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Susumu Sakimoto, Tomoyuki Okazaki, Shinichi Usui, Tomoyuki Ishibashi, Yoshihito Oura, Kentaro Nishida, Atsuya Miki, Ryo Kawasaki, Kenji Matsushita, Hirokazu Sakaguchi, Kohji Nishida
Purpose: To determine the relevance of epiretinal membranes (ERMs) in primary open-angle glaucoma (POAG) and potential risk for glaucoma severity. Methods: Sixty eyes of 30 patients with POAG who had a unilateral ERM were analyzed; 60 nonglaucomatous eyes of 30 patients with a unilateral ERM also were recruited in this institutional cross-sectional study. Patients underwent swept-source (SS) optical coherence tomography (OCT) imaging and visual field testing. Intraindividual differences in the SS-OCT retinal nerve fiber layer (RNFL) disc cupping area measurements and visual field outcomes were analyzed in the two groups...
December 3, 2018: Investigative Ophthalmology & Visual Science
Siamak Yousefi, Hiroshi Sakai, Hiroshi Murata, Yuri Fujino, Masato Matsuura, David Garway-Heath, Robert Weinreb, Ryo Asaoka
Purpose: The purpose of this study was to evaluate the rate of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). Methods: Four hundred forty eyes of 282 patients with POAG (aged 53.4 ± 12.0: mean ± standard deviation, years) and 79 eyes of 49 patients with PACG (aged 62.7 ± 9.0 years) with at least six or more reliable VF tests were studied. Point-wise, region-wise, and global rates of VF change were assessed for POAG and PACG eyes...
December 3, 2018: Investigative Ophthalmology & Visual Science
Grace M Richter, Beau Sylvester, Zhongdi Chu, Bruce Burkemper, Ingy Madi, Ryuna Chang, Alena Reznik, Rohit Varma, Ruikang K Wang
Purpose: To quantify peripapillary microvasculature within the retinal nerve fiber layer (RNFL) in primary open-angle glaucoma (POAG) and normal eyes, determine association of perfusion parameters with structural and functional measures, and report diagnostic accuracy of perfusion parameters. Patients and methods: POAG and normal patients underwent 6×6 mm2 optic nerve head scans (Angioplex optical coherence tomography angiography [OCTA]; Cirrus HD-OCT 5000) and Humphrey Field Analyzer II-i 24-2 visual field (VF) testing...
2018: Clinical Ophthalmology
Pravda Chaturvedi, Arvind Chauhan, Punit Kumar Singh
PURPOSE: An assessment of variation in Macular Volume and RNFL Thickness in myopes using OCT, and their significance for early diagnosis of Primary Open Angle Glaucoma(POAG). MATERIALS AND METHOD: Total of 122 eyes of 61 Indian Myopic subjects of both sex and various age groups underwent retinal nerve fiber layer thickness, macular volume in 6mm analysis by Rtvue Avanti SD-OCT, Optovue Technology V6.1.1,after taking due consent from ethical committee. Subjects were divided into two groups based on their refractive error, Group A <6 D and Group B >6D...
September 2018: Oman Journal of Ophthalmology
A F Gabdrakhmanova, L F Aznabaeva, G Sh Abizgil'dina, S A Kurbanov
PURPOSE: To evaluate the effectiveness of neuroprotective therapy in patients with primary open-angle glaucoma based on specific biochemical markers of neurotrophy and neurodegeneration. MATERIAL AND METHODS: In the course of the study, lacrimal fluid (LF) of 23 patients (46 eyes) with stage I-II primary open angle glaucoma (POAG) aged 66.3±10.8 was examined. The control group consisted of healthy individuals (12 control LF samples). Local antihypertensive therapy was complimented with 10 intramuscular injections of retinalamin (GEROPHARM LLC, St...
2018: Vestnik Oftalmologii
I Ya Baranov, I V Shiryaev, N A Molodkina, O A Efimov, N V Mitrofanova
PURPOSE: To evaluate the influence of different topical hypotensive drugs on incidence of choroidal effusion (CE) following laser trabeculoplasty as the second stage of combined laser-surgical treatment plan in patients with primary open-angle glaucoma (POAG). MATERIAL AND METHODS: The study included 60 patients with previously operated stage I and II POAG who has 'b-c' intraocular pressure (IOP) on maximum hypotensive therapy. Fistulizing subscleral removal of the outer wall of Schlemm's canal (a...
