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Lung cancer, radiation OR radiotherapy

Ji Hyun Hong, Yeon-Sil Kim, Sea-Won Lee, So Jung Lee, Jin Hyung Kang, Suk Hee Hong, Ju-Young Hong, GeumSeong Cheon
Purpose: Thoracic re-irradiation (re-RT) of lung cancer has been challenged by the tolerance doses of normal tissues. We retrospectively analyzed local control, overall survival (OS) and toxicity after thoracic re-RT using highly conformal radiotherapy, such as intensity modulated radiotherapy and stereotactic body radiotherapy (SBRT). Materials and Methods: Thirty-one patients who received high-dose thoracic re-RT were analyzed. Doses were recalculated to determine biologically equivalent doses...
November 29, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Gregory M Videtic, Rebecca Paulus, Anurag K Singh, Joe Y Chang, William Parker, Kenneth R Olivier, Robert D Timmerman, Ritsuko R Komaki, James J Urbanic, Kevin L Stephans, Sue S Yom, Clifford G Robinson, Chandra P Belani, Puneeth Iyengar, Munther I Ajlouni, Darindra D Gopaul, Shashikant B Lele, Ronald C McGarry, Hak Choy, Jeffrey D Bradley
PURPOSE/OBJECTIVE(S): To present long-term results of XXXX, a randomized lung stereotactic body radiotherapy (SBRT) trial of 34 Gy in 1 fraction versus 48 Gy in 4 fractions. MATERIALS/METHODS: This was a phase II multicenter study of medically inoperable non-small cell lung cancer patients with biopsy-proven peripheral T1 or T2 N0M0 tumors, with 1-year toxicity rates as primary endpoint and selected failure and survival outcomes as secondary endpoints. The study opened in September 2009 and closed in March 2011...
December 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Cheng Zhou, Bleddyn Jones, Mahmoud Moustafa, Bing Yang, Stephan Brons, Liji Cao, Ying Dai, Christian Schwager, Ming Chen, Oliver Jaekel, Longhua Chen, Juergen Debus, Amir Abdollahi
Background and purposes: Carbon ion radiotherapy (CIRT) with raster scanning technology is a promising treatment for lung cancer and thoracic malignancies. Determining normal tissue tolerance of organs at risk is of utmost importance for the success of CIRT. Here we report the relative biological effectiveness (RBE) of CIRT as a function of dose and fractionation for development of pulmonary fibrosis using well established fibrosis index (FI) model. Materials and Methods: Dose series of fractionated clinical quality CIRT versus conventional photon irradiation to the whole thorax were compared in C57BL6 mice...
January 2019: Clinical and Translational Radiation Oncology
Naomi Beck, Fieke Hoeijmakers, Erwin M Wiegman, Hans J M Smit, Franz M Schramel, Willem H Steup, Ad F T M Verhagen, Wilhelmina H Schreurs, Michel W J M Wouters
Background: Quality registries play an important role in the professional quality system for cancer treatment in The Netherlands. This article provides insight into the Dutch Lung Cancer Audit (DLCA); its core principles, initiation and development, first results and what lessons can be learned from the Dutch experience. Methods: Cornerstones of the DLCA are discussed in detail, including: audit aims; the leading role for clinicians; web-based registration and feedback; data handling; multidisciplinary evaluation of quality indicators; close collaborations with all stakeholders in healthcare and transparency of results...
October 2018: Journal of Thoracic Disease
M Augugliaro, G Marvaso, D Ciardo, D Zerini, G Riva, E Rondi, S Vigorito, S Comi, O De Cobelli, R Orecchia, B Alicja Jereczek-Fossa
The aim of our study was to retrospectively report on radiotherapy (RT) in the oligometastastic recurrence of bladder cancer. Thirteen patients treated for low-volume metastatic transitional cell urinary bladder carcinoma (TCC) were reviewed. The primary endpoint was to evaluate the safety and efficacy of RT, proposed as an alternative to systemic treatment and/or to defer the start of a systemic therapy. Inclusion criteria for our retrospective study were as follows: patients that received RT (without other local/systemic therapy) for oligometastatic TCC with lymph node, bone, lung lesions or local recurrence...
