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https://www.readbyqxmd.com/read/30340915/the-role-of-inhibitor-of-binding-or-differentiation-2-in-the-development-and-differentiation-of-immune-cells
#1
REVIEW
Haojie Wu, Qixiang Shao
Inhibitor of binding or differentiation 2 (Id2), a member of helix-loop-helix (HLH) transcriptional factors, is recently reported as an important regulator of the development or differentiation of immune cells. It has been demonstrated that Id2 plays a critical role in the early lymphopoiesis. However, it has been discovered recently that Id2 displays new functions in different immune cells. In the adaptive immune cells, Id2 is required for determining T-cell subsets and B cells. In addition, Id2 is also involved in the development of innate immune cells, including dendritic cells (DCs), natural killer (NK) cells, and other innate lymphoid cells (ILCs)...
September 20, 2018: Immunobiology
https://www.readbyqxmd.com/read/30339853/engulfment-of-mast-cell-secretory-granules-upon-skin-inflammation-boosts-dendritic-cell-migration-and-priming-efficiency
#2
Jan Dudeck, Julia Froebel, Johanna Kotrba, Christian H K Lehmann, Diana Dudziak, Stephan Speier, Sergei A Nedospasov, Burkhart Schraven, Anne Dudeck
BACKGROUND: Mast cells (MCs) are best known as key effector cells of allergic reactions but they also play an important role in host defense against pathogens. Despite increasing evidence for a critical impact of MCs on adaptive immunity, the underlying mechanisms are poorly understood. OBJECTIVE: Here, we monitored MC intercellular communication with dendritic cells (DCs), MC activation and degranulation and tracked the fate of exocytosed MC granules during skin inflammation...
October 16, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30337650/the-emergence-of-pathogenic-tnf-inos-producing-dendritic-cells-tip-dcs-in-a-malaria-model-of-acute-respiratory-distress-syndrome-ards-is-dependent-on-ccr4
#3
Bruno Galvão-Filho, Júlia Teixeira de Castro, Maria Marta Figueiredo, Claudio Gonçalves Rosmaninho, Lis Ribeiro do Valle Antonelli, Ricardo Tostes Gazzinelli
Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced MA-ALI/ARDS model that resembles human disease and confirmed that lung CD4+ and CD8+ T cells predominantly expressed Tbet and IFN-γ. Surprisingly, we found that development of MA-ALI/ARDS was dependent on functional CCR4, known to mediate the recruitment of Th2 lymphocytes and regulatory T cells...
October 18, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/30333837/porcine-reproductive-and-respiratory-syndrome-virus-type-1-3-lena-triggers-conventional-dendritic-cells-1-activation-and-t-helper-1-immune-response-without-infecting-dendritic-cells
#4
Elise Bordet, Fany Blanc, Mathieu Tiret, Elisa Crisci, Edwige Bouguyon, Patricia Renson, Pauline Maisonnasse, Mickael Bourge, Jean-Jacques Leplat, Elisabetta Giuffra, Luc Jouneau, Isabelle Schwartz-Cornil, Olivier Bourry, Nicolas Bertho
Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is an arterivirus responsible for highly contagious infection and huge economic losses in pig industry. Two species, PRRSV-1 and PRRSV-2 are distinguished, PRRSV-1 being more prevalent in Europe. PRRSV-1 can further be divided in subtypes. PRRSV-1.3 such as Lena are more pathogenic than PRRSV-1.1 such as Lelystad or Flanders13. PRRSV-1.3 viruses trigger a higher Th1 response than PRRSV-1.1, although the role of the cellular immune response in PRRSV clearance remains ill defined...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30333803/extracellular-vesicles-from-sporothrix-brasiliensis-are-an-important-virulence-factor-that-induce-an-increase-in-fungal-burden-in-experimental-sporotrichosis
#5
Marcelo Augusto Kazuo Ikeda, José Roberto Fogaça de Almeida, Grasielle Pereira Jannuzzi, André Cronemberger-Andrade, Ana Cláudia Trocoli Torrecilhas, Nilmar Silvio Moretti, Julia Pinheiro Chagas da Cunha, Sandro Rogério de Almeida, Karen Spadari Ferreira
Sporotrichosis is a mycosis that affects the skin, lymphatic system and other organs in humans and animals. The disease has a worldwide distribution, with endemic areas in Brazil, and is caused by a complex of species, including Sporothrix brasiliensis . Some fungi release extracellular vesicles (EVs) that can interact with the host cell and modulate the host immune response. The aim of this study was to analyze the participation of S. brasiliensis EVs in the modulation of dendritic cells (DCs) and in the control of infection in vivo ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30333312/targeting-antigen-presenting-cells-by-anti-pd-1-nanoparticles-augments-antitumor-immunity
#6
Farideh Ordikhani, Mayuko Uehara, Vivek Kasinath, Li Dai, Siawosh K Eskandari, Baharak Bahmani, Merve Yonar, Jamil R Azzi, Yousef Haik, Peter T Sage, George F Murphy, Nasim Annabi, Tobias Schatton, Indira Guleria, Reza Abdi
Recent studies in cancer research have focused intensely on the antineoplastic effects of immune checkpoint inhibitors. While the development of these inhibitors has progressed successfully, strategies to further improve their efficacy and reduce their toxicity are still needed. We hypothesized that the delivery of anti-PD-1 antibody encapsulated in PLGA nanoparticles (anti-PD-1 NPs) to the spleen would improve the antitumor effect of this agent. Unexpectedly, we found that mice treated with a high dose of anti-PD-1 NPs exhibited significantly higher mortality compared with those treated with free anti-PD-1 antibody, due to the overactivation of T cells...
