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https://www.readbyqxmd.com/read/30116526/a-multi-center-nested-case-control-study-on-hospitalization-costs-and-length-of-stay-due-to-healthcare-associated-infection
#1
Yu Lü, Min Hong Cai, Jian Cheng, Kun Zou, Qian Xiang, Jia Yu Wu, Dao Qiong Wei, Zhong Hua Zhou, Hui Wang, Chen Wang, Jing Chen
Background: In 2018, the Chinese government demanded nationwide implementation of medical insurance payment methods based on Single-Disease Payment (SDP), but during the operation process the medical insurance system did not fully consider the extra economic burden caused by healthcare-associated infection (HAI). HAIs can prolong the length of stay and increase the hospitalization costs, but only a few studies have been conducted in Sichuan province, China. We evaluated the hospitalization costs and length of stay due to HAI in Sichuan province based on the prevalence survey, and provided data reference for China's medical insurance reform...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/30114344/alterations-in-hub-organization-in-the-white-matter-structural-network-in-toddlers-with-autism-spectrum-disorder-a-2-year-follow-up-study
#2
Lu Qian, Yao Wang, KangKang Chu, Yun Li, ChaoYong Xiao, Ting Xiao, Xiang Xiao, Ting Qiu, YunHua Xiao, Hui Fang, XiaoYan Ke
Little is currently known about the longitudinal developmental patterns of hubs in the whole-brain white matter (WM) structural networks among toddlers with autism spectrum disorder (ASD). This study utilized diffusion tensor imaging (DTI) and deterministic tractography to map the WM structural networks in 37 ASD toddlers and 27 age-, gender- and developmental quotient-matched controls with developmental delay (DD) toddlers aged 2-3 years old at baseline (Time 1) and at 2-year follow-up (Time 2). Furthermore, graph-theoretical methods were applied to investigate alterations in the network hubs in these patients at the two time points...
August 16, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/30113806/plasmon-coupling-effect-enhanced-imaging-of-metal-ions-in-living-cells-using-dnazyme-assembled-core-satellite-structures
#3
Ting-Ting Zhai, Dekai Ye, Yi Shi, Qian-Wen Zhang, Xiang Qin, Chen Wang, Xing-Hua Xia
We demonstrate a core-satellite plasmonic nanoprobe assembled via metal ion-dependent DNA-cleaving DNAzyme linker for imaging intercellular metal ion based on plasmon coupling effect at a single particle level. As metal ions are present in the system, the DNAzyme linker will be cleaved, and thus, disassembly of the core-satellite nanoprobes occurs, which results in distinct blue shift of the scattering spectra of Au core-satellite probes and naked color change of the scattering light. This change in scattering spectra has been supported by theoretical simulations...
August 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30112058/effects-of-remote-ischemic-post-conditioning-on-platelet-activation-of-ami-patients
#4
Yun-Xia Qian, Ke-Sheng Dai, Li-Li Zhao, Xiang-Jun Yang
The recovery of ischemic myocardium blood perfusion is the main treatment option for acute myocardial infarction (AMI). However, this treatment option has multiple side effects that directly affect the quality of life of the patients. The activation of platelet function plays an important role in the occurrence, development and treatment of AMI. The aim of the present study was to analyze the effects of remote ischemic post-conditioning on platelet activation of AMI patients with primary PCI treatment and clinical prognosis...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30110177/mettl14-is-required-for-mouse-postimplantation-development-by-facilitating-epiblast-maturation
#5
Tie-Gang Meng, Xukun Lu, Lei Guo, Guan-Mei Hou, Xue-Shan Ma, Qian-Nan Li, Lin Huang, Li-Hua Fan, Zheng-Hui Zhao, Xiang-Hong Ou, Ying-Chun OuYang, Heide Schatten, Lei Li, Zhen-Bo Wang, Qing-Yuan Sun
N6-methyladenosine (m6 A) is the most prevalent and reversible internal modification of mammalian messenger and noncoding RNAs mediated by specific m6 A writer, reader, and eraser proteins. As an m6 A writer, the methyltransferase-like 3-methyltransferase-like 14 (METTL14)-Wilms tumor 1-associated protein complex dynamically regulates m6 A modification and plays important roles in diverse biologic processes. However, our knowledge about the complete functions of this RNA methyltransferase complex, the contributions of each component to the methylation, and their effects on different biologic pathways are still limited...
