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ceramide skin

Katsura Mori, Tsuyoshi Seki, Kazuhiro Kaizu, Yutaka Takagi, Masahiro Miyaki, Chiaki Ishizaki, Ichiro Katayama
BACKGROUND: Skin moisturizing is advocated to take care of the skin of patients with atopic dermatitis (AD). However, many patients stop using moisturizers in the summer because of excessive sweating and high humidity. OBJECTIVES: To examine the efficacy of a moisturizing gel containing a pseudo-ceramide and a eucalyptus extract, which enhances epidermal ceramide synthesis of patients with mild AD in the summer. METHODS: We performed a single-blinded 4-week clinical trial of body care on 44 Japanese subjects who had mild AD...
August 6, 2018: Journal of Cosmetic Dermatology
Matteo Ludovici, Nina Kozul, Stefano Materazzi, Roberta Risoluti, Mauro Picardo, Emanuela Camera
The skin surface lipids (SSL) result from the blending of sebaceous and epidermal lipids, which derive from the sebaceous gland (SG) secretion and the permeability barrier of the stratum corneum (SC), respectively. In humans, the composition of the SSL is distinctive of the anatomical distribution of the SG. Thus, the abundance of sebum biomarkers is consistent with the density of the SG. Limited evidence on the influence that the SG exerts on the SC lipidome is available. We explored the differential amounts of sebaceous and epidermal lipids in areas at different SG density with lipidomics approaches...
July 31, 2018: Scientific Reports
Djahida Bedja, Wenwen Yan, Viren Lad, Domenica Iocco, Nickash Sivakumar, Veera Venkata Ratnam Bandaru, Subroto Chatterjee
Sphingolipids have been accorded numerous biological functions however, the effects of feeding a western diet (diet rich in cholesterol and fat) on skin phenotypes, and color is not known. Here, we observed that chronic high-fat and high-cholesterol diet intake in a mouse model of atherosclerosis (ApoE-/-) decreases the level of ceramides and glucosylceramide. At the expense of increased levels of lactosylceramide due to an increase in the expression of lactosylceramide synthase (GalT-V). This is accompanied with neutrophil infiltration into dermis, and enrichment of tumor necrosis factor-stimulated gene-6 (TSG-6) protein...
July 30, 2018: Scientific Reports
Ken Cheng, Marta Bou, Bente Buyter, Jana Pickova, Emad Ehtesham, Liang Du, Claudia Venegas, Ali A Moazzami
Membrane lipids, including sphingolipids and glycerol-phospholipids, are essential in maintaining skin barrier function in mammals, but their composition in fish skin and their response to diets have not been evaluated. This study investigated the impacts of reducing dietary EPA and DHA on membrane lipids in skin of Atlantic salmon, through a 26-week feeding regime supplying different levels (0%‒2.0% of drymass) of EPA/DHA. Ceramide, glucosylceramide, sphingomyelin, sphingosine, and sphinganine in salmon skin were analyzed for the first time...
July 25, 2018: Journal of Agricultural and Food Chemistry
Núria Dalmau, Nathalie Andrieu-Abadie, Romà Tauler, Carmen Bedia
BACKGROUND: Ultraviolet (UV) radiation is known to be one of the most important environmental hazards acting on the skin. The most part of UV radiation is absorbed in the epidermis, where keratinocytes are the most abundant and exposed cell type. Lipids have an important role in skin biology, not only for their important contribution to the maintenance of the permeability barrier but also for the production and storage of energy, membrane organization and cell signalling functions. However, the effects on the lipid composition of keratinocytes under UV radiation are little explored...
July 10, 2018: Journal of Dermatological Science
Theodore Zaki, Keith Choate
The ichthyoses are a heterogeneous group of skin diseases characterized by localized or generalized scaling or both. Other common manifestations include palmoplantar keratoderma, erythroderma, recurrent infections, and hypohidrosis. Abnormal barrier function is a cardinal feature of the ichthyoses, which results in compensatory hyperproliferation and transepidermal water loss. Barrier function is maintained primarily by the stratum corneum, which is composed of cornified cells surrounded by a corneocyte lipid envelope and intercellular lipid layers...
