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metastasis in breast of renal cell carcinoma

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https://www.readbyqxmd.com/read/30522116/potential-role-of-microrna-183-as-a-tumor-suppressor-in-hepatocellular-carcinoma
#1
Wei Bian, Hongfei Zhang, Miao Tang, Shaojun Zhang, Lichao Wang, Longlong Liu, Wenyao Wang
BACKGROUND/AIMS: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC)...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30483771/mir%C3%A2-122-promotes-proliferation-and-invasion-of-clear-cell-renal-cell-carcinoma-by-suppressing-forkhead-box-o3
#2
Wenyuan Nie, Dong Ni, Xin Ma, Yu Zhang, Yu Gao, Cheng Peng, Xu Zhang
MicroRNAs (miRNAs) serve an important role in renal cancer, but renal cancer miRNA expression data remains inconsistent. Therefore, there is a requirement for integrated analysis of these data. An increasing number of studies demonstrate that miR‑122 is dysregulated in numerous cancer types, including liver, lung and breast cancer, yet its role in clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, an integrated analysis of four ccRCC miRNAs expression datasets was performed and the expression of miR‑122 in the present cohort was validated...
November 19, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30470124/asynchronous-tumour-quadruplicity-rectosigmoid-adenocarcinoma-renal-cell-carcinoma-prostate-adenocarcinoma-and-neuroendocrine-small-cell-lung-cancer-a-case-report
#3
R Adwan, P Prošvic, J Prošvicová, M Tomšová
INTRODUCTION: Multiple tumors belong to rare cancers. Almost all malignancies may occur in combination, the most common combination being gastrointestinal cancer with respiratory or urogenital tract cancer and with breast cancer in females. CASE REPORT: In 1999, a 66-year-old patient was diagnosed with a rectosigmoid tumor histologically proven as adenocarcinoma. Rectosigmoid resection was performed, followed by adjuvant radiotherapy and the Mayo Clinic FU/FA chemotherapy regimen...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/30396926/modified-nucleosides-molecular-markers-suitable-for-small-volume-cancer
#4
Philipp Opitz, Olf Herbarth, Annerose Seidel, Andreas Boehm, Milos Fischer, Christian Mozet, Andreas Dietz, Gunnar Wichmann
BACKGROUND: Modified nucleosides (mNS) in urine are shown to be encouraging markers in cancer, mostly in patients presenting with high tumor mass such is breast and lung cancer. To our knowledge, mNS have not been investigated in head and neck squamous cell carcinoma (HNSCC). HNSCC is characterized by early metastasis into locoregional lymph nodes and slow infiltrating growth, but even in the advanced stage exhibits only a relatively low cancer volume. Therefore, reliable distinction between HNSCC and healthy controls by urinary mNS might pose substantial analytical problems and even more as patients with HNSCC mostly have an increased exposure to tobacco smoke and excessive alcohol consumption which affect the renal mNS pattern...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30367684/predictive-factors-for-adrenal-metastasis-in-extra-adrenal-malignancy-patients-with-solitary-adrenal-mass
#5
Kyeong-Hyeon Byeon, Yun-Sok Ha, Seock-Hwan Choi, Bum Soo Kim, Hyun Tae Kim, Eun Sang Yoo, Tae Gyun Kwon, Jun Nyung Lee, Tae-Hwan Kim
BACKGROUND AND OBJECTIVES: The adrenal gland is a frequent site for metastasis, and a solitary adrenal mass is often observed during staging workup or imaging follow-up in patients with extra-adrenal malignancy. To create an appropriate management plan, it is essential to distinguish between benign adrenal lesions and metastasis in patients with extra-adrenal cancer having solitary adrenal masses. Therefore, here we evaluated the predictive factors for adrenal metastasis in patients with extra-adrenal malignancy having solitary adrenal mass...
October 27, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30261576/clear-cell-acanthoma-on-the-areola
#6
Luis J Borda, Joshua S Mervis, Paolo Romanelli, Hadar Lev-Tov
Clear cell acanthoma (CCA) is a rare, benign cutaneous condition most often seen on the lower extremities. Lesions are of variable morphology and have been described as polypoid, pigmented, giant, and cystic lesions. Although no racial or gender predilection has been reported, CCA on the breast is a very rare finding that has been observed mainly in young Korean women. Herein, we describe a case of CCA of the areola in an elderly woman with metastatic renal cell carcinoma. Physical exam revealed a pink plaque with central erosions on the left areola...
July 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/30131915/not-your-usual-suspect-clear-cell-renal-cell-carcinoma-presenting-as-ulcerative-esophagitis
#7
Saeed Ali, Basher Atiquzzaman, Konrad Krall, Ranjeet Kumar, Bo Liu, Shantel Hebert-Magee
Renal cell carcinoma (RCC) has the propensity to hematogenously metastasize to the lung, bone, or liver, however, metastasis to the esophagus is exceedingly rare. We report a case of ulcerative esophagitis secondary to recurrent metastatic renal cell cancer status post remote nephrectomy. An 82-year-old Caucasian male presented with dark tarry stools for two days, progressive dysphagia to solid food for several weeks and unintentional weight loss. His past medical history was significant for hypertension, diverticulosis and right-sided renal cell cancer for which he underwent nephrectomy 13 years ago...
