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https://www.readbyqxmd.com/read/30082752/anthropometric-and-glucometabolic-changes-in-an-aged-mouse-model-of-lipocalin-2-overexpression
#1
Elisa Principi, Ambra Buschiazzo, Andrea Papait, Patrizio Castagnola, Delfina Costa, Roberta Pece, Irena Maric, Mara Scussolini, Cecilia Marini, Gianmario Sambuceti, Felice Strollo, Sara Tavella
BACKGROUND: Lipocalin-2 (LCN2) is widely expressed in the organism with pleiotropic roles. In particular, its overexpression correlates with tissue stress conditions including inflammation, metabolic disorders, chronic diseases and cancer. OBJECTIVES: To assess the effects of systemic LCN2 overexpression on adipose tissue and glucose metabolism. SUBJECTS: Eighteen-month-old transgenic mice with systemic LCN2 overexpression (LCN2-Tg) and age/sex-matched wild-type mice...
August 6, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29901445/combination-of-high-sensitive-c-reactive-protein-with-logistic-euroscore-improves-risk-stratification-in-patients-undergoing-tavi
#2
Anja Stundl, Laura Busse, Philipp Leimkühler, Marcel Weber, Berndt Zur, Fritz Mellert, Eberhard Grube, Georg Nickenig, Nikos Werner, Jan-Malte Sinning
AIMS: To assess the clinical value of biomarkers to identify TAVI-patients at high risk for ad-verse outcome, to assess whether these provide prognostic information beyond that of estab-lished clinical risk scores, and to assess whether a combined multi-marker strategy can im-prove clinical decision-making. METHODS AND RESULTS: In 683 TAVI-patients, biomarkers reflecting various pathophysiologic systems were measured before TAVI. The primary endpoint was all-cause 1-year mortality...
June 12, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29736096/potential-anti-inflammatory-treatment-of-ischemic-heart-disease
#3
Enisa Hodzic
Introduction: Ischemic heart disease (IHD) is clinical manifestation of chronic inflammatory progressive pathological process of atherosclerosis in coronary arteries. IHD is the leading cause of morbidity and mortality in the world. The question is whether it is possible to improve and direct the therapeutic treatment of IHD patients in the treatment of the inflammatory process in the atherosclerotic leasions. Material and Methods: A prospective, comparative, analytica,clinically applicable, open-type study was performed...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29695672/comparison-of-post-operative-analgesic-efficacy-of-tolfenamic-acid-and-robenacoxib-in-ovariohysterectomized-cats
#4
Panpicha Sattasathuchana, Prangtip Phuwapattanachart, Naris Thengchaisri
The objective of this study was to evaluate the efficacy of a non-selective COX inhibitor (tolfenamic acid) and a selective COX-2 inhibitor (robenacoxib) for post-operative pain control in cats. Thirty cats undergoing ovariohysterectomy were randomly divided into three groups: the control (placebo) group, the tolfenamic acid (4 mg/kg/day) group, and the robenacoxib (1 mg/kg/day) group. Non-steroidal anti-inflammatory drugs (NSAIDs) were administered orally 2 hr before anesthesia induction and 24 and 48 hr post-operation...
June 29, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29411345/psychosomatic-symptoms-of-the-couvade-syndrome-in-finnish-and-polish-expectant-fathers
#5
Urszula Sioma Markowska, Michalina Zyg, Bogumiła Kiełbratowska
OBJECTIVES: The aim of the study was to assess the occurrence of symptoms associated with the Couvade syndrome in two groups of men of Polish and Finnish nationality, and to perform a comparative analysis. MATERIAL AND METHODS: The study was conducted in two groups of men (expectant fathers): 51 Poles and 40 Finns using a self-constructed questionnaire prepared in Polish and English languages. The statistical analysis was performed in Micro-soft Office Excel 2010 and Statistica 12...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29380448/longitudinal-assessment-of-denture-maintenance-needs-in-an-overdenture-population
#6
Ronald L Ettinger, Fang Qian
PURPOSE: To evaluate the longitudinal denture maintenance needs of a tooth-supported overdenture population. MATERIALS AND METHODS: This prospective cohort study was composed of patients who had received tooth-supported overdentures from 1974 to 1994 in the Department of Prosthodontics, University of Iowa. There were 272 persons with 662 abutments who fulfilled the inclusion criteria. To simplify analysis and reduce the number of confounding variables, only those participants wearing complete maxillary dentures and opposing complete mandibular overdentures supported by teeth #22 and #27 were included in this analysis...