2018: F1000Research
Dharmendra K Yadav, Surendra Kumar, Eun-Ha Choi, Praveen Sharma, Sanjeev Misra, Mi-Hyun Kim
In recent years, the role of reactive oxygen species (ROS) in regulating cancer cell apoptosis, inflammation, cell ischemia, and cell signaling pathways has been well established. The most common sources of intracellular ROS are the mitochondrial electron transport system, NADH oxidase, and cytochrome P450. In this study, we investigated the dynamics and permeability of ROS using molecular dynamics (MD) simulations on native skin-lipid bilayer membranes. Native skin-lipid bilayers are composed of ceramide, cholesterol, and free fatty acid in an almost equal molar ratio (1:1:1)...
2018: Frontiers in Pharmacology
Iuliana Popa, Adrian L Watson, Audrey Solgadi, Christina Butowski, David Allaway, Jacques Portoukalian
Few studies have investigated the influence of increased amounts of dietary linoleic acid on the epidermal lipid biochemistry and TEWL in healthy subject. The influence of dietary linoleic acid on canine stratum corneum (SC) lipids was studied by feeding two groups of five dogs differential amounts of linoleic acid (LA) for three months. SC was harvested by tape stripping and lipids were analyzed by thin-layer chromatography and mass spectrometry. The dogs that were fed the higher concentration of LA showed high increases in the contents of both linoleic acid and free ceramides in the SC, whereas the protein-bound ceramide content was unchanged...
July 11, 2018: Archives of Dermatological Research
Efrem N Tessema, Tsige Gebre-Mariam, Andrej Frolov, Johannes Wohlrab, Reinhard H H Neubert
Ceramides (CERs) are the backbone of the intercellular lipid lamellae of the stratum corneum (SC), the outer layer of the skin. Skin diseases such as atopic dermatitis, psoriasis, and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Replenishing the depleted epidermal CERs with exogenous CERs has been shown to have beneficial effects in improving the skin barrier and hydration. The exogenous CERs such as phyto-derived CERs (PhytoCERs) can be delivered deep into the SC using novel topical formulations...
August 2018: Analytical and Bioanalytical Chemistry
Chun-Ping Shen, Mu-Tong Zhao, Zhi-Xin Jia, Jin-Lan Zhang, Lei Jiao, Lin Ma
BACKGROUND: Atopic dermatitis (AD) is a common disease, which involves a disruption of the skin barrier function. Skin ceramide (CER) composition, which plays crucial roles in maintaining the barrier function of the stratum corneum, is changed in patients with AD. OBJECTIVE: The aim of this study was to identify and quantify skin CER subclasses in association with disease severity in pediatric patients with AD. METHODS: Two hundred thirteen patients were entered into the observational study...
July 2018: Dermatitis
Kazuhisa Maeda, Yuuka Ogino, Ayano Nakamura, Keiji Nakata, Manabu Kitagawa, Seiki Ito
Rice miso contains many ingredients derived from rice koji and has been a valuable source of nutrition since ancient times. We found that the consumption of rice miso led to improvements in the moisture content of cheek stratum corneum, skin viscoelasticity, and skin texture. Further, rice miso extract was found to increase the mRNA expression and activity of β-glucocerebrosidase (β-GCase), an enzyme involved in ceramide synthesis in the stratum corneum, in cultures. In this study, we identified the lipid-derived components of rice koji that increase the β-GCase activity in cultured human epidermal keratinocytes...
June 18, 2018: Foods (Basel, Switzerland)
Karan Agrawal, Lauren A Hassoun, Negar Foolad, Kamil Borkowski, Theresa L Pedersen, Raja K Sivamani, John W Newman
Skin disease alters cutaneous lipid mediator metabolism, and if skin secretions contain evidence of these changes, they may constitute useful clinical matrices with low associated subject burden. The influences of skin diseases on sebum lipid mediators are understudied. Here, sebum oxylipins, endocannabinoids, sphingolipids, and fatty acids were quantified from the non-lesional bilateral cheeks of subjects with and without quiescent atopic dermatitis (AD) using LC-MS/MS and GC-MS. AD decreased C36 [NS] and [NdS] ceramide concentrations...
July 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Hiroshi Takahashi, Kenta Takada, Kenichi Nishimura, Ryota Watanabe
The structure and thermal behavior of a synthetic D-erythro-ceramide [NDS], (2S,3R)-2-octadecanoylamino-octadecane-1,3-diol (CER), molecular assembly in a UV-curable acrylic adhesive resin (acResin® ) were investigated by differential scanning calorimetry (DSC), polarized-light microscopy, and X-ray diffraction (XRD). CER in the resin was found to exhibit a thermal-history-dependent polymorphic phase behavior that is similar but not identical to that observed for pure CER. The melting temperatures of the in-resin CER samples were lower than those of pure CER samples...