August 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30108712/identification-of-a-potent-kinase-inhibitor-targeting-eml4-alk-fusion-protein-in-non-small-cell-lung-cancer
#6
Lian-Xiang Luo, Ying Li, Yu-Zhen Niu, Yu-Wei Wang, Qian-Qian Wang, Xing-Xing Fan, Jia-Hui Xu, Liang Liu, Elaine Lai-Han Leung, Xiao-Jun Yao
ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.
October 1, 2017: MedChemComm
https://www.readbyqxmd.com/read/30107859/photoperiodic-diapause-in-a-subtropical-population-of-aedes-albopictus-in-guangzhou-china-optimized-field-laboratory-based-study-and-statistical-models-for-comprehensive-characterization
#7
Dan Xia, Xiang Guo, Tian Hu, Li Li, Ping-Ying Teng, Qing-Qing Yin, Lei Luo, Tian Xie, Yue-Hong Wei, Qian Yang, Shu-Kai Li, Yu-Ji Wang, Yu Xie, Yi-Ji Li, Chun-Mei Wang, Zhi-Cong Yang, Xiao-Guang Chen, Xiao-Hong Zhou
BACKGROUND: Aedes albopictus is among the 100 most invasive species worldwide and poses a major risk to public health. Photoperiodic diapause provides a crucial ecological basis for the adaptation of this species to adverse environments. Ae. albopictus is the vital vector transmitting dengue virus in Guangzhou, but its diapause activities herein remain obscure. METHODS: In the laboratory, yeast powder and food slurry were compared for a proper diapause determination method, and the critical photoperiod (CPP) was tested at illumination times of 11, 11...
August 14, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/30106449/inhibitor-of-apoptosis-protein%C3%A2-like-protein%C3%A2-2-a-novel-growth-accelerator-for-breast-cancer-cells
#8
Lin Zhu, Weihua Zhou, Xidi Zhu, Siqi Xiang, Siyuan Wang, Yingxia Peng, Bangyun Lu, Peizhi Tang, Qian Chen, Mengjuan Wu, Xia Peng, Ziyu Chen, Ziyi Sun, Kunliang Yang, Mingjun Xiang, Dandan Yu
Although the inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) has been shown as a serological biomarker for breast cancer, its effect on breast cancer cell growth remains elusive. The present study aimed to determine the role of ILP‑2 in breast cancer cell growth. We used immunohistochemistry to analyze ILP‑2 expression in 59 tissue paraffin‑embedded blocks, which included 35 breast cancer tissues and 24 galactophore hyperplasia tissues. Western blot analysis was used to detect protein expression levels of ILP‑2 in breast cancer cell lines such as HCC‑1937, MX‑1 and MCF‑7 as well as breast gland cell line MCF 10A...
October 2018: Oncology Reports
https://www.readbyqxmd.com/read/30103374/-fusarium-graminearum-atp-binding-cassette-transporter-gene-fgabcc9-is-required-for-its-transportation-of-salicylic-acid-fungicide-resistance-mycelial-growth-and-pathogenicity-towards-wheat
#9
Peng-Fei Qi, Ya-Zhou Zhang, Cai-Hong Liu, Jing Zhu, Qing Chen, Zhen-Ru Guo, Yan Wang, Bin-Jie Xu, Ting Zheng, Yun-Feng Jiang, Jiang-Ping Wang, Cai-Yi Zhou, Xiang Feng, Li Kong, Xiu-Jin Lan, Qian-Tao Jiang, Yu-Ming Wei, You-Liang Zheng
ATP-binding cassette (ABC) transporters hydrolyze ATP to transport a wide range of substrates. Fusarium graminearum is a major causal agent of Fusarium head blight, which is a severe disease in wheat worldwide. FgABCC9 ( FG05_07325 ) encodes an ABC-C (ABC transporter family C) transporter in F. graminearum , which was highly expressed during the infection in wheat and was up-regulated by the plant defense hormone salicylic acid (SA) and the fungicide tebuconazole. The predicted tertiary structure of the FgABCC9 protein was consistent with the schematic of the ABC exporter...
August 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30103286/association-between-dopamine-receptor-gene-polymorphisms-and-effects-of-risperidone-treatment-a-systematic-review-and-meta-analysis
#10
Lingyue Ma, Xiaodan Zhang, Qian Xiang, Shuang Zhou, Nan Zhao, Qiufen Xie, Xia Zhao, Ying Zhou, Yimin Cui
BACKGROUND: The effect of risperidone treatment in patients with schizophrenia varies according to the dopamine receptor genes. This study aimed to evaluate the relationship between genes of the dopamine receptors (D1, D2, and D3) and the effect of risperidone treatment. METHODS: Three electronic databases (PubMed, Embase and Cochrane Library) were searched for relevant cohort or case-control studies published before 9 May 2018. A systematic review and meta-analysis was performed for qualitative and quantitative assessment of the relationship between the dopamine receptors D1, D2 and D3 (DRD1, 2 and 3) and the effect of risperidone treatment...
