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Pyroptosis ceramide

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https://www.readbyqxmd.com/read/29956204/pathogenesis-of-nash-how-metabolic-complications-of-overnutrition-favour-lipotoxicity-and-pro-inflammatory-fatty-liver-disease
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Geoffrey C Farrell, Fahrettin Haczeyni, Shivakumar Chitturi
Overnutrition, usually with obesity and genetic predisposition, lead to insulin resistance, which is an invariable accompaniment of nonalcoholic fatty liver disease (NAFLD). The associated metabolic abnormalities, pre- or established diabetes, hypertension and atherogenic dyslipidemia (clustered as metabolic syndrome) tend to be worse for nonalcoholic steatohepatitis (NASH), revealing it as part of a continuum of metabolic pathogenesis. The origins of hepatocellular injury and lobular inflammation which distinguish NASH from simple steatosis have intrigued investigators, but it is now widely accepted that NASH results from liver lipotoxicity...
2018: Advances in Experimental Medicine and Biology
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