January 29, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29237922/outcomes-of-coronary-artery-bypass-graft-surgery-versus-percutaneous-coronary-intervention-in-patients-aged-18-45-years-with-diabetes-mellitus
#7
Yang Li, Ran Dong, Kun Hua, Tao-Shuai Liu, Shao-You Zhou, Ning Zhou, Hong-Jia Zhang
BACKGROUND: Debate on treatment for young patients with coronary artery disease still exists. This study aimed to investigate the intermediate- and long-term outcomes between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in patients aged 18-45 years with diabetes mellitus (DM). METHODS: Between January 2006 and March 2016, a total of 2018 DM patients aged 18-45 years including 517 cases of CABG and 1501 cases of PCI were enrolled in the study...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748127/gender-biased-regulation-of-human-il-17-producing-cells-in-vitro-by-peptides-corresponding-to-distinct-hla-drb1-allele-coded-sequences
#8
Luz P Blanco, Melissa Plegue, Wai-Ping Fung-Leung, Joseph Holoshitz
Susceptibility to rheumatoid arthritis (RA) is associated with HLA-DRB1 alleles coding a 5-amino acid sequence motif called the shared epitope (SE). To explore the potential mechanisms that lead to RA susceptibility, we analyze the in vitro effect of peptides bearing different HLA-DR4 sequences on human peripheral blood-derived cells. Three 15-mer peptides were used: 65-79*0401 (an HLA-DRB1*04:01-coded sequence carrying the SE motif, QKRAA); 65-79*0402 (an HLA-DRB1*04:02-coded sequence carrying a SE-negative motif, DERAA); 65-79*0403 (an HLA-DRB1*04:03-coded sequence carrying a SE-negative motif, QRRAE)...
July 2013: Journal of Immune Based Therapies, Vaccines and Antimicrobials
https://www.readbyqxmd.com/read/28748096/unemployment-and-hiv-mortality-in-the-countries-of-the-organisation-for-economic-co-operation-and-development-1981-2009
#9
Mahiben Maruthappu, Charlie Zhou, Callum Williams, Thomas Zeltner, Rifat Atun
OBJECTIVES: To determine an association between unemployment rates and human immunodeficiency virus (HIV) mortality in the Organisation for Economic Co-operation and Development (OECD). DESIGN: Multivariate regression analysis. PARTICIPANTS: OECD member states. SETTING: OECD. MAIN OUTCOME MEASURES: World Health Organization HIV mortality. RESULTS: Between 1981 and 2009, a 1% increase in unemployment was associated with an increase in HIV mortality in the OECD (coefficient for men 0...
July 2017: JRSM Open
https://www.readbyqxmd.com/read/28583474/the-effects-of-maternal-smoking-exposure-during-pregnancy-on-postnatal-outcomes-a-cross-sectional-study
#10
Shih-Hui Huang, Ken-Pen Weng, Shih-Ming Huang, Huei-Han Liou, Chung-Cheng Wang, Shan-Fu Ou, Chu-Chuan Lin, Kuang-Jen Chien, Ching-Chiang Lin, Ming-Tsang Wu
BACKGROUND: The purpose of this article was to evaluate the effect of maternal smoking exposure during pregnancy on postnatal outcomes. METHODS: This prospective study enrolled 278 pregnant women in the third trimester, who were asked to complete a questionnaire which included inquires about the nature and extent of smoking exposure during their pregnancy. In addition to the questionnaire, each study subject provided urine sample for the measurement of cotinine...
December 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28115532/marginal-prescription-equivalent-to-the-isocenter-prescription-in-lung-stereotactic-body-radiotherapy-preliminary-study-for-japan-clinical-oncology-group-trial-jcog1408
#11
Daisuke Kawahara, Shuichi Ozawa, Tomoki Kimura, Akito Saito, Teiji Nishio, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
A new randomized Phase III trial, the Japan Clinical Oncology Group (JCOG) 1408, which compares two dose fractionations (JCOG 0403 and JCOG 0702) for medically inoperable Stage IA NSCLC or small lung lesions clinically diagnosed as primary lung cancer, involves the introduction of a prescribed dose to the D95% of the planning target volume (PTV) using a superposition/convolution algorithm. Therefore, we must determine the prescribed dose in the D95% prescribing method to begin JCOG1408. JCOG 0702 uses density correction and the D95% prescribing method...
