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Félix Gil-Carrasco, Daniel Ochoa-Contreras, Marco A Torres, Jorge Santiago-Amaya, Fidel W Pérez-Tovar, Roberto Gonzalez-Salinas, Luis Nino-de-Rivera
Purpose: To determine the effect on intraocular pressure of transpalpebral specific exogenous voltages in a cohort of open-angle glaucoma patients. Methods: This is a prospective, comparative, and experimental pilot study. The electrical stimuli applied consisted of 10 Hz, biphasic, nonrectangular current pulses (100  μ A) delivered from an isolated constant current stimulator. At intake, baseline IOP measurements were obtained from each eye. The measurement was repeated before and after microstimulation until the end of the treatment...
2018: Journal of Ophthalmology
Zhongjing Lin, Shouyue Huang, Ping Huang, Changwei Li, Zhenghua Chen, Yisheng Zhong
The present study aimed to assess the concordance of 24-h intraocular pressure (IOP) curves between glaucomatous and contralateral eyes for patients with untreated unilateral primary open-angle glaucoma (POAG). A total of 32 patients with unilateral POAG and 32 age-matched normal subjects were enrolled. The IOP measurements were performed every 2 h over a 24-h period. The concordance of the 24-h IOP curves was assessed via the correlation coefficient (r), intraclass correlation coefficient (ICC) and repeated-measures analysis of variance (ANOVA)...
August 2018: Experimental and Therapeutic Medicine
Natalia Ivanovna Kurysheva, Lyudmila Vyacheslavovna Lepeshkina, Ekaterina Olegovna Shatalova
PURPOSE: To evaluate the efficacy of selective laser trabeculoplasty (SLT) for patients with primary angle closure glaucoma (PACG) following a YAG laser peripheral iridotomy (PI) in comparison with primary open angle glaucoma (POAG) and to assess the predictors of outcome of SLT. PATIENTS AND METHODS: In retrospective study 68 patients with PACG after PI (68 eyes) and 74 POAG patients (74 eyes) were observed for 6 years. The effectiveness of SLT (20% reduction of intraocular pressure) was assessed using Kaplan-Meier survival analysis...
August 14, 2018: Journal of Glaucoma
Xiaojiao Yu, Chunlin Chen, Min Sun, Denghao Dong, Shuoji Zhang, Pei Liu, Rongdi Yuan, Jian Ye
PURPOSE: To assess the safety and efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) combined with phacoemulsification in patients with primary open-angle glaucoma (POAG) and visually significant cataracts. MATERIALS AND METHODS: This was a prospective, uncontrolled, interventional case series. Seventeen patients (17 eyes) diagnosed with POAG and cataracts were enrolled starting in November 2015. All subjects underwent CLASS combined with phacoemulsification surgery by the same surgeon...
August 14, 2018: Journal of Glaucoma
Friederike Lindemann, David Kuerten, Eva Koch, Matthias Fuest, Claudia Fischer, Andreas Voss, Niklas Plange
PURPOSE: Vascular dysfunction and ischemia are believed to play an important part in the pathogenesis of glaucoma and especially of normal tension glaucoma (NTG). The aim of the present study was to analyze the blood pressure (BP) and heart rate variability patterns in patients with primary open-angle glaucoma (POAG) and NTG compared with controls. METHODS: In total, 37 patients with POAG, 27 patients with NTG, and 82 control subjects were included in a prospective clinical validation study...
August 15, 2018: Current Eye Research
Weiye Wang, Sayoko Moroi, Kelly Bakulski, Bhramar Mukherjee, Marc G Weisskopf, Debra Schaumberg, David Sparrow, Pantel S Vokonas, Howard Hu, Sung Kyun Park
BACKGROUND: Oxidative stress may play an important role in the etiology of primary open-angle glaucoma (POAG). The association between risk of POAG and lead exposure, which is an environmental source of oxidative stress, has not been fully investigated yet. OBJECTIVE: Our objective was to determine the association between bone lead-a biomarker of cumulative lead dose (tibia lead) or an endogenous source of stored lead (patella lead)-and incident POAG. METHODS: We examined a prospective cohort of 634 POAG-free men [mean baseline age=66...
August 2018: Environmental Health Perspectives
Rohit C Khanna, Gudlavalleti V S Murthy, Pyda Giridhar, Srinivas Marmamula, Hira B Pant, Ghanshyam Palamaner Subash Shantha, Subhabrata Chakrabarti, Clare E Gilbert, Gullapalli Nageswara Rao
AIM: To evaluate glaucoma-associated mortality in a rural cohort in India. METHODS: The study cohort comprised individuals aged 40 years and above who took part in the Andhra Pradesh Eye Disease Study (APEDS1) during 1996-2000. All participants underwent detailed comprehensive eye examination. Glaucoma was defined using International Society of Geographic and Epidemiologic Ophthalmology criteria. This cohort was followed up after a decade (June 2009 to January 2010; APEDS2)...
