Sufia Dadabhai, Victoria B Chou, Mauricio Pinilla, Lameck Chinula, Maxensia Owor, Avy Violari, Dhayendre Moodley, Lynda Stranix-Chibanda, Taguma Allen Matubu, Gift Tafadzwa Chareka, Gerhard Theron, Aarti Avinash Kinikar, Mwangelwa Mubiana-Mbewe, Lee Fairlie, Raziya Bobat, Blandina Theophil Mmbaga, Patricia M Flynn, Taha E Taha, Katie S McCarthy, Renee Browning, Lynne M Mofenson, Sean S Brummel, Mary Glenn Fowler
BACKGROUND: IMPAACT 1077BF/FF compared the safety/efficacy of two HIV antiretroviral therapy (ART) regimens to zidovudine (ZDV) alone during pregnancy for HIV prevention. PROMISE found an increased risk of preterm delivery (<37 weeks) with antepartum triple ART (TDF/FTC/LPV+r or ZDV/3TC/LPV+r) compared to ZDV alone. We assessed the impact of preterm birth, breastfeeding and antepartum ART regimen on 24-month infant survival. METHODS: We compared HIV-free and overall survival at 24-months for liveborn infants by gestational age, time-varying breastfeeding status, and antepartum ART arm at 14 sites in Africa and India...
March 4, 2024: AIDS