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Won Hyuk Oh, Bum Gi Kim, Haksu Kyung, Joo Hwa Lee
PURPOSE: To investigate the prevalence of normal intraocular pressure (IOP) at first visit among patients with primary angle closure glaucoma (PACG) and their ocular characteristics. PATIENTS AND METHODS: We retrospectively reviewed patients with PACG in a referral center. According to untreated IOP, we divided PACG eyes into two groups: those with normal IOP and those with high IOP (>21▒mmHg) at the first visit. RESULTS: One hundred sixty eyes of 160 Korean PACG patients were included...
October 8, 2018: Journal of Glaucoma
Dongpeng Hu, Shu Tu, Chengguo Zuo, Jian Ge
Purpose: To assess the efficacy and safety of HIFU-based ultrasonic cyclocoagulation in Chinese patients with end-stage refractory glaucoma. Method: Patients were recruited consecutively from May 2016 to May 2017 in the Zhongshan Ophthalmic Center. Ultrasonic cyclocoagulation was performed on every patient, using the EyeOP1 ultrasound emitting device. Return visits were set at 1 day, 7 days, 1 month, and 3 months after the treatment. An intraocular pressure (IOP) reduction of ≥20% while IOP ≥ 5 mmHg was deemed as success...
2018: Journal of Ophthalmology
Ke Xu, Lingling Wu, Zhizhong Ma, Yuling Liu, Fang Qian
PURPOSE: To investigate the frequency of primary angle closure (PAC) and primary angle closure glaucoma (PACG) in patients with retinal vein occlusion (RVO) based on a hospital population. METHODS: A total of 375 consecutive cases newly diagnosed with RVO by fluorescein fundus angiography at a single eye centre in Peking were reviewed. Gonioscopy was performed in all patients. Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology...
September 21, 2018: Acta Ophthalmologica
Karin R Pillunat, Eberhard Spoerl, Johanna Orphal, Lutz E Pillunat
PURPOSE: To investigate whether the peripheral thinning and shrinking of the iris as induced with Argon laser peripheral iridoplasty (ALPI) has an effect on intraocular pressure (IOP), angle structure and 3-D anterior segment (AS) morphology in Caucasians with chronic primary angle-closure (PAC) and primary angle-closure glaucoma (PACG). METHODS: Twenty-four eyes of 24 patients (age 67.7 ± 8.9 years; seven males; 17 females) diagnosed with PAC (n = 10) or PACG (n = 14) were assigned for ALPI prior to laser peripheral iridotomy (LPI) and consecutively enrolled in this prospective interventional study...
September 21, 2018: Acta Ophthalmologica
Seulggie Choi, Jin A Choi, Jin Woo Kwon, Sang Min Park, Donghyun Jee
Due to the rapidly increasing life-expectancy, the prevalence of glaucoma has increased steadily in recent years. We aimed to evaluate the patterns of care and primary treatment strategy patterns in Korea according to glaucoma subtypes to assess the quality of care for glaucoma patients.In this serial cross-sectional survey, the claims data from the Korean National Health Insurance Service was used to identify and group glaucoma patients into primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), other types of glaucoma, and ocular hypertension from 2002 to 2013...
September 2018: Medicine (Baltimore)
Lauren K Wareham, Ana C Dordea, Grigorij Schleifer, Vincent Yao, Annabelle Batten, Fei Fei, Joseph Mertz, Meredith Gregory-Ksander, Louis R Pasquale, Rebecca M Sappington, Emmanuel S Buys
The nitric oxide - guanylyl cyclase-1 - cyclic guanylate monophosphate (NO-GC-1-cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degeneration of retinal ganglion cells (RGCs) and their axons in the optic nerve. NO activates GC-1 to increase cGMP levels, which are lowered by cGMP-specific phosphodiesterase (PDE) activity. This pathway appears to play a role in both the regulation of IOP, where reduced cGMP levels in mice leads to elevated IOP and subsequent RGC degeneration...
September 10, 2018: Neurobiology of Disease
Xue Yin, Qinhua Cai, Run Song, Xuefei He, Peirong Lu
PURPOSE: To explore the relationship between the bleb vasculature and surgical outcome after trabeculectomy (TRAB) using optical coherence tomography angiography (OCT-A). METHODS: A prospective study was conducted, which included 26 eyes of 26 primary glaucoma patients in the final analysis. Thereinto, six patients underwent TRAB combined 5-FU and 12 patients received subconjunctival 5-FU injection postoperation. The bleb vessel was evaluated using OCT-A 1 week, 2 weeks, 1 month, 3 months, and 6 months after TRAB...
