinae is in continuous competition for reaching conscious access. Many complex cognitive operations can only be applied to consciously accessible visual information, thereby raising the question whether humans have the ability to select which parts of their visual input reaches consciousness. Top-down attention allows humans to flexibly assign more processing resources to certain parts of our visual input, making it a likely mechanism to volitionally bias conscious access...
September 10, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/30273101/effects-of-epigallocatechin-gallate-on-behavioral-and-cognitive-impairments-hypothalamic-pituitary-adrenal-axis-dysfunction-and-alternations-in-hippocampal-bdnf-expression-under-single-prolonged-stress
#15
Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm
Post-traumatic stress disorder (PTSD) is a traumatic stress-related psychiatric disorder stimulated by experience. Green tea has potent antioxidative properties, due, in part, to the catechin (-) epigallocatechin-3-gallate (EGCG). EGCG is an important polyphenol with advantageous effects on anxiety and depression. Nevertheless, the mechanism about the inhibition of PTSD-like symptoms of EGCG is still unidentified. We examined whether EGCG improved learning and memory deficit stimulated in rats after single prolonged stress (SPS)...
September 29, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/30262128/recent-progress-in-the-engineering-of-multifunctional-colloidal-nanoparticles-for-enhanced-photodynamic-therapy-and-bioimaging
#16
REVIEW
Łukasz Lamch, Agata Pucek, Julita Kulbacka, Michał Chudy, Elżbieta Jastrzębska, Katarzyna Tokarska, Magdalena Bułka, Zbigniew Brzózka, Kazimiera A Wilk
This up-to-date review summarizes the design and current fabrication strategies that have been employed in the area of mono- and multifunctional colloidal nanoparticles - nanocarriers well suited for photodynamic therapy (PDT) and diagnostic purposes. Rationally engineered photosensitizer (PS)-loaded nanoparticles may be achieved via either noncovalent (i.e., self-aggregation, interfacial deposition, interfacial polymerization, or core-shell entrapment along with physical adsorption) or covalent (chemical immobilization or conjugation) processes...
September 18, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/30253368/effect-of-anaerobic-aerobic-duration-on-nitrogen-removal-and-microbial-community-in-a-simultaneous-partial-nitrification-and-denitrification-system-under-low-salinity
#17
Wuyi Huang, Zonglian She, Mengchun Gao, Qun Wang, Chunji Jin, Yangguo Zhao, Liang Guo
In this study, the simultaneous partial nitrification and denitrification (SPND) process was investigated in a hybrid sequencing batch biofilm reactor (HSBBR) fed with synthetic wastewater with 1.2% salinity. Different anaerobic/aerobic (An/Ae) durations were selected for evaluating the removal performance of contaminants and the succession of the microbial community in the reactor. The highest organic matter removal efficiency was obtained at An/Ae hour ratio of 0/6.5, with an average chemical oxygen demand (COD) removal of 89...
September 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/30252169/mass-production-of-large-sized-nonlayered-2d-nanosheets-their-directed-synthesis-by-a-rapid-gel-blowing-strategy-and-applications-in-li-na-storage-and-catalysis
#18
Dong Wang, Weiwei Zhou, Rui Zhang, Jinjue Zeng, Yu Du, Shuai Qi, Chunxiao Cong, Chunyan Ding, Xiaoxiao Huang, Guangwu Wen, Ting Yu
2D nanomaterials are well suited for energy conversion and storage because of their thickness-dependent physical and chemical properties. However, current synthetic methods for translating 2D materials from the laboratory to industry cannot integrate both advantages of liquid-phase method (i.e., solution processibility, homogeneity, and massive production), and gas-phase method (i.e., high quality and large lateral size). Here, inspired by Chinese Sugar Figure Blowing Art, a rapid "gel-blowing" strategy is proposed for the mass production of 2D nonlayered nanosheets by thermally expanding the viscous gel precursors within a short time (≈1 min)...
September 4, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30251036/independent-processing-of-increments-and-decrements-in-odorant-concentration-by-on-and-off-olfactory-receptor-neurons
#19
REVIEW
Harald Tichy, Maria Hellwig
A salient feature of the insect olfactory system is its ability to detect and interpret simultaneously the identity and concentration of an odorant signal along with the temporal stimulus cues that are essential for accurate odorant tracking. The olfactory system of the cockroach utilizes two parallel pathways for encoding of odorant identity and the moment-to-moment succession of odorant concentrations as well as the rate at which concentration changes. This separation originates at the peripheral level of the ORNs (olfactory receptor neurons) which are localized in basiconic and trichoid sensilla...
September 24, 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/30249167/the-dual-mode-imaging-of-nanogold-labeled-cells-by-photoacoustic-microscopy-and-fluorescence-optical-microscopy
#20
Yu Zhang, Zhilie Tang, Yongbo Wu, Yueju Xue, Jinliang Jia
Photoacoustic microscopy is dominantly sensitive to the endogenous optical absorption, while a fluorescence optical microscopy can detect the fluorescence emission to obtain the image of a sample. To some extent, the physical processes of the 2 methods are opposite, one is absorption and another is emission, but both can be used to image cells. In this article, a simultaneous dual-mode imaging system of photoacoustic microscopy and fluorescence optical microscopy is set up to image tobacco cells. Furthermore, gold nanoparticles, which have a large absorption coefficient and enough fluorescence emission with wavelength of 512 nm, are used to label certain drugs and added to the tobacco cells...
January 1, 2018: Technology in Cancer Research & Treatment
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