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Qian Ma, Haoliang Qian, Sergio Montoya, Wei Bao, Lorenzo Ferrari, Huan Hu, Emroz Khan, Yuan Wang, Eric E Fullerton, Evgenii E Narimanov, Xiang Zhang, Zhaowei Liu
Optical metamaterial is capable to manipulate light in nanometer-scale that goes beyond what is possible with conventional materials. Taking advantage of this special property, metamaterial-assisted illumination nanoscopy (MAIN) possesses tremendous potential to extend the resolution far beyond the conventional structured illumination microscopy. Among the available MAIN designs, hyper-structured illumination that utilizes strong dispersion of a hyperbolic metamaterial (HMM), is one of the most promising and practical approaches but it is only theoretically studied...
October 17, 2018: ACS Nano
Xing-Xing Dai, Jun-Chao Jiang, Qian-Qian Sha, Yu Jiang, Xiang-Hong Ou, Heng-Yu Fan
Meiotic maturation of mammalian oocytes depends on the temporally and spatially regulated cytoplasmic polyadenylation and translational activation of maternal mRNAs. Cytoplasmic polyadenylation is controlled by cis-elements in the 3'-UTRs of mRNAs including the polyadenylation signal (PAS), which is bound by the cleavage and polyadenylation specificity factor (CPSF) and the cytoplasmic polyadenylation element (CPE), which recruits CPE binding proteins. Using the 3'-UTRs of mouse Cpeb1, Btg4 and Cnot6l mRNAs, we deciphered the combinatorial code that controls developmental stage-specific translation during meiotic maturation: (i) translation of a maternal transcript at the germinal vesicle (GV) stage requires one or more PASs that locate far away from CPEs; (ii) PASs distal and proximal to the 3'-end of the transcripts are equally effective in mediating translation at the GV stage, as long as they are not close to the CPEs; (iii) Both translational repression at the GV stage and activation after germinal vesicle breakdown require at least one CPE adjacent to the PAS; (iv) The numbers and positions of CPEs in relation to PASs within the 3'-UTR of a given transcript determines its repression efficiency in GV oocytes...
October 18, 2018: Nucleic Acids Research
You-Ping Liu, Hao Li, Rui You, Ji-Bin Li, Xue-Kui Liu, An-Kui Yang, Xiang Guo, Ming Song, Quan Zhang, Zhu-Ming Guo, Wen-Kuan Chen, Wei-Wei Liu, Xiong Zou, Yi-Jun Hua, Qi Yang, Yi-Nuan Zhang, Rui Sun, Hao-Yuan Mo, Ling Guo, Ai-Hua Lin, Hai-Qiang Mai, Chao-Nan Qian, Ming-Yuan Chen
OBJECTIVE: To compare survival effects of comprehensive neck dissection (CND) and selective neck dissection (SND) for patients with nasopharyngeal carcinoma (NPC) with only regional failure. METHODS: A total of 294 recurrent T0N1-3M0 NPC patients who underwent neck dissection in Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China, between January 1984 and February 2014, were enrolled in the survival and interaction analyses. Using propensity scores to adjust for potential prognostic factors, an additional well-balanced cohort of 210 patients was constructed by matching each patient who received SND with one patient who underwent CND (1:1); the differences were then compared between SND and CND in terms of overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS)...
October 16, 2018: Laryngoscope
Yi Ding, Chang Gong, De Huang, Rui Chen, Pinpin Sui, Kevin H Lin, Gehao Liang, Lifeng Yuan, Handan Xiang, Junying Chen, Tao Yin, Peter B Alexander, Qian-Fei Wang, Er-Wei Song, Qi-Jing Li, Kris C Wood, Xiao-Fan Wang
Intrinsic resistance to anti-HER2 therapy in breast cancer remains an obstacle in the clinic, limiting its efficacy. However, the biological basis for intrinsic resistance is poorly understood. Here we performed a CRISPR/Cas9-mediated loss-of-function genetic profiling and identified TALDO1, which encodes the rate-limiting transaldolase (TA) enzyme in the non-oxidative pentose phosphate pathway, as essential for cellular survival following pharmacological HER2 blockade. Suppression of TA increases cell susceptibility to HER2 inhibition in two intrinsically resistant breast cancer cell lines with HER2 amplification...
