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Pieter W M Bonnemaijer, Adriana I Iglesias, Girish N Nadkarni, Anna J Sanyiwa, Hassan G Hassan, Colin Cook, Mark Simcoe, Kent D Taylor, Claudia Schurmann, Gillian M Belbin, Eimear E Kenny, Erwin P Bottinger, Suzanne van de Laar, Susan E I Wiliams, Stephen K Akafo, Adeyinka O Ashaye, Linda M Zangwill, Christopher A Girkin, Maggie C Y Ng, Jerome I Rotter, Robert N Weinreb, Zheng Li, R Rand Allingham, Abhishek Nag, Pirro G Hysi, Magda A Meester-Smoor, Janey L Wiggs, Michael A Hauser, Christopher J Hammond, Hans G Lemij, Ruth J F Loos, Cornelia M van Duijn, Alberta A H J Thiadens, Caroline C W Klaver
Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans. So far, worldwide efforts to elucidate the genetic complexity of POAG in African populations has been limited. We conducted a genome-wide association study in 1113 POAG cases and 1826 controls from Tanzanian, South African and African American study samples. Apart from confirming evidence of association at TXNRD2 (rs16984299; OR[T] 1...
October 13, 2018: Human Genetics
L A Svetikova, E N Iomdina, N Y Ignatyeva, A N Serik, S F Migal, N A Nazarova
PURPOSE: To study the connective tissue (CT) structure of upper eyelid skin of primary open-angle glaucoma (POAG) patients. PATIENTS AND METHODS: Forty-seven patients aged 47-91 expecting blepharoplasty formed 3 groups: group 1 [16 subjects without POAG, median age 55 years (interquartile range 54-55.5)], group 2 [12 subjects without POAG, median age 73 (72-76.5)], and group 3 [(19 subjects with POAG, median age 74 (70-80.5)]. Age differences between groups 1 and 2 and groups 1 and 3 are significant (p < 0...
October 12, 2018: International Ophthalmology
Tomomi Higashide, Tsubasa Nishino, Kimikazu Sakaguchi, Yutaro Yamada, Kazuhisa Sugiyama
PURPOSE: To investigate factors associated with decreased corneal endothelial cell density (ECD) after trabeculectomy with mitomycin C (MMC). METHODS: Retrospective review of consecutive glaucoma cases who underwent trabeculectomy with MMC. The types of glaucoma included were primary open angle glaucoma (POAG), exfoliation glaucoma (XFG), neovascular glaucoma (NVG), and uveitic glaucoma (UG). The postoperative ECD changes compared to the preoperative ECD and risk factors for ECD decrease were analyzed using mixed-effects models...
October 11, 2018: Journal of Glaucoma
Pooja Patel, Alon Harris, Carol Toris, Leslie Tobe, Matthew Lang, Aditya Belamkar, Adrienne Ng, Alice C Verticchio Vercellin, Sunu Mathew, Brent Siesky
Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and visual field loss. Some speculate that gender plays a role in the risk of developing POAG and that the physiologic differences between men and women may be attributed to the variable effects of sex hormones on intraocular pressure (IOP), ocular blood flow, and/or neuroprotection. Estrogen, in the form of premenopausal status, pregnancy, and post-menopausal hormone therapy is associated with increase in ocular blood flow, decrease in IOP and neuroprotective properties...
October 11, 2018: Journal of Glaucoma
Yingcai Tan, Dingding Zhang, Bo Gong, Xiaohuan Zhang, Linxin Jiang, Ying Lin
OBJECTIVE: To assess the association of single nucleotide polymorphisms (SNP) rs547984, rs540782, rs693421 and rs2499601 of Zona Pellucida Glycoprotein 4 (ZP4) gene with primary open-angle glaucoma (POAG) among ethnic Han Chinese from Sichuan Province. METHODS: A dye terminator-based SNaPshot method was used to genotype 336 patients with POAG and 768 healthy controls. RESULTS: No significant difference was detected in allelic frequencies of rs547984, rs540782, rs693421 and rs2499601 between the two groups (P>0...
October 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Carla N Urata, Livia S Mazzoli, Niro Kasahara
Purpose: Falls are very prevalent in the older population. Visually impaired elderly patients are prone to falls as the result of visual loss and ageing. The purpose of the study was to compare the fear of falling (FoF) between primary open angle glaucoma (POAG) and age-related macular degeneration (ARMD) patients who live in a developing country. Methods: This was a cross-sectional observational study. After a complete eye examination including measurement of best-corrected visual acuity, ophthalmoscopy, and automated visual field, all subjects completed the Fall Efficacy Scale International Brazil (FES-I-Brazil) questionnaire...
September 2018: Translational Vision Science & Technology
Allison R Loiselle, Emile de Kleine, Pim van Dijk, Nomdo M Jansonius
The theory that glaucoma patients have a lower intracranial pressure (ICP) than healthy subjects is a controversial one. The aim of this study was to assess ICP noninvasively by determining the relationship between distortion product otoacoustic emission (DPOAE) phase and body position and to compare this relationship between patients with primary open angle glaucoma (POAG), patients with normal tension glaucoma (NTG), and controls. The relationship was also calibrated using published data regarding invasive measurements of ICP versus body position...