June 18, 2018: Curēus
https://www.readbyqxmd.com/read/30121715/management-of-brain-metastases-in-the-new-era-of-checkpoint-inhibition
#8
REVIEW
Adam Lauko, Bicky Thapa, Vyshak Alva Venur, Manmeet S Ahluwalia
PURPOSE OF THE REVIEW: Brain metastasis is a common complication of advanced malignancies, especially, lung cancer, breast cancer, renal cell carcinoma, and melanoma. Traditionally surgery, when indicated, and radiation therapy, either as whole-brain radiation therapy or stereotactic radiosurgery, constituted the major treatment options for brain metastases. Until recently, most of the systemic chemotherapy agents had limited activity for brain metastases. However, with the advent of small molecule tyrosine kinase inhibitors and immunotherapy agents, there has been renewed interest in using these agents in the management of brain metastases...
August 18, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/30105309/podocalyxin-is-crucial-for-the-growth-of-oral-squamous-cell-carcinoma-cell-line-hsc-2
#9
Shunsuke Itai, Shinji Yamada, Mika K Kaneko, Masato Sano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Kayo Hisamatsu, Yoshimi Nakamura, Yoshikazu Furusawa, Masato Fukui, Tomokazu Ohishi, Manabu Kawada, Hiroyuki Harada, Yukinari Kato
Oral cancers constitute approximately 2% of all cancers, with the most common histological type being oral squamous cell carcinoma (OSCC), representing 90% of oral cancers. Although diagnostic technologies and therapeutic techniques have progressed, the survival rate of patients with OSCC is still 60%, whereas the incidence rate has increased. Podocalyxin (PODXL) is a highly glycosylated type I transmembrane protein that is detected in normal tissues such as heart, breast, and pancreas as well as in many cancers, including lung, renal, breast, colorectal, and oral cancers...
September 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/30023978/where-do-these-guests-come-from-a-diagnostic-approach-for-metastatic-lymph-nodes
#10
Yelda Dere, Sümeyye Ekmekçi, Serkan Çelik, Özgür İlhan Çelik, Özcan Dere, Volkan Karakuş
Objective: In cases presenting with lymphadenopathies (LAP) without a primary focus detected by simple radiological methods, the primary tumor can be diagnosed by a histopathological evaluation of the metastatic lymph nodes. We aimed to discuss the nonhematological malignancies presenting with lymphadenopathies and the histopathological results for primary tumors. Material and Methods: In this retrospective study, cases diagnosed with metastasis in excisional lymph nodes between January 2013 and June 2016 were assessed for a histopathological diagnostic approach...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29928489/smad-proteins-directly-suppress-pax2-transcription-downstream-of-transforming-growth-factor-beta-1-tgf-%C3%AE-1-signalling-in-renal-cell-carcinoma
#11
Gagandeep Kaur, Caiyun Grace Li, Andrew Chantry, Cherie Stayner, Julia Horsfield, Michael R Eccles
Canonical TGF-β1 signalling promotes tumor progression by facilitating invasion and metastasis, whereby release of TGF-β1, by (for example) infiltrating immune cells, induces epithelial to mesenchymal transition (EMT). PAX2, a member of the Paired box family of transcriptional regulators, is normally expressed during embryonic development, including in the kidney, where it promotes mesenchymal to epithelial transition (MET). PAX2 expression is silenced in many normal adult tissues. However, in contrast, PAX2 is expressed in several cancer types, including kidney, prostate, breast, and ovarian cancer...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928349/kdm3a-is-not-associated-with-metastasis-and-prognosis-of-breast-cancer
#12
Juan Yao, Shutao Zheng, Baiyan Li, Xinxin Li, Wenya Liu
Lysine demethylase 3A (KDM3A), also known as JMJD1A, has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. However, little is known regarding the clinicopathological significance of KDM3A expression in breast cancer (BCa). To investigate the clinical relevance of KDM3A expression in the setting of BCa, immunohistochemistry was performed on a tissue microarray consisting of 150 commercially available BCa samples. No significant correlation was identified between KDM3A expression and various clinicopathological variables, including clinical stage, pathological grade, tumor size and the expression statuses of human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928210/intramammary-metastasis-in-a-patient-with-a-history-of-renal-cell-carcinoma-a-case-report
#13
Miyuki Kitahara, Yasuo Hozumi, Rio Asada, Aya Sawa, Hitoaki Saito, Tatsuo Iijima
Intramammary metastasis of renal cell carcinoma (RCC) is extremely rare, accounting for only 1.5% of all intramammary metastases. Distinguishing intramammary metastases from benign tumors and breast cancer is clinically problematic. Some patients undergo excessive surgery after a misdiagnosis of breast cancer instead of a mammary tumor. We performed a core needle biopsy (CNB) of a breast mass that developed in a 71-year-old woman after surgeries for bilateral RCC and breast cancer, leading to a diagnosis of intramammary metastasis of RCC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29903571/role-of-cxcl12-and-cxcr4-in-the-pathogenesis-of-hematological-malignancies
#14
Amnon Peled, Shiri Klein, Katia Beider, Jan A Burger, Michal Abraham
The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in many type of tumors including lymphoma, leukemia, glioma, and prostate, breast, colorectal, renal, and hepatocellular carcinomas...