October 15, 2018: Nature Communications
Chenlin Yang, Rui Hu, Qian Li, Shuang Li, Junfeng Xiang, Xudong Guo, Shuangqing Wang, Yi Zeng, Yi Li, Guoqiang Yang
G-quadruplexes (G4s) are unique four-stranded nucleic acid secondary structures formed by G-rich nucleic acid sequences which are prevalent in gene promoter and telomere regions and deemed to play essential roles in many biological and pathological processes. Although attentions to G4s have been paid for nearly 40 years, G4 selectivity and its topology discrimination in cells is still pending. Small fluorescence molecules are emerging as a versatile tool of interrogation of cellular features in vivo. Herein, a new class of bis(4-aminobenzylidene)acetone derivatives GD1, GD2, and GD3 with excellent environment-sensitive emission properties were developed and used for fluorescent detection of G4s...
September 30, 2018: ACS Omega
Dan He, Qian Li, Guangjin Xu, Zheng Hu, Xuefei Li, Yinping Guo, Shabei Xu, Wei Wang, Xiang Luo
INTRODUCTION: Right-to-left shunt (RLS) induced by a patent foramen ovale (PFO) is associated with an increased risk of cryptogenic stroke (CS). However, little is known about the relationship between the amount of RLS and the stroke pattern. In this study, we aimed to evaluate the distinct clinical features of PFO-related CS in different RLS degrees resulting from PFO. METHODS: This is a cohort study of 222 CS patients admitted to the Tongji Hospital from 1st May 2014 to 31st April 2017...
October 11, 2018: Brain and Behavior
Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu
PTB was initially discovered as a polypyrimidine tract-binding protein (hence the name), which corresponds to a specific RNA-binding protein associated with heterogeneous ribonucleoprotein particle (hnRNP I). The PTB family consists of three members in mammalian genomes, with PTBP1 (PTB) expressed in most cell types, PTBP2 (also known as nPTB or brPTB) exclusively found in the nervous system, and PTBP3 (also known as ROD1) predominately detected in immune cells. During neural development, PTB is down-regulated, which induces nPTB, and the expression of both PTB and nPTB becomes diminished when neurons mature...
2018: Biophysics Reports
Yue-Qin Li, Juan Chen, Ji-Ye Yin, Zhao-Qian Liu, Xiang-Ping Li
Objectives: Platinum-based chemotherapy is first-line treatment for non-small cell lung cancer (NSCLC) patients. The efficacy is limited by drug resistance. Recent studies suggest that ATP7B, a copper efflux transporter, may be involved in platinum resistance. However, the clinical significance of ATP7B expression in NSCLC is controversial. Moreover, the effects of single nucleotide polymorphisms (SNPs) in ATP7B gene on the response to platinum-based chemotherapy are scarcely understood. The aim of our study is to evaluate the clinical value of ATP7B in NSCLC patients and explore the interrelationships between ATP7B SNPs and protein expression, and their association with chemotherapy response...
2018: Journal of Cancer
Xiang Liu, Qian Yang, Jinyu Yan, Xiahui Zhang, Meiyun Zheng
Long noncoding RNAs (lncRNAs) have been discovered as significant regulators in a wide range of human cancers. Among them, lncRNA MNX1-AS1 has been proved to be an oncogene in ovarian cancer and glioblastoma. However, the regulatory mechanism of MNX1-AS1 in cervical cancer remains to be understood. Therefore, this study planned to explore the role of MNX1-AS1 in cervical cancer. In the beginning, we found that the expression of MNX1-AS1 was obviously upregulated in cervical cancer tissues and cell lines. Kaplan-Meier survival analysis revealed that patients with higher MNX1-AS1 expression level suffered from shorter overall survival time than those with lower MNX1-AS1 level...
