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https://www.readbyqxmd.com/read/30552287/sphingoid-bases-of-dietary-ceramide-2-aminoethylphosphonate-a-marine-sphingolipid-absorb-into-lymph-in-rats
#1
Nami Tomonaga, Tsuyoshi Tsuduki, Yuki Manabe, Tatsuya Sugawara
Various functions of dietary sphingolipids have been reported; however, little is known about marine sphingolipids. Ceramide 2-aminoethylphosphonate (CAEP), an abundant sphingolipid in marine molluscs, frequently has a unique triene-type of sphingoid base (2-amino-9-methyl-4,8,10-octadecatriene-1,3-diol, or d19:3). We previously reported that dietary CAEP prepared from the skin of squid was digested in the intestinal mucosa of mice via ceramides to yield free sphingoid bases. How dietary CAEP is then used in the body remains unclear...
December 14, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/30545248/identification-of-lipids-of-the-stratum-corneum-by-high-performance-thin-layer-chromatography-and-mass-spectrometry
#2
Emilien L Jamin, Carine Jacques, Laëtitia Jourdes, Jean-Claude Tabet, Nathalie Borotra, Sandrine Bessou-Touya, Laurent Debrauwer, Hélène Duplan
The stratum corneum, the outermost layer of the epidermis, is the most important skin barrier against exogenous physical and chemical effects, in addition to protecting against dehydration. Ceramides are integral parts of the intercellular lipid lamellae of the stratum corneum and play an important role in the barrier function of mammalian skin. Ceramides are sphingolipids consisting of sphingoid bases linked to fatty acids by an amide bond. Typical sphingoid bases in the skin are composed of dihydrosphingosine, sphingosine, phytosphingosine, and 6-hydroxysphingosine, and the fatty acid acyl chains are composed of non-hydroxy fatty acid, α-hydroxy fatty acid, ω-hydroxy fatty acid, and esterified ω-hydroxy fatty acid...
December 13, 2018: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/30513743/influence-of-oral-administration-of-lactic-acid-bacteria-metabolites-on-skin-barrier-function-and-water-content-in-a-murine-model-of-atopic-dermatitis
#3
Yoshihiro Tokudome
The effects of orally administered lactic acid bacteria metabolites on skin were studied using an atopic dermatitis-like murine model generated by feeding HR-AD to mice. Lactic acid bacteria metabolites were obtained by inoculating and culturing soy milk with 35 strains of 16 species of lactic acid bacteria. The atopic dermatitis-like murine model was generated by feeding HR-AD to HR-1 mice for 40 days. The skin condition of HR-AD-fed mice worsened compared with normal mice, showing reduced water content in the stratum corneum, increased transepidermal water loss (TEWL), reduced ceramide AP content in the stratum corneum, and increased epidermis thickness...
December 1, 2018: Nutrients
https://www.readbyqxmd.com/read/30486646/models-for-the-stratum-corneum-lipid-matrix-effects-of-ceramide-concentration-ceramide-hydroxylation-and-free-fatty-acid-protonation
#4
Eric Wang, Jeffery B Klauda
The primary barrier of the skin is provided by the outer layer known as the stratum corneum, making it the active target for transdermal drug delivery. A repeating structure of the SC known as the short periodicity phase is modeled as a bilayer composed of ceramides (Cer), cholesterol (Chol), and free fatty acids (FFA). This study simulates Cer/Chol/FFA bilayers composed of N-lignoceroylsphingosine, α-lignoceroylphytosphingosine, Chol, deprotonated lignoceric acid, and protonated lignoceric acid using the CHARMM36 force field to study the effects of Cer concentration, Cer hydroxylation, and FFA protonation...
November 28, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/30485658/from-stem-cells-protection-to-skin-microbiota-balance-orobanche-rapum-extract-a-new-natural-strategy
#5
Marie Meunier, Amandine Scandolera, Emilie Chapuis, Carole Lambert, Cyrille Jarrin, Patrick Robe, Hanane Chajra, Daniel Auriol, Romain Reynaud
BACKGROUND: Healthy skin is a delicate balance between skin renewal and microbiota homeostasis, and its imbalance promotes premature aging and dermatological disorders. Skin stem cells are key actors in this process but their sensitivity to aging and external stressors such as UV reduces the skin renewal power. The skin microbiota has been recently described as active in the healthy skin, and its imbalance could trigger some disorders. AIMS: We hypothesized that reactivation of stem cells and maintenance of microbiota could be a disruptive strategy for younger and healthier skin...