September 4, 2018: Neoplasma
Alice Y Ho, Ase Ballangrud, Guang Li, Gaorav P Gupta, Beryl McCormick, Richard Gewanter, Daphna Gelblum, Melissa Zinovoy, Boris Mueller, Borys Mychalczak, Pinaki Dutta, Karen Borofsky, Preeti Parhar, Marsha Reyngold, Lior Braunstein, Mohit Chawla, Kate Krause, Natasha Freeman, Chun Ting Siu, Zachary Cost, Brittany B Arnold, Zhigang Zhang, Simon N Powell
BACKGROUND: Multi-beam IMRT enhances the therapeutic index by increasing the dosimetric coverage of the targeted tumor tissues while minimizing volumes of adjacent organs receiving high doses of RT. The tradeoff is that a greater volume of lung is exposed to low doses of RT, raising concern about the risk of radiation pneumonitis (RP). METHODS: Between 7/2010-1/2013, patients with node-positive breast cancer received inverse-planned, multibeam IMRT to the breast/chest wall and regional nodes including the internal mammary nodes (IMN)...
November 30, 2018: International Journal of Radiation Oncology, Biology, Physics
Rongying Zhu, Xiang Xue, Mingjjng Shen, Ying Tsai, Peter C Keng, Yongbing Chen, Soo Ok Lee, Yuhchyau Chen
Cisplatin-resistant (A549CisR and H292CisR) and radioresistant (A549R26 and H292R22) sub-line non-small cell lung cancer (NSCLC) cells were developed in our lab by long term treatment of parental cells with cisplatin or radiation. Our data showed no cross-resistance between these two sets of cell lines, indicating that molecular mechanisms of developing each resistance may be different. Using these sub-line cells, we sought to reveal the most significantly up-regulated molecules in cisplatin-resistant and radioresistant lung cancer cells, compared with parental cells...
November 30, 2018: Experimental Cell Research
Emanuela Taioli, Wil Lieberman-Cribbin, Shoshana Rosenzweig, Maaike A G van Gerwen, Bian Liu, Raja M Flores
Background: The comparative effectiveness of stereotactic body radiation therapy (SBRT) and wedge resection in the treatment of early stage lung cancer is still under debate. This meta-analysis compares the 5-year overall survival (OS) of wedge resection and SBRT in patients with stage I non-small cell lung cancer (NSCLC). Methods: Original research articles published between 1995 and 2017 were identified through the National Library of Medicine and National Institutes of Health PubMed database and through the reference lists of reviewed articles...
October 2018: Journal of Thoracic Disease
Seo-Hyun Choi, A-Ram Kim, Jae-Kyung Nam, Jin-Mo Kim, Jee-Youn Kim, Haeng Ran Seo, Hae-June Lee, Jaeho Cho, Yoon-Jin Lee
It remains controversial whether targeting tumour vasculature can improve radiotherapeutic efficacy. We report that radiation-induced endothelial-to-mesenchymal transition (EndMT) leads to tumour vasculature with abnormal SMA+ NG2+ pericyte recruitment during tumour regrowth after radiotherapy. Trp53 (but not Tgfbr2) deletion in endothelial cells (ECs) inhibited radiation-induced EndMT, reducing tumour regrowth and metastases with a high CD44v6+ cancer-stem-cell (CSC) content after radiotherapy. Osteopontin, an EndMT-related angiocrine factor suppressed by EC-Trp53 deletion, stimulated proliferation in dormant CD44v6+ cells in severely hypoxic regions after radiation...