October 18, 2018: JCI Insight
https://www.readbyqxmd.com/read/30333120/murine-myeloproliferative-disorder-as-a-consequence-of-impaired-collaboration-between-dendritic-cells-and-cd4-t-cells
#7
Stéphanie Humblet-Baron, John S Barber, Carlos Roca, Aurelie Lenaerts, Pandelakis A Koni, Adrian Liston
Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in both murine studies with constitutive depletion of DCs, and in patients with congenital deficiency in DCs caused by mutations in GATA2 or IRF8 The mechanistic link between DC deficiency and MPD was not predicted through the known biology and has remained an enigma. Prevailing models suggest numerical DC deficiency leads to MPD through compensatory myeloid differentiation...
October 17, 2018: Blood
https://www.readbyqxmd.com/read/30328797/interleukin-23-a-new-atherosclerosis-target
#8
Wenjing Liu, Chao Chang, Haiying Hu, Hua Yang
Accumulating evidence has shown that atherosclerosis is an inflammatory disease. The pathogenesis of atherosclerosis has been confirmed to involve an imbalance in anti-inflammatory/proinflammatory processes. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of the IL-23p19 and IL-12p40 subunits of the IL-12 family. Experiments show that IL-23 induces CD4+ T cells to differentiate into T helper type 17 cells, promotes the expression of interferon-γ, and inhibits the production of Foxp3. Therefore, IL-23 induces and exacerbates effector T lymphocyte/regulatory T cell imbalance...
October 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/30327534/immature-lung-tnfr2-conventional-dc-2-subpopulation-activates-modcs-to-promote-cyclic-di-gmp-mucosal-adjuvant-responses-in-vivo
#9
Samira Mansouri, Seema Patel, Divya S Katikaneni, Steven M Blaauboer, Wei Wang, Stefan Schattgen, Katherine Fitzgerald, Lei Jin
Cyclic dinucleotides (CDNs), including cyclic di-GMP (CDG), are promising vaccine adjuvants in preclinical/clinical trials. The in vivo mechanisms of CDNs are not clear. Here we investigated the roles of lung DC subsets in promoting CDG mucosal adjuvant responses in vivo. Using genetically modified mice and adoptive cell transfer, we identified lung conventional DC 2 (cDC2) as the central player in CDG mucosal responses. We further identified two functionally distinct lung cDC2 subpopulations: TNFR2+ pRelB+ and TNFR2- pRelB- cDC2...
October 16, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/30327247/regulatory-perspective-on-in-vitro-potency-assays-for-human-dendritic-cells-used-in-anti-tumor-immunotherapy
#10
REVIEW
Charlotte DE Wolf, Marja VAN DE Bovenkamp, Marcel Hoefnagel
Dendritic cells (DCs) are key connectors between the innate and adaptive immune system and have an important role in modulating other immune cells. Therefore, their therapeutic application to steer immune responses is considered in various disorders, including cancer. Due to differences in the cell source and manufacturing process, each DC medicinal product is unique. Consequently, release tests to ensure consistent quality need to be product-specific. Although general guidance concerning quality control testing of cell-based therapies is available, cell type-specific regulation is still limited...