September 2018: Cytokine
https://www.readbyqxmd.com/read/29896402/oral-metastasis-of-renal-cell-carcinoma-mimicking-recurrence-of-excised-malignant-myoepithelioma-a-case-report
#15
Yoshihiro Morita, Takaki Iwagami, Chisato Kawakita, Yukiko Kusuyama, Atsuko Niki-Yonekawa, Nobuo Morita
Following breast and lung cancers, renal cell carcinoma (RCC) is the third most frequent cancer to metastasize to the head and neck region, though such cases are rarely reported. Distinguishing between malignant tumors of salivary gland origin and metastatic RCC is very important. The case of a 75-year-old man with an oral cavity lesion in the left buccal submucosa measuring 40×30 mm that had grown substantially over several weeks is presented. His medical history included left kidney cancer 26 years earlier and a malignant myoepithelioma of the left buccal region 7 years earlier...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29708403/detection-of-unknown-primary-tumor-in-patients-presented-with-brain-metastasis-by-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#16
Zehra Pınar Koç, Pelin Özcan Kara, Ahmet Dağtekin
AIM:  F-18 fluorodeoxyglucose (FDG) PET/CT has several advantages in diagnosis of cancer of unknown primary with reported incremental diagnostic value. In this study, we evaluated the patients who were presented with multiple brain metastasis and unknown primary tumor. MATERIALS & METHODS: 31 patients (17 males, 14 females; mean: 56.1 ± 14.22 years old) with diagnosis of brain metastasis according to histopathology and/or MRI were included into this retrospective study...
April 2018: CNS Oncology
https://www.readbyqxmd.com/read/29692595/unusual-presentation-of-renal-cell-carcinoma-a-rare-case-report
#17
Manjari Kishore, Devender Singh Chauhan, Shruti Dogra
Cutaneous and intraoral metastasis from any malignancy is not common. Cutaneous spread is usually noted in 5%-10% of high-grade malignancies, as in carcinoma breast, lung, colon, ovary, and malignant melanoma. Only 4.6% cases of cutaneous spread are from renal cell carcinoma (RCC). Intraoral spread from RCC is much rarer with an incidence of approximately 1% of all malignant oral tumors, noted sometimes in tongue, palate, buccal mucosa, gingiva, and lips. RCC is a highly aggressive tumor which requires early diagnosis for increasing the chance of cure...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29657704/successful-treatment-of-three-synchronous-primary-malignant-tumours-reflection-on-surgical-pathological-and-oncological-aspects-and-decision-making
#18
Emese Irma Ágoston, Áron Somorácz, Lilla Madaras, Attila Zaránd, Gyöngyvér Szentmártoni, Zsuzsanna Orosz, Magdolna Dank, Zsolt Baranyai
We report a case of a patient with triple synchronous primary malignancies (breast, colon, kidney) which has not been previously reported in the literature. A 70-year-old woman was diagnosed with invasive ductal carcinoma of the left breast with axillary lymph node metastasis. During the staging period, renal cell carcinoma on the left kidney and mucinous adenocarcinoma in the proximal colon were found. Since the breast tumour demonstrated favourable biology, aromatase inhibitor therapy had been started and simultaneous right colectomy and left nephrectomy was performed...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29604529/renal-cell-metastasis-to-the-thyroid-gland-an-emerging-phenomenon
#19
Catherine E Connolly
INTRODUCTION: Suspected thyroid malignancies are usually assumed to be primary in origin. Rarely, in 1-3% of cases, the tumour arises from a secondary source such as a melanoma or breast carcinoma. There is a growing body of research concerning metastatic spread of renal cell carcinoma to the thyroid gland. PRESENTATION OF CASE: This case report describes the presentation and diagnostic work-up of an 84yr male presenting with a goitre and hoarse voice. Histopathological examination of the excised 95 × 65 × 55 mm tissue mass revealed metastatic clear cell renal cell carcinoma...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29435287/secondary-tumours-of-the-ampulla-of-vater-case-report-and-review-of-the-literature
#20
Francesca Sarocchi, Magdalena M Gilg, Florian Schreiber, Cord Langner
Secondary tumours of the ampulla of Vater are rare. Underlying primary tumours, clinical presentation, macroscopic appearance, treatment strategies and outcome of secondary ampullary lesions have not been systematically analysed. The present case study reported a 57-year old patient with an ampullary metastasis from renal cancer and a literature review was performed in which a further 32 patients were included. The most common responsible primary tumours were malignant melanoma and renal clear cell carcinoma, followed by breast cancer...
February 2018: Molecular and Clinical Oncology
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