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Chronic Stroke

C Marchesoni, E Cisneros, P Pfister, P Yáñez, C Rollan, C Romero, I Kisinovsky, L Rattagan, L León Cejas, A Pardal, G Sevlever, R Reisin
OBJECTIVE: To evaluate the presence of white matter and hemorrhagic lesions in brain MRI of children and adolescents with Fabry disease (FD). METHODS: Brain MRI studies in 44 consecutive children and teenagers (20 boys, mean age 14.6 years, range 7-21 years) were evaluated using classic sequences as well as, GRE-weighted images, for white matter lesions (WML) and chronic microbleed detection. All patients lacked history of stroke or TIA. Brain MRI findings in 46 consecutive children and adolescents without FD, referred for the evaluation of headaches (36 females, mean age 14...
October 5, 2018: Journal of the Neurological Sciences
Xufeng Tao, Lianhong Yin, Lina Xu, Jinyong Peng
Currently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease, stroke and osteoporosis are increasing fast and fast. It's critical necessary to discovery lead compounds for new drug development. Dioscin, one active compound in some medicinal plants, has anti-inflammation, immunoregulation, hypolipidemic, anti-viral, anti-fungal and anti-allergic effects. In recent years, dioscin has reached more and more attention with its potent effects to treat liver, kidney, brain, stomach and intestine damages, and metabolic diseases including diabetes, osteoporosis, obesity, hyperuricemia as well as its anti-cancer activities through adjusting multiple targets and multiple signals...
October 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Miguel Cainzos-Achirica, Cristina Enjuanes, Philip Greenland, John W McEvoy, Mary Cushman, Zeina Dardari, Khurram Nasir, Matthew J Budoff, Mouaz H Al-Mallah, Joseph Yeboah, Michael D Miedema, Roger S Blumenthal, Josep Comin-Colet, Michael J Blaha
BACKGROUND AND AIMS: We aimed to evaluate the associations and prognostic value of interleukin-6 (IL6) for the prediction of atherosclerotic cardiovascular disease (ASCVD) events, heart failure (HF), and other chronic diseases in a large, multi-ethnic, contemporary population. METHODS: We included 6617 participants from the Multi-Ethnic Study of Atherosclerosis (5640 non-users, 977 users of statins at baseline). Main outcomes were hard ASCVD events and HF; secondary outcomes included all-cause death, atrial fibrillation, venous thromboembolism and cancer...
October 4, 2018: Atherosclerosis
Tia Powell
In writing these essays, we were asked to consider, "What makes a good life in late life?" I thought instantly, perhaps like many people, of photos and stories of older people taking up new careers and new hobbies-running marathons and soup kitchens, starting organic farms. This response is right and proper. Older people can leverage wisdom and creativity to make wonderful contributions to their communities and should be celebrated for doing so. But this happy picture is incomplete. We live longer than ever before, and with that long life, many of us can expect disability...
September 2018: Hastings Center Report
Christian Schoenfeld, Jan B Hinrichs, Karen M Olsson, Martin-Alexander Kuettner, Julius Renne, Till Kaireit, Christoph Czerner, Frank Wacker, Marius M Hoeper, Bernhard C Meyer, Jens Vogel-Claussen
OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) can be treated with balloon pulmonary angioplasty (BPA) in inoperable patients. Sensitive non-invasive imaging methods are missing to detect treatment response after a single BPA treatment session. Therefore, the aim of this study was to measure treatment response after a single BPA session using cardio-pulmonary MRI. MATERIALS AND METHODS: Overall, 29 patients with CTEPH were examined with cardio-pulmonary MRI before and 62 days after their initial BPA session...
October 11, 2018: European Radiology
Erzsébet Horváth-Puhó, Marit M Suttorp, Henrik Frederiksen, Tiny Hoekstra, Olaf M Dekkers, Lars Pedersen, Suzanne C Cannegieter, Friedo W Dekker, Henrik Toft Sørensen
Introduction: Erythropoiesis-stimulating agent (ESA) treatment has been associated with an increased risk of venous thromboembolism (VTE) in patients with solid tumors and with an increased risk of cardiovascular events in patients with chronic kidney disease. The ESA-related risk in patients with hematological neoplasms remains unclear. We, therefore, aimed to assess the ESA-related risk of VTE, myocardial infarction (MI), and stroke in patients with multiple myeloma (MM) and myelodysplastic syndrome (MDS)...
2018: Clinical Epidemiology
Elise Crayton, Alison J Wright, Mark Ashworth
BACKGROUND: Medications targeting stroke risk factors have shown good efficacy, yet adherence is suboptimal. A lack of underlying theory may contribute to the ineffectiveness of eliciting or sustaining behaviour change in many existing interventions targeting medication adherence in stroke. Intervention effectiveness and implementation could be enhanced by consideration of evidence base and theory to drive development. The purpose of this study is to identify appropriate components for a theory-driven and evidence-based medication adherence intervention for stroke survivors...
