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Xiao-Min Liu, Qian Wang, Zhe-Yi Dong, Wei-Guang Zhang, Guang-Yan Cai, Li Zhang, Yong Wang, Han-Yu Zhu, Li Tang, Wan-Jun Shen, Xiang-Mei Chen
Background: Diabetes mellitus (DM) has become the leading cause of chronic kidney disease (CKD). Nondiabetic renal diseases (NDRDs) have different clinicopathological features and prognosis from those of diabetic nephropathy. Our study sought to analyze the clinical and pathological features of NDRDs, in different age groups through a cross-sectional study. Methods: All patients with type 2 DM at our center who underwent renal biopsy between March 1997 and March 2017 were screened and divided into three groups by age: Group 1 (youth group), 18-44 years old; Group 2 (middle-aged group), 45-59 years old; and Group 3 (elderly group), ≥60 years old...
December 20, 2018: Chinese Medical Journal
Qian-Qian Chen, Cheng Zhang, Ming-Qiang Qin, Jian Li, Hua Wang, De-Xiang Xu, Jian-Qing Wang
Accumulating data demonstrated that hepatic endoplasmic reticulum (ER) stress was involved in the pathogenesis of liver fibrosis. Long-term chronic hepatocyte death contributed to liver fibrosis initiation and progression. Previous researches reported that ER stress sensor inositol-requiring enzyme 1 alpha (IRE1α) was first activated in the process of liver fibrosis. STF-083010 was an IRE1α RNase specific inhibitor. This study aimed to explore the effects of STF-083010 on carbon tetrachloride (CCl4 )-induced liver injury and subsequent liver fibrosis...
2018: Frontiers in Pharmacology
Bing Chen, Kun Shao, Hui-Min An, Hao-Qiang Shi, Jia-Qian Lu, Xiao-Hui Zhai, Xiao-Xue Liu, Xiang-Hui Wang, Da Xu, Pei-Jun Zhou
The aim of the present study is to establish a population pharmacokinetic (PPK) model of mycophenolic acid (MPA) and limited sampling strategy models for the estimation of MPA exposure in Chinese adult renal allograft recipients following oral administration of enteric coated mycophenolate sodium (EC-MPS). A total of 74 sets of full pharmacokinetic profiles and 47 sets of MPA-sparing samples were collected from 102 renal transplant recipients who received oral EC-MPS. The MPA concentration was determined by an enzyme-multiplied immunoassay technique, and the pathophysiologic data were recorded...
December 10, 2018: Journal of Clinical Pharmacology
Xiang Chu-Qing, Wen-Feng Liu, Xu Qian-Hui, Ting Su, Shu Yong-Qiang, You-Lan Min, Qing Yuan, Pei-Wen Zhu, Liu Kang-Cheng, Nang Jiang, Lei Ye, Yi Shao
OBJECTIVE: Neuroimaging studies have reported that patients with pain-related conditions have altered neuronal activity and structural functions. The purpose of this study was to investigate whether classical trigeminal neuralgia (CTN) patients exhibit changes in corresponding neuronal activity via analysis of neuronal activity regional homogeneity (ReHo). METHODS: A total of 28 patients presenting with sore eyes (12 men and 16 women) were matched with 28 healthy controls (12 men and 16 women)...
December 11, 2018: Pain Practice: the Official Journal of World Institute of Pain
Liang Hu, Peng-Xiang Shen, Qian Shao, Kai Hong, Jennifer X Qiao, Jin-Quan Yu
Pd(II)-catalyzed enantioselective C(sp3)-H cross-coupling of free carboxylic acids with organoborons has been realized using either mono-protected amino acid (MPAA) ligands or mono-protected aminoethyl amine (MPAAM) ligands. A diverse range of aryl- and vinyl-boron reagents can be used as coupling partners to provide chiral carboxylic acids. This reaction provides an alternative approach to the enantioselective synthesis of cyclopropanecarboxylic acids and cyclobutanecarboxylic acids containing α-chiral tertiary and quaternary stereocenters...
