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https://www.readbyqxmd.com/read/30110645/large-scale-human-dendritic-cell-differentiation-revealing-notch-dependent-lineage-bifurcation-and-heterogeneity
#1
Sreekumar Balan, Catharina Arnold-Schrauf, Abdenour Abbas, Norbert Couespel, Juliette Savoret, Francesco Imperatore, Alexandra-Chloé Villani, Thien-Phong Vu Manh, Nina Bhardwaj, Marc Dalod
The ability to generate large numbers of distinct types of human dendritic cells (DCs) in vitro is critical for accelerating our understanding of DC biology and harnessing them clinically. We developed a DC differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs (pDCs) and both types of conventional DCs (cDC1s and cDC2s). The identity of the cells generated in vitro and their strong homology to their blood counterparts were demonstrated by phenotypic, functional, and single-cell RNA-sequencing analyses...
August 14, 2018: Cell Reports
https://www.readbyqxmd.com/read/30108595/interleukin-33-contributes-to-the-induction-of-th9-cells-and-antitumor-efficacy-by-dectin-1-activated-dendritic-cells
#2
Jintong Chen, Yinghua Zhao, Yuxue Jiang, Sujun Gao, Yiming Wang, Dongjiao Wang, Alison Wang, Huanfa Yi, Rui Gu, Qing Yi, Siqing Wang
We recently discovered that dectin-1-activated dendritic cells (DCs) drive potent T helper (Th) 9 cell responses and antitumor immunity. However, the underlying mechanisms need to be further defined. The cytokine microenvironment is critical for Th cell differentiation. Here, we show that dectin-1 activation enhances interleukin (IL)-33 expression in DCs. We found that blocking IL-33/ST2 inhibits dectin-1-activated DC-induced Th9 cell differentiation. More importantly, the addition of IL-33 further promotes Th9 cell priming and antitumor efficacy induced by dectin-1-activated DCs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30108532/creating-images-with-the-stroke-of-a-hand-depiction-of-size-and-shape-in-sign-language
#3
Jenny C Lu, Susan Goldin-Meadow
In everyday communication, not only do speakers describe, but they also depict. When depicting, speakers take on the role of other people and quote their speech or imitate their actions. In previous work, we developed a paradigm to elicit depictions in speakers. Here we apply this paradigm to signers to explore depiction in the manual modality, with a focus on depiction of the size and shape of objects. We asked signers to describe two objects that could easily be characterized using lexical signs (Descriptive Elicitation), and objects that were more difficult to distinguish using lexical signs, thus encouraging the signers to depict (Depictive Elicitation)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30107273/direct-loading-of-ctl-epitopes-onto-mhc-class-i-complexes-on-dendritic-cell-surface-in-vivo
#4
Peng Wang, Shuyun Dong, Peng Zhao, Xiao He, Mingnan Chen
Dendritic cell (DC)-based cytotoxic T lymphocyte (CTL) epitope vaccines are effective to induce CTL responses but require complex ex vivo DC preparation and epitope-loading. To take advantage of DC-based epitope vaccines without involving the ex vivo procedures, we aimed to develop carriers to directly load CTL epitopes onto DCs in vivo. Here, we first engineered a carrier consisting of a hydrophilic polypeptide, immune-tolerant elastin-like polypeptide (iTEP) and a substrate peptide of matrix metalloproteinases-9 (sMMP)...
August 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/30106470/a-universal-anti-cancer-vaccine-chimeric-invariant-chain-potentiates-the-inhibition-of-melanoma-progression-and-the-improvement-of-survival
#5
Adi Sharbi-Yunger, Mareike Grees, Cafri Gal, David Bassan, Stefan B Eichmüller, Esther Tzehoval, Jochen Utikal, Viktor Umansky, Lea Eisenbach
For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs based vaccine platforms are effective in generating detectable CD4 and CD8 T cell responses against tumor associated antigens. Several platforms include DC transfection with mRNA of the desired tumor antigen...