October 11, 2018: BMC Health Services Research
Haijun Wang, Guobin Song, Haoyu Chuang, Chengdi Chiu, Ahmed Abdelmaksoud, Youfan Ye, Lei Zhao
Fibrosis is formed after injury in most of the organs as a common and complex response that profoundly affects regeneration of damaged tissue. In central nervous system (CNS), glial scar grows as a major physical and chemical barrier against regeneration of neurons as it forms dense isolation and creates an inhibitory environment, resulting in limitation of optimal neural function and permanent deficits of human body. In neurological damages, glial scar is mainly attributed to the activation of resident astrocytes which surrounds the lesion core and walls off intact neurons...
January 2018: International Journal of Immunopathology and Pharmacology
Daan Meester, Emad Al-Yahya, Andrea Dennis, Johnny Collett, Derick T Wade, Martin Ovington, Francesca Liu, Meaney Andy, Cockburn Janet, Heidi Johansen-Berg, Helen Dawes
OBJECTIVE: To evaluate the tolerability of, adherence to and efficacy of a community walking training programme with simultaneous cognitive demand (dual-task) compared to a control walking training programme without cognitive distraction. METHODS: Adult stroke survivors, at least 6 months after stroke with a visibly obvious gait abnormality or reduced two-minute walk distance were included into a 2-arm parallel randomized controlled trial of complex intervention with blinded assessments...
October 11, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
A Orea-Tejeda, A Navarrete-Peñaloza, L Verdeja-Vendrell, A Jiménez-Cepeda, D González-Islas, R Hernández-Zenteno, C Keirns-Davis, R Sánchez-Santillán, A Velazquez-Montero, G A Puentes Rodríguez
BACKGROUND: The prognosis in patients with Chronic Obstructive Pulmonary Disease (COPD) depends in large part on the frequency of exacerbations. Cardiovascular diseases, including heart failure (HF), are risk factors for exacerbations. However, its unknown the importance of HF type over the exacerbations in COPD patients. OBJECTIVE: To determine whether right heart failure (RHF) is an independent risk factor for severe exacerbations in patients with COPD. METHODS: A prospective cohort study of 133 patients diagnosed with COPD with a follow-up period from 2010 to 2016...
October 11, 2018: Clinical Respiratory Journal
Josje D Schoufour, Jessica C Kiefte-de Jong, Trudy Voortman
OBJECTIVE: We aimed to evaluate the criterion validity of the 2015 food-based Dutch dietary guidelines, which were formulated based on evidence on the relation between diet and major chronic diseases. DESIGN: We studied 9,701 participants of the Rotterdam Study, a population-based prospective cohort in individuals aged 45 years and over. METHOD: Dietary intake was assessed at baseline with a food-frequency questionnaire. For all participants, we examined adherence (yes/no) to fourteen items of the guidelines: vegetables (≥200g/d), fruit (≥200g/d), whole-grains (≥90g/d), legumes (≥135g/wk), nuts (≥15g/d), dairy (≥350g/d), fish (≥100g/wk), tea (≥450mL/d), ratio whole-grains:total grains (≥50%), ratio unsaturated fats & oils:total fats (≥50%), red and processed meat (<300g/wk), sugar-containing beverages (<150mL/d), alcohol (<10 g/d) and salt (≤6g/d)...
September 19, 2018: Nederlands Tijdschrift Voor Geneeskunde
Sergio Barros-Gomes, Abdallah El Sabbagh, Mackram F Eleid, Sunil V Mankrad
Non-atherosclerotic myocardial infarction (MI) is an important but often misdiagnosed cause of acute MI. Furthermore, non-atherosclerotic MI with concomitant acute stroke and pulmonary embolism due to in-transit thrombus across a patent foramen ovale (PFO) is a rare but potentially fatal combination (1, 2, 3). Early detection of this clinical entity can facilitate delivery of targeted therapies and avoid poor outcome (1, 2). Here, we describe a 68-year-old female with hypertension, tobacco abuse and chronic obstructive pulmonary disease presenting with facial droop, right arm weakness and aphasia...
December 1, 2018: Echo Research and Practice
Sampath Gunda, Santosh K Padala, Aditya Saini, Le Kang, Kenneth A Ellenbogen, Jayanthi N Koneru
Aims: Outcome data on ventricular tachycardia (VT) ablation has been limited to few experienced centres. We sought to identify complication rates, predictors, and create a risk score model for predicting complications in patients from real-world data. Methods and results: A total of 25 451 patients undergoing VT ablation from year 2006 to 2013 were identified from the National Inpatient Sample (NIS) database. The whole cohort was randomly divided into derivation cohort to derive the model and validation cohort to validate the model...