January 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/27755946/tcf7l2-and-ccnd1-polymorphisms-and-its-association-with-colorectal-cancer-in-mexican-patients
#12
M A Rosales-Reynoso, A R Arredondo-Valdez, C I Juárez-Vázquez, L I Wence-Chavez, P Barros-Núñez, M P Gallegos-Arreola, S E Flores-Martínez, M C Morán-Moguel, J Sánchez-Corona
Accumulative evidence suggests that alterations due to mutations or genetic polymorphisms in the TCF7L2 and CCND1 genes, which are components of the Wnt signaling pathway, contributes to carcinogenesis. The present study was designated to clarify whether common single nucleotide polymorphisms (SNPs) of the transcription factor 7- like 2 (TCF7L2) and cyclin D1 (CCND1) genes are associated with colorectal cancer risk in Mexican patients. A case-control study including 197 colorectal cancer patients and 100 healthy subjects was conducted in a Mexican population...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27704637/retrospective-analysis-of-in-vivo-recovery-and-clearance-during-continuous-infusion-of-recombinant-factor-viii-products-a-single-institution-study
#13
N Suzuki, A Hirakawa, M Kishimoto, T Kanematsu, M Ogawa, H Kiyoi, T Matsushita
BACKGROUND: Continuous infusion (CI) of recombinant FVIII (rFVIII) concentrates has been reported as an effective and safe method to achieve haemostasis during major surgeries or severe bleeding events. For more effective and safer CI, better understanding of in vivo recovery (IVR) and clearance (CL) issues is imperative. OBJECTIVE: We investigated the following factors affecting IVR and CL using univariate and multivariate regression analyses during 47 CIs in 34 patients: rFVIII concentrate type, haemophilia severity, blood type, the presence of hepatitis C virus (HCV) or human immunodeficiency virus (HIV), age and body mass index (BMI)...
March 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27555956/n-1e-5-nitro-furan-2-yl-methyl-idene-thio-phene-2-carbohydrazide-crystal-structure-and-hirshfeld-surface-analysis
#14
Laura N F Cardoso, Thais C M Nogueira, James L Wardell, Solange M S V Wardell, Marcus V N de Souza, Mukesh M Jotani, Edward R T Tiekink
In the title carbohydrazide, C10H7N3O4S, the dihedral angle between the terminal five-membered rings is 27.4 (2)°, with these lying to the same side of the plane through the central CN2C(=O) atoms (r.m.s. deviation = 0.0403 Å), leading to a curved mol-ecule. The conformation about the C=N imine bond [1.281 (5) Å] is E, and the carbonyl O and amide H atoms are anti. In the crystal, N-H⋯O hydrogen bonds lead to supra-molecular chains, generated by a 41 screw-axis along the c direction. A three-dimensional architecture is consolidated by thienyl-C-H⋯O(nitro) and furanyl-C-H⋯O(nitro) inter-actions, as well as π-π inter-actions between the thienyl and furanyl rings [inter-centroid distance = 3...
July 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27498080/active-surveillance-in-metastatic-renal-cell-carcinoma-a-prospective-phase-2-trial
#15
MULTICENTER STUDY
Brian I Rini, Tanya B Dorff, Paul Elson, Cristina Suarez Rodriguez, Dale Shepard, Laura Wood, Jordi Humbert, Linda Pyle, Yu-Ning Wong, James H Finke, Patricia A Rayman, James M G Larkin, Jorge A Garcia, Elizabeth R Plimack
BACKGROUND: A subset of patients with metastatic renal-cell carcinoma show indolent growth of metastases. Because of the toxicity and non-curative nature of systemic therapy, some of these patients could benefit from initial active surveillance. We aimed to characterise the time to initiation of systemic therapy in patients with metastatic renal-cell carcinoma under active surveillance. METHODS: In this prospective phase 2 trial, we enrolled patients with treatment-naive, asymptomatic, metastatic renal-cell carcinoma from five hospitals in the USA, Spain, and the UK...