November 30, 2018: Nature Communications
U-Ging Lo, Rey-Chen Pong, Diane Yang, Leah Gandee, Elizabeth Hernandez, Andrew Dang, Chun-Jung Lin, John Santoyo, Shihong Ma, Rajni Sonavane, Jun Huang, Shu-Fen Tseng, Loredana Moro, Arnaldo A Arbini, Payal Kapur, Ganesh V Raj, Dalin He, Chih-Ho Lai, Ho Lin, Jer-Tsong Hsieh
Interferon-γ (IFNγ), a potent cytokine known to modulate tumor immunity and tumoricidal effects, is highly elevated in prostate cancer (PCa) patients after radiation. In this study, we demonstrate that IFNγ can induce epithelial-to-mesenchymal transition (EMT) in PCa cells via the JAK-STAT signaling pathway, leading to the transcription of IFN-stimulated genes (ISG) such as interferon-induced tetratricopeptide repeat 5 (IFIT5). We unveil a new function of IFIT5 complex in degrading precursor microRNAs (pre-miRNA) that include pre-miR-363 from the miR-106a-363 cluster as well as pre-miR-101 and pre-miR-128, who share a similar 5'-end structure with pre-miR-363...
November 30, 2018: Cancer Research
Vinicius Ernani, Adams Kusi Appiah, Alissa Marr, Chi Zhang, Weining Zhen, Lynette M Smith, Apar Kishor Ganti
INTRODUCTION: Stereotactic body radiation therapy (SBRT) is commonly used to treat nonsurgical patients with early-stage NSCLC. There are no prospective data on the role of adjuvant chemotherapy in this setting. METHODS: Patients (≥18 years) diagnosed with clinical stages I-II NSCLC from 2004 to 2013 were identified using the National Cancer Database (n=11,836). The Kaplan-Meier method was used to estimate overall survival (OS) distributions and the log-rank test was used to compare distributions by treatment strategy...
November 29, 2018: Journal of Thoracic Oncology
Ahmed Hosny, Chintan Parmar, Thibaud P Coroller, Patrick Grossmann, Roman Zeleznik, Avnish Kumar, Johan Bussink, Robert J Gillies, Raymond H Mak, Hugo J W L Aerts
BACKGROUND: Non-small-cell lung cancer (NSCLC) patients often demonstrate varying clinical courses and outcomes, even within the same tumor stage. This study explores deep learning applications in medical imaging allowing for the automated quantification of radiographic characteristics and potentially improving patient stratification. METHODS AND FINDINGS: We performed an integrative analysis on 7 independent datasets across 5 institutions totaling 1,194 NSCLC patients (age median = 68...
November 2018: PLoS Medicine
Robert Roskoski
The EGFR family is among the most investigated receptor protein-tyrosine kinase groups owing to its general role in signal transduction and in oncogenesis. This family consists of four members that belong to the ErbB lineage of proteins (ErbB1-4). The ErbB proteins function as homo and heterodimers. These receptors contain an extracellular domain that consists of four parts: domains I and III are leucine-rich segments that participate in growth factor binding (except for ErbB2) and domains II and IV contain multiple disulfide bonds...
November 27, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Yasuhiro Chikaishi, Masatoshi Kanayama, Akihiro Taira, Yusuke Nabe, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Ayako Hirai, Koji Kuroda, Naoko Imanishi, Yoshinobu Ichiki, Fumihiro Tanaka
Background: The standard therapy for brain metastasis (BM) in non-small cell lung cancer (NSCLC) is radiation therapy (RT), although it is associated with complications such as leukoencephalopathy. In the current report, we retrospectively review data from eight patients who had NSCLC and harbored epidermal growth factor receptor (EGFR) mutations, and who were received erlotinib plus bevacizumab (E+B) as first-line therapy for BM. Methods: Patients were given E+B as first therapy for BM until August 2017 at our institution...
October 2018: Annals of Translational Medicine
S K Chaya Devi, T Satya Savithri
Lung cancer is one of the major types of cancer in the world. Survival rate can be increased if the disease can be identified early. Posterior and anterior chest radiography and computerized tomography scans are the most used diagnosis techniques for detecting tumor from lungs. Posterior and anterior chest radiography requires less radiation dose and is available in most of the diagnostic centers and it costs less compared to the remaining diagnosis techniques. So PA chest radiography became the most commonly used technique for lung cancer detection...