August 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30106334/effect-of-irradiance-and-exposure-duration-on-temperature-and-degree-of-conversion-of-dual-cure-resin-cement-for-ceramic-restorations
#6
J S Shim, S H Han, N Jha, S T Hwang, W Ahn, J Y Lee, J J Ryu
This study investigated the effects of irradiance and exposure duration on dual-cured resin cements irradiated through ceramic restorative materials. A single light-curing unit was calibrated to three different irradiances (500, 1000, and 1500 mW/cm2 ) and irradiated to three different attenuating materials (transparent acryl, lithium disilicate, zirconia) with 1-mm thicknesses for 20 or 60 seconds. The changes in irradiance and temperature were measured with a radiometer (or digital thermometer) under the attenuating materials...
August 14, 2018: Operative Dentistry
https://www.readbyqxmd.com/read/30106248/d-cycloserine-augmented-one-session-treatment-of-specific-phobias-in-children-and-adolescents
#7
Lara J Farrell, Allison M Waters, Ella L Oar, Evelin Tiralongo, Vinay Garbharran, Clair Alston-Knox, Harry McConnell, Nigel Collings, Melanie Zimmer-Gembeck, Caroline L Donovan, Chris Testa, Eric A Storch, Thomas H Ollendick
BACKGROUND: D-Cycloserine has potential to enhance exposure therapy outcomes. The current study presents a preliminary randomized, placebo-controlled double-blind pilot trial of DCS-augmented one-session treatment (OST) for youth (7-14 years) with specific phobia. A secondary aim of this pilot study was to explore the effects of youth age and within-session fear reduction as potential moderators of DCS outcomes in order to generate hypotheses for a larger trial. It was hypothesized that DCS would be associated with greater improvements than placebo, that children (7-10 years) would have greater benefits than adolescents (11-14 years), and that DCS effects would be stronger for participants with the greater within-session fear reduction during the OST...
June 2018: Brain and Behavior
https://www.readbyqxmd.com/read/30105033/uncovering-the-mysteries-of-langerhans-cells-inflammatory-dendritic-epidermal-cells-and-monocyte-derived-langerhans-cell-like-cells-in-the-epidermis
#8
REVIEW
Masayuki Otsuka, Gyohei Egawa, Kenji Kabashima
The identity of Langerhans cells (LCs) has been called into question of late due to the increasing evidence that LCs originate from macrophage lineage instead of dendritic cell (DC) lineage as previously thought. For many years, LCs have been assumed to be DCs due to its migratory capabilities. However, recent studies have demonstrated that LCs are from macrophage lineage of the adult fetal liver (FL) progenitor. Bona fide LCs are now considered tissue-resident macrophages as they originate from the FL as shown by fate mapping models...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30104575/cancer-stem-cells-as-targets-for-dc-based-immunotherapy-of-colorectal-cancer
#9
Magdalena Szaryńska, Agata Olejniczak, Jarosław Kobiela, Dariusz Łaski, Zbigniew Śledziński, Zbigniew Kmieć
The therapy of colorectal cancer (CRC) patients is often unsuccessful because of the presence of cancer stem cells (CSCs) resistant to conventional approaches. Dendritic cells (DC)-based protocols are believed to effectively supplement CRC therapy. Our study was aimed to assess how the number and properties of CSCs isolated from tumor tissue of CRC patients will affect the biological characteristics of in vitro modified DCs. Similar procedures were conducted with the using of CRC HCT116 and HT29 cell lines...
August 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30103789/dual-effect-of-dlbcl-derived-exos-in-lymphoma-to-improve-dc-vaccine-efficacy-in-vitro-while-favor-tumorgenesis-in-vivo
#10
Zhenzhen Chen, Liangshun You, Lei Wang, Xianbo Huang, Hui Liu, Ju Ying Wei, Li Zhu, Wenbin Qian
BACKGROUND: Exosomes derived from tumor cells (TEXs) are involved in both immune suppression, angiogenesis, metastasis and anticancer stimulatory, but the biological characteristics and role of diffuse large B cell lymphoma (DLBCL)-derived exosomes have been less investigated. METHODS: Exosomes (EXOs) were isolated from OCI-LY3, SU-DHL-16, and Raji cells and biological characteristics of EXOs were investigated using electron microscopy, flow cytometry analysis, and Western blot analysis...
