Dana Bielopolski, Luca Musante, Ewout J Hoorn, Henrik Molina, Douglas Barrows, Thomas Carroll, Michael A Harding, Samantha Upson, Adam Qureshi, Max M Weder, Jonathan N Tobin, Rhonda G Kost, U Erdbrügger
The Dietary Approach to Stop Hypertension (DASH) diet, with its low sodium and high potassium content, acts like a diuretic by reducing sodium reabsorption in the kidney's distal convoluted tubule but without the side effects. Previous studies based on animal models didn't explore changes in human ion channel proteins. Recent insights into urinary extracellular vesicles (uEVs) suggest they reflect kidney tissue and physiological modifications. In our inpatient study, we shifted hypertensive volunteers from an American diet to the DASH diet, examining changes in those with stage 1 untreated hypertension...
April 18, 2024: American Journal of Physiology. Renal Physiology