2018: International Journal of Biomedical Imaging
Hongliang Chen, Mingdi Zhang, Maoli Wang, Peng Zhang, Fang Bai, Kejin Wu
BACKGROUND: Controversy exists regarding the appropriateness of immediate breast reconstruction (IBR) in patients with metastatic breast cancer (MBC). PATIENTS AND METHODS: By using the Surveillance, Epidemiology, and End Results (SEER) database, data of patients with de novo MBC undergoing mastectomy with or without IBR were assessed. The trend of IBR in de novo MBC was explored. Comparisons of the distribution of clinicopathologic characteristics were evaluated by chi-square and Fisher exact tests...
November 5, 2018: Clinical Breast Cancer
Anurag K Singh, Mark Hennon, Sung Jun Ma, Todd L Demmy, Anthony Picone, Elizabeth U Dexter, Chumy Nwogu, Kristopher Attwood, Wei Tan, Gregory M Hermann, Simon Fung-Kee-Fung, Harish K Malhotra, Sai Yendamuri, Jorge A Gomez-Suescun
BACKGROUND: Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body radiation therapy (SBRT) would be a safe alternative. METHODS: Patients with stage IIIA (multistation N2) or IIIB non-small cell lung cancer were enrolled from March 2013 to December 2015. The protocol included transcervical extended mediastinal lymphadenectomy (TEMLA) followed by surgical resection, 10 Gy SBRT directed to the involved mediastinum/hilar stations and/or positive surgical margins, and adjuvant systemic therapy...
November 29, 2018: BMC Cancer
Feng-Ming Spring Kong, Vitali Moiseenko, Jing Zhao, Michael T Milano, Ling Li, Andreas Rimner, Shiva Das, X Allen Li, Moyed Miften, ZhongXing Liao, Mary Martel, Soren M Bentzen, Andrew Jackson, Jimm Grimm, Lawrence B Marks, Ellen Yorke
PURPOSE: Stereotactic body radiation therapy (SBRT) has become standard of care for inoperable early stage non-small cell lung cancer and is often used for recurrent lung cancer and pulmonary metastases. Radiation-induced lung toxicity (RILT), including radiation pneumonitis and pulmonary fibrosis, is a major concern for which it is important to understand dosimetric and clinical predictors. METHODS: This study was undertaken through the American Association of Physicists in Medicine's Working Group on Biological Effects of Stereotactic Body Radiotherapy...
November 26, 2018: International Journal of Radiation Oncology, Biology, Physics
Ky-Nam B Nguyen, Destiny Hause, Jennifer Novak, Arta M Monjazeb, Megan E Daly
PURPOSE: Increased rates of toxicity have been described following stereotactic body radiotherapy (SBRT) for central lung tumors within 2 cm of the proximal bronchial tree (PBT). Recent studies have defined a new class of "ultracentral" tumors. We report our experience treating ultracentral, central, and paramediastinal tumors with SBRT and compare toxicity, disease control, and survival. METHODS AND MATERIALS: We reviewed the records of patients with central lung tumors treated with SBRT between September 2009-July 2017...
November 26, 2018: Practical Radiation Oncology
Taranga Jyoti Baruah, Lakhon Kma
Non-small cell lung cancer (NSCLC) has a very high rate of incidence and is resistant to chemo- and radiotherapy. Vicenin-2 (VCN-2) is a flavonoid obtained from Ocimum sanctum L. and it has been reported to have radioprotective, anticancer, and radiosensitizing properties. We have conducted this study to check the effect of VCN-2 on the cell viability and the effect on PTEN (Phosphatase and tensin homolog), PI3KCA (Phosphatidylinositol 4, 5-biphosphate 3-kinase catalytic subunit alpha isoform/PI3K 110α subunit), and Akt1 when VCN-2 was used alone and in combination with radiation in the NSCLC cell line NCI-H23 (H23)...
November 29, 2018: BioFactors
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