November 28, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/30467204/sphingolipid-dysregulation-due-to-lack-of-functional-kdsr-impairs-proplatelet-formation-causing-thrombocytopenia
#6
Tadbir K Bariana, Veerle Labarque, Jessica Heremans, Chantal Thys, Mara De Reys, Daniel Greene, Benjamin Jenkins, Luigi Grassi, Denis Seyres, Frances Burden, Deborah Whitehorn, Olga Shamardina, Sofia Papadia, Keith Gomez, Chris Van Geet, Albert Koulman, Willem H Ouwehand, Cedric Ghevaert, Mattia Frontini, Ernest Turro, Kathleen Freson
Sphingolipids are fundamental to membrane trafficking, apoptosis and cell differentiation and proliferation. KDSR or 3-keto-dihydrosphingosine reductase is an essential enzyme for de novo sphingolipid synthesis, and pathogenic mutations in KDSR result in the severe skin disorder erythrokeratodermia variabilis et progressiva-4. Four of the eight reported cases also had thrombocytopenia but the underlying mechanism has remained unexplored. Here we expand upon the phenotypic spectrum of KDSR deficiency with studies in two siblings with novel compound heterozygous variants associated with thrombocytopenia, anemia and minimal skin involvement...
November 22, 2018: Haematologica
https://www.readbyqxmd.com/read/30460697/phytosphingosine-increases-biosynthesis-of-phytoceramide-by-uniquely-stimulating-the-expression-of-dihydroceramide-c4-desaturase-des2-in-cultured-human-keratinocytes
#7
Hyun Kyung Choi, Hyun-Ji Kim, Kwang-Hyeon Liu, Chang Seo Park
Ceramide NP is known to be the most abundant class of 12 ceramide (CER) families that form a permeability barrier in the human skin barrier. However, not many studies have been reported on the regulation of the biosynthesis of ceramide NP. Recently, it has been reported that phytosphingosine (PHS) treatment in the cultured keratinocytes (KC) notably increased the content of ceramide NP. However, the mechanism behind the PHS-induced enhancement of ceramide NP has not been elucidated. In this study, we investigated the effects of PHS on the expression of several essential genes for the biosynthesis of CER...
September 2018: Lipids
https://www.readbyqxmd.com/read/30458189/effect-of-saponins-from-quinoa-on-a-skin-mimetic-lipid-monolayer-containing-cholesterol
#8
Ilona Jurek, Ilona Góral, Krzysztof Gęsiński, Kamil Wojciechowski
The study discusses the effect of a quinoa seed coat extract on a cholesterol-based Langmuir monolayer mimicking the intercellular lipid mixture in the skin's outermost layer - stratum corneum. Besides cholesterol (CHOL), the monolayer contains also stearic acid (SA) and ceramide VI (CER), in a molar ratio of 10:14:14. Three quinoa extracts were tested for their surface activity: a) from the whole seed, b) from the dehulled seed, and c) from the seed coat. The latter shows significantly higher ability to reduce surface tension (increase surface pressure) than the others...
November 17, 2018: Steroids
https://www.readbyqxmd.com/read/30458166/microscopic-models-of-drug-chemical-diffusion-through-the-skin-barrier-effects-of-diffusional-anisotropy-of-the-intercellular-lipid
#9
Ludwig C Nitsche, Gerald B Kasting, Johannes M Nitsche
Owing to the systematic alignment and ordering of fatty acid and/or ceramide chains, lipid layers in biological membranes have strongly anisotropic diffusion properties. The diffusivity D|| lip for solute transport in the direction parallel to the lipid layer is typically 103 -105 times the diffusivity D⊥ lip for the perpendicular direction. This paper explores the consequences of this strong degree of anisotropy on solute diffusion through the stratum corneum (SC, barrier) layer of skin based upon a realistic representation of a unit cell of the microstructure...