2018: PloS One
Xikun Han, Emmanuelle Souzeau, Jue-Sheng Ong, Jiyuan An, Owen M Siggs, Kathryn P Burdon, Stephen Best, Ivan Goldberg, Paul R Healey, Stuart L Graham, Jonathan B Ruddle, Richard A Mills, John Landers, Anna Galanopoulos, Andrew J R White, Robert Casson, David A Mackey, Alex W Hewitt, Puya Gharahkhani, Jamie E Craig, Stuart MacGregor
Importance: The p.Gln368Ter (rs74315329) risk allele in the myocilin gene (MYOC) was initially reported to have high penetrance in glaucoma registry-based studies, but much lower estimates were recently obtained from population-based studies. We investigated this disparity using data from Australia and the United Kingdom. Objectives: To examine the penetrance and effect size of the MYOC p.Gln368Ter variant with glaucoma and ocular hypertension (OHT). Design, Setting, and Participants: This cross-sectional study within the UK Biobank (UKBB) included participants of white British ancestry...
September 27, 2018: JAMA Ophthalmology
Ikuyo Chono, Dai Miyazaki, Hitomi Miyake, Naoki Komatsu, Fumie Ehara, Daisuke Nagase, Yukimi Kawamoto, Yumiko Shimizu, Ryuichi Ideta, Yoshitsugu Inoue
Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery. To accomplish this, we determined the profiles of pro-inflammatory cytokines in the aqueous humor of 101 glaucoma patients; 31 primary open angle glaucoma (POAG), 38 pseudoexfoliation glaucoma (PEG), and 32 neovascular glaucoma (NVG). We also studied 100 normal subjects as controls. In eyes with POAG or PEG, the level of interleukin (IL)-1α, IL-2, IL-4, IL-8, IL-23, and CCL2 were significantly elevated...
September 28, 2018: Scientific Reports
Anselm G M Jünemann, Bernhard Michalke, Marianna Lucio, Anwar Chaudhri, Ursula Schlötzer-Schrehardt, Robert Rejdak, Marek Rękas, Bettina Hohberger
PURPOSE: Selenium supplementation was seen to be linked to glaucoma disease in a previous study (Lillico A. JE, Reid M et al. (2002) Selenium Supplementation and Risk of Glaucoma in the NPC trial University of Arizona, Tucson, AZ., Arizona Cancer Center). As aqueous humor levels of selenium seemed to be associated with primary open-angle glaucoma (POAG), the aim of this study was to analyze concentrations of selenium in aqueous humor samples of patients with POAG and pseudoexfoliation glaucoma (PEXG) in comparison to normal samples...
December 2018: Journal of Trace Elements in Medicine and Biology
Tanuj Dada, Deepti Mittal, Kuldeep Mohanty, Muneeb A Faiq, Muzaffer A Bhat, Raj K Yadav, Ramanjit Sihota, Talvir Sidhu, Thirumurthy Velpandian, Mani Kalaivani, Ravindra M Pandey, Ying Gao, Bernhard A Sabel, Rima Dada
BACKGROUND: Reducing intraocular pressure (IOP) in primary open angle glaucoma (POAG) is currently the only approach to prevent further optic nerve head damage. However, other mechanisms such as ischemia, oxidative stress, glutamate excitotoxicity, neurotrophin loss, inflammation/glial activation, and vascular dysregulation are not addressed. Because stress is a key risk factor affecting these mechanisms, we evaluated if mindfulness based stress reduction (MBSR) can lower IOP and normalize typical stress biomarkers...
September 25, 2018: Journal of Glaucoma
Nicole A Restrepo, Sarah M Laper, Eric Farber-Eger, Dana C Crawford
BACKGROUND: Glaucoma is a leading cause of blindness in developed countries. Primary open-angle glaucoma (POAG), the most prevalent clinical subtype of glaucoma in the United States, affects African Americans at a higher rate compared with European Americans. Risk factors identified for POAG include increased age and family history, which coupled with heritability estimates, suggest this complex condition is associated with genetic and environmental factors. To date, several genome-wide studies have identified loci significantly associated with POAG risk, but most of these studies were performed in populations of European-descent...