October 9, 2018: Journal of Cellular Biochemistry
Kai Zhang, Xiaorong Zhang, Zhiqiang Cai, Jie Zhou, Ran Cao, Ya Zhao, Zonggui Chen, Dehe Wang, Wen Ruan, Qian Zhao, Guangqiao Liu, Yuanchao Xue, Yan Qin, Bing Zhou, Ligang Wu, Timothy Nilsen, Yu Zhou, Xiang-Dong Fu
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports have also indicated the ability of miRNAs to target protein-coding sequences (CDS); however, miRNAs have been generally believed to function through similar mechanisms regardless of the locations of their sites of action. Here, we report a class of miRNA-recognition elements (MREs) that function exclusively in CDS regions. Through functional and mechanistic characterization of these 'unusual' MREs, we demonstrate that CDS-targeted miRNAs require extensive base-pairing at the 3' side rather than the 5' seed; cause gene silencing in an Argonaute-dependent but GW182-independent manner; and repress translation by inducing transient ribosome stalling instead of mRNA destabilization...
October 8, 2018: Nature Structural & Molecular Biology
Datian Chen, Xiang Zhang, Guangyi Gao, Lili Shen, Jiaqi Xie, Xiaoping Qian, Huiyu Wang
BACKGROUND: Previous studies have demonstrated that left-sided tumors have better prognoses than right-sided tumors in RAS wild-type mCRC (metastatic colorectal cancer) patients, while anti-EGFR mAbs appear to have no advantage compared with bevacizumab for right-sided tumors in these patients. Nevertheless, it remains unclear whether primary tumor location affects patients' options for potentially curative resection. METHODS: PubMed, the Cochrane Library, Embase, ASCO, and ESMO conference abstracts were searched...
October 8, 2018: World Journal of Surgical Oncology
Ling Xu, Zhuo Zhang, Qianxin Liu, Bin Zhou, Yinhua Liu, Qian Xiang, Sainan Zhu, Xuening Duan, Yimin Cui
Prognostic assessment after preoperative systemic therapy (PST) is critical to develop a therapeutic strategy for breast cancer management. Currently, a clinical-pathologic staging system that incorporates ER status and nuclear grading (CPS + EG), and the Neo-Bioscore system that includes HER2 status into CPS + EG, are used to predict outcomes in patients with breast cancer after PST. While HER2-positive is recognized as a favorable factor in the Neo-Bioscore system based on results in patients administered one year of trastuzumab as anti-HER2 therapy, most HER2-positive cases have difficulty accessing anti-HER2 treatment in China...
September 17, 2018: Thoracic Cancer
Shi-Xiang Zhao, Zhi-Xiang Lu, Li-Qun Yu, Xin Guan, Hai-Ping He, Ke-Qian Shi, Ren-Bin Zhao, Tong-Hua Yang
OBJECTIVE: To better define the effect of JAK2V617F mutant allele burden on clinical presentation of patients with essential thrombo cythamia (ET), especially thrombosis. METHODS: Two ml of heparin anti-coagulated bone marrow was collected from 229 ET cases, who were diagnosed and treated in the First People's Hospital of Yunnan Province during 2013.10 to 2016.12. and then the mononuclear cells were separated by Red Blood Cell Lysis Buffer, genomic DNA was extracted from mononuclear cells by using a commercial DNA isolation kit and amplified by allele specific polymerase chain reaction (PCR)...
October 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Ran Wei, Fan Yang, Ruixue Gu, Qian Liu, Jukai Zhou, Xiang Zhang, Weifeng Zhao, Changsheng Zhao
In this study, poly (ionic liquids/N-isopropylacrylamide) (PIL/NIPAM) modified polyethersulfone (PES) microporous membranes were prepared using a pore-filling method. Due to the anion sensitive wettability of the PIL and the thermal sensitive phase transformation of PNIPAM, the permeability of the modified membranes showed robust anion and thermal dual-responsive behaviors. In addition, the response temperature of the membranes could be adjusted precisely from 30 to 55 oC by anion exchange, which was attributed to the cooperative interaction of the PIL and PNIPAM...