November 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30447108/sex-related-differences-in-response-to-zinc-pyrithione-shampoo-versus-non-anti-dandruff-shampoo
#10
L Z Collins, F L Baines, J R Matheson, G A Turner, Y Diao, Y Li, Y Pi
OBJECTIVE: Sex-related differences in skin properties may be expected to impact on dandruff formation and treatment. A meta-analysis approach was undertaken to investigate potential differences between males and females in response to zinc pyrithione (ZnPT) treatment versus non-anti-dandruff (AD) shampoo. A separate pooled statistical analysis of ceramide and total protein loss endpoints was also undertaken to assess potential sex-related differences in stratum corneum properties that might influence response to ZnPT versus non-AD shampoo in subjects with dandruff...
November 17, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/30440687/non-invasive-method-to-monitor-molecular-changes-in-human-stratum-corneum-during-acute-barrier-disruption-using-reflectance-nir-spectroscopy
#11
Eui Seok Shin, June-Young Lee, Seung Jun Lee, Sung Hyun Nam
Stratum corneum is the outer most part of skin for barrier function. Disorder in stratum corneum is related with many skin diseases including acne, atopic dermatitis and psoriasis. In developed countries, about 20% of the population has disorder in the barrier function of stratum corneum. Adhesive tape stripping is a method to disrupt skin barrier function in studying disorder in stratum corneum. In this study, we obtained NIR (Near-Infrared) spectrum of human skin after tape stripping. Changes in skin spectra after barrier disruption were investigated through principal component analysis (PCA) of spectrum...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30410378/skin-hydration-is-significantly-increased-by-a-cream-formulated-to-mimic-the-skin-s-own-natural-moisturizing-systems
#12
Fabrizio Spada, Tanya M Barnes, Kerryn A Greive
Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin. Materials and methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin's own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30399362/pharmacological-inhibition-of-serine-palmitoyl-transferase-and-sphingosine-kinase-1-2-inhibits-merkel-cell-carcinoma-cell-proliferation
#13
Vishwanath Kumble Bhat, Eva Bernhart, Ioanna Plastira, Kaiji Fan, Nassim Ghaffari Tabrizi-Wizsy, Christian Wadsack, Gerald Rechberger, Thomas Eichmann, Martin Asslaber, Ivelina Spassova, Monique E Verhaegen, Ernst Malle, Jürgen C Becker, Wolfgang Sattler
The majority of Merkel cell carcinoma (MCC), a highly aggressive neuroendocrine cancer of the skin, is associated with Merkel cell polyomavirus (MCPyV) infection. Polyomavirus binding, internalization and infection is mediated by glycosphingolipids (GSL). Besides receptor function, bioactive sphingolipids (SL) are increasingly recognized as potent regulators of several hallmarks of cancer. MCPyV+ and MCPyV- cells express serine palmitoyltransferase (SPT) subunits and sphingosine kinase (SK)1/2 mRNA. Induced expression of MCPyV-large tumor antigen in human lung fibroblasts resulted in upregulation of SPTLC1-3 and SK1/2 expression...
November 3, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30390585/interactions-of-nipam-nanogels-with-model-lipid-multi-bilayers-a-neutron-reflectivity-study
#14
Huihui Sun, Katarzyna Zielinska, Marina Resmini, Ali Zarbakhsh
In dermal drug delivery, the influence of the chemical structure of the carriers on their penetration mechanisms is not yet fully understood. This is a key requirement in order to design highly efficient delivery systems. In this study, neutron reflectivity is used to provide insights into the interactions between thermoresponsive N-isopropylacrylamide based nanogels, cross-linked with 10%, 20% and 30% N,N'-methylenebisacrylamide, and skin lipid multi-bilayers models. Ceramide lipid multi-bilayers and ceramide/cholesterol/behenic acid mixed lipid multi-bilayers were used for this work...
February 15, 2019: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30387538/measuring-epidermal-effects-of-ostomy-skin-barriers
#15
Gary Grove, Tim Houser, Gary Sibbald, Ginger Salvadalena
BACKGROUND: Ostomy barriers are adhesive devices designed to hold pouching systems to the abdomen and protect the peristomal skin from stoma effluent. The objective of this study was to determine differences in the extent of skin trauma resulting from serially applying and removing two types of ostomy barriers. METHODS: The study was a randomized, prospective, repeated measure trial involving healthy volunteers. The ostomy skin barriers were applied to the abdomen and changed every 3-4 days over a 17-day period...
