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Hung-Yu Wang, Ping-Tao Tseng, Brendon Stubbs, Andre F Carvalho, Dian-Jeng Li, Tien-Yu Chen, Pao-Yen Lin, Yu-Te Hsueh, Yu-Zhen Chen, Yen-Wen Chen, Che-Sheng Chu
BACKGROUND: The aim of current study was to conduct a systematic review and meta-analysis to explore the relationship between antidepressant use and glaucoma. METHODS: Eight major electronic databases were searched from inception until March 19th, 2018 to obtain relevant studies that evaluated associations of antidepressants [including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)] treatment and the risk of primary open-angle glaucoma (POAG) or primary angle-closure glaucoma (PACG) as well as intraocular pressure (IOP), and related anterior chamber parameters compared to participants not exposed to antidepressant treatment...
July 31, 2018: Journal of Affective Disorders
Sasan Moghimi, Ali Torkashvand, Massood Mohammadi, Mehdi Yaseri, Luke J Saunders, Shan C Lin, Robert N Weinreb
PURPOSE: To classify subjects with primary angle closure into clusters based on features from anterior segment optical coherence tomography (ASOCT) imaging and to explore how these clusters correspond to disease subtypes, including primary angle closure suspect (PACS), primary angle closure glaucoma(PACG), acute primary angle closure (APAC) and fellow eyes of APAC and reveal the factors that become more predominant in each subtype of angle closure. METHOD: A cross-sectional study of 248 eyes of 198 subjects(88 PACS eyes, 53 PACG eyes, 54 APAC eyes and 53 fellow eyes of APAC) that underwent complete examination including gonioscopy, A-scan biometry, and ASOCT...
2018: PloS One
Fatemeh Suri, Shahin Yazdani, Marjan Chapi, Iman Safari, Paniz Rasooli, Narsis Daftarian, Mohammad Reza Jafarinasab, Saghar Ghasemi Firouzabadi, Elham Alehabib, Hossein Darvish, Brandy Klotzle, Jian-Bing Fan, Casey Turk, Elahe Elahi
Primary angle closure glaucoma (PACG) is a common form of glaucoma in the Far East. Its defining feature is iridocorneal angle closure. In addition to PACG, indications of angle closure are included in the diagnostic criteria of related conditions primary angle closure suspect (PACS) and primary angle closure (PAC). To the best of our knowledge, a causative gene for iridocorneal angle closure in humans has not been identified. This study aimed to identify the genetic cause of iridocorneal angle closure in a pedigree with at least ten individuals diagnosed with PACS, PAC or PACG...
July 11, 2018: Human Molecular Genetics
Srishti Raj, Basavraj Tigari, T T Faisal, Natasha Gautam, Sushmita Kaushik, Parul Ichhpujani, Surinder S Pandav, Jagat Ram
BACKGROUND: To study the role of selective laser trabeculoplasty (SLT) in intraocular pressure (IOP) reduction in post-laser iridotomy primary angle-closure disease patients with inadequately controlled IOP. METHODS: In this prospective cross-sectional study, 34 patients with primary angle-closure disease with post-laser iridotomy open angles up to at least 180° were recruited. Following SLT, patients were examined at 1 day, 1 week, 1 and 3 months, 6 months and 1 year post SLT...
July 9, 2018: Eye
Ramanjit Sihota, Sailesh Kumar, Talvir Sidhu, Neha Midha, Ajay Sharma, Suresh Yadav, Viney Gupta, Tanuj Dada
PURPOSE: Primary adult glaucomas that have an occludable angle with peripheral anterior synechiae which are too few to account for the chronically raised IOP, or the glaucomatous optic neuropathy, do not fit the definition of either POAG or PACG and can be considered as combined mechanism glaucoma (CMG). We aimed to compare the clinical features and anatomical parameters of combined mechanism glaucoma with age, sex, and refraction-matched POAG and chronic PACG eyes. METHODS: Consecutive adult patients with definitive optic nerve head and perimetric changes of glaucoma were screened at a tertiary care center...
June 20, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Silvia P Gennari, Rebecca E Millman, Mark Hymers, Sven L Mattys
Perceiving speech while performing another task is a common challenge in everyday life. How the brain controls resource allocation during speech perception remains poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated the effect of cognitive load on speech perception by examining brain responses of participants performing a phoneme discrimination task and a visual working memory task simultaneously. The visual task involved holding either a single meaningless image in working memory (low cognitive load) or four different images (high cognitive load)...