2018: Vestnik Oftalmologii
Huiyuan Hou, Sasan Moghimi, Linda M Zangwill, Takuhei Shoji, Elham Ghahari, Rafaella C Penteado, Tadamichi Akagi, Patricia Isabel C Manalastas, Robert N Weinreb
PURPOSE: To characterize and compare the ganglion cell complex (GCC) thickness and macula vessel density in pre-perimetric and early primary open angle glaucoma (POAG) eyes. DESIGN: Cross-sectional study. METHODS: 57 healthy eyes, 68 pre-perimetric and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma Study. Optical coherence tomography angiography (OCT-A) based superficial macula vessel density and OCT based GCC thickness were evaluated simultaneously...
November 26, 2018: American Journal of Ophthalmology
Pierre Dubrulle, Antoine Labbé, Emmanuelle Brasnu, Hong Liang, Pascale Hamard, Lyes Meziani, Christophe Baudouin
PURPOSE: The purpose of this study was to evaluate the effect of treating ocular surface disease (OSD) in patients with medically uncontrolled primary open-angle glaucoma (POAG) associated with OSD. METHODS: We compiled a retrospective observational case series of 10 patients with POAG that remained uncontrolled with topical treatments and who were referred for filtering glaucoma surgery. All patients underwent a complete assessment of their glaucoma and ocular surface for both eyes...
December 2018: Journal of Glaucoma
Uday Kumar Addepalli, Ganesh B Jonnadula, Chandra Sekhar Garudadri, Rohit C Khanna, Eric B Papas
PURPOSE: To report the prevalence of primary glaucoma as identified by study optometrists of the L. V. Prasad Eye Institute - Glaucoma Epidemiology and Molecular Genetics Study (LVPEI-GLEAMS). METHODS: Two study optometrists and a total number of 3833 individuals participated in the LVPEI-GLEAMS. All subjects underwent a complete medical history and comprehensive eye examination including slit lamp photography, imaging of anterior and posterior segment, frequency doubling technology and standard automated perimetry including gonioscopy with a Sussman 4 mirror goniolens, post dilated evaluation of the optic disc and fundus was done with a 90 D lens by the study optometrist...
November 29, 2018: Ophthalmic Epidemiology
Gilda Cennamo, Daniela Montorio, Maria Angelica Breve, Vincenzo Brescia Morra, Feliciana Menna, Giovanni Cennamo
OBJECTIVES: To measure Optic Nerve Subarachnoid Space (ONSAS) in patients with primary open-angle glaucoma (POAG) and controls using A-scan ultrasound and to evaluate the measurement of the ONSAS in relation to age patient and OCT parameters. METHODS: This retrospective study included 53 consecutive eyes of 27 patients with POAG and 64 normal eyes of 32 controls. Both glaucomatous and control groups were divided into 2 subgroups according to age: <60 age (glaucomatous and control group 1) and 61-90 age (glaucomatous and control group 2)...
2018: PloS One
Hongwei Wang, Mingzhe Li, Zhenzhen Zhang, Haifeng Xue, Xing Chen, Yong Ji
Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction of the TM, potentially leading to increased IOP. High IOP is a well‑known primary risk factor for glaucoma. Myocilin mutations are common among glaucoma patients, and they are implicated in juvenile‑onset open‑angle glaucoma (JOAG) and adult‑onset primary open‑angle glaucoma (POAG). Aggregation of aberrant mutant myocilins is closely associated with glaucoma pathogenesis...
November 20, 2018: International Journal of Molecular Medicine
S Lazreg, Z Merad, M T Nouri, R Garout, A Derdour, N Ghroud, R Kherroubi, M Meziane, S Belkacem, O Ouhadj, C Baudouin, M Tiar
GOALS: To assess the efficacy and safety of preservative-free timolol 0.1% gel in patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). METHODS: In this multicenter, open-label, non-controlled clinical trial in Algeria, treatment-naïve patients with intraocular pressure (IOP)>20mmHg and<31mmHg (treatment-naïve patients, group 1) and patients with IOP controlled by current ocular monotherapy but presenting with local intolerance in at least one eye (intolerant patients; group 2) were eligible...
November 23, 2018: Journal Français D'ophtalmologie
Qing Yang, Ying Li, Lin Luo
Background: Primary open angle glaucoma (POAG) is the most common form of glaucoma, with a multifactorial etiology that results in retinal ganglion cell death and loss of vision. In this study, we assessed the effects of myricetin on the trabecular meshwork cells in POAG. Methods: In the in-vivo model, glaucoma was induced in Sprague-Dawley rats by injecting hyaluronic acid into the anterior chamber of the eye (every week for six-weeks). Treatment group rats were administered myricetin (25, 50 or 100 mg/ kg body weight via oral gavage) each day for of six weeks...