August 13, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/30101273/targeting-sting-with-cyclic-di-gmp-greatly-augmented-immune-responses-of-glycopeptide-cancer-vaccines
#11
Jun-Jun Wu, Wen-Hao Li, Pu-Guang Chen, Bo-Dou Zhang, Hong-Guo Hu, Qian-Qian Li, Lang Zhao, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei Li
Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to high titers of IgG antibodies and the expression of multiple cytokines.
August 13, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/30098566/combined-intra-and-extracellular-reduction-involved-in-the-anaerobic-biodecolorization-of-cationic-azo-dye-by-shewanella-oneidensis-mr-1
#12
Qian Li, Xiaoli Feng, Xuerong Lu, Tingting Li, Xue Han, Xiang Xiao, Xiangyang Wu, Zhaoying Liu, Mingfeng Yang, Yujie Feng
Microbial reduction decolorization is a promising strategy for cationic azo dye pollution remediation, but the reduction mechanism is unclear yet. In this work, the anaerobic reduction decolorization mechanism of cationic red X-GRL (X-GRL) by Shewanella oneidensis MR-1 (MR-1) was investigated from both intracellular and extracellular aspects. The exogenous additional riboflavin treatment test was used to analyze the extracellular reduction mechanism of X-GRL, and the actual role of riboflavin during the reduction of X-GRL was identified by three-dimensional fluorescence analysis for the first time...
August 6, 2018: Chemosphere
https://www.readbyqxmd.com/read/30096898/effects-of-regulated-deficit-irrigation-on-amino-acid-profiles-and-their-derived-volatile-compounds-in-cabernet-sauvignon-vitis-vinifera-l-grapes-and-wines
#13
Yan-Lun Ju, Guo-Qian Xu, Xiao-Feng Yue, Xian-Fang Zhao, Ting-Yao Tu, Jun-Xiang Zhang, Yu-Lin Fang
Amino acid contents and their derived volatile compositions in Cabernet Sauvignon grapes and wines after regulated deficit irrigation (RDI) were investigated during the 2015 and 2016 growing seasons in Yinchuan (NingXia, China). High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) were used for amino acid and volatile compound analyses. Three RDI strategies were tested: 60% (RDI-1), 70% (RDI-2), and 80% (RDI-3) of grapevine estimated evapotranspiration (ETc), and 100% ETc was used as the control group (CK)...
August 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30094095/aryl-hydrocarbon-receptor-activated-by-benzo-a-pyrene-promotes-smarca6-expression-in-nsclc
#14
Chao Mao, Min Wang, Banglun Qian, Lianlian Ouyang, Ying Shi, Na Liu, Ling Chen, Desheng Xiao, Xiang Wang, Ya Cao, Shuang Liu, Yongguang Tao, Wenliang Liu
Recent studies suggest that individual subunits of chromatin-remodeling complexes generate epigenetically specific signaling in tumorigenicity. The impact of environmental factors on the chromatin-remodeling factor has not been thoroughly elucidated to date. We detected the expression level of SMARCA6 (SWI/SNF2-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 6) in NSCLC (Non-small-cell lung carcinoma) and measured it through quantitative real-time PCR (qRT-PCR) and immunohistochemistry...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30086422/a-correlation-study-of-continuously-monitored-gamma-dose-rate-and-meteorological-conditions
#15
Yan-Jun Huang, Zhi-Hong Shang-Guan, Feng Zhao, Ming-Gui Lin, Xiang-Dong Sha, Dun-Ye Luo, Qian Chen, Kai Peng
In this paper, the correlations between the continuously monitored gamma dose rate (GDR) and meteorological parameters, including precipitation, air temperature, relative humidity, air pressure, wind direction, and wind speed, were analyzed by using one year of the hourly dataset from a monitoring system with ten stations. The correlation coefficients are varied by the range of each meteorological parameter. Precipitation would enhance the GDR up to 84%, which is highly related to precipitation intensity and ground type...