October 9, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Juliana Valente Francica Grilletti, Katia Bilhar Scapini, Nathalia Bernardes, Jaqueline Spadari, Aline Bigongiari, Flavia de Andrade E Souza Mazuchi, Erico Chagas Caperuto, Iris Callado Sanches, Bruno Rodrigues, Kátia De Angelis
OBJECTIVES: Acute post-stroke patients present cardiovascular autonomic dysfunction, which manifests as lower heart rate variability and impaired baroreflex sensitivity. However, few studies performed to date have evaluated cardiovascular autonomic function in chronic post-stroke patients. The aim of this study was to evaluate cardiovascular autonomic modulation in chronic post-ischemic stroke patients. METHODS: The seventeen enrolled subjects were divided into a stroke group (SG, n=10, 5±1 years after stroke) and a control group (CG, n=7)...
October 8, 2018: Clinics
Bruno Oliveira de Figueiredo Brito, Antônio Luiz Pinho Ribeiro
Since the initial descriptions of Chagas cardiomyopathy (ChCM), the electrocardiography has played a key role in patient evaluations. The diagnostic criterion of chronic ChCM is the presence of characteristic electrocardiographic (ECG) abnormalities in seropositive individuals, regardless of the presence of symptoms. However, these ECG abnormalities are rarely specific to ChCM and, particularly among the elderly, can be caused by other simultaneous cardiomyopathies. ECG abnormalities can predict the occurrence of heart failure, stroke, and even death...
September 2018: Revista da Sociedade Brasileira de Medicina Tropical
Ying Gao, Cheng Yu, Shulan Pi, Ling Mao, Bo Hu
Atherosclerosis is a chronic and progressive disease of the arterial walls and a leading cause of non-cardioembolic ischemic stroke. P2Y12 is a well-recognized receptor that is expressed on platelets and is a target of thienopyridine-type antiplatelet drugs. In the last few decades, P2Y12 receptor inhibitors, such as clopidogrel, have been applied for the secondary prevention of non-cardioembolic ischemic stroke. Recent clinical studies have suggested that these P2Y12 receptor inhibitors may be more effective than other antiplatelet drugs in patients with ischemic stroke/transient ischemic attack of atherosclerotic origin...
October 9, 2018: Cellular and Molecular Life Sciences: CMLS
Audrey Hemadou, Jeanny Laroche-Traineau, Ségolène Antoine, Philippe Mondon, Alexandre Fontayne, Yannick Le Priol, Stéphane Claverol, Stéphane Sanchez, Martine Cerutti, Florence Ottones, Gisèle Clofent-Sanchez, Marie-Josée Jacobin-Valat
Atherosclerosis is a chronic, progressive inflammatory disease that may develop into vulnerable lesions leading to thrombosis. This pathology is characterized by the deposition of lipids within the arterial wall and infiltration of immune cells leading to amplification of inflammation. Nowadays there is a rising interest to assess directly the molecular and cellular components that underlie the clinical condition of stroke and myocardial infarction. Single chain fragment variable (scFv)-phages issuing from a human combinatorial library were selected on the lesions induced in a rabbit model of atherosclerosis after three rounds of in vivo phage display...
October 9, 2018: Scientific Reports
Pfunzo T Muvhali, Maud Bonato, Anel Engelbrecht, Irek A Malecki, Denise Hough, Jane E Robinson, Neil P Evans, Schalk W P Cloete
The effect of extensive human presence and regular gentle handling performed at an early age (0⁻3 months old) on stress responses and reactivity of juvenile ostriches towards humans was investigated. A total of 416 ostrich chicks over two years were exposed to one of three treatments for three months after hatching; namely, Human Presence 1 (HP1, N = 144): extensive/prolonged human presence with physical contact (touch, stroking), gentle human voice, and visual stimuli; Human Presence 2 (HP2, N = 136): extensive/prolonged human presence without physical contact, but with gentle human voice and visual stimuli; and the Standard treatment (S, N = 136): human presence limited to routine feed and water supply as a control...
October 5, 2018: Animals: An Open Access Journal From MDPI
Christina Wolfson, Seyed-Mohammad Fereshtehnejad, Romain Pasquet, Ron Postuma, Mark R Keezer
BACKGROUND: Our objective was to study the association between the presence of a neurological disease and the comorbidity burden, as well as healthcare utilization. METHODS: Using baseline data from the Canadian Longitudinal Study on Aging (CLSA), we examined the burden of five neurological conditions. The CLSA is a population-based study of approximately 50,000 individuals, aged 45 to 85 years at baseline. We used multivariable Poisson regression to identify correlates of comorbidity burden and healthcare utilization...
October 9, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Angela Rossetti, Calogero Malfitano, Chiara Malloggi, Elisabetta Banco, Viviana Rota, Luigi Tesio
Twenty-six months after a left hemispheric ischemic stroke an aphasic patient showed a significant improvement in verbal fluency following ten daily sessions of inhibitory 1 Hz repetitive transcranial magnetic stimulation over the right cortex homologous to the Broca's area.No improvement was observed for other linguistic functions or for executive ones. Results confirm the segregation of neural circuitries subtending phonemic and semantic fluency and suggest a selective usefulness of the repetitive transcranial magnetic stimulation treatment...
October 8, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
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