November 2, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/30372477/sebaceous-gland-abnormalities-in-fatty-acyl-coa-reductase-2-far2-null-mice-result-in-primary-cicatricial-alopecia
#16
John P Sundberg, Tong Shen, Oliver Fiehn, Robert H Rice, Kathleen A Silva, Victoria E Kennedy, Nicholas E Gott, Louise A Dionne, Lesley S Bechtold, Stephen A Murray, Raoul Kuiper, C Herbert Pratt
In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory's KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alopecia as they aged. As sebocytes matured in wildtype C57BL/NJ mice they became pale with fine, uniformly sized clear lipid containing vacuoles that were released when sebocytes disintegrated in the duct. By contrast, the Far2-/- null mice had sebocytes that were similar within the gland but become brightly eosinophilic when the cells entered the sebaceous gland duct...
2018: PloS One
https://www.readbyqxmd.com/read/30368923/comparison-of-ceramide-retention-in-the-stratum-corneum-between-dry-skin-and-normal-skin-using-animal-model-with-fluorescent-imaging-method
#17
Miku Aoki, Kazuhiro Ogai, Masato Kobayashi, Takeo Minematsu, Toshio Nakatani, Mayumi Okuwa, Hiromi Sanada, Junko Sugama
BACKGROUND/PURPOSE: Skin care via moisturization compensates for the lack of skin barrier function. However, moisturizer application methods are not clearly decided. Here, we focused on and examined the retention of externally applied ceramide in the stratum corneum (SC) using fluorescent imaging method. This study aimed to compare ceramide retention in the SC between normal skin and dry skin using an animal model. METHODS: Nine-week-old Sprague-Dawley rats were divided into two groups: normal skin and dry skin model...
October 27, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/30361410/abhd5-stimulates-pnpla1-mediated-omega-o-acylceramide-biosynthesis-essential-for-a-functional-skin-permeability-barrier
#18
Benedikt Kien, Susanne Grond, Guenter Haemmerle, Achim Lass, Thomas O Eichmann, Franz P W Radner
Mutations in the genes coding for patatin-like phospholipase domain-containing 1 (PNPLA1) and α/β-hydrolase domain-containing 5 (ABHD5), also known as comparative gene idenfication-58 (CGI-58), are causative for a severe skin barrier disorder, termed ichthyosis. Individuals with mutations in either of these genes show a defect in epidermal ω-O-acylceramide (AcylCer) biosynthesis, suggesting that PNPLA1 and ABHD5 act in the same metabolic pathway. In this report, we identified ABHD5 as a coactivator of PNPLA1 that stimulates the esterification of ω-hydroxy ceramides with linoleic acid for AcylCer biosynthesis...
October 25, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/30358557/histological-evaluation-of-therapeutic-effects-of-dexpanthenol-composition-with-ceramides-in-rats-with-skin-burn-injury
#19
Ya Butko, V Ulanova, O Tkacheva, O Mishchenko
The objective of our research was histological evaluation of therapeutic effects in case of burn injury in rats. Experiment was conducted on 84 test rats with burn injury of III-A stage. Therapeutical effect of studied medicines was evaluated using histological methods. Results achived gave evidence that on 18-th day of treatment with ceremids cream and dexpanthenol with ceramids cream the level granulation tissue maturing increased by 1,4 and 1,7 times and intensity of burn injury epithelization rose by 1,5 and 1,9 times in comparison with non-treated animals...
September 2018: Georgian Medical News
https://www.readbyqxmd.com/read/30348640/reduction-of-stratum-corneum-ceramides-in-neu-laxova-syndrome-caused-by-phosphoglycerate-dehydrogenase-deficiency
#20
Takuya Takeichi, Yusuke Okuno, Akane Kawamoto, Takeshi Inoue, Eiko Nagamoto, Chiaki Murase, Eri Shimizu, Kenichi Tanaka, Yuichi Kageshita, Satoshi Fukushima, Michihiro Kono, Junko Ishikawa, Hironobu Ihn, Yoshiyuki Takahashi, Masashi Akiyama
Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin, caused by mutations in any of the three genes involved in de novo L-serine biosynthesis: PHGDH , PSAT1 and PSPH L-serine is essential for the biosynthesis of phosphatidylserine and sphingolipids. The extracellular lipid of the stratum corneum, of which sphingolipid constitutes a significant part, plays a primary role in the skin barrier function...
October 22, 2018: Journal of Lipid Research
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