August 4, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/30085062/efficient-co-expression-of-multiple-enzymes-from-a-single-promoter-mediated-by-virus-2a-sequence-in-the-oleaginous-yeast-rhodosporidium-toruloides
#16
Xiang Jiao, Qi Zhang, Sufang Zhang, Xiaobing Yang, Qian Wang, Zongbao Kent Zhao
The red yeast Rhodosporidium toruloide is a versatile host for production of lipids and carotenoids. Genetic tools are underdeveloped for red yeasts due to their unique genetics and physiology. Currently expression of a heterogonous gene in red yeasts is largely based on integration of the designed cassette by Agrobacterium mediated transformation, yet this method is somewhat restricted when multiple genes are required to be expressed due to the lack of functional genetic elements. Here we demonstrate that virus 2A sequence is effective to mediate co-expression of multiple enzymes in R...
July 30, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/30084212/coupling-interface-constructions-of-mos-2-fe-5-ni-4-s-8-heterostructures-for-efficient-electrochemical-water-splitting
#17
Yi Wu, Fan Li, Wenlong Chen, Qian Xiang, Yanling Ma, Hong Zhu, Peng Tao, Chengyi Song, Wen Shang, Tao Deng, Jianbo Wu
Water splitting is considered as a pollution-free and efficient solution to produce hydrogen energy. Low-cost and efficient electrocatalysts for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) are needed. Recently, chemical vapor deposition is used as an effective approach to gain high-quality MoS2 nanosheets (NSs), which possess excellent performance for water splitting comparable to platinum. Herein, MoS2 NSs grown vertically on FeNi substrates are obtained with in situ growth of Fe5 Ni4 S8 (FNS) at the interface during the synthesis of MoS2 ...
August 6, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30080672/adaptions-of-field-prrsvs-in-marc-145-cells-were-determined-by-variations-in-the-minor-envelope-proteins-gp2a-gp3
#18
Hong-Liang Zhang, Yan-Dong Tang, Chun-Xiao Liu, Li-Run Xiang, Wen-Li Zhang, Chao-Liang Leng, Qian Wang, Tong-Qing An, Jin-Mei Peng, Zhi-Jun Tian, Xue-Hui Cai
The recent rapid evolution of PRRSVs has resulted in certain biological characteristic changes, such as the fact that an increasing number of field PRRSVs can be isolated from PAMs but not from Marc-145 cells. In this study, we first isolated Marc-145-unadaptive field PRRSV strains from PAMs; sequence analysis showed that these PRRSVs belong to the HP-PRRSV (lineage 8) branch or NADC30-Like (lineage 1) branch. We further found major variations in ORF2-4 regions. To explore the viral adaptation mechanisms in detail, we constructed a full-length cDNA clone of MY-376, a Marc-145-unadaptive PRRSV...
August 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/30074149/enhanced-response-of-acute-monocytic-leukemia-cells-to-low-dose-cytarabine-by-1-25-dihydroxyvitamin-d3
#19
Hao Guo, Sheng-Yan Lin, Wen-Xiang Ren, Qian Lei, Zhi-Chao Chen, Lu Zhang, Qiu-Bai Li
Low-dose cytarabine combined with differentiating or DNA hypomethylating agents, such as vitamin D compounds, is a potential regimen to treat acute myeloid leukemia (AML) patients who are unfit for high-intensity chemotherapy. The present study aimed to determine which subset of AML would be most responsive to low-dose cytarabine with the differentiating agent 1,25-dihydroxyvitamin D3 (1,25-D3). Here, firstly, cBioPortal database was used and we found out that vitamin D receptor (VDR) was highly expressed in acute monocytic leukemia (M5) and high VDR expression was associated with a poor survival of AML patients...
February 2018: Current medical science
https://www.readbyqxmd.com/read/30074127/dual-functionality-of-rassf1a-overexpression-in-a375-cells-is-mediated-by-activation-of-il-6-stat3-regulatory-loop
#20
Mei Yi, Wei Wang, Shengnan Chen, Ya Peng, Junjun Li, Jing Cai, Ying Zhou, Qian Peng, Yuanyuan Ban, Zhaoyang Zeng, Xiaoling Li, Wei Xiong, Guiyuan Li, Bo Xiang
The RASSF1A, a microtubule associated protein, is a well-known tumor suppressor silenced in various cancer via promoter hypermethylation. RASSF1A is implicated in the regulation of cellular proliferation and apoptosis. However, its role in melanoma A375 cells invasion and metastasis remain unclear. Here, we report an unusual dual function role of ectopic RASSF1A in A375 cells. RASSF1A suppressed A375 cells proliferation but enhanced cells migration, invasiveness and metastatic potential in vivo. We demonstrated RASSF1A simultaneously up-regulated p21 and vimentin expression in A375 cells...
August 3, 2018: Molecular Biology Reports
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