2018: Translational Neuroscience
Mae O Gordon, Eve J Higginbotham, Dale K Heuer, Richard K Parrish, Alan L Robin, Patricia A Morris, Deborah A Dunn, Bradley S Wilson, Michael A Kass
PURPOSE: To assess the impact of a masked Endpoint Committee on estimates of the incidence of primary open angle glaucoma (POAG), treatment efficacy and statistical power of the Ocular Hypertension Treatment Study-Phase 1, 1994-2002 (OHTS-1). DESIGN: Retrospective inter-rater reliability analysis of endpoint attribution by the Endpoint Committee METHODS: After study closeout, we re-calculated estimates of endpoint incidence, treatment efficacy and statistical power using all-cause endpoints and POAG endpoints...
November 21, 2018: American Journal of Ophthalmology
Xiang-Yuan Song, Zhen Puyang, Ai-Hua Chen, Jin Zhao, Xiao-Jiao Li, Ya-Ying Chen, Wei-Jun Tang, Yu-Yan Zhang
Ocular hypertension (OHT), the common situation in adult patients in the outpatients, occurs ∼5% worldwide. However, there are still some practical problems in differentiation of OHT with early primary open-angle glaucoma (POAG) using current standard methods. Application of high resolution diffusion tensor imaging (DTI) enables us to the differentiate axonal architecture of visual pathway between POAG and OHT subjects. Among 32 POAG patients recruited (15 OHT and 14 control subjects), 62.5% of glaucoma were in early stage for the current study...
2018: Frontiers in Human Neuroscience
H R Liu, D Y Yang, T Ma, W Y Shi, Y H Chen, R Q Pang, J L Du, Q Zhu, N L Wang
Objective: To investigate the ultrasonographic measurements of the optic nerve subarachnoid space (ONSAS) in patients with normal tension glaucoma (NTG). Methods: Cross-sectional study. Patients with NTG or primary open-angle glaucoma (POAG) but without any anti-glaucoma treatment and the control group were collected from June 2016 to March 2017 at Beijing Tongren Hospital affiliated to Capital Medical University. Measurements of 24-h intraocular pressure, central corneal thickness, mean visual field damage, visual axis, blood pressure and body mass index and ocular ultrasound scans were performed...
November 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
X M Wang, X H Sun, Y Dai, X M Kong, Y H Chen
Objective: To investigate the characteristics of impairment of the visual field (VF) and retinal nerve fiber layer (RNFL) and the differences of progression pattern of early, middle and late stages of primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) , and to analyze the correspondence of structure and function. Methods: Cross-sectional study. POAG patients, NTG patients and healthy volunteers who were enrolled from February 2008 to May 2017 at Department of Ophthalmology, Eye & ENT Hospital of Fudan University, underwent basic ophthalmic examination, Humphrey central 24-2 threshold test and optical coherence tomography...
November 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Fritz H Hengerer, Gerd U Auffarth, Christoffer Riffel, Ina Conrad-Hengerer
INTRODUCTION: The aim of this study was to assess 36-month outcomes after cataract surgery and implantation of two second-generation trabecular micro-bypass stents (iStent inject, Glaukos Corporation, San Clemente, CA, USA) into eyes with predominantly primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PEX). METHODS: This prospective, non-randomized, consecutive cohort study included eyes with POAG (n = 60), PEX (n = 15), appositional narrow-angle (n = 4), pigmentary (n = 1), or neovascular (secondary) (n = 1) glaucoma and cataract requiring surgery...
December 2018: Ophthalmology and Therapy
Mark J Gallardo, Richard A Supnet, Iqbal Ike K Ahmed
Purpose: The aim of this study was to compare the 1-year efficacy and safety profile of ab-interno canaloplasty (ABiC) when performed as a stand-alone procedure or as an adjunct to cataract extraction in reducing IOP and glaucoma medication dependence. Patients and methods: This retrospective, comparative, consecutive case series included patients with uncontrolled primary open-angle glaucoma (POAG) who underwent ABiC as a stand-alone procedure or in conjunction with cataract extraction...
2018: Clinical Ophthalmology
Yuhong Chen, Chen Qiu, Shaohong Qian, Junyi Chen, Xueli Chen, Li Wang, Xinghuai Sun
To investigate the association of known candidate genes with the visual field (VF) progression of primary open angle glaucoma (POAG) in a Han Chinese population. We included 440 POAG patients in this study. Fourteen previously reported single nucleotide polymorphisms (SNPs) at five different gene regions ( TGFBR3-CDC7 , TMCO1 , CDKN2B-AS1 , ATOH7 , and SIX1/SIX6 ) were genotyped. Age at diagnosis, gender, intraocular pressure (IOP), mean defect (MD) of VF, vertical cup disk ratio (VCDR), best corrected visual acuity (BCVA), central corneal thickness (CCT), and axial length (AL) were recorded at baseline...
2018: Frontiers in Genetics
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