September 2018: NeuroImage
Carol Y Cheung, Sophia Ling Li, Noel Chan, Mandy Wong, Poemen Chan, Isabel Lai, Nafees Baig, Shaoying Tan, Xiaofei Man, Fangyao Tang, Yu Meng Wang, Clement C Tham
PURPOSE: To determine the demographic, ocular, and systemic factors associated with long-term intraocular pressure (IOP) fluctuation in primary angle closure disease (PACD). METHODS: This prospective cohort study included 422 PACD eyes from 269 Chinese patients, including 274 primary angle closure glaucoma (PACG) eyes and 152 primary angle closure / primary angle closure suspect (PAC/PACS) eyes. Long-term IOP fluctuation defined as the standard deviation of all IOP measurements over 2 years (at least 5 measurements in total)...
June 4, 2018: Journal of Glaucoma
Pouya Alaghband, Ian As Rodrigues, Saurabh Goyal
Primary angle closure glaucoma (PACG) is more blinding (1 in 4 cases) than primary open angle glaucoma (1 in 10 cases). Cataract surgery is an effective initial treatment for majority of cases of PACG. However, cataract surgery alone may not be enough to control intraocular pressure (IOP) in cases with extensive synechial angle closure glaucoma. It is reported that glaucoma drainage surgery is needed in 12% of PACG cases after cataract surgery. Some experts combine cataract surgery with either goniosynechialysis (GSL) or endocyclophotocoagulation (ECP) to enhance IOP control...
January 2018: Journal of Current Glaucoma Practice
Tenley Bower, Deborah Anne Samek, Ahmed Mohammed, Ali Mohammed, Paul Kasner, David Camoriano, Oscar Kasner
OBJECTIVE: To study the prevalence of the systemic use of some common classes of medications by glaucoma patients and their relationship to the prevalence and severity of chronic open-angle glaucoma (COAG) and primary-angle closure glaucoma (PACG). DESIGN: Observational prospective single-centre cross-sectional study. METHODS: Glaucoma patients or their pharmacist provided an updated list of all systemic medications that they presently use...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Lanhua Wang, Wenyong Huang, Shengsong Huang, Jian Zhang, Xinxing Guo, David S Friedman, Paul J Foster, Mingguang He
PURPOSE: To determine the 10-year incidence of all forms of primary angle closure (PAC) in phakic eyes and its risk factors in an urban Chinese population aged 50 years and older. METHODS: Survivors of 1405 baseline participants were invited to attend the 10-year follow-up visit in the Liwan Eye Study. Participants with established baseline angle closure, including primary angle closure suspects (PACS), PAC and primary angle closure glaucoma (PACG), or those who underwent bilateral cataract surgery during the 10-year period, as well as those who did not tolerate gonioscopic examinations, were excluded from this analysis...
May 18, 2018: British Journal of Ophthalmology
Tutul Chakravarti
PURPOSE: To evaluate the association of socioeconomic status (SES) with severity of glaucoma and assess the impacts of both SES and disease-severity factors on the costs of glaucoma medications among different glaucoma subtypes in West Bengal, India. METHODS: This cross-sectional study (2014-16) followed the treatment of 304 primary glaucoma patients for at least 18 months. The visual field based glaucoma staging was followed for stages 0-3; patients with field of vision <10° were categorized as stage 4 (end stage)...
May 15, 2018: Journal of Ocular Pharmacology and Therapeutics
Li Nie, Aiwu Fang, Weihua Pan, Han Ye, Yau Kei Chan, Lin Fu, Jia Qu
PURPOSE: To evaluate the feasibility, efficacy, and safety of Ex-PRESS implantation combined with phacoemulsification surgery in primary angle-closure glaucoma (PACG) with cataract. MATERIALS AND METHODS: This is a prospective, nonrandomized study. A total of 34 eyes of 34 subjects were enrolled. The assessments were conducted preoperatively and postoperatively at 1 week and 1, 3, 6, 12, 18, 24, 30, and 36 months. The assessments included intraocular pressure (IOP), best-corrected visual acuity (BCVA), the number of glaucoma medications, corneal endothelial cell density (ECD), and related complications, if any...
August 2018: Current Eye Research
Sunee Chansangpetch, Sasiprapa Prombhul, Visanee Tantisevi, Pimpayao Sodsai, Anita Manassakorn, Nattiya Hirankarn, Shan C Lin
Background/Aims: Epigenetic mechanisms via DNA methylation may be related to glaucoma pathogenesis. This study aimed to determine the global DNA methylation level of the trabeculectomy specimens among patients with different types of glaucoma and normal subjects. Methods: Trabeculectomy sections from 16 primary open-angle glaucoma (POAG), 12 primary angle-closure glaucoma (PACG), 16 secondary glaucoma patients, and 10 normal controls were assessed for DNA methylation using combined-bisulfite restriction analysis...
