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https://www.readbyqxmd.com/read/29414774/hexokinase-2-and-nuclear-factor-erythroid-2-related-factor-2-transcriptionally-coactivate-xanthine-oxidoreductase-expression-in-stressed-glioma-cells
#1
Touseef Sheikh, Piyushi Gupta, Pruthvi Gowda, Shruti Patrick, Ellora Sen
A dynamic network of metabolic adaptations, inflammatory responses, and redox homeostasis is known to drive tumor progression. A considerable overlap among these processes exists, but several of their key regulators remain unknown. To this end, here we investigated the role of the proinflammatory cytokine IL-1β in connecting these processes in glioma cells. We found that glucose starvation sensitizes glioma cells to IL-1β-induced apoptosis in a manner that depended on reactive oxygen species (ROS). Although IL-1β-induced JNK had no effect on cell viability under glucose deprivation, it mediated nuclear translocation of hexokinase 2 (HK2)...
March 30, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27568560/jnk-phosphorylates-sirt6-to-stimulate-dna-double-strand-break-repair-in-response-to-oxidative-stress-by-recruiting-parp1-to-dna-breaks
#2
Michael Van Meter, Matthew Simon, Gregory Tombline, Alfred May, Timothy D Morello, Basil P Hubbard, Katie Bredbenner, Rosa Park, David A Sinclair, Vilhelm A Bohr, Vera Gorbunova, Andrei Seluanov
The accumulation of damage caused by oxidative stress has been linked to aging and to the etiology of numerous age-related diseases. The longevity gene, sirtuin 6 (SIRT6), promotes genome stability by facilitating DNA repair, especially under oxidative stress conditions. Here we uncover the mechanism by which SIRT6 is activated by oxidative stress to promote DNA double-strand break (DSB) repair. We show that the stress-activated protein kinase, c-Jun N-terminal kinase (JNK), phosphorylates SIRT6 on serine 10 in response to oxidative stress...
September 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/23135512/a-sirtuin-link-between-metabolism-and-heart-disease
#3
COMMENT
Keith A Webster
The sirtuins (SIRTs) have gained preeminence for their roles in the response to caloric restriction and the regulation of aging and lifespan. A new study now identifies gene promoters that bind the transcription factor AP1 as targets for silencing by SIRT6, providing possible links between SIRT6 deficiency and dysregulation of insulin-like growth factor signaling, hypertrophic cardiomyopathy and heart failure (pages 1643-1650).
November 2012: Nature Medicine
https://www.readbyqxmd.com/read/23086477/the-sirtuin-sirt6-blocks-igf-akt-signaling-and-development-of-cardiac-hypertrophy-by-targeting-c-jun
#4
Nagalingam R Sundaresan, Prabhakaran Vasudevan, Lei Zhong, Gene Kim, Sadhana Samant, Vishwas Parekh, Vinodkumar B Pillai, P V Ravindra, Madhu Gupta, Valluvan Jeevanandam, John M Cunningham, Chu-Xia Deng, David B Lombard, Raul Mostoslavsky, Mahesh P Gupta
Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the development of various diseases, including heart failure. However, the molecular mechanisms that regulate activation of this signaling pathway are not completely understood. Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice developed cardiac hypertrophy and heart failure, whereas SIRT6 transgenic mice were protected from hypertrophic stimuli, indicating that SIRT6 acts as a negative regulator of cardiac hypertrophy...
November 2012: Nature Medicine
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