August 13, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30103457/early-investigations-and-recent-advances-in-intraperitoneal-immunotherapy-for-peritoneal-metastasis
#11
REVIEW
Anusha Thadi, Marian Khalili, William F Morano, Scott D Richard, Steven C Katz, Wilbur B Bowne
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance. These strategies include heightening T-cell response and vaccine induction of anti-cancer memory against tumor-associated antigens. Early investigations with chimeric antigen receptor T cells (CAR-T cells), vaccine-based therapies, dendritic cells (DCs) in combination with pro-inflammatory cytokines and natural killer cells (NKs), adoptive cell transfer, and immune checkpoint inhibitors represent significant advances in the treatment of PM...
August 10, 2018: Vaccines
https://www.readbyqxmd.com/read/30102291/identification-and-isolation-of-oligopotent-and-lineage-committed-myeloid-progenitors-from-mouse-bone-marrow
#12
Alberto Yáñez, Helen S Goodridge
Myeloid progenitors that yield neutrophils, monocytes and dendritic cells (DCs) can be identified in and isolated from the bone marrow of mice for hematological and immunological analyses. For example, studies of the cellular and molecular properties of myeloid progenitor populations can reveal mechanisms underlying leukemic transformation, or demonstrate how the immune system responds to pathogen exposure. Previously described flow cytometry strategies for myeloid progenitor identification have enabled significant advances in many fields, but the fractions they identify are very heterogeneous...
July 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30097531/autocrine-il-10-signaling-promotes-dendritic-cell-type-2-activation-and-persistence-of-murine-cryptococcal-lung-infection
#13
Seagal Teitz-Tennenbaum, Steven P Viglianti, Jonathan A Roussey, Stuart M Levitz, Michal A Olszewski, John J Osterholzer
The substantial morbidity and mortality caused by invasive fungal pathogens, including Cryptococcus neoformans , necessitates increased understanding of protective immune responses against these infections. Our previous work using murine models of cryptococcal lung infection demonstrated that dendritic cells (DCs) orchestrate critical transitions from innate to adaptive immunity and that IL-10 signaling blockade improves fungal clearance. To further understand interrelationships among IL-10 production, fungal clearance, and the effect of IL-10 on lung DCs, we performed a comparative temporal analysis of cryptococcal lung infection in wild type C57BL/6J mice (designated IL-10+/+ ) and IL-10-/- mice inoculated intratracheally with C...
August 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30097529/conventional-dendritic-cells-impair-recovery-after-myocardial-infarction
#14
Jun Seong Lee, Se-Jin Jeong, Sinai Kim, Lorraine Chalifour, Tae Jin Yun, Mohammad Alam Miah, Bin Li, Abdelilah Majdoubi, Antoine Sabourin, Tibor Keler, Jean V Guimond, Elie Haddad, Eui-Young Choi, Slava Epelman, Jae-Hoon Choi, Jacques Thibodeau, Goo Taeg Oh, Cheolho Cheong
Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular dendritic cells. To address this limitation, we used detailed lineage tracing and genetic studies to identify bona fide murine and human CD103+ conventional dendritic cell (cDC)1s, CD11b+ cDC2s, and plasmacytoid DCs (pDCs) in the heart of normal mice and immunocompromised NSG mice reconstituted with human CD34+ cells, respectively...
August 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30097177/lactobacillus-rhamnosus-gg-induced-protective-effect-on-allergic-airway-inflammation-is-associated-with-gut-microbiota
#15
Juan Zhang, Jing-Yi Ma, Qiu-Hong Li, Hui Su, Xin Sun
Great interest has been taken in the use of beneficial bacteria for allergic diseases recently, but the underlying mechanisms through which probiotics induces immune regulation or immune tolerance are poorly understood. We aimed to explore whether Lactobacillus rhamnosus GG (LGG)-induced beneficial effect relates to the change of microbiota. LGG was administered orally to mouse model of ovalbumin (OVA)-induced allergic airway inflammation. Our findings manifested that LGG-treatment contributes to protect against OVA-induced allergic airway inflammation by expanding mesenteric CD103+ DCs and accumulating mucosal Tregs...
