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Cardiac carcinoid

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https://www.readbyqxmd.com/read/30467193/fifty-seven-year-old-man-with-progressive-dyspnoea
#1
Nikoloz Koshkelashvili, Priya Kohli, Jason Linefsky
CLINICAL INTRODUCTION: A 57-year-old man from the USA with a history of atrial fibrillation and hypertension was evaluated for progressive dyspnoea and decreased energy. The patient denied a history of congestive heart failure, systemic symptoms or myocardial infarction. He was found to have a 3/6 holosystolic murmur radiating to the axilla. Transthoracic echocardiography (TTE) reported a reduced ejection fraction of 40%, mitral valve regurgitation and absence of interatrial shunts. The remaining cardiac valves were without abnormality...
November 22, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30415870/a-prospective-study-of-the-pathophysiology-of-carcinoid-crisis
#2
Mary E Condron, Nora E Jameson, Kristen E Limbach, Ann E Bingham, Valerie A Sera, Ryan B Anderson, Katie J Schenning, Shaun Yockelson, Izumi Harukuni, Edward A Kahl, Elizabeth Dewey, SuEllen J Pommier, Rodney F Pommier
BACKGROUND: Sudden massive release of serotonin, histamine, kallikrein, and bradykinin is postulated to cause an intraoperative carcinoid crisis. The exact roles of each of these possible agents, however, remain unknown. Optimal treatment will require an improved understanding of the pathophysiology of the carcinoid crisis. METHODS: Carcinoid patients with liver metastases undergoing elective abdominal operations were studied prospectively, using intraoperative, transesophageal echocardiography, pulmonary artery catheterization, and intraoperative blood collection...
November 8, 2018: Surgery
https://www.readbyqxmd.com/read/30375927/cardiac-ct-angiography-in-carcinoid-heart-disease
#3
Ali A Alsaad, Carlos A Rojas
No abstract text is available yet for this article.
October 30, 2018: Radiology
https://www.readbyqxmd.com/read/30352418/intraoperative-carcinoid-syndrome-during-small-bowel-neuroendocrine-tumour-surgery
#4
Myrtille Fouché, Yves Bouffard, Mary-Charlotte Legoff, Johanne Prothet, François Malavieille, Pierre Sagnard, Françoise Christin, Davy Hayi-Slayman, Arnaud Pasquer, Gilles Poncet, Thomas Walter, Thomas Rimmelé
Only few descriptions of Intraoperative carcinoid syndrome (ioCS) have been reported. The primary objective of this study was to describe ioCS. A second aim was to identify risk factors of ioCS. We retrospectively analyzed patients operated for small-bowel neuroendocrine tumour in our institution between 2007 and 2015, and receiving our preventive local regimen of octreotide continuous administration. ioCS was defined as highly-probable in case of rapid (<5min) arterial blood pressure changes ≥ 40%, not explained by surgical/anaesthetic management and regressive ≥ 20% after octreotide bolus injection...
October 1, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/30344876/-asystole-during-surgery-to-manage-small-intestine-cancer-are-we-dealing-with-anaphylaxis-or-carcinoid-crisis
#5
Ismail Aissa, Aziz Benakrout, Mohamed Meziane, Mustapha Bensghir, Salim Jaafar Lalaoui
Cardiac arrest in the operating room is a life-threatening event with multiple causes. We report the case of a 53-year old female patient with no particular past medical history scheduled for surgery to manage small intestine cancer. Twenty minutes after anesthetic induction the patient had asystole rapidly reversible after resuscitation measures. The association of face rash with chest rash gave rise to suspicion of late anaphylactic reaction. Rapid patient recovery allowed to resume surgical procedure. Tumor manipulation immediately caused a second severe bradycardia rapidly reversible after the administration of 0...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30227376/gastric-carcinoid-tumor-after-laparoscopic-gastric-banding-case-report-of-a-patient-with-weight-regain
#6
Daniel N Velasco Hernández, Santiago B De Battista, Héctor R Horiuchi, Maria M Zicavo
INTRODUCTION: Although carcinoid tumours are a rare gastrointestinal neoplasm with an incidence rate of 1-2.5 cases per 100 000 inhabitants, they are the most common neuroendocrine tumour of the stomach. PRESENTATION OF CASE: A 70-year-old-man consulted for epigastric pain and dyspepsia symptoms. His past medical and surgical history included obesity (BMI: 53.9 kg/m2 ), hypertension, hyperlipidemia, diabetes mellitus type 2, cardiac failure and a surgical treatment with laparoscopic gastric banding...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30184038/quadruple-valve-replacement-for-carcinoid-heart-disease
#7
Syed Saleem Mujtaba, Stephen Clark
INTRODUCTION: Carcinoid heart disease most frequently involves the tricuspid or, more rarely, the pulmonary valve and presents with right heart failure as 5-HT is metabolized by the lung. Left-sided valve involvement is quite rare. We describe our experience of 3 patients presenting with heart failure secondary to carcinoid heart disease affecting all four cardiac valves. There are only four previous isolated case reports in the literature. METHODS: All three patients underwent quadruple valve replacement during a single operation...