October 2, 2018: ACS Applied Materials & Interfaces
Shan Yu, Xiang-Bing Fan, Xian Wang, Jingguo Li, Qian Zhang, Andong Xia, Shiqian Wei, Li-Zhu Wu, Ying Zhou, Greta R Patzke
Photocatalytic hydrogen evolution is a promising technique for the direct conversion of solar energy into chemical fuels. Colloidal quantum dots with tunable band gap and versatile surface properties remain among the most prominent targets in photocatalysis despite their frequent toxicity, which is detrimental for environmentally friendly technological implementations. In the present work, all-inorganic sulfide-capped InP and InP/ZnS quantum dots are introduced as competitive and far less toxic alternatives for photocatalytic hydrogen evolution in aqueous solution, reaching turnover numbers up to 128,000 based on quantum dots with a maximum internal quantum yield of 31%...
October 1, 2018: Nature Communications
Xiang Xia, Ying Qian
A fluorescence probe, Cz-BDP-NBD, for detecting biothiols with two photon excited fluorescence has been designed and used under irradiation from sapphire pulsed lasers at 800 nm. Upon addition of biothiols, NBD was removed through a SNAr reaction and the fluorophore Carbazyl BODIPY (Cz-BDP) was released simultaneously. A two photon excited fluorescence was turned on and accompanied by a strong red emission at 660 nm, the two-photon absorption (TPA) cross section of the Cz-BDP reached a value of 198.5 GM at 800 nm...
October 1, 2018: Analyst
P Agnes, I F M Albuquerque, T Alexander, A K Alton, G R Araujo, D M Asner, M Ave, H O Back, B Baldin, G Batignani, K Biery, V Bocci, G Bonfini, W Bonivento, B Bottino, F Budano, S Bussino, M Cadeddu, M Cadoni, F Calaprice, A Caminata, N Canci, A Candela, M Caravati, M Cariello, M Carlini, M Carpinelli, S Catalanotti, V Cataudella, P Cavalcante, S Cavuoti, R Cereseto, A Chepurnov, C Cicalò, L Cifarelli, A G Cocco, G Covone, D D'Angelo, M D'Incecco, D D'Urso, S Davini, A De Candia, S De Cecco, M De Deo, G De Filippis, G De Rosa, M De Vincenzi, P Demontis, A V Derbin, A Devoto, F Di Eusanio, G Di Pietro, C Dionisi, M Downing, E Edkins, A Empl, A Fan, G Fiorillo, K Fomenko, D Franco, F Gabriele, A Gabrieli, C Galbiati, P Garcia Abia, C Ghiano, S Giagu, C Giganti, G K Giovanetti, O Gorchakov, A M Goretti, F Granato, M Gromov, M Guan, Y Guardincerri, M Gulino, B R Hackett, M H Hassanshahi, K Herner, B Hosseini, D Hughes, P Humble, E V Hungerford, Al Ianni, An Ianni, V Ippolito, I James, T N Johnson, Y Kahn, K Keeter, C L Kendziora, I Kochanek, G Koh, D Korablev, G Korga, A Kubankin, M Kuss, M La Commara, M Lai, X Li, M Lisanti, M Lissia, B Loer, G Longo, Y Ma, A A Machado, I N Machulin, A Mandarano, L Mapelli, S M Mari, J Maricic, C J Martoff, A Messina, P D Meyers, R Milincic, S Mishra-Sharma, A Monte, M Morrocchi, B J Mount, V N Muratova, P Musico, R Nania, A Navrer Agasson, A O Nozdrina, A Oleinik, M Orsini, F Ortica, L Pagani, M Pallavicini, L Pandola, E Pantic, E Paoloni, F Pazzona, K Pelczar, N Pelliccia, V Pesudo, E Picciau, A Pocar, S Pordes, S S Poudel, D A Pugachev, H Qian, F Ragusa, M Razeti, A Razeto, B Reinhold, A L Renshaw, M Rescigno, Q Riffard, A Romani, B Rossi, N Rossi, D Sablone, O Samoylov, W Sands, S Sanfilippo, M Sant, R Santorelli, C Savarese, E Scapparone, B Schlitzer, E Segreto, D A Semenov, A Shchagin, A Sheshukov, P N Singh, M D Skorokhvatov, O Smirnov, A Sotnikov, C Stanford, S Stracka, G B Suffritti, Y Suvorov, R Tartaglia, G Testera, A Tonazzo, P Trinchese, E V Unzhakov, M Verducci, A Vishneva, B Vogelaar, M Wada, T J Waldrop, H Wang, Y Wang, A W Watson, S Westerdale, M M Wojcik, M Wojcik, X Xiang, X Xiao, C Yang, Z Ye, C Zhu, A Zichichi, G Zuzel