October 13, 2018: Cytotherapy
https://www.readbyqxmd.com/read/30326865/co-culture-of-dendritic-cells-and-cytokine-induced-killer-cells-effectively-suppresses-liver-cancer-stem-cell-growth-by-inhibiting-pathways-in-the-immune-system
#11
Tao Yang, Wenjun Zhang, Li Wang, Chunyan Xiao, Li Wang, Yi Gong, Dehong Huang, Bingling Guo, Qiying Li, Ying Xiang, Yingyu Nan
BACKGROUND: Application of dendritic cells (DC) for cancer immunotherapy involves tumor-associated immunogenic antigens for effective therapeutic strategies. The present study investigated whether DC co-cultured with autologous cytokine-induced killer cells (CIK) could induce a more specific immune response against liver cancer stem cells (LCSC) generated from human hepatocellular carcinoma (HCC) cells in vitro and in vivo. METHODS: Human DC and CIK were generated from peripheral blood mononuclear cells (PBMCs) taken from consenting liver cancer patients...
October 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30324853/ebv-reduces-autophagy-intracellular-ros-and-mitochondria-to-impair-monocyte-survival-and-differentiation
#12
M S Gilardini Montani, R Santarelli, M Granato, R Gonnella, M R Torrisi, A Faggioni, M Cirone
EBV has been reported to impair monocyte in vitro differentiation into dendritic cells (DCs) and reduce cell survival. In this study, we added another layer of knowledge to this topic and showed that these effects correlated with macroautophagy/autophagy, ROS and mitochondrial biogenesis reduction. Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs...
October 16, 2018: Autophagy
https://www.readbyqxmd.com/read/30323872/mouse-dendritic-cell-migration-in-abdominal-lymph-nodes-by-intraperitoneal-administration
#13
Bin Wang, Chong Sun, Sijia Wang, Na Shang, Junjie Shangguan, Matteo Figini, Liang Pan, Kang Zhou, Quanhong Ma, Daniele Procissi, Yury Velichko, Vahid Yaghmai, Guoxin Li, Zhuoli Zhang
Dendritic cell (DC) based immunotherapy is a promising approach for cancer treatment and has been approved in clinical settings for decades. Clinical trials have demonstrated relatively poor therapeutic efficacy. The efficacy of DC immunotherapy is strongly influenced by their ability to migrate to the draining lymph nodes (LNs). Therefore, it is critical to deliver DCs and monitor the in vivo biodistributions of DCs after administration. The purpose of this study is to determine whether a novel injection route of DCs improves DC migration to LNs, tissues, organs and lymphatics...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30322965/differentiation-of-langerhans-cells-from-monocytes-and-their-specific-function-in-inducing-il-22-specific-th-cells
#14
Yohei Otsuka, Eri Watanabe, Eiji Shinya, Sadayuki Okura, Hidehisa Saeki, Teunis B H Geijtenbeek, Hidemi Takahashi
Human mucosal tissues and skin contain two distinct types of dendritic cell (DC) subsets, epidermal Langerhans cells (LCs) and dermal DCs, which can be distinguished by the expression of C-type lectin receptors, Langerin and DC-SIGN, respectively. Although peripheral blood monocytes differentiate into these distinct subsets, monocyte-derived LCs (moLCs) induced by coculture with GM-CSF, IL-4, and TGF-β1 coexpress both Langerin and DC-SIGN, suggesting that the environmental cues remain unclear. In this study, we show that LC differentiation is TGF-β1 dependent and that cofactors such as IL-4 and TNF-α promote TGF-β1-dependent LC differentiation into Langerin+ DC-SIGN- moLCs but continuous exposure to IL-4 blocks differentiation...
October 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30321818/restoration-of-stemness-high-tumor-cell-mediated-suppression-of-murine-dendritic-cell-activity-and-inhibition-of-tumor-growth-by-low-molecular-weight-oyster-polysaccharide
#15
Ming Zhong, Cheng Zhong, Pei Hu, Wen Cui, Guanghui Wang, Huijei Gao, Chao Liu, Zhiqiang Liu, Zhihua Li, Chunxia Li, Eiichi Gohda
Dendritic cells (DCs) play key regulatory roles in tumor immunity: increased activity of DCs infiltrating tumor tissues leads to enhancement of tumor immunity. Functions of DCs are also modulated by tumor cell-derived factors. Here, we investigated the effects of low molecular weight oyster polysaccharide (LMW-OPS) on differentiation and function of bone marrow-derived DCs (BMDCs) exposed to a conditioned medium (CM) obtained from spheres of stemness-high colorectal cancer cell lines CMT93 and CT26. The CM containing a detectable level of TGF-β1 was found to down-regulate the surface expression of major histocompatibility complex class II of BMDCs and to inhibit the potency of BMDCs to stimulate T cells...