December 10, 2018: Angewandte Chemie
Yibin Zhu, Jianjian Xiang, Wei Liu, Qian Cao, Wei Zhou
Background and Aims: Laparoscopic approach is recommended as the first-choice option for simple ileocecal resections. However, there are no randomized trials that have focused on patients with Crohn's disease (CD) treated by laparoscopy and enhanced recovery pathway. The aim of the present study is to prospectively evaluate the feasibility, safety, and short-term outcomes of laparoscopy with enhanced recovery pathway for CD patients undergoing ileocecal resection. Methods: A consecutive cohort of 32 CD patients who underwent laparoscopic ileocecal resection between December 2015 and December 2016 was randomized to enhanced recovery after surgery (ERAS) group or standard care group...
2018: Gastroenterology Research and Practice
Wei Chen, Xiang-Ming Fang, Ping-Yan Qian, P S Sanjeev Kumar, Hong-Wei Chen, H U Xiao-Yun
Background: Cervical pedicle screw fixation through posterior approach has shown greater cervical stability advantage. The cervical pedicle screw fixation technique through posterior approach is demanding. The key to the technique is the choice of point and angle of screw entrance. The angle of screw placement is variable. Morphometric measurements of the cervical pedicle are a prerequisite for individualized screw. CT imaging has become the most reliable and important means to obtain cervical pedicle's measurement data and morphology in vivo ...
November 2018: Indian Journal of Orthopaedics
Wu-Qiong Liao, Shao-Yuan Cui, Qing Ouyang, Yan Mei, Guang-Yan Cai, Bo Fu, Qian Ma, Xue-Yuan Bai, Qing-Gang Li, Xiang-Mei Chen
Mesangial cell (MC) activation and macrophage infiltration are 2 major events closely related with each other in mesangial proliferative glomerulonephritis. In the anti-Thy 1 nephritis model, macrophages mediate the damage and also the expansion of mesangium through secreting various inflammatory factors; however, in glomerular microenvironment how MCs affect macrophage activity in the presence of various stimuli have not yet been understood. In the present study, we found that resting human MCs (HMCs) constitutively expressed chemokine [C-C motif] ligand 2 (CCL-2) and interleukin (IL)-6 and induced M2 polarization of macrophages in the coculture system...
December 5, 2018: Journal of Interferon & Cytokine Research
Fei Han, Ming-Qian Zhang, Wen-Bin Liu, Lei Sun, Xiang-Lin Hao, Li Yin, Xiao Jiang, Jia Cao, Jin-Yi Liu
BACKGROUND: Different histological subtypes of non-small cell lung cancer (NSCLC) show different molecular characteristics and responses to therapeutic strategy. Identification of specific gene, clarification of its special roles and molecular mechanisms are crucial for developing new therapeutic approach for particular subtype patients. METHODS: Surgical specimens of 540 NSCLC patients were recruited. Immunohistochemistry was used to detect SOX30 expression, and correlations with clinical parameters were analyzed...
December 4, 2018: Respiratory Research
Guijuan Deng, Lu Yin, Weida Liu, Xiaoyun Liu, Quanyong Xiang, Zhenzhen Qian, Juntao Ma, Hui Chen, Yang Wang, Bo Hu, Wei Li, Yu Jiang
BACKGROUND AND OBJECTIVE: The association between hypertension and obesity has been confirmed, while no agreement has been reached about which anthropometric adiposity index is the best. This meta-analysis aimed to perform a systematic review and meta-analysis on the associations of hypertension risk with body mass index (BMI), waist circumstance (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), and a prospective urban and rural epidemiology study from China (PURE-China) was added into this meta-analysis as an individual study...