2018: Journal of Ophthalmology
Siamak Yousefi, Hiroshi Sakai, Hiroshi Murata, Yuri Fujino, David Garway-Heath, Robert Weinreb, Ryo Asaoka
Purpose: To compare the hemifield asymmetry of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) across all severity levels. Methods: A total of 522 eyes of 327 patients with POAG (mean age ± SD, 54.1 ± 12.4 years) and 375 eyes of 204 patients with PACG (67.3 ± 8.9 years) were included. Subjects meeting the definitions of POAG or PACG were included. Means of the total deviation (TD) values (Humphrey 24-2 VF) in the Glaucoma Hemifield Test (GHT) regions were calculated in early (≥ -6 dB), moderate (< -6 dB and ≥ -12 dB), and advanced (< -12 dB) stages of POAG and PACG eyes...
March 1, 2018: Investigative Ophthalmology & Visual Science
Kai Gao, Fei Li, Yingqi Li, Xingyi Li, Wenbin Huang, Shida Chen, Yaoming Liu, Tin Aung, Xiulan Zhang
Purpose: To compare the anterior and posterior choroid thickness (ACT and PCT, respectively) in primary open-angle glaucoma (POAG), primary angle-closure disease (PACD), and healthy control subjects. Methods: A total of 29 POAG patients (56 eyes), 37 PACD patients (64 eyes), and 34 healthy volunteers (68 eyes) were enrolled in this study; 50 POAG eyes were divided into 25 early/moderate-stage and 25 advanced-stage eyes by visual field loss, while 64 PACD eyes were classified as primary angle-closure suspect (PACS), 8 eyes; primary angle closure (PAC), 18 eyes; and primary angle-closure glaucoma (PACG), 38 eyes...
March 1, 2018: Investigative Ophthalmology & Visual Science
Ramanjit Sihota, Dewang Angmo, Deepa Ramaswamy, Tanuj Dada
Lowering of intraocular pressure is currently the only therapeutic measure for Glaucoma management. Many longterm, randomized trials have shown the efficacy of lowering IOP, either by a percentage of baseline, or to a specified level. This has lead to the concept of 'Target" IOP, a range of IOP on therapy, that would stabilize the Glaucoma/prevent further visual field loss, without significantly affecting a patient's quality of life. A clinical staging of Glaucoma by optic nerve head evaluation and perimetric parameters, allows a patient's eye to be categorized as having - mild, moderate or severe Glaucomatous damage...
April 2018: Indian Journal of Ophthalmology
Sunil S Adav, Jin Wei, Jingru Qian, Nicola Yi'An Gan, Leonard W L Yip, Siu Kwan Sze
PURPOSE: Primary angle-closure glaucoma (PACG) is associated with increased intraocular pressure, optic nerve damage, and progressive vision loss, but the molecular mechanism that underpins retinal ganglion neuropathy in PACG remains poorly understood. To better understand the pathogenesis of human PACG, we performed the first comprehensive proteomic analysis of aqueous humor (AH) samples from PACG patients and matched control donors to study pathogenic alteration in AH composition in disease...
March 13, 2018: International Ophthalmology
Jingyuan Zhu, Yang Xu, Hongyuan Wang, Dongjing Liu, Jingbo Zhu, Huijuan Wu
In this study, the seasonality of acute attack of primary angle-closure glaucoma (PACG) was analysed. This retrospective case series included 283 patients (200 women, 83 men; mean age, 68.2 ± 10.3 years; range, 37-96 years) with acute attack of PACG from a university-based clinic over 4 years. Patients' age and sex, and the date and season of onset of PACG attack, were analysed. Descriptive analysis and von Mises distribution were used for statistical analysis. The highest incidence of acute attack of PACG was observed in those aged 60-69 years (34...
March 5, 2018: Scientific Reports
Sunita Radhakrishnan, Philip P Chen, Anna K Junk, Kouros Nouri-Mahdavi, Teresa C Chen
PURPOSE: To examine the efficacy and complications of laser peripheral iridotomy (LPI) in subjects with primary angle closure (PAC). METHODS: Literature searches in the PubMed and Cochrane databases were last conducted in August 2017 and yielded 300 unique citations. Of these, 36 met the inclusion criteria and were rated according to the strength of evidence; 6 articles were rated level I, 11 articles were rated level II, and 19 articles were rated level III. RESULTS: Reported outcomes were change in angle width, effect on intraocular pressure (IOP) control, disease progression, and complications...
July 2018: Ophthalmology
Nanamika Thakur, Manu Kupani, Rajeev Kumar Pandey, Rashim Mannan, Archna Pruthi, Sanjana Mehrotra
MMP (Matrix metalloproteinase) 9 is reported to affect glaucoma pathogenesis by altering intraocular pressure (IOP) through its role in remodeling the extracellular matrix (ECM) in the trabecular meshwork. A genetic variant at the promoter region in the MMP9 gene (-1562C>T) has a putative role in regulating its transcription rate and hence can affect genetic predisposition to primary glaucoma. The present study examined the association of -1562C>T promoter polymorphism in the MMP9 gene with Primary Open Angle Glaucoma (POAG) and Primary Angle Closure Glaucoma (PACG) in a north Indian population...
2018: PloS One
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