July 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/30098723/carcinoid-heart-disease-a-review
#8
REVIEW
Aimee R Hayes, Joseph Davar, Martyn E Caplin
Carcinoid heart disease remains a major cause of morbidity and mortality among patients with carcinoid syndrome and metastatic neuroendocrine tumors. Screening of all patients with N-terminal pro-B-type natriuretic peptide and transthoracic echocardiography is critical for early detection, as early symptoms and signs have low sensitivity for the disease. Cardiac surgery, in appropriate cases, is the only definitive therapy for advanced carcinoid heart disease, and it improves patient symptoms and survival. Management of carcinoid heart disease is complex, and multidisciplinary assessment of cardiac status, hormonal syndrome, and tumor burden is critical in guiding optimal timing of surgery...
September 2018: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/30080311/exercise-cardiac-magnetic-resonance-imaging-with-pulmonary-artery-catheter-monitoring-in-carcinoid-heart-disease-a-shift-towards-early-intervention
#9
Philippe Timmermans, Filip Rega, Jan Bogaert, Marie-Christine Herregods
Neuroendocrine tumours are a rare malignancy, which can be complicated by a carcinoid syndrome and, in more rare cases, also valve destruction. The correct timing for surgical repair remains unknown. We report the first-in-men exercise cardiac magnetic resonance imaging with pulmonary artery catheter measurements in order to better understand the haemodynamic impact of isolated tricuspid valve insufficiency in a low symptomatic patient. Not pressure but volume overload is the key factor in the development of symptoms, as long as the right ventricular function is intact...
October 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29976295/neoplasia-and-the-heart-pathological-review-of-effects-with-clinical-and-radiological-correlation
#10
REVIEW
Joseph J Maleszewski, Melanie C Bois, John P Bois, Philip M Young, John M Stulak, Kyle W Klarich
The intersection of oncological and cardiovascular diseases is an increasingly recognized phenomenon. This recognition has led to the emergence of cardio-oncology as a true subspecialty. This field is not simply limited to primary cardiac tumors or complications of chemotherapeutic medications. Rather, it also encompasses metastatic cardiovascular complications and secondary cardiovascular effects of the underlying neoplasia. This review will broadly cover primary and metastatic cardiac neoplasms, as well as secondary cardiovascular effects of extracardiac neoplasia (e...
July 10, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29916914/somatostatin-receptor-pet-ct-features-of-carcinoid-heart-disease
#11
Saurabh Arora, Averilicia Passah, Nishikant A Damle, Rajiv Narang, Atul Sharma, Madhav P Yadav, Sanjana Ballal, Dinkar Bhasin, Chandrasekhar Bal
We present the case of a 35-year-old woman with metastatic neuroendocrine tumor undergoing treatment with long-acting octreotide and Lu-DOTATATE therapy. We present features of carcinoid heart disease on Ga-DOTANOC PET/CT, which revealed dilated right atrium, pericardial effusion, ascites, and congestive hepatopathy apart from the metastatic lesions in the liver. The scan cardiac findings were confirmed by echocardiography. This highlights the significance of identifying such patients early because additional management is required for carcinoid heart disease per se and a cautious approach is needed in administering amino acid infusion during PRRT that can result in fluid overload...
August 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29914291/the-path-to-surgery-in-carcinoid-heart-disease-a-retrospective-study-and-a-multidisciplinary-proposal-of-a-new-algorithm
#12
Philippe Mortelmans, Marie-Christine Herregods, Filip Rega, Philippe Timmermans
BACKGROUND: Development of carcinoid heart disease (CHD) is the major negative prognostic factor in patients with the carcinoid syndrome. The only effective treatment is valve replacement. However, the selection of candidates and determination of optimal timing remain unclear. Considerable variability in local screening and treatment strategies exist. METHODS: In this single-centre study, we retrospectively analysed the diagnostic process and outcome of all CHD patients who underwent valve surgery between 2000 and 2016...