September 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Fei Jiang, Fei-Fei Zeng, Chen Yu, Yin-Quan Ye, Xian-Jun Zeng
The study aimed to compare the whole-brain gray matter volume (GMV) and white matter volume (WMV) difference between primary angle closure glaucoma (PACG) patients and health controls (HCs) using a voxel-based morphometry method. A total of 27 patients with PACG (17 males and 10 females) and 27 HCs (17 males and 10 females), closely matched for age and education, were enrolled in the study. All subjects underwent magnetic resonance imaging (MRI) scans. The MRI data were processed using SPM8 software in voxel-based morphometry 8 toolbox...
November 7, 2018: Neuroreport
Xiangxi Chen, Xinxing Guo, Xiaoyu Xu, Hui Xiao, Xing Liu
PURPOSE: The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG). METHODS: In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patient was diagnosed with PACG initially and later with MG after trabeculectomy, and the fellow eyes were diagnosed with PACG, PAC, or PAC suspect. Thirty-seven eyes from 37 PACG patients were recruited as controls...
2018: Ophthalmic Research
Xiao-Ping Ma, Man-Yi Shen, Guang-Lin Shen, Qiao-Ran Qi, Xing-Huai Sun
AIM: To determine whether glaucoma patients exhibit an abnormal melatonin concentration in serum and the effects of psychiatric disorders caused by glaucoma in melatonin secretion. METHODS: A sample of 80 primary angle-closure glaucoma (PACG) patients, 120 primary open angle glaucoma (POAG) patients, and 120 normal controls were enrolled in this study. All the participants were asked to complete the following questionnaires: Pittsburgh sleep quality index (PSQI), self-rating anxiety scale (SAS), and self-rating depression scale (SDS)...
2018: International Journal of Ophthalmology
Xiang-Ji Li, Richard Filek, Xiang-Ge He, Wei Wang, Hong Liu, Lian He, Yu-Rong Tang, Lin Xie
AIM: To investigate the incidence rate and risk factors for grade III flat anterior chamber (FAC) after glaucoma filtration surgery based on 5-year data. METHODS: Patients who underwent glaucoma filtration surgery in Daping hospital from January 2009 to December 2013 were enrolled in this retrospective study. The incidence of grade III FAC following glaucoma filtration surgery was determined. Regression analysis was performed to investigate the influence of glaucoma type, surgical approach, age, and preoperative intraocular pressure (IOP) on the risk of postoperative FAC...
2018: International Journal of Ophthalmology
Chengguo Zuo, Ruowen Gong, Weirong Chen, Chuyin Chen, Jinai Su, Kun Wei, Xinbo Gao, Mingkai Lin, Jian Ge
PURPOSE: To analyze the demographics and distribution of corneal astigmatism before lens extraction in patients with primary angle closure disease (PACD). METHODS: Preoperative partial coherence interferometry was performed in patients with PACD. The demographic and biometric data, including corneal astigmatism and keratometry (K), were recorded. RESULTS: The study comprised 808 cases (1001 eyes) with a mean age of 67.66±9.07 years, and the mean axial length was 22...
August 21, 2018: Journal of Glaucoma
Chandrima Paul, Subhrangshu Sengupta, Souvik Banerjee, Sumit Choudhury
Purpose: To estimate the prevalence, features, and associations of primary angle closure disease (PACD) in rural and urban populations from West Bengal in eastern India. Methods: This was a population-based cross-sectional study with two arms, rural and urban. The rural study area consisted of 28 contiguous villages from 13 gram panchayats in Balagarh Police Station, with rural base hospital at Dhobapara, Balagarh Police Station, in the village Kuliapara of Hooghly district...
September 2018: Indian Journal of Ophthalmology
Natalia I Kurysheva, Lyudmila V Lepeshkina, Ekaterina O Shatalova
PURPOSE: To evaluate the efficacy of selective laser trabeculoplasty (SLT) for patients with primary angle-closure glaucoma (PACG) following a YAG laser peripheral iridotomy (PI) in comparison with primary open-angle glaucoma (POAG) and to assess the predictors of outcome of SLT. PATIENTS AND METHODS: In retrospective study 68 patients with PACG after PI (68 eyes) and 74 POAG patients (74 eyes) were observed for 6 years. The effectiveness of SLT (20% reduction of intraocular pressure) was assessed using Kaplan-Meier survival analysis...