September 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27493587/nasal-inflammation-and-its-response-to-local-glucocorticoid-regular-treatment-in-patients-with-persistent-non-allergic-rhinitis-a-pilot-study
#16
Donatella Poletti, Valeria Iannini, Paolo Casolari, Marco Contoli, Alberto Papi, Paul Kirkham, Trevor T Hansel, Kian Fan Chung, Peter J Barnes, Antonio Pastore, Stefano Pelucchi, Ian M Adcock, Gaetano Caramori
BACKGROUND: The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasal symptoms and quality of life. METHODS: In this pilot study we recruited 12 healthy subjects and 24 patients with recently diagnosed persistent NAR [12 untreated and 12 under regular treatment with nasal fluticasone furoate (two sprays of 27.5 μg each in each nostril once daily, total daily dose = 110 μg) for at least 20 days]...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27277277/hosvd-based-3d-active-appearance-model-segmentation-of-lung-fields-in-ct-images
#17
Qingzhu Wang, Wanjun Kang, Haihui Hu, Bin Wang
An Active Appearance Model (AAM) is a computer vision model which can be used to effectively segment lung fields in CT images. However, the fitting result is often inadequate when the lungs are affected by high-density pathologies. To overcome this problem, we propose a Higher-order Singular Value Decomposition (HOSVD)-based Three-dimensional (3D) AAM. An evaluation was performed on 310 diseased lungs form the Lung Image Database Consortium Image Collection. Other contemporary AAMs operate directly on patterns represented by vectors, i...
July 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27211051/from-genetic-predisposition-to-molecular-mechanisms-of-autoimmune-primary-adrenal-insufficiency
#18
REVIEW
Alberto Falorni, Annalisa Brozzetti, Roberto Perniola
Autoimmune Addison's disease (AAD) is a complex disease that results from the interaction of a predisposing genetic background with still unknown environmental factors. Pathogenic variants in the autoimmune regulator (AIRE) gene are responsible for autoimmune polyendocrine syndrome type 1, of which AAD is a major disease component. Among the genetic factors for isolated AAD and autoimmune polyendocrine syndrome type 2, a key role is played by HLA class II genes: HLA-DRB1*0301-DQA1*0501-DQB1*0201 and DRB1*04-DQA1*0301-DQB1*0302 are positively, and DRB1*0403 is negatively, associated with genetic risk for AAD...
2016: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/27015052/comprehensive-medication-management-and-medication-adherence-for-chronic-conditions
#19
Amanda Brummel, Angeline M Carlson
BACKGROUND: The beneficial clinical effects of medication adherence have been consistently reported across most chronic diseases. Medication nonadherence carries significant economic and clinical burden. Medication therapy management (MTM) services aim to optimize pharmacotherapy and improve medication adherence. OBJECTIVE: To evaluate the impact of exposure to face-to-face comprehensive medication management (CMM) services on medication adherence across 4 classes of chronic disease medications: oral diabetes medications, statins, angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), and beta-blockers...
January 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/26807576/association-between-anti-ganglionic-nicotinic-acetylcholine-receptor-gachr-antibodies-and-hla-drb1-alleles-in-the-japanese-population
#20
Yasuhiro Maeda, Kiyoshi Migita, Osamu Higuchi, Akihiro Mukaino, Hiroshi Furukawa, Atsumasa Komori, Minoru Nakamura, Satoru Hashimoto, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Hidenori Matsuo, Atsushi Kawakami, Michio Yasunami, Shunya Nakane
BACKGROUND/AIMS: Anti-ganglionic nicotinic acetylcholine receptor (gAChR) antibodies are observed in autoimmune diseases, as well as in patients with autoimmune autonomic ganglionopathy. However, the genetic background of anti-gAChR antibodies is unclear. Here, we investigated HLA alleles in autoimmune hepatitis (AIH) patients with or without anti-gAChR antibodies. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from 260 patients with type-1 autoimmune hepatitis (AIH) were genotyped for HLA-A, B, DRB1, and DQB1 loci...
2016: PloS One
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