July 1, 2018: Journal of Oleo Science
Ehrhardt Proksch
The pH plays an important physiological role in nature and humans. pH varies from 1 to 8 in human organs with tight regulation in blood and epithelia of barrier organs. The physiological pH of the stratum corneum is 4.1-5.8 and several mechanisms contribute to its formation: filaggrin degradation, fatty acid content, sodium-hydrogen exchanger (NHE1) activation and melanosome release. First, the acidic pH of the stratum corneum was considered to present an antimicrobial barrier preventing colonization (e.g. by Staphylococcus aureus and Malassezia)...
June 4, 2018: Journal of Dermatology
Thomas Schmitt, Rakesh Gupta, Stefan Lange, Stefan Sonnenberger, Bodo Dobner, Thomas Hauß, Beena Rai, Reinhard H H Neubert
For this study mixtures based on the ceramides [NS] (NS = non-hydroxy-sphingosine) and [AP] (AP = α-hydroxy-phytosphingosine) in a 2:1 and 1:2 ratio, together with cholesterol and lignoceric acid, were investigated. These mixtures are modelling the uppermost skin layer, the stratum corneum. Neutron diffraction, utilizing specifically deuterated ceramide molecules, was used to obtain a maximum amount of experimental detail. Highly detailed molecular dynamics simulations were used to generate even more information from the experimental data...
August 2018: Chemistry and Physics of Lipids
Jack L Arbiser, Michael Y Bonner, Nicole Ward, Justin Elsey, Shikha Rao
BACKGROUND: A link between selenium deficiency and inflammatory skin diseases have been noted by many, but this link is still not well understood. We have previously studied the efficacy of ceramide analogs, based on the fire ant venom Solenopsin A, against our psoriasis animal model. Treatment of animals with solenopsin analogs resulted in significantly improved skin as well as in a coordinate downregulation of selenoproteins, namely Glutathione Peroxidase 4 (GPX4). We thus hypothesize that ferroptosis may be a physiologic process that may protect the skin from both inflammatory and neoplastic processes...
May 28, 2018: Biochimica et Biophysica Acta
Sebastian Huth, Laurenz Schmitt, Yvonne Marquardt, Ruth Heise, Bernhard Lüscher, Philipp M Amann, Jens M Baron
Atopic dermatitis (AD) is a chronically relapsing, pruritic inflammation of the skin with dryness and disturbed skin barrier function. Recently, we established that IL-31 treatment of human 3D skin models resulted in a disrupted skin barrier phenotype resembling AD. In this model, we found that IL-31 interferes with the differentiation of keratinocytes and inhibits the expression of terminal differentiation markers. In the present study, we investigated the effects of a ceramide-containing water-in-oil skin care ointment on the physical skin barrier structure and function in disrupted skin barrier models, generated either by using primary normal human epidermal keratinocytes (NHEK) or HaCaT cells...
May 31, 2018: Experimental Dermatology
Zoe Diana Draelos, Isabelle Raymond
Objective: The goal of this study was to determine if a therapeutic cream containing PC-104 synthetic ceramides and other ingredients could help to ameliorate signs and symptoms of mild-to-moderate atopic dermatitis and other xerotic or pruritic dermatoses. Design: In this single-site, four-week study, subjects (n=50) were instructed to apply the study product three times daily to all affected areas, including a target site for evaluation and photography at baseline, Week 2, and Week 4 visits. Setting: This study took place in the private practice of the senior author...
May 2018: Journal of Clinical and Aesthetic Dermatology
Hiroshi Nojiri, Koichi Ishida, Xueqiu Yao, Wei Liu, Genji Imokawa
We determined whether compensating ceramides in the stratum corneum (SC) may ameliorate the impaired barrier function and subsequently attenuate the enhanced skin sensitivity. Treatment for 4 weeks with the ceramide complex cream or the placebo cream significantly ameliorated the intensity of lactic acid sensations in 39 female subjects with sensitive skin, the degree of which was attenuated to a greater extent at 1 week by the ceramide complex cream compared with the placebo cream. The amelioration of skin sensations was accompanied by a significant increase in total ceramide content in the SC elicited by the ceramide complex cream that was significantly more effective than the placebo cream at 4 weeks...
August 2018: Archives of Dermatological Research
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May 2018: Journal of Wound, Ostomy, and Continence Nursing
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