August 2, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/30095866/the-role-of-mononuclear-phagocytes-in-ebola-virus-infection
#16
REVIEW
Kai J Rogers, Wendy Maury
The filovirus, Zaire Ebolavirus (EBOV), infects tissue macrophages (Mϕs) and dendritic cells (DCs) early during infection. Viral infection of both cells types is highly productive, leading to increased viral load. However, virus infection of these two cell types results in different consequences for cellular function. Infection of Mϕs stimulates the production of proinflammatory and immunomodulatory cytokines and chemokines, leading to the production of a cytokine storm, while simultaneously increasing tissue factor production and thus facilitating disseminated intravascular coagulation...
August 10, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/30093900/quantitative-measurement-of-na%C3%A3-ve-t-cell-association-with-dendritic-cells-frcs-and-blood-vessels-in-lymph-nodes
#17
Humayra Tasnim, G Matthew Fricke, Janie R Byrum, Justyna O Sotiris, Judy L Cannon, Melanie E Moses
T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested that T cell positioning facilitates DC colocalization leading to T:DC interaction. Despite the influence chemical signals, cells, and structures can have on naïve T cell positioning, relatively few studies have used quantitative measures to directly compare T cell interactions with key cell types...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30092832/high-mammographic-density-in-women-is-associated-with-protumor-inflammation
#18
Cecilia W Huo, Prue Hill, Grace Chew, Paul J Neeson, Heloise Halse, Elizabeth D Williams, Michael A Henderson, Erik W Thompson, Kara L Britt
BACKGROUND: Epidemiological studies have consistently shown that increased mammographic density (MD) is a strong risk factor for breast cancer. We previously observed an elevated number of vimentin+ /CD45+ leukocytes in high MD (HMD) epithelium. In the present study, we aimed to investigate the subtypes of immune cell infiltrates in HMD and low MD (LMD) breast tissue. METHODS: Fifty-four women undergoing prophylactic mastectomy at Peter MacCallum Cancer Centre or St...
August 9, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/30092402/the-supercarbonate-apatite-microrna-complex-inhibits-dextran-sodium-sulfate-induced-colitis
#19
Tadafumi Fukata, Tsunekazu Mizushima, Junichi Nishimura, Daisuke Okuzaki, Xin Wu, Haruka Hirose, Yuhki Yokoyama, Yui Kubota, Kazuya Nagata, Naoto Tsujimura, Akira Inoue, Norikatsu Miyoshi, Naotsugu Haraguchi, Hidekazu Takahashi, Taishi Hata, Chu Matsuda, Hisako Kayama, Kiyoshi Takeda, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto
The incidence of inflammatory bowel disease (IBD) is increasing. Nucleic acid-based medicine has potential as a next-generation treatment, but it is rarely successful with IBD. The aim of this study was to establish a microRNA-based therapy in an IBD model. For this purpose, we used microRNA-29 (miR-29) and a supercarbonate apatite (sCA) nanoparticle as a drug delivery system. Injection of sCA-miR-29a-3p or sCA-miR-29b-3p into mouse tail veins markedly prevented and restored inflammation because of dextran sulfate sodium (DSS)-induced colitis...
August 6, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30092362/cellular-traffic-through-afferent-lymphatic-vessels
#20
REVIEW
Philipp Schineis, Peter Runge, Cornelia Halin
The lymphatic system has long been known to serve as a highway for migrating leukocytes from peripheral tissue to draining lymph nodes (dLNs) and back to circulation, thereby contributing to the induction of adaptive immunity and immunesurveillance. Lymphatic vessels (LVs) present in peripheral tissues upstream of a first dLN are generally referred to as afferent LVs. In contrast to migration through blood vessels (BVs), the detailed molecular and cellular requirements of cellular traffic through afferent LVs have only recently started to be unraveled...
August 6, 2018: Vascular Pharmacology
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