October 2018: Journal of Glaucoma
Anup Dev Pant, Priyanka Gogte, Vanita Pathak-Ray, Syril K Dorairaj, Rouzbeh Amini
Purpose: Previous studies have shown that iris mechanical properties may play a role in the pathophysiology of primary angle-closure glaucoma (PACG). Such studies, however, were not conducted in vivo and as such were limited in application and scope, especially for the development of diagnostic methods or new treatment options. The purpose of this study was to quantify in vivo iris mechanical properties both in patients with a history of angle-closure glaucoma and in healthy volunteers...
August 1, 2018: Investigative Ophthalmology & Visual Science
Hung-Yu Wang, Ping-Tao Tseng, Brendon Stubbs, Andre F Carvalho, Dian-Jeng Li, Tien-Yu Chen, Pao-Yen Lin, Yu-Te Hsueh, Yu-Zhen Chen, Yen-Wen Chen, Che-Sheng Chu
BACKGROUND: The aim of current study was to conduct a systematic review and meta-analysis to explore the relationship between antidepressant use and glaucoma. METHODS: Eight major electronic databases were searched from inception until March 19th, 2018 to obtain relevant studies that evaluated associations of antidepressants [including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)] treatment and the risk of primary open-angle glaucoma (POAG) or primary angle-closure glaucoma (PACG) as well as intraocular pressure (IOP), and related anterior chamber parameters compared to participants not exposed to antidepressant treatment...
December 1, 2018: Journal of Affective Disorders
Sasan Moghimi, Ali Torkashvand, Massood Mohammadi, Mehdi Yaseri, Luke J Saunders, Shan C Lin, Robert N Weinreb
PURPOSE: To classify subjects with primary angle closure into clusters based on features from anterior segment optical coherence tomography (ASOCT) imaging and to explore how these clusters correspond to disease subtypes, including primary angle closure suspect (PACS), primary angle closure glaucoma(PACG), acute primary angle closure (APAC) and fellow eyes of APAC and reveal the factors that become more predominant in each subtype of angle closure. METHOD: A cross-sectional study of 248 eyes of 198 subjects(88 PACS eyes, 53 PACG eyes, 54 APAC eyes and 53 fellow eyes of APAC) that underwent complete examination including gonioscopy, A-scan biometry, and ASOCT...
2018: PloS One
Fatemeh Suri, Shahin Yazdani, Marjan Chapi, Iman Safari, Paniz Rasooli, Narsis Daftarian, Mohammad Reza Jafarinasab, Saghar Ghasemi Firouzabadi, Elham Alehabib, Hossein Darvish, Brandy Klotzle, Jian-Bing Fan, Casey Turk, Elahe Elahi
Primary angle closure glaucoma (PACG) is a common form of glaucoma in the Far East. Its defining feature is iridocorneal angle closure. In addition to PACG, indications of angle closure are included in the diagnostic criteria of related conditions primary angle closure suspect (PACS) and primary angle closure (PAC). To the best of our knowledge, a causative gene for iridocorneal angle closure in humans has not been identified. This study aimed to identify the genetic cause of iridocorneal angle closure in a pedigree with at least ten individuals diagnosed with PACS, PAC or PACG...
July 11, 2018: Human Molecular Genetics
Srishti Raj, Basavraj Tigari, T T Faisal, Natasha Gautam, Sushmita Kaushik, Parul Ichhpujani, Surinder S Pandav, Jagat Ram
BACKGROUND: To study the role of selective laser trabeculoplasty (SLT) in intraocular pressure (IOP) reduction in post-laser iridotomy primary angle-closure disease patients with inadequately controlled IOP. METHODS: In this prospective cross-sectional study, 34 patients with primary angle-closure disease with post-laser iridotomy open angles up to at least 180° were recruited. Following SLT, patients were examined at 1 day, 1 week, 1 and 3 months, 6 months and 1 year post SLT...
July 9, 2018: Eye
Ramanjit Sihota, Sailesh Kumar, Talvir Sidhu, Neha Midha, Ajay Sharma, Suresh Yadav, Viney Gupta, Tanuj Dada
PURPOSE: Primary adult glaucomas that have an occludable angle with peripheral anterior synechiae which are too few to account for the chronically raised IOP, or the glaucomatous optic neuropathy, do not fit the definition of either POAG or PACG and can be considered as combined mechanism glaucoma (CMG). We aimed to compare the clinical features and anatomical parameters of combined mechanism glaucoma with age, sex, and refraction-matched POAG and chronic PACG eyes. METHODS: Consecutive adult patients with definitive optic nerve head and perimetric changes of glaucoma were screened at a tertiary care center...
June 20, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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