August 12, 2018: British Journal of Ophthalmology
Sunee Chansangpetch, Kevin Lau, Claudio I Perez, Ngoc Nguyen, Travis C Porco, Shan C Lin
PURPOSE: To evaluate the effectiveness of trabecular microbypass stent (iStent) implantation in combined mechanism glaucoma (CMG). DESIGN: Retrospective cohort study METHODS: We reviewed the medical charts of patients with the following scenarios: (1) primary open angle glaucoma (POAG) undergoing phacoemulsification (PE), (2) POAG undergoing PE with iStent (POAG-PE/iStent), (3) CMG undergoing PE (CMG-PE), and (4) CMG undergoing PE with iStent (CMG-PE/iStent). CMG was defined as narrow angle glaucoma patients whose angle had opened after iridotomy...
August 8, 2018: American Journal of Ophthalmology
Hung-Yu Wang, Ping-Tao Tseng, Brendon Stubbs, Andre F Carvalho, Dian-Jeng Li, Tien-Yu Chen, Pao-Yen Lin, Yu-Te Hsueh, Yu-Zhen Chen, Yen-Wen Chen, Che-Sheng Chu
BACKGROUND: The aim of current study was to conduct a systematic review and meta-analysis to explore the relationship between antidepressant use and glaucoma. METHODS: Eight major electronic databases were searched from inception until March 19th, 2018 to obtain relevant studies that evaluated associations of antidepressants [including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs)] treatment and the risk of primary open-angle glaucoma (POAG) or primary angle-closure glaucoma (PACG) as well as intraocular pressure (IOP), and related anterior chamber parameters compared to participants not exposed to antidepressant treatment...
July 31, 2018: Journal of Affective Disorders
Elaine M Wells-Gray, Stacey S Choi, Mark Slabaugh, Paul Weber, Nathan Doble
PURPOSE: To examine the microstructural changes in the inner nuclear layer (INL) and ganglion cell layer (GCL) in a primary open angle glaucoma (POAG) patient at 2 time points, 4 months apart. PATIENTS AND METHODS: This case-control study (one POAG patient and one normal control) used the single cell, three-dimensional volumetric imaging capability of an adaptive optics-optical coherence tomography-scanning laser ophthalmoscopy system to examine the inner retina...
August 7, 2018: Journal of Glaucoma
Kaweh Mansouri, Kevin Gillmann, Harsha L Rao, Jacopo Guidotti, André Mermoud
PURPOSE: To compare the safety and efficacy of XEN gel implant surgery (Allergan Inc., Irvine, USA) in patients with pseudoexfoliative glaucoma (PEXG) and primary open angle glaucoma (POAG). SETTING: Prospective, interventional study in a tertiary glaucoma center. METHODS: Fifty-seven eyes (43 patients) with POAG and 53 eyes (42 patients) with PEXG with uncontrolled intraocular pressure (IOP) despite medical treatment underwent combined XEN+cataract surgery or standalone XEN surgery...
August 7, 2018: Journal of Glaucoma
Tadamichi Akagi, Linda M Zangwill, Takuhei Shoji, Min Hee Suh, Luke J Saunders, Adeleh Yarmohammadi, Patricia Isabel C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To evaluate microvasculature dropout in the optic disc (Mvd-D) using optical coherence tomography angiography (OCTA) and investigate factors associated with Mvd-D in primary open-angle glaucoma (POAG) eyes. METHODS: One hundred twenty-three eyes of 123 POAG patients were included from the Diagnostic Innovations in Glaucoma Study. The 3.0×3.0-mm optic nerve head OCTA scans were acquired using a spectral-domain OCT instrument. Images with whole-signal-mode were evaluated...
2018: PloS One
Julian Garcìa-Feijoo, Helmut Höh, Rossen Uzunov, Jaime E Dickerson
PURPOSE: The aim of the study was to report longer term (24-month) outcomes for primary open-angle glaucoma (POAG) patients refractory to medical therapy implanted with a supraciliary microstent (CyPass Micro-Stent, Alcon) in the DUETTE clinical study. METHODS: Sixty-five eyes were enrolled in this multicenter single-arm trial. Enrolled patients had POAG and intraocular pressure (IOP) >21 mmHg at baseline on 1-4 ocular hypotensive medications. Microstent implantation was performed as stand-alone surgery in these phakic or pseudophakic patients through a standard clear corneal approach...