October 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30321268/fact-box-decision-support-tools-reduce-decisional-conflict-about-antibiotics-for-pneumonia-and-artificial-hydration-in-advanced-dementia-a-randomized-controlled-trail
#16
Andrea J Loizeau, Nathan Theill, Simon M Cohen, Stefanie Eicher, Susan L Mitchell, Silvio Meier, Michelle McDowell, Mike Martin, Florian Riese
Background: fact Boxes are decision support tools that can inform about treatment effects. Objectives: to test whether Fact Box decision support tools impacted decisional conflict, knowledge and preferences about the use of antibiotics and artificial hydration in advanced dementia. Design: randomized controlled trial. Setting: Swiss-German region of Switzerland. Subjects: two hundred thirty-two participants (64 physicians, 100 relatives of dementia patients, 68 professional guardians) randomly allocated to intervention (N = 114) or control (N = 118)...
October 15, 2018: Age and Ageing
https://www.readbyqxmd.com/read/30319969/interactions-between-nanoparticles-and-dendritic-cells-from-the-perspective-of-cancer-immunotherapy
#17
REVIEW
Jianbo Jia, Yi Zhang, Yan Xin, Cuijuan Jiang, Bing Yan, Shumei Zhai
Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology stands as a promising strategy for cancer immunotherapy. The physicochemical properties of nanoparticles (NPs) influence their interactions with DCs, thus altering the immune outcome of DCs by changing their functions in the processes of maturation, homing, antigen processing and antigen presentation. In this review, we summarize the recent progress in targeting DCs using NPs as a drug delivery carrier in cancer immunotherapy, the recognition of NPs by DCs, and the ways the physicochemical properties of NPs affect DCs' functions...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30319653/the-nontoxic-cholera-b-subunit-is-a-potent-adjuvant-for-intradermal-dc-targeted-vaccination
#18
Laura Antonio-Herrera, Oscar Badillo-Godinez, Oscar Medina-Contreras, Araceli Tepale-Segura, Alberto García-Lozano, Lourdes Gutierrez-Xicotencatl, Gloria Soldevila, Fernando R Esquivel-Guadarrama, Juliana Idoyaga, Laura C Bonifaz
CD4+ T cells are major players in the immune response against several diseases; including AIDS, leishmaniasis, tuberculosis, influenza and cancer. Their activation has been successfully achieved by administering antigen coupled with antibodies, against DC-specific receptors in combination with adjuvants. Unfortunately, most of the adjuvants used so far in experimental models are unsuitable for human use. Therefore, human DC-targeted vaccination awaits the description of potent, yet nontoxic adjuvants. The nontoxic cholera B subunit (CTB) can be safely used in humans and it has the potential to activate CD4+ T cell responses...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30319629/determination-of-t-follicular-helper-cell-fate-by-dendritic-cells
#19
REVIEW
Jayendra Kumar Krishnaswamy, Samuel Alsén, Ulf Yrlid, Stephanie C Eisenbarth, Adam Williams
T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4+ effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30317470/the-evolution-and-impact-of-the-damage-control-orthopedics-paradigm-in-combat-surgery-a-review
#20
REVIEW
Georgios Kalinterakis, Antonios Koutras, Athanasios Syllaios, Nikolaos Michalakeas, Dimitrios Lytras, Ioannis Tsilikis
The idea of damage control (DC) is grounded on a sequential therapeutic strategy that supports physiological restoration over anatomic repair in critically injured patients. This concept is firstly described as damage control surgery (DCS) for war-wounded patients with abdominal exsanguinating trauma. The goal was to avoid prolonged operative times and prevent the outset of the lethal cycle of hypothermia, acidosis and coagulopathy. Damage control orthopedics (DCO) is also based on this concept and it is applied in the treatment of some polytrauma patients with pelvic and long bones fractures as to avoid the "second hit" of a lengthy definitive operation and eliminate initial morbidity and mortality...
October 13, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
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