September 14, 2018: BMC Medical Genomics
Mohammad Arish, Omid Bagherzadeh, Seyed Sajad Ahmadi, Javad Sadeghi-Allahabadi, Samira Hassanzadeh
This study was performed to assess the short-term effect of sutureless scleral tunnel trabeculectomy procedure with and without topical bevacizumab. Thirty patients with Primary Open-Angle Glaucoma (POAG) were enrolled and randomly divided to two groups. Patients in the first group (15 patients) underwent sutureless trabeculectomy without topical bevacizumab and patients in the second group (15 patients) underwent sutureless trabeculectomy with 1.25 mg of topical bevacizumab. Intraocular Pressure (IOP) of both groups was measured by an expert ophthalmologist, without awareness of the patient's study group before the operation and six months post-operatively...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Ji-Ah Kim, Eun Ji Lee, Hyunjoong Kim, Tae-Woo Kim
The degree of visual field (VF) loss can vary widely at a given level of retinal nerve fiber layer (RNFL) thickness. The cause of this variability is not fully understood. This cross-sectional study investigated whether the presence of choroidal microvasculature dropout (MvD) influences on the structure-function relationship among glaucomatous eyes. Seventy-one primary open-angle glaucoma (POAG) patients with choroidal MvD as determined by optical coherence tomography angiography (MvD+ group), and 71 age- and inferotemporal (IT) RNFL thickness-matched POAG patients without MvD (MvD- group) were included...
September 21, 2018: Scientific Reports
Hemma Resch, Christoph Mitsch, Ivania Pereira, Florian Schwarzhans, Lorenz Wasserman, Anton Hommer, Andreas Reitner, Clemens Vass
PURPOSE: Optic nerve head (ONH) parameters as well as circumpapillary retinal nerve fibre layer (RNFL) thickness values measured with two different spectral domain optical coherence tomography (SD-OCT) machines (Spectralis® and Cirrus® OCT) have been compared between two patient groups, primary open-angle glaucoma (POAG), nonarteritic anterior ischaemic optic neuropathy (NAION) and healthy controls. A comparison of the performance of the two OCT machines was made. METHODS: Twenty healthy controls, 20 POAG and 20 NAION patients with comparable visual field defects were included...
September 21, 2018: Acta Ophthalmologica
Seulggie Choi, Jin A Choi, Jin Woo Kwon, Sang Min Park, Donghyun Jee
Due to the rapidly increasing life-expectancy, the prevalence of glaucoma has increased steadily in recent years. We aimed to evaluate the patterns of care and primary treatment strategy patterns in Korea according to glaucoma subtypes to assess the quality of care for glaucoma patients.In this serial cross-sectional survey, the claims data from the Korean National Health Insurance Service was used to identify and group glaucoma patients into primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), other types of glaucoma, and ocular hypertension from 2002 to 2013...
September 2018: Medicine (Baltimore)
Jordan Stanley, Carrie E Huisingh, Thomas A Swain, Gerald McGwin, Cynthia Owsley, Christopher A Girkin, Lindsay A Rhodes
PURPOSE: To determine the level of adherence to the American Academy of Ophthalmology (AAO) preferred practice pattern (PPP) guidelines for quality primary open angle glaucoma (POAG) and POAG suspect (POAGS) care among retail-based optometrists. METHODS: Patients with a diagnosis of POAG or POAGS who participated in a telemedicine pilot project were included. Patients' charts were evaluated for 15 elements of PPP guidelines for glaucoma care. Results were further stratified by number of follow-up visits and diagnosis...
September 18, 2018: Journal of Glaucoma
Sung Uk Baek, Jin-Soo Kim, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate, in primary open-angle glaucoma (POAG) and healthy subjects, the pattern and magnitude of diurnal variation in macular choroidal thickness (mCT). METHODS: A prospective study was conducted on Koreans comprising 21 patients with POAG and 17 healthy subjects. All underwent mCT, systemic blood pressure (BP), and intraocular pressure (IOP) measurements during the daytime at five time points (8 AM, 11 AM, 2 PM, 5 PM and 8 PM). The mCT was determined at five sites using swept-source optical coherence tomography...
September 18, 2018: Journal of Glaucoma
João Barbosa-Breda, Karel Van Keer, Luis Abegão-Pinto, Vahid Nassiri, Geert Molenberghs, Koen Willekens, Evelien Vandewalle, Amândio Rocha-Sousa, Ingeborg Stalmans
PURPOSE: Vascular factors have been suggested to influence the development and progression of glaucoma. They are thought to be especially relevant for normal-tension glaucoma (NTG) patients. We aim to investigate which vascular factors, including advanced vascular examinations, better describe patients with NTG comparing to those with primary open-angle glaucoma (POAG). METHODS: The Leuven Eye Study database (182 NTG and 202 POAG patients; similar structural and functional damage) was used to compute three multivariate logistic regression models: a conventional model (conventional parameters only, including vascular-related self-reported phenomena, such as migraine or peripheral vasospasm); an advanced vascular model (advanced vascular parameters only: colour Doppler imaging (CDI), retinal oximetry, ocular pulse amplitude and choroidal thickness); and a global model, in which both types of parameters were allowed...
September 17, 2018: Acta Ophthalmologica
Miroslav Stamenkovic, Vesna Lukic, Sonja Suvakov, Tatjana Simic, Ivan Sencanic, Marija Pljesa-Ercegovac, Vesna Jaksic, Sinisa Babovic, Marija Matic, Aleksandra Radosavljevic, Ana Savic-Radojevic, Tatjana Djukic
AIM: To evaluate glutathione transferase theta 1 and mu 1 ( GSTT1 and GSTM1 ) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t -test or χ 2 test...
2018: International Journal of Ophthalmology
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