November 2018: Medicine (Baltimore)
Na Gao, Yun-Peng Huang, Ting-Ting Chu, Qian-Qian Li, Bing Zhou, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei Li
TAR DNA binding protein 43 (TDP-43) is a key target in amyotrophic lateral sclerosis (ALS) treatment. Here, based on hydrophobic tagging strategy, we designed and synthesized a series of single or double hydrophobic tags conjugated peptides D1-D8. Among them, it was found that D4 displayed strongest ability to induce TDP-43 degradation in cells. D4 could reduce TDP-43 induced cytotoxicity. Besides, D4 could reduce TDP-43 levels in a transgenic drosophila model.
November 27, 2018: Bioorganic Chemistry
Xiang Zhou, Qian Hao, Hua Lu
Since wild-type p53 is central for maintaining genomic stability and preventing oncogenesis, its coding gene TP53 is highly mutated in ~50% of human cancers, and its activity is almost abrogated in the rest of cancers. Approximately 80% of p53 mutations are single point mutations with several hotspot mutations. Besides loss of function and dominant-negative effect on the wild-type p53 activity, the hotspot mutant p53s also acquire new oncogenic functions, so-called 'gain-of-functions' (GOF). Because the GOF of mutant p53s is highly associated with late stage malignance and drug resistance, these p53 mutants have become hot targets for developing novel cancer therapies...
December 3, 2018: Journal of Molecular Cell Biology
Lei Xiang, Yong Chen, Weitang Chang, Yiqiang Zhan, Weili Lin, Qian Wang, Dinggang Shen
T1-weighted image (T1WI) and T2-weighted image (T2WI) are the two routinely acquired magnetic resonance (MR) modalities that can provide complementary information for clinical and research usages. However, the relatively long acquisition time makes the acquired image vulnerable to motion artifacts. To speed up the imaging process, various algorithms have been proposed to reconstruct high-quality images from under-sampled k-space data. However, most of the existing algorithms only rely on mono-modality acquisition for the image reconstruction...
November 29, 2018: IEEE Transactions on Bio-medical Engineering
Xuefei Li, Zheng Hu, Qian Li, Yinping Guo, Shabei Xu, Wei Wang, Dan He, Xiang Luo
BACKGROUND: Endovascular treatment in patients with acute anterior circulation stroke could be performed under either conscious sedation (CS) or general anesthesia (GA). Although several studies have investigated the association between the clinical outcomes and the two anesthesia methods, consensus is lacking. METHODS: PubMed and EMBASE searches were used to select full-text articles comparing the effects of GA and CS on functional outcome and complications in patients with anterior circulation ischemic stroke...
December 3, 2018: Brain and Behavior
Suchithranga M D C Perera, Udeep Chawla, Utsab Raj Shrestha, Debsindhu Bhowmik, Andrey V Struts, Shuo Qian, Xiang-Qiang Chu, Michael F Brown
Knowledge of the activation principles for G-protein-coupled receptors (GPCRs) is critical to development of new pharmaceuticals. Rhodopsin is the archetype for the largest GPCR family, yet the changes in protein dynamics that trigger signaling are not fully understood. Here we show that rhodopsin can be investigated by small-angle neutron scattering (SANS) in fully protiated detergent micelles under contrast matching to resolve the protein structure. In SANS studies of membrane proteins, the zwitterionic detergent [(Cholamidopropyl)dimethylammonio]-propanesulfonate (CHAPS) is advantageous because of the low contrast difference between the hydrophobic core and hydrophilic head groups as compared to alkyl glycoside detergents...