June 18, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29607196/metastatic-small-bowel-neuroendocrine-tumour-and-carcinoid-heart-disease-with-aortic-valve-involvement-a-rare-occurrence
#13
Siang Yuin Lee, Sheila Li, Karan Sian, Rosauro Mejia
Carcinoid disease of the heart commonly affects the tricuspid and pulmonary valves causing thickening and stenosis. However in very rare circumstances, the disease can also involve the mitral and aortic valves. We present an unusual case of left sided carcinoid heart disease (CHD) and triple valve replacement without the presence of proven intra-cardiac shunts or bronchial carcinoid lesions.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29600100/unusual-cardiac-paraganglioma-mimicking-an-atypical-carcinoid-tumor-of-the-lung
#14
Dean Spencer, Mark Evans, Beverly Wang, J Lawrence Delrosario, Timmy Cheng, Jeffrey Milliken
We present a case of unusual cardiac paraganglioma (PG) initially misdiagnosed as atypical carcinoid tumor of the lung and discuss key clinical and pathologic characteristics that guide surgical management of these rare chromaffin cell tumors. A 64-year-old female with persistent cough and back pain was found to have a 4 cm × 3 cm mass abutting multiple cardiopulmonary structures. A biopsy was performed at an outside institution and pathology reported "atypical neuroendocrine carcinoma, consistent with carcinoid"...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29527003/a-case-of-carcinoid-syndrome-due-to-malignant-metastatic-carcinoid-tumor-with-carcinoid-heart-disease-involving-four-cardiac-valves
#15
Brianna J Shinn, Laura J Tafe, Pantila Vanichakarn
BACKGROUND Carcinoid tumor, benign, low-grade malignant, and high-grade malignant, can be associated with the release of vasoactive substances that cause symptoms including cutaneous flushing, diarrhea, and bronchospasm. In 50-60% of patients with carcinoid syndrome, the vasoactive substances cause fibrosis of the pulmonary and tricuspid heart valves which lead to regurgitation and right-sided heart failure. The right side of the heart is usually affected because monoamine oxidases in the lungs usually inactivate the vasoactive substances...
March 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29509220/valvular-unvolvement-in-carcinoid-disease-a-case-report
#16
Saoussen Antit, Lilia Zakhama, Sarra Chenik, Mohamed Saadi, Ahmed Houmed, Samar Mohamed, Elhem Boussabeh, Moez Thameur, Soraya Ben Youssef
Carcinoid tumors are rare, mainly located in the gastrointestinal tract particularly in the small intestine. Cardiac involvement, fairly frequent and usually affecting right sided heart valves, had a poor prognosis that is improved by an earlier detection and valve surgery. We report the case of a 50-years old woman with neuroendocrine tumor and liver metastases, in whom carcinoid involvement of the right heart was diagnosed following exertional dyspnea. She had dilated right cavities, severe tricuspid regurgitation, mild tricuspid stenosis and a moderate pulmonary stenosis...
May 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29485963/carcinoid-heart-disease-early-outcomes-after-surgical-valve-replacement-in-nine-patients
#17
Syed Saleem Mujtaba, Stephen Clark
AIM: To describe the early outcomes of carcinoid patients undergoing surgical heart valve replacement. METHODS: In a retrospective study, records of patients with symptomatic carcinoid heart disease referred for valve surgery between 2012 and 2016 were reviewed. The perioperative and early postoperative outcomes were analyzed. RESULTS: Nine patients, with a mean age of 61 years (range 55-70 years) underwent cardiac surgery for carcinoid syndrome...
February 16, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29386066/carcinoid-heart-disease-revealed-by-cyanosis-with-both-right-and-left-valvular-involvement-a-case-report
#18
Khadija Khay, Salim Arous, Tarik Bentaoune, Abdenasser Drighil, Rachida Habbal
BACKGROUND: Carcinoid heart disease is a frequent complication of carcinoid syndrome. It is related to the release by the carcinoid tumor and/or its metastases of bioactive substances such as serotonin. It is characterized by right-sided valvular involvement and can lead to right-sided heart failure. It is a prognostic factor of carcinoid syndrome. CASE PRESENTATION: We report the case of a 53-year-old African woman with an endocrine tumor of her small intestine complicated by carcinoid heart disease, revealed by right-sided heart failure...
January 31, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29302947/fenfluramine-phentermine-is-associated-with-an-increase-in-cellular-proliferation-ex-vivo-and-in-vitro
#19
COMPARATIVE STUDY
Nalini M Rajamannan
BACKGROUND AND AIM OF THE STUDY: Fenfluraminephentermine (FenPhen) has been implicated in accelerated valvular heart disease, characterized by valvular regurgitation and thickening, and resembling the histopathologic lesions found in carcinoid. The study aim was to determine whether cellular proliferation is present in FenPhen-exposed valves, by utilizing an in-vitro model to test whether FenPhen has a direct mitogenic effect on cardiac valvular cells, as compared to serotonin. METHODS: Ex-vivo valves were tested for proliferation in surgically removed FenPhen-exposed valves (n = 10) and compared to proliferation levels in normal human cardiac valves removed at autopsy (n = 10)...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29141071/usefulness-of-total-12-lead-qrs-voltage-as-a-clue-to-diagnosis-of-patients-with-cardiac-sarcoidosis-severe-enough-to-warrant-orthotopic-heart-transplant
#20
William C Roberts, Tiffany M Becker, Shelley A Hall
Importance: Severe heart failure caused by cardiac sarcoidosis is difficult to diagnosis without biopsy. Objective: To assess whether total electrocardiographic 12-lead QRS voltage may be a clue to diagnosis. Design, Setting, Participants: Case-series study with cases collected at Baylor University Medical Center at Dallas, Dallas, Texas, from January 13, 2005, to January 24, 2017. The clinical records of 16 patients with severe heart failure caused by cardiac sarcoidosis were studied...
January 1, 2018: JAMA Cardiology
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