August 3, 2018: Journal of Ocular Pharmacology and Therapeutics
Stuart MacGregor, Jue-Sheng Ong, Jiyuan An, Xikun Han, Tiger Zhou, Owen M Siggs, Matthew H Law, Emmanuelle Souzeau, Shiwani Sharma, David J Lynn, Jonathan Beesley, Bronwyn Sheldrick, Richard A Mills, John Landers, Jonathan B Ruddle, Stuart L Graham, Paul R Healey, Andrew J R White, Robert J Casson, Stephen Best, John R Grigg, Ivan Goldberg, Joseph E Powell, David C Whiteman, Graham L Radford-Smith, Nicholas G Martin, Grant W Montgomery, Kathryn P Burdon, David A Mackey, Puya Gharahkhani, Jamie E Craig, Alex W Hewitt
Intraocular pressure (IOP) is currently the sole modifiable risk factor for primary open-angle glaucoma (POAG), one of the leading causes of blindness worldwide1 . Both IOP and POAG are highly heritable2 . We report a combined analysis of participants from the UK Biobank (n = 103,914) and previously published data from the International Glaucoma Genetic Consortium (n = 29,578)3,4 that identified 101 statistically independent genome-wide-significant SNPs for IOP, 85 of which have not been previously reported4-12 ...
August 2018: Nature Genetics
Keith R Martin, Kaweh Mansouri, Robert N Weinreb, Robert Wasilewicz, Christophe Gisler, Jean Hennebert, Dominique Genoud
PURPOSE: To test the hypothesis that contact lens sensor (CLS)-based 24-hour profiles of ocular volume changes contain information complementary to intraocular pressure (IOP) to discriminate between primary open angle glaucoma (POAG) and healthy (H) eyes. DESIGN: Development and evaluation of a diagnostic test with machine learning. SUBJECTS: From 435 subjects (193 healthy and 242 POAG), 136 POAG and 136 age-matched healthy subjects were selected...
July 24, 2018: American Journal of Ophthalmology
Anna Leszczynska, Lisa Ramm, Eberhard Spoerl, Lutz E Pillunat, Naim Terai
Introduction: To investigate the effect of acupuncture on different ocular blood flow (OBF) parameters in patients with primary open-angle glaucoma (POAG). Patients and methods: In a prospective, randomized study, 56 POAG patients were randomly assigned either to an eye-specific acupuncture (group I, n=28) or to an eye-unspecific acupuncture treatment (group II, n=28). Blood flow parameters were measured before and 10 minutes after treatment. Parapapillary retinal blood flow was determined by the Heidelberg retina flowmeter...
2018: Clinical Ophthalmology
Dan Călugăru, Mihai Călugăru, Ştefan Ţălu
AIM: To prospectively evaluate the cumulative prevalence and the management of ocular hypertension (OH) in patients with unilateral acute central/hemicentral retinal vein occlusions (C/HCRVOs) over the course of 3y. METHODS: The study included 57 patients with unilateral acute C/HCRVOs. All patients underwent a comprehensive ophthalmological examination of both eyes. OH associated with C/HCRVO in patients showing a score >5% for the risk of conversion to primary open angle glaucoma (POAG) was treated with OH medication...
2018: International Journal of Ophthalmology
Pei-Wen Lin, Hsueh-Wen Chang, Jih-Pin Lin, Ing-Chou Lai
AIM: To analyze the diagnostic capabilities of peripapillary retinal nerve fiber layer (pRNFL) thickness and segmented inner macular layer (IML) thickness measured by spectral-domain optical coherence tomography for detection of early glaucoma. METHODS: Fifty-three patients with primary open angle glaucoma (POAG), 60 patients with normal tension glaucoma (NTG) and 32 normal control subjects were enrolled. Thicknesses of pRNFL, total macular layers (TML), and the IML, including macular RNFL (mRNFL) and macular ganglion cell layer (mGCL) were assessed...
2018: International Journal of Ophthalmology
Jung Hee In, So Yeon Lee, Seok Ho Cho, Young Jae Hong
Purpose: To evaluate the microvascular changes at the peripapillary area and optic disc in glaucomatous eyes after IOP lowering by trabeculectomy using OCT angiography. Methods: 25 patients with primary open-angle glaucoma (POAG) who underwent trabeculectomy by a single surgeon were evaluated. Using optical coherence tomography angiography, vessel density was evaluated within the whole image, peripapillary, nasal region, and temporal region. Peripapillary vessel density was measured preoperative, 1 week, 1 month, and 3 months postoperatively in POAG patients...
2018: Journal of Ophthalmology
Joshua S Hardin, Christopher I Lee, Lydia F Lane, Christian C Hester, R Grant Morshedi
PURPOSE: Corneal hysteresis (CH) is a corneal biomechanical property measured by the ocular response analyzer (ORA). It is associated with primary open-angle glaucoma development, progression, and severity as well as intraocular pressure (IOP) measurement. Decreases in CH and changes in IOP measurements have been described for laser-assisted refractive surgery; however, patients with prior radial keratotomy (RK) have not been examined. We have performed a cohort study examining CH and intraocular pressure measurements (Goldmann applanation and ORA values including Goldmann-correlated and cornea-compensated IOP [adjusted for corneal hysteresis]) in RK patients and myopic controls with POAG...
July 23, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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