We present new constraints on sub-GeV dark-matter particles scattering off electrons based on 6780.0 kg d of data collected with the DarkSide-50 dual-phase argon time projection chamber. This analysis uses electroluminescence signals due to ionized electrons extracted from the liquid argon target. The detector has a very high trigger probability for these signals, allowing for an analysis threshold of three extracted electrons, or approximately 0.05 keVee. We calculate the expected recoil spectra for dark matter-electron scattering in argon and, under the assumption of momentum-independent scattering, improve upon existing limits from XENON10 for dark-matter particles with masses between 30 and 100  MeV/c^{2}...
September 14, 2018: Physical Review Letters
Jie Xiang, Wei Wang, Weifeng Jiang, Qiuchen Qian
OBJECTIVE: To evaluate whether extracorporeal shock wave therapy significantly improves spasticity in post-stroke patients. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, EMBASE, EBSCO, Web of Science, Cochrane CENTRAL electronic databases. STUDY SELECTION: Randomized controlled trials assessing the effect of extracorporeal shock wave therapy on post-stroke patients with spasticity were selected for inclusion...
September 28, 2018: Journal of Rehabilitation Medicine
Rui Zhai, Xiaoyun Gong, Jie Xie, Yifeng Yuan, Fei Xu, You Jiang, Zejian Huang, Xinhua Dai, Yangjun Zhang, Xiaohong Qian, Xiang Fang
The early diagnosis of liver cancer by target biomarkers is of great significance for improving the survival rate of cancer patients. However, it is still a challenging task to sensitively detect circulating protein biomarkers due to decreased binding activity of antibodies originating from uncontrolled orientation of immobilization on the surface of a solid matrix. In this work, a novel immunoaffinity probe, Fe3 O4 @TpBD-DSS-Ab-MEG, based on magnetic COFs with ordered arrangement of anchored antibodies has been developed and applied for the first time to detection of a cancer biomarker, heat shock protein 90alpha (Hsp90α)...
January 1, 2019: Talanta
Ling Yang, Lingyun Cao, Ruiyun Huang, Zhong-Wei Hou, Xiang-Yang Qian, Bing An, Hai-Chao Xu, Wenbin Lin, Cheng Wang
Application of metal-organic frameworks (MOFs) in electrocatalysis is of great interest, but is limited by low electrical conductivities of most MOFs. To overcome this limitation, a two-dimensional version of MOF-metal-organic layer (MOL) was constructed on conductive multi-walled carbon nanotubes (CNTs) via facile solvothermal synthesis. The redox active MOLs supported on the CNT efficiently catalyze electrochemical oxidation of alcohols to aldehydes and ketones. Interestingly, this CNT/MOL assembly also endowed the selectivity for primary vs...
September 27, 2018: ACS Applied Materials & Interfaces
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