November 29, 2018: Journal of Physical Chemistry Letters
Jian-Feng Li, Yu-Ting Dai, Henrik Lilljebjörn, Shu-Hong Shen, Bo-Wen Cui, Ling Bai, Yuan-Fang Liu, Mao-Xiang Qian, Yasuo Kubota, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Linda Olsson, Ah Moy Tan, Hany Ariffin, Jing Chen, Junko Takita, Takahiko Yasuda, Hiroyuki Mano, Bertil Johansson, Jun J Yang, Allen Eng-Juh Yeoh, Fumihiko Hayakawa, Zhu Chen, Ching-Hon Pui, Thoas Fioretos, Sai-Juan Chen, Jin-Yan Huang
Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion of BCP ALL remains poorly characterized in relation to its underlying genomic abnormalities. We therefore initiated a large-scale international study to reanalyze and delineate the transcriptome landscape of 1,223 BCP ALL cases using RNA sequencing. Fourteen BCP ALL gene expression subgroups (G1 to G14) were identified. Apart from extending eight previously described subgroups (G1 to G8 associated with MEF2D fusions, TCF3-PBX1 fusions, ETV6-RUNX1 -positive/ ETV6-RUNX1 -like, DUX4 fusions, ZNF384 fusions, BCR-ABL1 /Ph-like, high hyperdiploidy, and KMT2A fusions), we defined six additional gene expression subgroups: G9 was associated with both PAX5 and CRLF2 fusions; G10 and G11 with mutations in PAX5 (p...
November 28, 2018: Proceedings of the National Academy of Sciences of the United States of America
Xiao-Qing Ma, Fei Xiang, Fei Qin, Wen-Hao Qian
PURPOSE: To study the clinical effect of double miniscrews for extraction of horizontally impacted wisdom tooth adjacent to the inferior alveolar nerve canal. METHODS: Eight horizontally impacted wisdom teeth requiring extraction because of orthodontic treatment were proven to be adjacent to the inferior alveolar nerve canal by means of cone-beam CT scan. The treatment began with double miniscrews traction under the help of cantilever beam. After 6~9 months, they left the canal and then were extracted...
August 2018: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Wei-Ling He, Xiang-Tao Weng, Jue-Lian Wang, Yong-Kai Lin, Tian-Wen Liu, Qian-Yi Zhou, Yue Hu, Yunbao Pan, Xin-Lin Chen
Background: There is debate as to whether c-Myc predicts prognosis in colorectal cancer (CRC). In this study, we aimed to review the association between c-Myc and CRC prognosis. Methods: Pertinent studies were identified by searching electronic databases and carefully reviewing the reference lists of pertinent studies until March 2016. The summary hazard ratio (HR) and corresponding 95% confidence interval (CI) were calculated to study the association between c-Myc and CRC prognosis. Results: Eight cohort studies (including seven studies about overall survival [OS] and one study about disease free survival [DFS]) were included...
2018: Frontiers in Physiology
Dan He, Qiang Shi, Guangjing Xu, Zheng Hu, Xuefei Li, Qian Li, Yinping Guo, Shabei Xu, Yongbo Lin, Zhiyuan Yu, Wei Wang, Xiang Luo
Objectives: The higher than expected PFO rate in CS patients has raised concerns that paradoxical embolism maybe the pathophysiologic mechanism for strokes. However, only a small proportion of pathogenic PFOs cause CS. Therefore, accurate recognition of patients with pathogenic PFOs among all CS patients could guide clinical decision making in selecting the most appropriate treatment. The aim of this study was to devise a new algorithm to stratify cryptogenic stroke (CS) patients into pathogenic patent foramen ovale (p-PFO)- and non-p-PFO-related patients...
November 2018: Annals of Clinical and Translational Neurology
Qian Nie, Lan Yang, Wenjie Qing, Jie Xie, Xiaodong Gong, Huimin Chen, Yuwen Gan, Ling Wang, Jia-Wen Xiang, Yuan Xiao, Zhigang Chen, David Wan-Cheng Li
It is now well established that protein sumoylation is an important mechanism to regulate multiple cellular processes including gene transcription, chromatin structure, cell proliferation and differentiation, as well as pathogenesis. In the vertebrate eye, we and other have previously shown that sumoylation can regulate differentiation of major ocular tissues including retina and lens. However, the expression patterns of the three types of sumoylation enzymes, the activating enzymes SAE1 and UBA2, the conjugating enzyme UBC9, and the ligating enzymes such as RanBP2 and PIAS1 have not be well studied in the ocular tissues...
November 15, 2018: Current Molecular Medicine
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